Erectile Dysfunction

About the Disease
Impotence, also known as erectile dysfunction, is related to vasculogenic impotence and prolactinoma, and has symptoms including angina pectoris, pelvic pain and tremor. An important gene associated with Impotence is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Signal Transduction and MIF Mediated Glucocorticoid Regulation. The drugs Selegiline and Nebivolol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, prostate and spinal cord, and related phenotypes are no effect and no effect

Common Targets
KDM5B | LRRK2 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | Prostanoid Receptor (nonspecified subtype) | G7124 | G4780 | PHACTR2 | KCNN3 | GLI2 | SLC18A2 | Serine/Threonine Kinase (nonspecified subtype) | DRD2 | FKBP4 | NOS1 | RMDN2 | KCNQ4 | DRD4 | ADRA1A | ROCK1 | GNB3 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | ESR2 | Alpha-2 Adrenergic receptors (nonspecified subtype) | GH1 | HTR1A | FSHR | SLC6A2 | DNA Topoisomerase II (nonspecified subtype) | G142 | HMGCR | TRPC5 | F13B | Steroid 5-alpha-Reductase (nonspecified subtype) | PDCD4 | PPID | TRPV2 | VIP | PDE9A | ARG1 | alpha-Adrenoceptor (nonspecified subtype) | Raf kinase (nonspecified subtype) | Tyrosine Kinase (nonspecified subtype) | Chloride channel (nonspecified subtype) | PTPN1 | ADRB3 | G3630 | AKR1B1 | Guanylate cyclase (nonspecified subtype) | NTRK1 | VIPR1 | OXT | F2 | CES1 | cAMP-Dependent protein kinase (PKA) | G367 | MC3R | IGFBP3 | ARHGEF12 | PTGER4 | ADORA3 | K(ATP) Channel (nonspecified subtype) | NPY5R | PTGDR | TEK | G1956 | LOC105374318 | NOS3 | DRD1 | MME | SLC6A4 | beta-Adrenoceptor (nonspecified subtype) | CELA2A | PDE5A | KCNQ5 | Dopamine receptor (nonspecified subtype) | PDE2A | TTC7A | HTR2A | ADRA1D | G7422 | ROCK2 | TXNRD1 | Poly [ADP-ribose] polymerase (nonspecified subtype) | NOX3 | G3569 | AOPEP | GUCY2C | CYP19A1 | MC4R | alpha1-Adrenoceptor (nonspecified subtype) | AGER | P2RX2 | HTR2C | DRD3 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | NPR1 | LRP1B | CNNM3 | NADPH Oxidase Complex | KCNMB1 | Arginase (nonspecified subtype) | Glutathione S-Transferase (GST) (nonspecified subtype) | SLC6A3 | Potassium Channels (nonspecified subtype) | ADRA1B | CDK1 | OXTR | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | LOC105376767 | Rho kinase (ROCK) (nonspecified subtype) | NADPH Oxidase (nonspecified subtype) | Bombesin receptor (nonspecified subtype) | SCN5A | Soluble guanylyl cyclase | GRIN3A | CDK7 | Melanocortin receptor (nonspecified subtype) | NGF | ARG2 | MC5R | PDE3A | Phosphodiesterase (nonspecified subtype) | TRPM3 | MC1R | EDNRA | HIF1A | AMP-activated protein kinase (AMPK) | Vasoactive intestinal polypeptide receptor (VIP-R) (nonspecified subtype) | PTGFRN | AVPR1A | Phosphodiesterase 6 (PDE6) (nonspecified subtype)

Note: If you'd like to get a target analysis report for Erectile Dysfunction, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Erectile Dysfunction at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

Other Diseases

Corneal Dystrophies, Hereditary | Uveitis | Skin Fragility-woolly Hair Syndrome | Hypertensive Nephropathy | Mitochondrial Disease | Primary Hyperoxaluria | Gout | LEOPARD Syndrome | Sarcoidosis | Chorioretinitis | Tangier Disease | Seizures | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Oculocutaneous Albinism Type 1 | Communication Disorders | Congenital Myopathy | Hypercholesterolemia, Familial | Renal Hypomagnesemia 3 | Cheilitis | Sarcosinemia | Hypopituitarism | Thyroiditis | Focal Cortical Dysplasia Type 2 | Rheumatoid Arthritis | Wolff-Parkinson-White Syndrome | Joubert Syndrome | Infantile Liver Failure Syndrome 1 | Purpura | Epilepsy, Generalized | Acute Coronary Syndrome | Kashin-Beck Disease | Rotor Syndrome | Chromosome 9q34.3 Deletion Syndrome | Retinal Dystrophy, Early-onset Severe | Benign Familial Neonatal Convulsions | Alpha-mannosidosis | Cornelia De Lange Syndrome | Polycystic Ovary Syndrome | Apparent Mineralocorticoid Excess Syndrome | Frontometaphyseal Dysplasia | Vici Syndrome | Cardiofaciocutaneous Syndrome | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Diabetes | Sandhoff Disease | Thalassemia | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Borjeson-Forssman-Lehmann Syndrome | Panniculitis | Fibrosarcoma | Gitelman Syndrome | Kindler Syndrome | Saethre-Chotzen Syndrome | Irritable Bowel Syndrome | Calcium Pyrophosphate Deposition Disease | Diabetic Encephalopathy | Lactose Intolerance | Pseudohermaphroditism | Methylmalonic Aciduria And Homocystinuria, CblC Type | Hemolytic Uremic Syndrome, Atypical | Dysfibrinogenemia | Osteopetrosis | Dental Caries | Vertigo | Aldosterone Synthase Deficiency | Motor Neuron Diseases | Chylomicron Retention Disease | Schizophrenia, Paranoid | Lennox-Gastaut Syndrome | Sialoadenitis | Spinal And Bulbar Muscular Atrophy | Congenital Hereditary Endothelial Dystrophy Type II | Lymphoproliferative Disease, X-linked | Cysticercosis | Glycogen Storage Disease | Retinal Degeneration | Goldenhar Syndrome | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Spinocerebellar Ataxia | Non-Hodgkin Lymphoma | Pulmonary Vein Stenosis | Histiocytic Sarcoma | Cholangiocarcinoma | Mosaic Variegated Aneuploidy Syndrome 2 | Hepatitis D | Bietti Crystalline Dystrophy | Chordoma | Sitosterolemia | Hepatitis C, Chronic | Birt-Hogg-Dube Syndrome | DICER1 Syndrome | Noonan Syndrome-like Disorder With Loose Anagen Hair | Takayasu's Arteritis | Neurocutaneous Melanocytosis | Mumps | Delayed Sleep Phase Syndrome | Papulopustular Rosacea | Congenital Lipoid Adrenal Hyperplasia | Metatropic Dysplasia | Lymphopenia | Trimethylaminuria | Pierpont Syndrome | Protein S Deficiency | Adenoma, Pleomorphic | Multiple Sclerosis, Chronic Progressive | Neural Tube Defect | Glycogen Storage Disease Type 0 | Walker-Warburg Syndrome | Antiphospholipid Syndrome | Leiomyoma | Stromal Corneal Dystrophy | Atelosteogenesis Type 2 | Episodic Ataxia Type 1 | Primary Cutaneous Amyloidosis | Greig Cephalopolysyndactyly Syndrome | Leber Hereditary Optic Neuropathy | Craniosynostosis | Cholelithiasis | Geleophysic Dysplasia | Motion Sickness | Leukocyte Adhesion Deficiency Type 1 | Cousin Syndrome | Thrombosis | Ichthyosis, X-linked | Panic Disorder | Endometritis | Bronchiolitis | Chordoid Glioma | Gestational Trophoblastic Disease | Congenital Ichthyosiform Erythroderma | Seminoma | Galactosemia | Osteogenesis Imperfecta Type I | Oculodentodigital Dysplasia | Pemphigus Vulgaris | Basal Ganglia Disease, Biotin-responsive | Pulverulent Zonular Cataract | Pyloric Stenosis, Infantile Hypertrophic | Nager Acrofacial Dysostosis | Nutrition Disorders | Hyper IgE Syndrome | Hypertrophy | Neurodermatitis | Gaucher Disease | Myoclonic Epilepsy With Ragged Red Fibers | Adrenoleukodystrophy, X-linked | Lattice Corneal Dystrophy | Mucolipidosis Type II | Blepharoconjunctivitis | Metachromatic Leukodystrophy | Hypoplastic Left Heart Syndrome | Celiac Disease | Krabbe Disease | Angina Pectoris | Neurodevelopmental Disorders | Placenta Previa | Lipid Metabolism Disorders | Interstitial Lung Diseases | Spinal Muscular Atrophy Type 3 | Adrenomyeloneuropathy | Leber Congenital Amaurosis | Hyperuricemia | X-linked Myotubular Myopathy | Neurofibroma, Plexiform | Intracranial Hypertension | Carotid Artery Disease | Usher Syndrome | Hidradenitis Suppurativa | Kaposi Sarcoma | Tendinitis | Barakat Syndrome | Keratocystic Odontogenic Tumor | Spondylocostal Dysostosis | T-cell Lymphoma, Subcutaneous Panniculitis-like | Pouchitis | Adenylosuccinate Lyase Deficiency | Retinal Vasculitis | REM Sleep Behavior Disorder | Crigler-Najjar Syndrome | Encephalopathy, Ethylmalonic | Takotsubo Cardiomyopathy | Aromatic L-amino Acid Decarboxylase Deficiency | Infantile Spasm | Sarcoma, Endometrial Stromal | Lissencephaly 2 | Traboulsi Syndrome | Gangliosidosis | Vascular Calcification | Corneal Neovascularization | Diabetes Type 1 | Spinal Muscular Atrophy Type 2 | Epilepsy | Pyoderma Gangrenosum | Myoclonus-dystonia Syndrome | Nicotine Addiction | Okihiro Syndrome | Thrombophilia | Tibial Muscular Dystrophy | Granular Corneal Dystrophy Type 1 | Dubin-Johnson Syndrome | Thyroid Dyshormonogenesis | Lymphomatoid Granulomatosis | Multicystic Renal Dysplasia | Spinocerebellar Ataxia Type 1 | AIDS | Immunoproliferative Disorders | Neurocysticercosis | Aldosteronism | DiGeorge Syndrome | 3-methylcrotonyl-CoA Carboxylase Deficiency | Schindler Disease | Peritonitis | Whipple's Disease | Spondylometaphyseal Dysplasia | Progressive External Ophthalmoplegia | Reye Syndrome | Hennekam Lymphangiectasia-lymphedema Syndrome | Colitis, Lymphocytic | Spondyloarthritis | Fraser Syndrome | Epithelioid Hemangioma | Adenoid Cystic Carcinoma | Dystonia Musculorum Deformans | Ectodermal Dysplasia | Hydrocephalus | Robinow Syndrome | Neuroectodermal Tumors, Primitive | Alkaptonuria | Gilbert Syndrome | Cardiomyopathy, Hypertrophic | Glomerulonephritis, Membranous | Bronchiectasis | Ichthyosis Hystrix, Curth-Macklin Type | Fetal And Neonatal Alloimmune Thrombocytopenia | Corneal Edema | Idiopathic Multicentric Castleman Disease | Empyema | Carcinoma, Merkel Cell | Liver Diseases | Nemaline Myopathy | Localized Scleroderma | Spinocerebellar Ataxia Type 5 | Centronuclear Myopathy | Myopia | Mountain Sickness | Facioscapulohumeral Muscular Dystrophy Type 2 | Neurofibroma | Hereditary Spherocytosis | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Hyperparathyroidism, Secondary | Diabetes Type 2 | Fibromuscular Dysplasia | Basan Syndrome | Thyrotoxic Periodic Paralysis | Dwarfism | Fahr Disease | Osteosclerosis | Hypereosinophilic Syndrome | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Coloboma | Amyotrophic Lateral Sclerosis | Hypospadias | Familial Hemiplegic Migraine | Renal Hypouricemia | Hepatorenal Syndrome | Familial Digital Arthropathy-brachydactyly | Delirium | Peters-plus Syndrome | Pycnodysostosis | Herpes Genitalis | Myhre Syndrome | Hepatitis, Chronic | Batten Disease | Hypercalcemia | Mast Cell Leukemia | Leukemia-lymphoma, Adult T-cell | Benign Hereditary Chorea | Autoimmune Autonomic Ganglionopathy | Blue Rubber Bleb Nevus Syndrome | Ovarian Sex Cord-stromal Tumor | Melnick-Needles Syndrome | Microphthalmia, Syndromic 7 | Premature Ejaculation | Basal Cell Nevus Syndrome | Coffin-Lowry Syndrome | Hemolytic Anemia | Hypertension, Renovascular | Sick Sinus Syndrome | Ichthyosis | Keratitis | Vitelliform Macular Dystrophy | Kallmann Syndrome | Hypothyroidism | Methylmalonic Acidemia | Amblyopia | Juvenile Myoclonic Epilepsy | Juvenile Myelomonocytic Leukemia | Pseudoexfoliation Syndrome | Uremia | Necrobiosis Lipoidica | Cold Agglutinin Disease | Duchenne Muscular Dystrophy | Adenomatoid Tumor | Hypohidrotic Ectodermal Dysplasia, X-linked | Lymphoma | Tetanus | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Dystrophy, Cone-rod | Myocarditis | 3-methylglutaconic Aciduria | Spinocerebellar Ataxia Type 6 | Esophageal Motility Disorders | Autoimmune Hemolytic Anemia | Dysequilibrium Syndrome | Premenstrual Syndrome | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Hypertension, Renal | Trachoma | Stevens-Johnson Syndrome | Chronic Periodontitis | Niemann-Pick Disease, Type B | Myositis, Focal | Otopalatodigital Syndrome Type 2 | Anemia | Astigmatism | Sporadic Inclusion Body Myositis | Blastoma, Pleuropulmonary | Eczema | Skin Carcinoma | Ligneous Conjunctivitis | Primary Progressive Nonfluent Aphasia | Keratoconus | Congenital Disorders Of Glycosylation Type II | X-linked Acrogigantism | Hypohidrotic Ectodermal Dysplasia | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Lymphangioma | Glutaric Aciduria Type 2 | Succinic Semialdehyde Dehydrogenase Deficiency | Waardenburg Syndrome Type 2E | Opisthorchiasis | Angioimmunoblastic T-cell Lymphoma | ICF Syndrome | Granular Corneal Dystrophy | Carey-Fineman-Ziter Syndrome | Impetigo | Rhabdomyosarcoma, Embryonal | Measles | Pleomorphic Xanthoastrocytoma | Osteochondroma | Alzheimer Disease, Late Onset | Wolcott-Rallison Syndrome | Huntington's Disease-like 2 | Senior-Loken Syndrome | Carney-Stratakis Syndrome | Transcobalamin Deficiency | Lysosomal Acid Lipase Deficiency | Hyperlipidemia Type V | Waldenstrom Macroglobulinemia | Asplenia | Acute Tubular Necrosis | Systemic Mastocytosis | Congenital Dysfibrinogenemia | Pneumonia, Mycoplasma | Porphyria, Acute Intermittent | Personality Disorders | Glycogen Storage Disease Type 1b | Cutis Laxa | Johanson-Blizzard Syndrome | Narcolepsy | Acute Anterior Uveitis | Hypersensitivity | Histiocytosis | Bloom Syndrome | Adult Polyglucosan Body Disease | Learning Disability | Glycogen Storage Disease Type 0, Muscle | CDKL5 Deficiency Disorder | Brooke-Spiegler Syndrome | Arthropathy | Mandibuloacral Dysplasia With Type A Lipodystrophy | Klinefelter Syndrome | Kohlschutter-Tonz Syndrome | Haim-Munk Syndrome | Hemochromatosis | Congenital Nephrotic Syndrome | Malaria, Cerebral | Cystitis, Interstitial | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Macular Corneal Dystrophy Type 1 | Schizotypal Personality Disorder | Hartnup Disease | Hypertension | Neuroleptic Malignant Syndrome | Usher Syndrome Type IIC | Hypogonadism | Agranulocytosis | Hepatic Steatosis | Bartsocas-Papas Syndrome | Vasculitis