Constipation

About the Disease
Constipation is related to irritable bowel syndrome and hirschsprung disease 1. An important gene associated with Constipation is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Class A/1 (Rhodopsin-like receptors) and Signal Transduction. The drugs Bupivacaine and Tramadol have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, kidney and colon, and related phenotypes are nervous system and normal

Common Targets
SULT1A1 | OPRM1 | OPRK1 | GHSR | CYP2C19 | DGAT1 | CYP7A1 | Calcium channel (nonspecified subtype) | P2RY2 | T-Type Calcium Channel | CHRM1 | SLCO2B1 | ANO1 | HTR4 | ADORA1 | PTGS1 | Small Conductance Calcium-Activated Potassium Channel (SK) (nonspecified subtype) | SLC26A3 | ADORA2B | G9429 | GALR3 | Opioid receptor (nonspecified subtype) | SLC9A3 | ACHE | Voltage-Gated Sodium Channel Complex | Chloride channel (nonspecified subtype) | ADORA2A | PTPN1 | CYP2C8 | G5743 | Guanylate cyclase (nonspecified subtype) | FLNA | CES1 | Epithelial Sodium Channel (ENaC) | OPRL1 | G5243 | SLC19A1 | OPRD1 | Sodium channel (nonspecified subtype) | ADGRV1 | CLCN2 | TRPA1 | MLNR | NOX3 | SLC5A1 | CCKAR | CFTR | SLC10A2 | Adenosine receptor (nonspecified subtype) | SLCO1B1 | UGT1A1 | GUCY2C | CES1P1 | 5-Hydroxytryptamine Receptor (nonspecified subtype) | EPHX1 | NADPH Oxidase Complex | NQO1 | Tryptophan 5-Monooxygenase (nonspecified subtype) | SLCO1A2 | MUC5AC | Rho kinase (ROCK) (nonspecified subtype) | NADPH Oxidase (nonspecified subtype) | GALR2 | PER3 | SLCO1B3 | CYP3A4 | SNCA | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | GPBAR1

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