Pachyonychia Congenita

About the Disease
Pachyonychia Congenita 1, also known as pachyonychia congenita, is related to pachyonychia congenita 2 and palmoplantar keratosis, and has symptoms including hoarseness An important gene associated with Pachyonychia Congenita 1 is KRT16 (Keratin 16), and among its related pathways/superpathways are Nervous system development and COPI-independent Golgi-to-ER retrograde traffic. The drugs Miconazole and Sirolimus have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and kidney, and related phenotypes are palmoplantar keratoderma and nail dystrophy

Common Targets
FLG | KRT17 | KRT6A | KRT6B | Proteasome Complex | CCR5 | KRT6C | CD19 | KRT16 | G2475

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