Disease

Hereditary Spherocytosis

About the Disease
Hereditary Spherocytosis, also known as congenital spherocytic hemolytic anemia, is related to bilirubin metabolic disorder and thalassemia, and has symptoms including icterus An important gene associated with Hereditary Spherocytosis is SPTB (Spectrin Beta, Erythrocytic), and among its related pathways/superpathways are Interaction between L1 and Ankyrins and Miscellaneous transport and binding events. The drugs Papaya and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include spleen, skin and heart, and related phenotypes are increased red cell osmotic fragility and muscle weakness

Common Targets
NOTCH3 | GSR | GAPDH | EPB41 | HFE | EPB42 | DNAH3 | SLC25A38 | BBS2 | PKLR | SPTA1 | SLC4A1 | ANK1 | HPDL | PIEZO1 | Oxysterols receptor LXR (nonspecified subtype) | HBA1 | SPTB | MAF1 | CNDP1 | PGAM5 | KIF22 | SLC22A5 | QRFPR | ALDOB | UGT1A1 | YBX3 | OVCA2

疾病靶点研报
Hereditary Spherocytosis

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