Interstitial Cystitis

About the Disease
Interstitial Cystitis, also known as painful bladder syndrome, is related to chronic pain and low compliance bladder, and has symptoms including unspecified symptom associated with female genital organs, mittelschmerz and pain and other symptoms associated with female genital organs. An important gene associated with Interstitial Cystitis is P3H4 (Prolyl 3-Hydroxylase Family Member 4 (Inactive)), and among its related pathways/superpathways are Signal Transduction and Overview of interferons-mediated signaling pathway. The drugs Hesperidin and Polidocanol have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and smooth muscle, and related phenotypes are abnormality of the menstrual cycle and abnormality of the urethra

Common Targets
Protein Phosphatase 2B | IL10 | G114548 | CRBN | G3576 | G7124 | CYSLTR1 | Gamma-Aminobutyric acid type B receptor | FGFR2 | HER (erbB) (nonspecified subtype) | G3620 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | BTK | NPM1 | SLC22A12 | IL1B | FKBP1A | CNR2 | PPP3R2 | Lipoxygenase (nonspecified subtype) | P2RX3 | G3569 | PPP3CC | ADRB3 | SLC6A2 | NF-kappaB (NFkB) | TRPV2 | Interleukin-12 (IL-12) | TRPV1 | Prostanoid TP receptor (nonspecified subtype) | SIX5 | FAAH | RORB | Sodium channel (nonspecified subtype) | CYSLTR2 | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | GUCY2C | SLC6A4 | PPP3CB | AGTR2 | HCAR2 | IL2 | PPP3R1 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | NR3C1 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | VDR | MIF | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | ALOX5 | INPP5D | G5743 | IFNG | FGF2 | NGF

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