Perry Syndrome

About the Disease
Perry Syndrome, also known as parkinsonism with alveolar hypoventilation and mental depression, is related to parkinsonism and frontotemporal lobar degeneration with tdp43 inclusions, grn-related, and has symptoms including sleeplessness An important gene associated with Perry Syndrome is DCTN1 (Dynactin Subunit 1), and among its related pathways/superpathways are Vesicle-mediated transport and COPI-independent Golgi-to-ER retrograde traffic. Affiliated tissues include brain, and related phenotypes are sleep disturbance and tremor

Common Targets
TARDBP | NPEPPS | DCTN1 | PRKN

Note: If you'd like to get a target analysis report for Perry Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Perry Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

Other Diseases

Sitosterolemia | Ectodermal Dysplasia | Arthrogryposis | Hypertension, Pulmonary | Pterygium | Hereditary Folate Malabsorption | Osteochondrosis | Microtia | Myosin Storage Myopathy | Multiple Sclerosis, Relapsing-remitting | Chromosome 8q21.11 Deletion Syndrome | Barrett Esophagus | 3-methylcrotonyl-CoA Carboxylase Deficiency | Mitochondrial Encephalomyopathy | Williams Syndrome | Hepatitis C, Chronic | Anorectal Fistula | Neuronal Ceroid Lipofuscinosis | Retinal Coloboma | Leishmaniasis, Visceral | Bipolar Disorder | Protein S Deficiency | Exfoliative Dermatitis | Pericarditis | Hypothalamic Obesity | Obesity, Morbid | Myelitis | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Dentinogenesis Imperfecta | Hypokalemia | Arthritis | Hypohidrotic Ectodermal Dysplasia, X-linked | Prediabetes | Hyperuricemia | Congenital Aniridia | Cervical Dystonia | Conjunctivitis | Anosmia, Congenital | Neurofibroma, Plexiform | Holt-Oram Syndrome | Succinic Semialdehyde Dehydrogenase Deficiency | Cocaine-Related Disorders | Angiomyolipoma | Neurotoxicity | Mannosidase Deficiency Diseases | Twin-to-twin Transfusion Syndrome | Familial Isolated Hyperparathyroidism | Giant Cell Arteritis | Schwartz-Jampel-Aberfeld Syndrome | Mevalonate Kinase Deficiency | Tatton-Brown-Rahman Syndrome | Rolandic Epilepsy | Glutathione Synthetase Deficiency | Epidermolytic Ichthyosis, Annular | Shprintzen-Goldberg Syndrome | Aromatic L-amino Acid Decarboxylase Deficiency | Trismus-pseudocamptodactyly Syndrome | Borderline Personality Disorder | Odonto-onycho-dermal Dysplasia | Distal Myopathy | Meningeal Melanocytoma | Cholangitis | Angiosarcoma Of The Breast | Tonsillitis | Phosphoglycerate Dehydrogenase Deficiency | Gilbert Syndrome | Creatine Deficiency Syndrome | Charcot-Marie-Tooth Disease Type 4E | Shwachman-Bodian-Diamond Syndrome | VEXAS Syndrome | Achromatopsia | Keratosis, Actinic | Steel Syndrome | Mandibuloacral Dysplasia With Type A Lipodystrophy | Cri-du-chat Syndrome | Cardiomyopathy, Dilated, 1L | Neuromuscular Disorders | Aneurysm, Abdominal Aortic | Chronic Inflammatory Demyelinating Polyneuropathy | Galactosialidosis | Papilledema | Cardiofaciocutaneous Syndrome | Pelvic Inflammatory Disease | Spinocerebellar Ataxia Type 27 | Congenital Torticollis | 3-methylglutaconic Aciduria Type IV | Botulism | Fraser Syndrome | Tetanus | Disseminated Intravascular Coagulation | Mountain Sickness | Bone Marrow Necrosis | Wolcott-Rallison Syndrome | Hypopituitarism | Cardiomyopathy, Restrictive | Tinea | Familial Retinal Arterial Macroaneurysm | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Dystonia-parkinsonism, X-linked | Nemaline Myopathy 8 | Stuve-Wiedemann Syndrome | Spinocerebellar Ataxia Type 13 | Azoospermia | Pseudoexfoliation Syndrome | Harlequin Ichthyosis | Bulimia Nervosa | Alagille Syndrome | Retinal Vasculitis | Cluster Headache | Bacterial Meningitis | Carcinoma, Merkel Cell | Hemorrhagic Disorders | Guanidinoacetate Methyltransferase Deficiency | Ichthyosis Hystrix, Curth-Macklin Type | Feingold Syndrome | Giant Axonal Neuropathy | Carpenter Syndrome | Diverticulitis | Atelosteogenesis Type 2 | Cystinuria | Frank-ter Haar Syndrome | Polyarteritis Nodosa | Coffin-Lowry Syndrome | Mabry Syndrome | Acquired Partial Lipodystrophy | Diabetes Type 1 | Subacute Sclerosing Panencephalitis | Charcot-Marie-Tooth Disease, Type 2 | Arthritis, Psoriatic | Liver Failure, Acute Infantile | Tetraplegia | Agoraphobia | Asplenia | Waardenburg Syndrome Type 1 | Hereditary Coproporphyria | Eclampsia | Adenoma, Pleomorphic | Platelet Disorders | Heterotopic Ossification | Basal Ganglia Cerebrovascular Disease | Acute Myeloid Leukemia | Influenza | Subcortical Band Heterotopia | Ocular Hypertension | Panuveitis | Eiken Syndrome | Best Macular Dystrophy | Presbyopia | Bronchiectasis | Apraxia | Ophthalmia, Sympathetic | Gingivitis | Epilepsy | Motion Sickness | Spitzoid Melanoma | Neurocutaneous Syndromes | Bartter Syndrome | Coronary Restenosis | Hypocalcemia | Nicolaides-Baraitser Syndrome | Cancer, Kidney | GAPO Syndrome | Sclerocornea | Oligoasthenoteratozoospermia | Familial Thoracic Aortic Aneurysm | Familial Hyperaldosteronism | Cold-induced Sweating Syndrome | Hyperprolactinemia | Hyperinsulinism-hyperammonemia Syndrome | Obsessive-compulsive Disorder | Dental Caries | Motor Neuron Diseases | Crisponi Syndrome | Riboflavin Transporter Deficiency Neuronopathy | Graft-versus-host Disease | Tardive Dyskinesia | Common Cold | Hepatitis D | Polymicrogyria | Autism Spectrum Disorders | Oligospermia | Carotid Artery Disease | Diffuse Intrinsic Pontine Glioma | HUPRA Syndrome | Diabetic Encephalopathy | Leukoplakia, Oral | Orotic Aciduria | Medulloblastoma | Smith-Kingsmore Syndrome | Synpolydactyly | Renal Hypouricemia | Birk-Barel Syndrome | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Renal-hepatic-pancreatic Dysplasia | Infertility, Male | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | High Molecular Weight Kininogen Deficiency | Swine Influenza | Spasticity | Primary Erythromelalgia | Antenatal Bartter Syndrome Type 1 | Noonan Syndrome-like Disorder With Loose Anagen Hair | Hemolytic Anemia | Hyper IgE Syndrome | Acute Generalized Exanthematous Pustulosis | DNA Ligase IV Deficiency | Raynaud Phenomenon | Hepatic Steatosis | Hepatitis | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Vitreoretinopathy, Proliferative | Connective Tissue Disorders | Glycogen Storage Disease Type 1 | Renal Hypomagnesemia 3 | Abetalipoproteinemia | Congenital Absence Of Vas Deferens | Robinow Syndrome | Stickler Syndrome | Sepiapterin Reductase Deficiency | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Parkinsonism | Thrombosis | D-2-Hydroxyglutaric Aciduria | Cat Eye Syndrome | Spinal Muscular Atrophy | Congenital Bile Acid Synthesis Defect | Cerebral Amyloid Angiopathy | Hemochromatosis Type 2 | Aplasia Cutis Congenita | Congenital Ichthyosiform Erythroderma | Amelogenesis Imperfecta | Infantile Spasm | Kabuki Syndrome | CDKL5 Deficiency Disorder | Nanophthalmos | Craniosynostosis | Osteopetrosis | Meleda Disease | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Neuroleptic Malignant Syndrome | Tay-Sachs Disease | Pulverulent Zonular Cataract | Chitayat Syndrome | Asthma | Renal Dysplasia | Pseudoachondroplasia | Congenital Poikiloderma | Carcinoma In Situ | Exotropia | Retinitis Pigmentosa 3 | Goldenhar Syndrome | Osteogenesis Imperfecta Type VI | Pulmonary Alveolar Microlithiasis | Majeed Syndrome | Kashin-Beck Disease | Leri Pleonosteosis | Diabetes Mellitus, Transient Neonatal | Trimethylaminuria | Basal Cell Nevus Syndrome | Schistosomiasis Mansoni | Angelman Syndrome | Arthritis, Reactive | Metachromatic Leukodystrophy | Saul-Wilson Syndrome | LEOPARD Syndrome | Hemolytic Uremic Syndrome, Atypical | Chondrodysplasia Punctata | Tyrosinemia | Immunoproliferative Disorders | Early Infantile Epileptic Encephalopathy 13 | Aldosterone Synthase Deficiency | Polyomavirus Nephropathy | Enhanced S-cone Syndrome | Behcet's Disease | Diabetic Macular Edema | Thalassemia | Pierpont Syndrome | Schwannoma | Myositis, Focal | Hypercholesterolemia, Familial | Otopalatodigital Syndrome Type 2 | Chronic Granulomatous Disease | Alcoholism | Sarcoma | Disseminated Superficial Actinic Porokeratosis | Leiomyosarcoma | Stomatitis | Osteogenesis Imperfecta Type III | Spinocerebellar Ataxia Type 40 | Corneal Neovascularization | Familial Male-limited Precocious Puberty | Intracranial Hypertension | Rhabdomyosarcoma, Embryonal | Astigmatism | Lesch-Nyhan Syndrome | Thanatophoric Dysplasia Type 1 | Scabies | Peripheral T-cell Lymphoma | Prolymphocytic Leukemia | Thyroiditis | Non-epidermolytic Palmoplantar Keratoderma | Thrombophlebitis | Discoid Lupus Erythematosus | Sialidosis Type I | Anal Fissure | Asphyxia Neonatorum | Conn Syndrome | Hypospadias | Hyperbilirubinemia | ACTH-independent Macronodular Adrenal Hyperplasia | Multiple Sulfatase Deficiency | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Apert Syndrome | Mucolipidosis Type III | Osmotic Demyelination Syndrome | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Schizoaffective Disorder | Genitopatellar Syndrome | Cabezas Syndrome | Chronic Lymphocytic Leukemia | Mastitis | Diabetes Insipidus, Neurogenic | Keratosis, Seborrheic | Batten Disease | Lymphoma, AIDS-related | Spondyloepiphyseal Dysplasia Tarda, X-linked | Keratitis | 3C Syndrome | Methemoglobinemia | Spondylocostal Dysostosis | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Myositis | Ischemia | Tracheal Disorders | Kaposiform Hemangioendothelioma | Giant Cell Glioblastoma | Schnyder Crystalline Corneal Dystrophy | Epidermolysis Bullosa Simplex | Charcot-Marie-Tooth Disease, Type 1A | Rhizomelic Chondrodysplasia Punctata | Sleep Apnea, Obstructive | Lymphopenia | Dementia, Vascular | Neurocutaneous Melanocytosis | Neuroblastoma | Hyperoxaluria | Sarcoma, Ewing | Raine Syndrome | Sturge-Weber Syndrome | Ameloblastic Carcinoma | Heroin Dependence | Spinocerebellar Ataxia Type 3 | Nestor-Guillermo Progeria Syndrome | Keratopathy | Chondrodysplasia Punctata 1, X-linked Recessive | Tenosynovial Giant Cell Tumor | Ichthyosis Bullosa Of Siemens | Vascular Calcification | Opisthorchiasis | Inflammatory Joint Disease | Hyperglycemia | Dystonia Musculorum Deformans | Exostoses | Cardiospondylocarpofacial Syndrome | Schizophrenia | Colitis, Microscopic | Stroke, Ischemic | Lupus Erythematosus | Costello Syndrome | Pancytopenia | Orthostatic Intolerance | Protein C Deficiency | Epidermodysplasia Verruciformis | Thrombocytopenia | Multiple Hamartoma Syndrome | Dermatitis Herpetiformis | Iron Deficiency Anemia | Sclerosteosis 2 | Jawad Syndrome | Angiosarcoma | Marfan Syndrome | Cranial Nerve Disease | Aspergillosis | Arteriosclerosis | Basal Ganglia Disease, Biotin-responsive | Acrodermatitis | Eczema | Amenorrhea | 5-oxoprolinase Deficiency | Mixed Connective Tissue Disease | Autosomal Recessive Bestrophinopathy | Fowler's Syndrome | Early Infantile Epileptic Encephalopathy 4 | Cheilitis | Bronchiolitis | Congenital Myopathy | Frontotemporal Dementia | Epidermolysis Bullosa Simplex, Generalized | Macrophagic Myofasciitis | Choriocarcinoma