Neurofibromatosis Type 2

About the Disease
Acoustic Neuroma, also known as neurofibromatosis type 2, is related to neuroma and neurofibromatosis, type i, and has symptoms including back pain, coughing and headache. An important gene associated with Acoustic Neuroma is NF2 (NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor), and among its related pathways/superpathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Development VEGF signaling via VEGFR2 - generic cascades. The drugs Lapatinib and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and eye, and related phenotypes are neuroma and sensorineural hearing impairment

Common Targets
FKBP1A | HDAC1 | LIMK1 | MAP2K1 | G5243 | G1956 | LIMK2 | ROS1 | G2064 | G3480 | G836 | Mitogen-Activated Protein Kinase (nonspecified subtype) | NF-kappaB (NFkB) | ERBB4 | MAP2K2 | Proteasome Complex | Transcriptional Enhancer Factor (TEAD) (nonspecified subype) | SMARCB1 | G238 | HDAC2 | G10413 | G2475 | Heat shock protein 90 (nonspecified subtype) | NF2

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Other Diseases

Conjunctivitis | Focal Facial Dermal Dysplasia | Osteochondrosis | Bacterial Meningitis | Carey-Fineman-Ziter Syndrome | Renal Oncocytoma | Priapism | Hepatitis, Autoimmune | Intellectual Disability, Autosomal Dominant 5 | Graves Disease | Hyperbilirubinemia | Angioimmunoblastic T-cell Lymphoma | Ameloblastoma | Nicotine Dependence | Gastrointestinal Disorders | Renal Dysplasia | Behcet's Disease | Isovaleric Acidemia | Influenza | Histoplasmosis | Sleep Disorder | Colorectal Adenoma | Holoprosencephaly | Adrenomyeloneuropathy | Woodhouse-Sakati Syndrome | Senior-Loken Syndrome | Atopic Dermatitis | Anorexia Nervosa | Familial Advanced Sleep Phase Syndrome | Lymphangioma | Adrenal Insufficiency | Infantile Liver Failure Syndrome 1 | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Wiedemann-Steiner Syndrome | Cranial Nerve Disease | Intermittent Claudication | Vitamin A Deficiency | Clouston Hidrotic Ectodermal Dysplasia | Primary Ovarian Insufficiency | Metatropic Dysplasia | Takenouchi-Kosaki Syndrome | Medulloblastoma | Ulcerative Colitis | Renal-hepatic-pancreatic Dysplasia | Waardenburg Syndrome Type 4 | Retinitis Pigmentosa 3 | Blepharitis | Mitochondrial Encephalomyopathy | Desmosterolosis | Encephalopathy, Hepatic | Argininosuccinic Aciduria | Keratitis | Atrial Septal Defect | Bipolar Disorder | POEMS Syndrome | Raine Syndrome | CHOPS Syndrome | Danon Disease | Poretti-Boltshauser Syndrome | Wolfram Syndrome 2 | Vitamin B12 Deficiency | Arthritis, Reactive | Cardiomyopathy, Restrictive | Choriocarcinoma | Progressive Familial Intrahepatic Cholestasis | Diabetes Insipidus, Nephrogenic | Bethlem Myopathy | Glycogen Storage Disease | Pupil Disorders | Pure Autonomic Failure | Hyperkeratosis | Peutz-Jeghers Syndrome | Spinocerebellar Ataxia Type 40 | Ophthalmia, Sympathetic | Hereditary Hemorrhagic Telangiectasia Type 2 | Ollier Disease | Osteoporosis, Postmenopausal | X-linked Myotubular Myopathy | Keratoacanthoma | Plasma Cell Dyscrasia | Ameloblastic Carcinoma | Sarcosinemia | Fibrosis | FG Syndrome | Agranulocytosis | Paget's Disease Of The Breast | Benign Familial Neonatal Convulsions | Hyperthyroidism | Dystonia-parkinsonism, X-linked | Neutrophilia | Cyclic Vomiting Syndrome | Cataplexy | Prurigo Nodularis | Congenital Stromal Corneal Dystrophy | Pachyonychia Congenita | N-acetylglutamate Synthase Deficiency | Retinoblastoma | Xeroderma Pigmentosum Variant Type | Polyradiculopathy | Oligodendroglioma | Meningococcal Infections | Ectopia Lentis, Isolated, Autosomal Recessive | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Tenosynovial Giant Cell Tumor | Stromal Corneal Dystrophy | Knobloch Syndrome | Fanconi Anemia | Postpartum Depression | Parkinsonism | Constipation | Scapuloperoneal Spinal Muscular Atrophy | Hemoglobinopathies | Familial Hyperaldosteronism | Autonomic Neuropathy | Retinal Dystrophy | Primary Aldosteronism | Hydrocephalus, Normal Pressure | X-linked Creatine Transporter Deficiency | Gliosarcoma | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Encephalocele | Cockayne Syndrome | Brugada Syndrome 1 | Portal Vein Thrombosis | T-cell Prolymphocytic Leukemia | Hypertrophy | Myoclonus | 3-methylglutaconic Aciduria Type IV | Alopecia Areata | Hypercholesterolemia | Spinocerebellar Ataxia Type 23 | Microcephaly | Schwartz-Jampel-Aberfeld Syndrome | Myofibrillar Myopathy | Epidermolysis Bullosa | Malonyl-CoA Decarboxylase Deficiency | Malignant Fibrous Histiocytoma | Congenital Central Hypoventilation Syndrome | Pitt-Hopkins Syndrome | Erdheim-Chester Disease | Gestational Trophoblastic Disease | Onchocerciasis | Proteus Syndrome | Guanidinoacetate Methyltransferase Deficiency | Dyskeratosis Congenita | Waardenburg Syndrome Type 2E | Sclerosteosis 2 | Neurocysticercosis | Insulinoma | Lesch-Nyhan Syndrome | Jalili Syndrome | Pneumonia, Bacterial | IMAGe Syndrome | Autoimmune Autonomic Ganglionopathy | Rhabdomyosarcoma, Embryonal | Antisynthetase Syndrome | Ehlers-Danlos Syndrome | Cardiospondylocarpofacial Syndrome | Marinesco-Sjogren Syndrome | Glutathione Synthetase Deficiency | Hyperostosis | Pneumococcal Meningitis | Cardiomyopathy, Hypertrophic | Early Infantile Epileptic Encephalopathy 28 | Congenital Bile Acid Synthesis Defect | Hypopituitarism | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Apert Syndrome | Vascular Cognitive Impairment | Desbuquois Syndrome | Frank-ter Haar Syndrome | Strabismus | Chronic Thromboembolic Pulmonary Hypertension | Spastic Paraplegia Type 7 | Liebenberg Syndrome | Canavan Disease | 3-methylglutaconic Aciduria Type I | Centronuclear Myopathy | Cutis Laxa | Meningioma, Benign | Spinocerebellar Ataxia Type 13 | Chronic Enteropathy Associated With SLCO2A1 Gene | Sezary Syndrome | Alpers Syndrome | Anuria | Chronic Inflammatory Demyelinating Polyneuropathy | Imerslund-Grasbeck Syndrome | Nephrotic Syndrome | Glycogen Storage Disease Type 0 | Usher Syndrome Type IIC | Williams Syndrome | Premature Ejaculation | Conn Syndrome | Carotid Artery Disease | Tinea Versicolor | Pseudohermaphroditism | Congenital Primary Aphakia | Sarcoma, Ewing | Bronchiectasis | Cleidocranial Dysplasia | Nephrosclerosis | Pleural Tuberculosis | Gnathodiaphyseal Dysplasia | Heart Block | Galactosemia | Stevens-Johnson Syndrome | Hypopigmentation | Hodgkin Lymphoma | Hyperekplexia | Combined Malonic And Methylmalonic Acidemia | L-2-Hydroxyglutaric Aciduria | Leprosy | Synpolydactyly | Transcobalamin Deficiency | Pyruvate Dehydrogenase Deficiency | Androgenic Alopecia | Neonatal Progeroid Syndrome | Vestibular Disease | Epilepsy Of Infancy With Migrating Focal Seizures | Motion Sickness | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Phenylketonuria | Scleroderma, Diffuse | Porphyria Cutanea Tarda | Birk-Barel Syndrome | Leukocyte Adhesion Deficiency | Angiodysplasia | Autosomal Recessive Congenital Ichthyosis | Periodontitis | Large Granular Lymphocytic Leukemia | Hyperlipidemia Type V | Von Hippel-Lindau Disease | Liver Diseases | Wolfram Syndrome | Tracheal Disorders | 3-hydroxy-3-methylglutaric Aciduria | Meconium Ileus | Familial Isolated Hyperparathyroidism | Barakat Syndrome | Mixed Connective Tissue Disease | Sick Sinus Syndrome 1 | Anencephaly | Vitamin D Deficiency | Hereditary Spastic Paraplegia | Hyperuricemic Nephropathy, Familial Juvenile | Adult Polyglucosan Body Disease | Gyrate Atrophy Of The Choroid And Retina | Toxic Epidermal Necrolysis | Antisocial Personality Disorder | Myoclonic Epilepsy With Ragged Red Fibers | Cluster Headache | Panniculitis | Meesmann Corneal Dystrophy | Spinocerebellar Ataxia Type 2 | Leri-Weill Dyschondrosteosis | Hyperhomocysteinemia | Epithelioid Hemangioma | Polymicrogyria | Pelvic Inflammatory Disease | Megalencephaly | Split Hand-foot Malformation | Angioedema, Acquired | Phenylketonuria II | Spinocerebellar Ataxia Type 17 | Anal Fissure | Esophagitis, Eosinophilic | Kawasaki Disease | Chordoid Glioma | Cancer, Prostate | Auriculocondylar Syndrome | Coffin-Lowry Syndrome | Cholangitis | Bloom Syndrome | Acrodermatitis | AIDS | Juvenile Myoclonic Epilepsy | Neurotoxicity | Cholelithiasis | Cri-du-chat Syndrome | Pseudo-pseudohypoparathyroidism | Eosinophilic Asthma | Hypersomnia | Congenital Afibrinogenemia | Cornelia De Lange Syndrome | Diffuse Mesangial Sclerosis | Malnutrition | Malaria | Acute Anterior Uveitis | Duane Retraction Syndrome | Congenital Hypofibrinogenemia | Spinocerebellar Ataxia Type 28 | Takayasu's Arteritis | Hemophilia | Periodic Limb Movement Disorder | CHARGE Syndrome | Lattice Corneal Dystrophy | Aneurysm, Abdominal Aortic | Congenital Heart Defects | Lactose Intolerance | Acral Lentiginous Melanoma | Fowler's Syndrome | DiGeorge Syndrome | Fibronectin Glomerulopathy | Niemann-Pick Disease, Type A | Spinocerebellar Ataxia Type 20 | Retinal Vasculitis | Mitochondrial Myopathy | Hypospadias | Ichthyosis, X-linked | Keloid | Dystonia Musculorum Deformans | Renal Hypomagnesemia 3 | Spinocerebellar Ataxia Type 3 | Arterial Tortuosity Syndrome | Spermatocele | HELLP Syndrome | Stomatitis | Hypersensitivity Pneumonitis | Still Disease | Pancreatitis, Chronic | Agoraphobia | Congenital Torticollis | Hemochromatosis Type 1 | Blue Nevus | Carbonic Anhydrase VA Deficiency | Diastrophic Dysplasia | Hyperlipidemia, Familial Combined | Teratozoospermia | Holt-Oram Syndrome | Melnick-Needles Syndrome | IgA Deficiency | Fibrosarcoma | Dystonia | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Progressive Encephalopathy-optic Atrophy Syndrome | Brachydactyly | Cantu Syndrome | Myocardial Infarction | Polycystic Ovary Syndrome | Gray Platelet Syndrome | Enlarged Vestibular Aqueduct | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Achondrogenesis | Lymphoma, Mantle Cell | Arteriovenous Malformations | Oculocutaneous Albinism | Asperger Syndrome | Peroxisomal Disorder | Lymphoma, B-cell | Spinocerebellar Ataxia Type 10 | Gastritis, Atrophic | Sarcomatoid Carcinoma Of The Lung | Birt-Hogg-Dube Syndrome | Neurocutaneous Melanocytosis | Panic Disorder | Adrenoleukodystrophy, X-linked | Lymphangioleiomyomatosis | Cholestasis | Ebstein Anomaly | Hypertensive Retinopathy | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Macrophagic Myofasciitis | Adenoma, Pituitary | Retinopathy, Diabetic | Rash | Astrocytoma | Jawad Syndrome | Marshall-Smith Syndrome | Corticobasal Syndrome | Major Depression | Hartnup Disease | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Hydrops Fetalis | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Empyema | Cannabis Abuse | Poirier-Bienvenu Neurodevelopmental Syndrome | Encephalopathy | Diabetes Mellitus, Transient Neonatal | Greenberg Dysplasia | Essential Fructosuria | Intestinal Pseudo-obstruction | Osteochondroma | Cysticercosis | Hepatopulmonary Syndrome | Anorchia | Pierson Syndrome | LRBA Deficiency | Cancer, Lung | Porokeratosis | Hyperglycemia | DRESS Syndrome | Wolcott-Rallison Syndrome | Congenital Heart Block | Hypotension, Orthostatic | Peritonitis | Hypercalciuria | Alstrom Syndrome | Familial Exudative Vitreoretinopathy