Thromboembolism

About the Disease
Thrombophilia Due to Thrombin Defect, also known as venous thromboembolism, is related to homocysteinemia and cerebral sinovenous thrombosis. An important gene associated with Thrombophilia Due to Thrombin Defect is F13A1 (Coagulation Factor XIII A Chain), and among its related pathways/superpathways are Collagen chain trimerization and Response to elevated platelet cytosolic Ca2+. The drugs Dronedarone and Norethisterone have been mentioned in the context of this disorder. Affiliated tissues include lung, spinal cord and liver, and related phenotypes are pulmonary embolism and deep venous thrombosis

Common Targets
TEC | CD3 Complex (T Cell Receptor Complex) | F9 | Prolyl 4-hydroxylase | HLA-E | CYP2D6 | F13A1 | ESR2 | EGFL8 | PTGER3 | BRD4 | ANO6 | PTGIR | P4HA3 | VKORC1 | AK4 | G2099 | F3 | ABCA1 | F10 | PCSK9 | F2 | AKR1B1 | MTHFR | Guanylate cyclase (nonspecified subtype) | SERPINE1 | IRAK4 | G1956 | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | NCK1 | KCNA5 | P4HB | PDE5A | P2RY12 | F5 | HTR2A | PRMT7 | KDM1A | G3569 | TLR9 | Kallikrein (nonspecified subtype) | CYP2C9 | GGCX | JAK2 | SLC26A2 | JAK3 | F11 | F2RL3 | KLKB1 | CYP4F2 | FTO | F7 | KCNA1 | CRP | Soluble guanylyl cyclase | TCF7L2 | P4HA2 | G7124 | ADRA2C | BTK | F12 | TBXAS1 | LPAR5 | CYP2C19 | PROC

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