Stroke, Ischemic

About the Disease
Stroke, Ischemic, also known as cerebral infarction, is related to sneddon syndrome and brain small vessel disease 1, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Stroke, Ischemic is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Diseases of hemostasis. The drugs Heparin, bovine and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include Bone and Brain, and related phenotypes are stroke and homeostasis/metabolism

Common Targets
GLP1R | PTAFR | HLF | G5743 | CAPN2 | SENP3 | KMO | MicroRNA 4792 | KCNQ2 | F12 | MGP | CCDC159 | NLRP3 Inflammasome | MIR130B | PGAP1 | LOC105375175 | TCF7L2 | GRIN2B | NPR3 | CUBN | MIR4432 | RNLS | PM20D1 | KCNJ11 | MIRLET7I | RPS6KA4 | DNASE1 | TNFSF4 | CARD8 | ALOX15 | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | Superoxide dismutase (SOD) (nonspecified subtype) | SLC12A2 | KLHL31 | MTHFR | Phosphodiesterase (nonspecified subtype) | CYP19A1 | CGAS | MIR149 | MMP1 | MIR4698 | GSTP1 | SCN5A | PRDX1 | HMOX1 | SCN2A | TBXAS1 | UGT1A10 | CD36 | CAT | MAS1L | PROKR2 | Glutamate Receptor Ionotropic AMPA Receptor | PROC | LINC01394 | CETP | ADK | SELE | PHACTR1 | G7422 | ADAMTS7 | LPL | MIR150 | TNFRSF11B | P2RY1 | CASP7 | RGS7 | Prolyl 4-hydroxylase | RTN4R | LRP6 | NAPA | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | MIR320A | MTCL1 | PIK3CG | FFAR4 | Proteasome Complex | SLC9A1 | MIR323B | HRH3 | Na+/H+ Exchanger (NHE) (nonspecified subtype) | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | PLBD2 | XRCC1 | G5243 | CYP3A4 | VWF | CACNA1B | P2RX1 | G5599 | CTNNB1 | PUF60 | NTRK2 | HLA-DMA | SERPINA3 | G6647 | EDNRA | MPO | TRAF2 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | G6714 | ATP6V0A4 | PDE4D | KCNAB2 | ADGRF1 | GPR35 | XIRP1 | XPC | GCH1 | ZPR1 | RPS6KA2 | m-Calpain | MIR200B | TLR7 | GHRL | Kainate Receptor (GluR) (nonspecified subtype) | Integrin alpha4beta1 (VLA-4) receptor | THSD4 | COMMD7 | SNORD78 | ZNF778 | NGFR | Calpain (nonspecified subtype) | IL10 | SKIC2 | LDLR | CALD1 | MIR933 | KNG1 | NOTCH3 | HP | RAC1 | HACD4 | TTR | SMG6 | GJA4 | PTPRD | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | FKBP4 | AVPR1A | TBPL1 | CAMSAP3 | Voltage-gated K(v) channel (nonspecified subtype) | XPNPEP1 | PTPRS | BDNF | ABL1 | GRIK1 | ABCA7 | PTGES | G114548 | ST3GAL3 | COX3 | CRBN | RYR1 | SLC18A2 | MC1R | F13A1 | HLA-DQB1 | TMCC3 | gamma-Secretase | APOA5 | CPS1 | CELF1 | IPCEF1 | NR1I3 | JCAD | G3576 | SRR | KCNA3 | TPP1 | BSG | TRAF3 | GRIN1 | GRM5 | GAS5 | L-type voltage-dependent calcium channel complex | CASS4 | NOS1AP | Cyclophilins (nonspecified subtype) | SFRP2 | GLIS3 | XPNPEP2 | EPHA1-AS1 | WNT2B | POR | AQP4 | ORAI1 | PTGER3 | Endothelin-Converting Enzymes (ECE) (nonspecified subtype) | IL12B | CYP2D6 | P4HA3 | ITGA2 | NUP210 | ANKS1A | SCNN1A | Tyrosine-Protein Kinases Src (nonspecified subtype) | SMO | G5594 | PTGIR | JAK2 | AHCY | NOS1 | P2RY2 | GNB3 | CEP170B | UBR3 | ALOX5AP | ADRA1A | CSK | Interleukin-1 (nonspecified subtype) | LGALS3 | MIR34A | ADTRP | PLA2G4A | MIR4268 | TRPV4 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | IKBKB | DRD4 | OPRK1 | MIR4277 | SLC17A3 | CYSLTR1 | SKIC3 | IL1RN | RPS6KA3 | CYP2C19 | THBS2 | FLG | G7015 | FGFR2 | GP1BA | ITGA2B | G7124 | DLGAP4 | C-X-C Chemokine Receptor CXCR1/CXCR2 (IL-8 Receptor) (nonspecified subtype) | VKORC1 | DGAT2 | MGLL | AGT | SLC35E1 | AVPR1B | MIR492 | LPAR1 | ADIPOQ | AMP-activated protein kinase (AMPK) | MIR155 | HDAC6 | Integrin alphavbeta3 (vitronectin) receptor | CD2AP | LOC105375733 | RTN4 | KCNQ3 | Calcium release-activated channel (CRAC) | Phospholipase A2 (nonspecified subtype) | PLCL1 | ICAM4 | G3620 | ACSL1 | PIP5K1B | HLA-DOA | Steroid 5-alpha-Reductase (nonspecified subtype) | EPHX2 | ALOX12 | AMBP | HDAC5 | MIR494 | Hedgehog Protein (nonspecified subtype) | NTN4 | G3725 | CA1 | T-Type Calcium Channel | COL4A1 | CALM1 | KCTD2 | PDE1C | MAPK11 | IMPA2 | ND1 | JMJD1C | HDAC7 | URAHP | HIF1A | APLNR | C5 | GSTO1 | MMAB | ROCK1 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | G6774 | OPRM1 | MIR2117 | BAK1 | Heat shock protein 90 (nonspecified subtype) | MIR495 | HRH2 | CA12 | RAPGEF2 | IGFBP1 | UBE2Z | SLC22A3 | LPAL2 | CIRBP | MIR596 | SIGMAR1 | Alpha-2 Adrenergic receptors (nonspecified subtype) | MMP3 | CHRM1 | G6352 | Ribonucleoside-diphosphate reductase | ANXA5 | G3479 | IL-1 Receptor (nonspecified subtype) | ACE | ELANE | LOC102724428 | MIR497 | MIR122 | PINX1 | HTR4 | MED12L | CASR | CFDP1 | PLAA | MAPK12 | KCNK2 | NINJ2 | NOX4 | FLJ30679 | MIR143 | TF | ALDH2 | G842 | LCK | Alcohol Dehydrogenase (nonspecified subtype) | PIM3 | SPG21 | LIPA | MIR34B | LSM3 | PPARA | Integrin Receptor (nonspecified subtype) | Calcium channel (nonspecified subtype) | LTA | TRAF6 | F3 | NRF1 | GP5 | G5728 | CNR2 | IL1B | G1432 | MMP12 | ALPK1 | PDGFRL | TCF21 | CHFR | Lipoxygenase (nonspecified subtype) | IL4R | TGFB1 | CLU | Matrix Metalloproteinase (MMP) (nonspecified subtype) | LDHAL6A | PDE9A | CDK5 | PSMA6 | Glutamate Transporter (nonspecified subtype) | Calcium-Activated K(Ca) Potassium Channel (nonspecified subtype) | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | DHX15 | PUM1 | RHPN1 | ADD1 | CXCR1 | ADAM17 | HHIPL1 | TNFSF11 | PTGIS | Myosin Class II (nonspecified subtype) | SLC6A9 | PSRC1 | FGA | PANX1 | KEAP1 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | MTHFD1L | SLC44A2 | G3569 | MIR605 | ESR2 | APOC3 | CYP2C8 | Opioid receptor (nonspecified subtype) | NDRG2 | Neurotrophic Factor (nonspecified subtype) | Chloride channel (nonspecified subtype) | Raf kinase (nonspecified subtype) | MVK | ZFHX3 | PRKAG2 | AVPR2 | F10 | CACNA1C | PCSK9 | Guanylate cyclase (nonspecified subtype) | HTR1A | ADORA1 | LOC650157 | TRPM8 | CELSR1 | VCAM1 | PECAM1 | LOC105374207 | HMGCR | PTPRJ | SLC6A2 | MAP2K1 | BCR | PGAM5-KEAP1-NRF2 Complex | FERMT2 | ROS1 | G4780 | G23411 | CD14 | Adenosine deaminase (nonspecified subtype) | DRD2 | MTRR | NPPA | G6772 | NEDD4 | NPPA-AS1 | GPX1 | KCNE1 | MASP2 | CDKN2B-AS1 | NR1I2 | CCL11 | MIR124-1 | CHRNA7 | MIR21 | EDNRB | ANAPC11 | PGR | ADA | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | NF-kappaB (NFkB) | ABCA1 | CELSR2 | MIR34C | SETBP1 | HSD17B6 | ICAM1 | SELP | KCNC3 | NELFE | HLA-B | BCHE | G673 | MECOM | G7852 | CCNL2 | ZCWPW1 | CASP2 | PRKCH | MAP4K4 | SLC66A3 | Estrogen receptor (nonspecified subtype) | NPPB | P2RX4 | PSKH2 | TADA2B | CYP24A1 | ZNF208 | GCKR | GABA(A) receptor | SOD2 | MEF2C-AS1 | CNR1 | GALNT17 | CCR2 | DNAH11 | GSTO2 | MYH2 | NPY | DLG4 | P4HB | MAPK9 | CES1 | Na+/K+-ATPase (nonspecified subtype) | ND3 | PPARD | IGFBP3 | STAT5 (nonspecified subtype) | TRIM71 | ABCC9 | CD40 | PTK2B | MX1 | TRIM27 | VAPA | G581 | IL15RA | LOC100130987 | PTCH1 | SLC52A3 | TRIM46 | PDE4DIP | APAF1 | 15-Lipoxygenase (nonspecified subtype) | KCNA5 | TCN2 | FGB | OXT | CPB2 | SLC19A1 | MIR210 | PLAT | SNORD81 | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | Reverse transcriptase (Telomerase) | G142 | AKT2 | K(ATP) Channel (nonspecified subtype) | G7099 | LHCGR | FERMT3 | PLG | HLA-DRB1 | RYR2 | P2RY12 | MIR3922 | Pyruvate dehydrogenase kinase (nonspecified subtype) | AKR1B1 | CYP2R1 | ADORA2A | LRRC26 | SYK | TSPO | FBXL7 | MIR3622A | G9734 | COL4A2 | SMARCA4 | MIR627 | MME | NTNG1 | FOXF2 | CASP8 | G3605 | Voltage-Gated Sodium Channel Complex | WRAP53 | WDR12 | F2 | BDNF-AS | STMN4 | MIR3679 | CXCL1 | sigma Receptor (nonspecified subtype) | Heme Oxygenase (HO) (nonspecified subtype) | Class III phosphatidylinositol 3-kinase (PI3-kinase) sub-complex | ADORA3 | CYP2J2 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | NTSR1 | OPRD1 | SERPINE1 | CBS | RASIP1 | ANKS1B | CHN1 | CHRM3 | TRPV1 | MIR3674 | PPP5C | CHUK | Prostanoid TP receptor (nonspecified subtype) | LRP1 | CHSY1 | SNORD80 | KCNE3 | TRPM4 | LIPC | FOLH1 | CAPN1 | GCLM | MIR499B | Integrin alpha2beta3 Receptor | XDH | PIK3C3 | TNFRSF11A | GSTT1 | OGA | LINC02210-CRHR1 | LOC105372028 | MALAT1 | TRPM2 | GSK3B | PTGS1 | PTPN1 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | KCNE4 | ACHE | G9429 | HLA-A | Glycine receptor | CRYBA2 | EPOR | PPARG | NAA25 | SERPINF2 | NRXN2 | HDAC4 | F5 | CXCL2 | CYP3A5 | HNF1A | G3480 | IL5RA | Integrin alphaLbeta2 (LFA-1) receptor | PKM | GGT1 | ASB10 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | SST | PROKR1 | ABCC8 | MMP13 | CR1 | PAPPA | CRHR1 | PCK1 | BCAP29 | Caspase (nonspecified subtype) | ZC3HC1 | G2099 | KCNE2 | ST3GAL4 | PDE11A | MIR4669 | KIF21A | CHI3L1 | CHRM5 | FGFR1 | EFCAB12 | RNF126 | CLK1 | TXNRD1 | FGFR4 | GABRA5 | GRM1 | RAF1 | G3630 | MIPOL1 | KCNJ8 | L-Type calcium channel (nonspecified subtype) | KCNQ1 | VAMP8 | Sodium channel (nonspecified subtype) | LMOD1 | PATJ | Heat shock protein 70 (nonspecified subtype) | CISD1 | LIMASI | SHH | SLC2A1 | GMDS | PTGER1 | PTGES2 | GP6 | F2RL3 | KL | Adenosine receptor (nonspecified subtype) | CYP2C9 | FLT1 | TMEM97 | A1CF | FASN | SIK2 | G836 | CYSLTR2 | APOA1 | SLC24A4 | VCP | CYP4F2 | ITGB3 | HIF3A | Poly [ADP-ribose] polymerase (nonspecified subtype) | MAPK10 | KCNS3 | PON1 | ACYP2 | CTCFL | SLC2A9 | SGCZ | SRSF2 | ASIC1 | ECE1 | ERCC4 | PTPN22 | SNORD47 | KCNK17 | ADAMTS2 | AP-1 Transcription Factor Complex | CYP2B6 | LINC01094 | EGLN1 | NECTIN2 | SLC22A5 | HBEGF | GLB1L | PLAU | MMP8 | BAMBI | ASIC3 | ANXA1 | IL21 | Neurotensin receptor (nonspecified subtype) | IL1A | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | MIR126 | TBXA2R | TIMP2 | C14orf119 | ARHGEF10 | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | KCNH1 | G4318 | CDK5RAP3 | F11 | NOS3 | STK39 | Angiotensin receptor (AT) (nonspecified subtype) | LRRFIP1 | SEMA3A | VDAC2 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | CXCR2 | PEAR1 | TACR1 | MRAS | ATF6 | SMAD3 | G7157 | RAP1B | ITPKB | SIK1 | LIPE | LTC4S | PPM1A | SORL1 | ROCK2 | CYP4A11 | MIR4520-1 | RETN | HRH1 | Endothelin receptor (nonspecified subtype) | SLC6A4 | FGG | MTHFSD | LPA | SH2B3 | MAP2K2 | NLN | CXCL16 | F7 | RUVBL2 | Calcium/calmodulin-dependent protein kinase type II (CaMK-II) | CTSB | KLKB1 | SIRT7 | PDE5A | AGTR2 | RIPK3 | Gamma-glutamyl transferase (nonspecified subtype) | WT1 | APOB | APP | AGTR1 | ND5 | CASP1 | CASP6 | alpha-Amylase (nonspecified subtype) | ITCH | LOC105379030 | G3146 | IL2 | NMDA receptor | MIR146A | C3 | PANK1 | PARP2 | RGMA | PON2 | AGER | ABAT | PARG | MIA3 | SPSB3 | Glutamate Receptor Ionotropic (nonspecified subtype) | NT5E | Nitric oxide synthase (NOS) (nonspecified subtype) | GPR182 | KCNA2 | PGK1 | HNF4G | NQO1 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | MMP2 | MYH7B | DNAH14 | CNNM2 | IRAG1 | JMY | G367 | NLGN1 | Na+/Ca2+ Exchanger (NCX) (nonspecified subtype) | TERC | G4233 | ABCC1 | MS4A2 | PDE1A | P4HA2 | PLPP3 | MIR6843 | KRR1 | CYP2C18 | MYO5B | CCL2 | CRP | CX3CR1 | SLC8A1 | CYP11B2 | SLC1A2 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | SVIL | HTR2A | RPS6KA5 | PTPN11 | MIR196A2 | PIK3CA | TLR4/MD-2 complex | ADGRA2 | VAV3 | PRNP | MIR130A | GSTM1 | TAOK1 | ADH1C | ITPR1 | LTA4H | FCER1G | TRPA1 | Potassium Channels (nonspecified subtype) | VDR | LY96 | GLA | ECE2 | Rho kinase (ROCK) (nonspecified subtype) | OR2B6 | LINC00494 | KCNB1 | RIPK1 | Epoxide Hydrolase (nonspecified subtype) | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | RPS6KA1 | NOS2 | TLR9 | GNAZ | TERF1 | UCP2 | LLGL2 | OXTR | ALOX5 | LIPG | MIR499A | CCR5 | IL21R | MIR300 | SLC22A11 | INPP5D | S1PR1 | PDGFRA | mu-Calpain (calpain 1) | RHOA | VHL | SETD7 | EGLN3 | APOE | SHMT1 | SLC6A3 | MAOB | NGF

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