Disease

Hereditary Xerocytosis

About the Disease
Dehydrated Hereditary Stomatocytosis 1 with or Without Pseudohyperkalemia and/or Perinatal Edema, also known as dehydrated hereditary stomatocytosis, is related to hereditary stomatocytosis and pseudohyperkalemia, familial, 2, due to red cell leak. An important gene associated with Dehydrated Hereditary Stomatocytosis 1 with or Without Pseudohyperkalemia and/or Perinatal Edema is PIEZO1 (Piezo Type Mechanosensitive Ion Channel Component 1), and among its related pathways/superpathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Disorders of transmembrane transporters. Affiliated tissues include spleen, monocytes and lung, and related phenotypes are increased red cell osmotic fragility and nonspherocytic hemolytic anemia

Common Targets
ABCB6 | KCNN4 | PIEZO1 | PROP1 | HBB

疾病靶点研报
Hereditary Xerocytosis

Note: If you'd like to get a target analysis report for Hereditary Xerocytosis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Hereditary Xerocytosis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Neurodevelopmental Disorders | Hypopituitarism | Eclampsia | Astrocytoma | Neurodermatitis | Hypoproteinemia, Hypercatabolic | Neural Tube Defect | Chronic Myeloid Leukemia | Motion Sickness | Toxic Epidermal Necrolysis | VEXAS Syndrome | Amblyopia | Spinal Muscular Atrophy Type 3 | Anxiety Disorders | Seborrheic Dermatitis | Brachial Plexus Neuropathy | Polycythemia | Atelosteogenesis Type 1 | Anemia | Basan Syndrome | Open-angle Glaucoma | Costello Syndrome | Dermatomyositis | Glycogen Storage Disease Type 1b | Progressive Encephalopathy-optic Atrophy Syndrome | Autoimmune Polyendocrinopathy Syndrome Type I | Avellino Corneal Dystrophy | Non-small Cell Lung Cancer | Usher Syndrome Type IIC | Galloway-Mowat Syndrome | Hydrocephalus, Normal Pressure | Ocular Albinism Type 1 | Cornelia De Lange Syndrome | Kaposi Sarcoma | Lipid Storage Myopathy | High Molecular Weight Kininogen Deficiency | Hashimoto Thyroiditis | Hypertrophy | Giant Cell Arteritis | Cancer, Kidney | Ocular Surface Squamous Neoplasia | Hairy Cell Leukemia | Vestibular Disease | Cutaneous Angiosarcoma | Acromicric Dysplasia | Primary Carnitine Deficiency | Agoraphobia | Auriculocondylar Syndrome | Splenomegaly | Sickle Cell Disease | Liddle Syndrome | Pulmonary Tuberculosis | Bartter Syndrome | Hyperphenylalaninemia | Fuchs Heterochromic Iridocyclitis | Metachondromatosis | Craniosynostosis | Angiosarcoma Of The Breast | Osteogenesis Imperfecta Type IV | Charcot-Marie-Tooth Disease Type 3 | Brenner Tumor | Ehlers-Danlos Syndrome | Osteoporosis | Cutis Laxa | Myosin Storage Myopathy | Papilledema | Adenoma, Pituitary | Blomstrand Osteochondrodysplasia | Perry Syndrome | H Syndrome | Dysfibrinogenemia | Congenital Hereditary Endothelial Dystrophy Type I | Calcium Pyrophosphate Deposition Disease | Niemann-Pick Disease, Type B | Optic Nerve Diseases | Mycosis Fungoides | Niemann-Pick Disease | Hyperinsulinemic Hypoglycemia | Diabetes Mellitus, Transient Neonatal | Spastic Paraplegia Type 7 | Shprintzen-Goldberg Syndrome | Low Phospholipid Associated Cholelithiasis | Gynecomastia | Bacterial Meningitis | Hepatic Veno-occlusive Disease | Pneumothorax | Metatropic Dysplasia | Oligoastrocytoma | Peters-plus Syndrome | Hyperinsulinism-hyperammonemia Syndrome | Carotid Artery Disease | Hoyeraal-Hreidarsson Syndrome | Niemann-Pick Disease, Type C | Noonan Syndrome-like Disorder With Loose Anagen Hair | Subcortical Band Heterotopia | Goiter | Cholecystitis | Charcot-Marie-Tooth Disease Type 2D | Tibial Muscular Dystrophy | Hypogonadism | Encephalopathy | Myoclonus | Seizures | Primary Pigmented Nodular Adrenocortical Disease | Osteomyelitis | Lymphoma, Follicular | Hyperhomocysteinemia | Malonyl-CoA Decarboxylase Deficiency | Meesmann Corneal Dystrophy | Pneumococcal Meningitis | Retinal Detachment | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Hereditary Inclusion Body Myopathy | Mitochondrial DNA Depletion Syndrome | Vascular Cognitive Impairment | Gyrate Atrophy Of The Choroid And Retina | Chorea | Nephronophthisis | Spinocerebellar Ataxia Type 1 | Myotonia | Episodic Ataxia | Uveitis, Anterior | Retinal Vasculitis | Primary Aldosteronism | Parapsoriasis | Larsen Syndrome | Anti-NMDA Receptor Encephalitis | Amelogenesis Imperfecta | 3-methylglutaconic Aciduria | Lipid Metabolism Disorders | Congenital Nephrotic Syndrome | Renal Tubular Acidosis | Reticular Dysgenesis | Spondylocarpotarsal Synostosis Syndrome | Cataplexy | Kabuki Syndrome 2 | Chronic Neutrophilic Leukemia | Tremor | Keratitis-ichthyosis-deafness Syndrome | Mitochondrial Myopathy | Bruck Syndrome | Cholera | Familial Glucocorticoid Deficiency | Giant Axonal Neuropathy | Chronic Enteropathy Associated With SLCO2A1 Gene | Proctitis | Inflammatory Bowel Disease | Gerodermia Osteodysplastica | Congenital Tufting Enteropathy | Chromosome 16p11.2 Deletion Syndrome | Lafora Disease | Molybdenum Cofactor Deficiency | Pneumoconiosis | Empyema | Corneal Dystrophy | MIRAGE Syndrome | Glutaric Aciduria Type 2 | X-linked Sideroblastic Anemia | Proteasome-associated Autoinflammatory Syndrome 2 | Paroxysmal Nocturnal Hemoglobinuria | Lymphedema | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Adrenoleukodystrophy, X-linked | Pierpont Syndrome | Pericarditis | Urticaria | Mastitis | Vitelliform Macular Dystrophy | Osteogenesis Imperfecta Type I | Charcot-Marie-Tooth Disease Type 4D | Cutaneous Lupus Erythematosus | HANAC Syndrome | Keratosis, Actinic | Erythromelalgia | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Amish Infantile Epilepsy Syndrome | DOCK8 Immunodeficiency Syndrome | Lymphoma, B-cell | Delirium | Parkinsonism | Bronchiolitis | Gastroenteritis | Pancytopenia | Acromegaly | Maternally Inherited Diabetes And Deafness | Apparent Mineralocorticoid Excess Syndrome | Persistent Mullerian Duct Syndrome | Prader-Willi Syndrome | Mitochondrial Disease | Bernard-Soulier Syndrome | Spondyloperipheral Dysplasia | Pyruvate Dehydrogenase Deficiency | X-linked Myotubular Myopathy | Pneumonia, Viral | Gaucher Disease | Cri-du-chat Syndrome | Cold Agglutinin Disease | D-2-Hydroxyglutaric Aciduria | Wiedemann-Steiner Syndrome | Hypermethioninemia | Hemorrhage | Raine Syndrome | Majeed Syndrome | Panniculitis | Trimethylaminuria | Familial Dysautonomia | Hypertensive Nephropathy | Persistent Fetal Circulation | Neuroblastoma | Rothmund-Thomson Syndrome | Amelanotic Melanoma | Diffuse Intrinsic Pontine Glioma | FG Syndrome | Hereditary Spherocytosis | Basal Ganglia Disease | Myelomeningocele | Polymicrogyria | Graves Disease | Loeys-Dietz Syndrome | Meningioma | Aceruloplasminemia | Hyperuricemic Nephropathy, Familial Juvenile | Amyloidosis | Familial Hyperaldosteronism | Peroxisomal Disorder | TARP Syndrome | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Bainbridge-Ropers Syndrome | Cockayne Syndrome | Peutz-Jeghers Syndrome | Kallmann Syndrome | McKusick Type Metaphyseal Chondrodysplasia | Hereditary Xerocytosis | Ichthyosis Hystrix, Curth-Macklin Type | Multiple Sclerosis, Chronic Progressive | Pontocerebellar Hypoplasia | Transient Bullous Dermolysis Of The Newborn | Trichomegaly | Basal Ganglia Cerebrovascular Disease | Influenza | Membranous Nephropathy | Subacute Sclerosing Panencephalitis | Hepatitis, Alcoholic | 3C Syndrome | CDKL5 Deficiency Disorder | Still Disease | Choroideremia | Chudley-McCullough Syndrome | Turner's Syndrome | Retinoschisis | Cardiomyopathy, Dilated, 1L | Papulopustular Rosacea | Dysmorphophobia | Atopic Dermatitis | Spondylolisthesis | Non-bullous Congenital Ichthyosiform Erythroderma | Leukocyte Adhesion Deficiency Type 1 | Thyroid Dyshormonogenesis | Myofibrillar Myopathy | Pulmonary Vein Stenosis | Leigh Syndrome | Progressive Familial Intrahepatic Cholestasis Type 2 | Nicolaides-Baraitser Syndrome | Hereditary Hemorrhagic Telangiectasia Type 2 | Osteitis | Coffin-Siris Syndrome | Hyperbilirubinemia, Neonatal | Keratoconus | Microcephalic Primordial Dwarfism | Duane Retraction Syndrome | Alzheimer Disease, Late Onset | Communication Disorders | Pterygium | Spasticity | Tendinopathy | Leukemia | Schizophrenia, Paranoid | Light Chain Amyloidosis | Retinal Dystrophy, Early-onset Severe | DEND Syndrome | Tay-Sachs Disease | Esophagitis, Eosinophilic | Brachydactyly | Proopiomelanocortin Deficiency | Adenocarcinoma | Cirrhosis | Combined Malonic And Methylmalonic Acidemia | Otitis Media | Heterotaxy | IgA Deficiency | Sezary Syndrome | Ectrodactyly | Pfeiffer Syndrome | Infantile Nephropathic Cystinosis | Fatty Aldehyde Dehydrogenase Deficiency | Retinal Coloboma | Ectodermal Dysplasia | Thromboembolism | Eosinophilic Asthma | B-cell Chronic Lymphocytic Leukemia | Micro Syndrome | Schistosomiasis Mansoni | Feingold Syndrome | Bietti Crystalline Dystrophy | Myopathy | Hodgkin Lymphoma | Osteoporosis, Postmenopausal | Malignant Peripheral Nerve Sheath Tumor | Carcinoma, Signet Ring Cell | Vitamin K Deficiency | Rubeosis Iridis | Corticobasal Syndrome | Vitamin D Deficiency | Cutaneous Mastocytosis | Autoimmune Polyendocrine Syndrome | Macrophage Activation Syndrome | Kaposiform Hemangioendothelioma | Myasthenia | Angioimmunoblastic T-cell Lymphoma | Withdrawal Syndrome | Cryptococcal Meningitis | Cohen Syndrome | Anorectal Malformations | Infantile Liver Failure Syndrome 1 | Congenital Hemolytic Anemia | Gastritis, Atrophic | Leukocyte Adhesion Deficiency | Schizoaffective Disorder | Incontinentia Pigmenti | Hidradenitis Suppurativa | Encephalitis | Hepatic Steatosis | Zimmermann-Laband Syndrome | Campomelic Dysplasia | Intestinal Hypomagnesemia 1 | Antisocial Personality Disorder | Neutropenia | Arthritis | Measles | Arterial Tortuosity Syndrome | Corneal Edema | Amenorrhea | Epidermolysis Bullosa Simplex, Localized | Long QT Syndrome Type 1 | Vitamin A Deficiency | Hyperparathyroidism-jaw Tumor Syndrome | Benign Familial Neonatal Convulsions | Myelitis | Hamartoma | Mohr-Tranebjaerg Syndrome | Argininosuccinic Aciduria | Spinocerebellar Ataxia Type 27 | Crimean-Congo Hemorrhagic Fever | Diabetic Encephalopathy | Optic Nerve Hypoplasia, Bilateral | Spinocerebellar Ataxia Type 21 | Pulmonary Stenosis | Cat Eye Syndrome | Avian Influenza | Takotsubo Cardiomyopathy | Endocarditis | Pulmonary Sclerosing Hemangioma | Dystonia | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Cerebrovascular Disorders | Congenital Sodium Diarrhea | Early Infantile Epileptic Encephalopathy 28 | Fibrillation, Atrial | Demyelinating Diseases | 5-oxoprolinase Deficiency | Skin Papilloma | Pseudoexfoliation Syndrome | Congenital Stromal Corneal Dystrophy | Porphyria, Variegate | Charcot-Marie-Tooth Disease, Type 1A | Restless Legs Syndrome | Myositis, Focal | Dyskeratosis Congenita | Adams-Oliver Syndrome | Transcobalamin Deficiency | Takayasu's Arteritis | Congenital Nystagmus | Glomerulonephritis, Membranous | Spinocerebellar Ataxia Type 7 | Focal Cortical Dysplasia Type 2 | COACH Syndrome | Spermatocele | ADNP Syndrome | Patent Ductus Arteriosus | Peripheral Neuropathy | Poretti-Boltshauser Syndrome | Borderline Personality Disorder | Achondrogenesis | Hyperbilirubinemia | Glioblastoma Multiforme | Alkaptonuria | Hypoplastic Left Heart Syndrome | Strabismus | Synovitis | Stevens-Johnson Syndrome