Disease

Leukoplakia

About the Disease
Leukoplakia, also known as leukoplakia of oral epithelium, is related to oral leukoplakia and lip and oral cavity cancer. An important gene associated with Leukoplakia is DKC1 (Dyskerin Pseudouridine Synthase 1), and among its related pathways/superpathways are COPI-independent Golgi-to-ER retrograde traffic and Keratinization. The drugs Rosiglitazone and Aminolevulinic acid have been mentioned in the context of this disorder. Affiliated tissues include tongue, cervix and bone marrow, and related phenotype is Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435).

Common Targets
TYR | G5743 | BCL11A | G3630 | CYP1A1 | GSTM1 | PPARG | Carbonic Anhydrase (nonspecified subtype)

疾病靶点研报
Leukoplakia

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