Personality Disorders

About the Disease
Avoidant Personality Disorder, also known as anxious personality disorder, is related to narcissistic personality disorder and personality disorder, and has symptoms including sleep disturbances, photophobia and personality changes. An important gene associated with Avoidant Personality Disorder is PIR (Pirin), and among its related pathways/superpathways are Digestion and absorption and Monoamine transport. The drugs Dopamine and Fluoxetine have been mentioned in the context of this disorder. Affiliated tissues include cingulate cortex, cortex and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Common Targets
ALDH2 | GABA(A) receptor | SLC6A4 | GRIN2B | DRD2 | KCNIP4 | COL25A1 | COMT | MAOA

Note: If you'd like to get a target analysis report for Personality Disorders, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Personality Disorders at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

Other Diseases

Bicuspid Aortic Valve | Epithelial-myoepithelial Carcinoma | Tyrosinemia | Dysplastic Nevus | Glycogen Storage Disease | Antenatal Bartter Syndrome Type 1 | Spinal Cord Diseases | Arthritis, Reactive | Scleritis | Chiari Malformation Type I | Brugada Syndrome 1 | Sarcoidosis, Pulmonary | Fibrillation, Atrial | Achromatopsia | Juvenile Myoclonic Epilepsy | Vertigo | Angioedema, Acquired | Gitelman Syndrome | Angioedema | Spitz Nevus | Gardner Syndrome | Heroin Dependence | Hemochromatosis Type 1 | Congenital Nephrotic Syndrome | Melanocytic Nevus | Hidradenitis | Vogt-Koyanagi-Harada Syndrome | Nemaline Myopathy 8 | Inflammatory Joint Disease | Hypopigmentation | Noonan Syndrome-like Disorder With Loose Anagen Hair | Fanconi Syndrome | Dengue Shock Syndrome | Rhabdoid Tumor | Angioedema, Hereditary | Primary Torsion Dystonia | IgA Nephropathy | Pneumonia, Bacterial | IMAGe Syndrome | Walker-Warburg Syndrome | Anorectal Malformations | Intestinal Hypomagnesemia 1 | Ventricular Septal Defect | Double Outlet Right Ventricle | Nanophthalmos | Congenital Primary Aphakia | Ameloblastic Carcinoma | Babesiosis | Spinocerebellar Ataxia Type 42 | Neurocysticercosis | Coffin-Siris Syndrome | Reye Syndrome | Creatine Deficiency Syndrome | VACTERL Association | Hepatic Veno-occlusive Disease | Carpal Tunnel Syndrome | Delayed Sleep Phase Syndrome | Myelitis, Transverse | Hemolytic Anemia | Purpura | Knobloch Syndrome | Necrotizing Autoimmune Myopathy | Poretti-Boltshauser Syndrome | Hemoglobinopathies | Parvovirus B19 Infection | Esophagitis | Peroxisomal Disorder | Hereditary Folate Malabsorption | Cholangitis | Spinocerebellar Ataxia Type 20 | Pterygium | Congenital Poikiloderma | Pachyonychia Congenita | Keratoconjunctivitis | Crouzon Syndrome With Acanthosis Nigricans | Congenital Mirror Movements | Anodontia | Eosinophilic Asthma | Lateral Meningocele Syndrome | Alopecia | Lymphoma, AIDS-related | Ependymoma | 3C Syndrome | Burn-McKeown Syndrome | Anuria | Multifocal Motor Neuropathy | Intestinal Tuberculosis | Beare-Stevenson Syndrome | Primary Lateral Sclerosis | Tyrosinemia Type 1 | Polycystic Ovary Syndrome | Frank-ter Haar Syndrome | Multiple System Atrophy | Polymicrogyria | Impetigo | Wolff-Parkinson-White Syndrome | Prolactinoma | Persistent Hyperplastic Primary Vitreous | Hepatitis E | Von Willebrand Disease | Dyggve-Melchior-Clausen Disease | Hyperuricemic Nephropathy, Familial Juvenile | Cornelia De Lange Syndrome | Erysipelas | Lathosterolosis | Cluster Headache | Keloid | Fascioliasis | Antley-Bixler Syndrome | Silver-Russell Syndrome | Lymphoma, B-cell | Osteonecrosis Of The Jaw | Succinic Semialdehyde Dehydrogenase Deficiency | CHOPS Syndrome | Otitis Media | Sertoli Cell-only Syndrome | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Absence Epilepsy | Optic Nerve Diseases | Stevens-Johnson Syndrome | Transcobalamin Deficiency | Anemia | Hyperammonemia | Li-Fraumeni Syndrome | Branchiootorenal Syndrome | Charcot-Marie-Tooth Disease, Type 1A | Waardenburg Syndrome Type 2 | Takotsubo Cardiomyopathy | Trimethylaminuria | Hepatitis C, Chronic | Periodic Limb Movement Disorder | Facioscapulohumeral Muscular Dystrophy | Paraplegia | Usher Syndrome Type II | Charcot-Marie-Tooth Disease Type 3 | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Exocrine Pancreatic Insufficiency | Canavan Disease | Pneumothorax | Hartsfield Syndrome | Alopecia Areata | Cavitary Optic Disc Anomalies | Rash | Polycythemia | Diabetes Type 1 | T-cell Lymphoma, Subcutaneous Panniculitis-like | Smoldering Myeloma | Spinocerebellar Ataxia Type 21 | Facioscapulohumeral Muscular Dystrophy Type 1 | Kallmann Syndrome | Meier-Gorlin Syndrome | Polycystic Kidney, Autosomal Dominant | PHARC Syndrome | Pseudohypoaldosteronism | Inflammatory Myofibroblastic Tumor | Nephronophthisis | Juvenile Polyposis | Cutaneous Angiosarcoma | Psoriasis | Hereditary Spherocytosis | Maternally Inherited Diabetes And Deafness | Metanephric Adenoma | Hyperparathyroidism | Cardiac Arrest | Metachondromatosis | Communication Disorders | Ileitis | Hepatitis D | Familial Mediterranean Fever | Craniometaphyseal Dysplasia | Preaxial Polydactyly | Herpes Simplex Dermatitis | Mucolipidosis | Aplasia Cutis Congenita | Non-Hodgkin Lymphoma | CDKL5 Deficiency Disorder | Encephalitis | Fetal Alcohol Syndrome | Motor Neuron Diseases | Diverticulitis | Aromatic L-amino Acid Decarboxylase Deficiency | Dental Caries | Myotonic Disorders | Bernard-Soulier Syndrome | Colorectal Adenoma | Megalencephaly | Cardiomyopathy, Dilated, 1L | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Osmotic Demyelination Syndrome | Nephropathy | Xeroderma Pigmentosum Variant Type | Moyamoya Disease | Diabetes Insipidus, Neurogenic | Familial Dysautonomia | Angiosarcoma Of The Breast | Amyloidosis | Desbuquois Syndrome | Neuroleptic Malignant Syndrome | Osteochondrosis | Smith-Magenis Syndrome | Asplenia | Chordoma | Unverricht-Lundborg Syndrome | Oculocutaneous Albinism Type 1 | Primary Cutaneous Amyloidosis | HELLP Syndrome | Homocystinuria | Acute Anterior Uveitis | Episodic Ataxia | Pierson Syndrome | Hypertension, Essential | Hyperparathyroidism, Secondary | Trichorhinophalangeal Syndrome | Opisthorchiasis | Pheochromocytoma | Osteogenesis Imperfecta Type V | Odonto-onycho-dermal Dysplasia | Spermatocele | Stomatitis | Blue Rubber Bleb Nevus Syndrome | Vascular Calcification | Common Variable Immunodeficiency | Autoimmune Disease | Fibrodysplasia Ossificans Progressiva | Takayasu's Arteritis | Crigler-Najjar Syndrome | Achondrogenesis | Lupus Erythematosus | Skin Carcinoma | Muscular Dystrophy | Takenouchi-Kosaki Syndrome | Hernia, Inguinal | Withdrawal Syndrome | Porphyria, Variegate | Glycogen Storage Disease Type 1 | Reticular Dysgenesis | Raine Syndrome | Cryptorchidism | Addison Disease | Schamberg Disease | Leukoplakia | Proximal Symphalangism | Light Chain Amyloidosis | Sialidosis | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Chorea | Hypertelorism | Glomerulonephritis, Membranous | Epilepsy Of Infancy With Migrating Focal Seizures | Osteoporosis-pseudoglioma Syndrome | Pyruvate Dehydrogenase Deficiency | Inborn Errors Of Metabolism | Spinocerebellar Ataxia Type 10 | Papillon-Lefevre Syndrome | Chromosome 5q Deletion Syndrome | Varices | Renal-hepatic-pancreatic Dysplasia | Pulmonary Stenosis | Budd-Chiari Syndrome | Malaria | Gastroenteritis, Eosinophilic | Muscle Wasting | Epidermodysplasia Verruciformis | Niemann-Pick Disease, Type B | Congenital Hemolytic Anemia | Restless Legs Syndrome | Sweet Syndrome | Perivascular Epithelioid Cell Tumor | Chronic Neutrophilic Leukemia | Optic Nerve Hypoplasia, Bilateral | Chromosome 16p11.2 Deletion Syndrome | Holoprosencephaly | Infantile Refsum Disease | Acromicric Dysplasia | Neurogenic Bladder | Neurofibroma, Plexiform | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Usher Syndrome Type I | Sclerosteosis 2 | Schnyder Crystalline Corneal Dystrophy | Familial Episodic Pain Syndrome | Sotos Syndrome | Lymphopenia | Oculocutaneous Albinism Type 2 | Cancer, Colon | Maple Syrup Urine Disease | Membranous Nephropathy | Smith-Kingsmore Syndrome | Urticaria | Anxiety Disorders | Diabetes Mellitus, Transient Neonatal | Apraxia | Hypermethioninemia | Choriocarcinoma | Cholelithiasis | Dominant Optic Atrophy | Hypoalbuminemia | Ocular Albinism Type 1 | Giant Cell Glioblastoma | Anovulation | Lattice Corneal Dystrophy Type 1 | Familial Hemiplegic Migraine | Bronchitis | Metatropic Dysplasia | Chanarin-Dorfman Syndrome | Essential Fructosuria | Esophageal Adenocarcinoma | Periodontitis | Corneal Edema | Pigment Dispersion Syndrome | Diabetes Type 2 | Thin Basement Membrane Disease | Rhinitis | Donnai-Barrow Syndrome | Adenoma, Pleomorphic | Exotropia | Hypophosphatasia | Perry Syndrome | Autoimmune Polyendocrine Syndrome | Niemann-Pick Disease, Type C | Syndactyly | Retinal Detachment | Coloboma | Chronic Beryllium Disease | Aspartylglycosaminuria | Spinocerebellar Ataxia Type 16 | Fragile X Syndrome | Oligospermia | Hemosiderosis | Tumoral Calcinosis | Kaposiform Hemangioendothelioma | Hairy Cell Leukemia | Fuchs Dystrophy | Richter's Syndrome | Anorectal Fistula | Mixed Connective Tissue Disease | Facioscapulohumeral Muscular Dystrophy Type 2 | Bronchiolitis | Joubert Syndrome 2 | Hepatitis A | Headache | Long QT Syndrome Type 3 | Chronic Granulomatous Disease | Waardenburg Syndrome Type 1 | Xeroderma Pigmentosum | Proteus Syndrome | Sleep Apnea | Dentinogenesis Imperfecta | Cholestasis, Intrahepatic | Paraganglioma, Carotid Body | C3 Glomerulopathy | Auriculocondylar Syndrome | Myosin Storage Myopathy | Retinitis Pigmentosa 3 | Temporal Lobe Epilepsy | Pseudoachondroplasia | Choroideremia | Hoyeraal-Hreidarsson Syndrome | Still Disease | Pyloric Stenosis, Infantile Hypertrophic | Insulinoma | Acquired Partial Lipodystrophy | Inflammatory Bowel Disease | Leprosy | Neurofibromatosis | Fibrosis | Kearns-Sayre Syndrome | Alpha-mannosidosis | Craniopharyngioma | Pseudoexfoliation Syndrome | Adenomatoid Tumor | Glycogen Storage Disease Type 5 | Acute Motor Axonal Neuropathy | Cushing Syndrome | Asthma, Exercise-induced | Cannabis Abuse | Renpenning Syndrome | Lymphoma, Mantle Cell | Macrophagic Myofasciitis | Pulmonary Alveolar Proteinosis | Congenital Absence Of Vas Deferens | Wolfram Syndrome | Occipital Neuralgia | Arrhythmogenic Right Ventricular Cardiomyopathy | Majeed Syndrome | Hartnup Disease | Loeys-Dietz Syndrome Type 4 | Cockayne Syndrome | Hyperekplexia | Retinal Degeneration | Wiedemann-Steiner Syndrome | Precocious Puberty | NGLY1 Deficiency | Esthesioneuroblastoma | Anti-glomerular Basement Membrane Disease | Paternal Uniparental Disomy Of Chromosome 14 | CEDNIK Syndrome | Hereditary Multiple Exostoses | Glycogen Storage Disease Type 1b | Gout