Disease

Erectile Dysfunction

About the Disease
Impotence, also known as erectile dysfunction, is related to vasculogenic impotence and prolactinoma, and has symptoms including angina pectoris, pelvic pain and tremor. An important gene associated with Impotence is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Signal Transduction and MIF Mediated Glucocorticoid Regulation. The drugs Selegiline and Nebivolol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, prostate and spinal cord, and related phenotypes are no effect and no effect

Common Targets
KDM5B | LRRK2 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | Prostanoid Receptor (nonspecified subtype) | G7124 | G4780 | PHACTR2 | KCNN3 | GLI2 | SLC18A2 | Serine/Threonine Kinase (nonspecified subtype) | DRD2 | FKBP4 | NOS1 | RMDN2 | KCNQ4 | DRD4 | ADRA1A | ROCK1 | GNB3 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | ESR2 | Alpha-2 Adrenergic receptors (nonspecified subtype) | GH1 | HTR1A | FSHR | SLC6A2 | DNA Topoisomerase II (nonspecified subtype) | G142 | HMGCR | TRPC5 | F13B | Steroid 5-alpha-Reductase (nonspecified subtype) | PDCD4 | PPID | TRPV2 | VIP | PDE9A | ARG1 | alpha-Adrenoceptor (nonspecified subtype) | Raf kinase (nonspecified subtype) | Tyrosine Kinase (nonspecified subtype) | Chloride channel (nonspecified subtype) | PTPN1 | ADRB3 | G3630 | AKR1B1 | Guanylate cyclase (nonspecified subtype) | NTRK1 | VIPR1 | OXT | F2 | CES1 | cAMP-Dependent protein kinase (PKA) | G367 | MC3R | IGFBP3 | ARHGEF12 | PTGER4 | ADORA3 | K(ATP) Channel (nonspecified subtype) | NPY5R | PTGDR | TEK | G1956 | LOC105374318 | NOS3 | DRD1 | MME | SLC6A4 | beta-Adrenoceptor (nonspecified subtype) | CELA2A | PDE5A | KCNQ5 | Dopamine receptor (nonspecified subtype) | PDE2A | TTC7A | HTR2A | ADRA1D | G7422 | ROCK2 | TXNRD1 | Poly [ADP-ribose] polymerase (nonspecified subtype) | NOX3 | G3569 | AOPEP | GUCY2C | CYP19A1 | MC4R | alpha1-Adrenoceptor (nonspecified subtype) | AGER | P2RX2 | HTR2C | DRD3 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | NPR1 | LRP1B | CNNM3 | NADPH Oxidase Complex | KCNMB1 | Arginase (nonspecified subtype) | Glutathione S-Transferase (GST) (nonspecified subtype) | SLC6A3 | Potassium Channels (nonspecified subtype) | ADRA1B | CDK1 | OXTR | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | LOC105376767 | Rho kinase (ROCK) (nonspecified subtype) | NADPH Oxidase (nonspecified subtype) | Bombesin receptor (nonspecified subtype) | SCN5A | Soluble guanylyl cyclase | GRIN3A | CDK7 | Melanocortin receptor (nonspecified subtype) | NGF | ARG2 | MC5R | PDE3A | Phosphodiesterase (nonspecified subtype) | TRPM3 | MC1R | EDNRA | HIF1A | AMP-activated protein kinase (AMPK) | Vasoactive intestinal polypeptide receptor (VIP-R) (nonspecified subtype) | PTGFRN | AVPR1A | Phosphodiesterase 6 (PDE6) (nonspecified subtype)

疾病靶点研报
Erectile Dysfunction

Note: If you'd like to get a target analysis report for Erectile Dysfunction, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Erectile Dysfunction at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Calcium Pyrophosphate Deposition Disease | Rubeosis Iridis | Leri Pleonosteosis | Isobutyryl-CoA Dehydrogenase Deficiency | Ebstein Anomaly | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Auriculocondylar Syndrome | Tardive Dyskinesia | Progressive Familial Intrahepatic Cholestasis Type 1 | Arthrogryposis | Li-Fraumeni Syndrome | Takotsubo Cardiomyopathy | Guillain-Barre Syndrome | Chronic Inflammatory Demyelinating Polyneuropathy | Osteogenesis Imperfecta Type V | Hyperthyroidism | Trichomegaly | Prostatitis | Delayed Sleep Phase Syndrome | Prader-Willi Syndrome | B-cell Chronic Lymphocytic Leukemia | Acute Motor Axonal Neuropathy | Pseudohypoparathyroidism Type 2 | LMNA-related Congenital Muscular Dystrophy | Chorea | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Aceruloplasminemia | Centronuclear Myopathy | Eccrine Porocarcinoma | Chronic Thromboembolic Pulmonary Hypertension | Polycystic Kidney, Autosomal Recessive | Shprintzen-Goldberg Syndrome | Malonyl-CoA Decarboxylase Deficiency | Erythrokeratodermia Variabilis | Anal Fissure | Parkinson Disease 6, Autosomal Recessive Early-onset | Connective Tissue Disorders | Schwannomatosis | Fibronectin Glomerulopathy | Leukocyte Adhesion Deficiency Type 1 | Leukemia-lymphoma, Adult T-cell | Ocular Hypertension | Hypoproteinemia, Hypercatabolic | Basal Ganglia Disease | Retinal Vasculitis | Hypoalbuminemia | Iron Deficiency Anemia | Pilomatrix Carcinoma | Amyloidosis | Congenital Heart Defects | Scleroderma | Acrodermatitis Enteropathica | Measles | Congenital Dyserythropoietic Anemia Type 1 | Kindler Syndrome | Reye Syndrome | Lichen Planus | Pulmonary Vein Stenosis | Fundus Albipunctatus | Rhabdomyosarcoma, Embryonal | Carcinoma, Merkel Cell | Myopathy | Nail Disorder, Nonsyndromic Congenital | Hyperostosis | Hypolipoproteinemia | Mitochondrial Disease | Gilbert Syndrome | Generalized Epilepsy With Febrile Seizures Plus | Urticaria | Ehlers-Danlos Syndrome | Renal Tubular Acidosis | Fraser Syndrome | Basal Ganglia Cerebrovascular Disease | Diabetic Encephalopathy | Spinocerebellar Ataxia Type 7 | Apert Syndrome | Cockayne Syndrome | Optic Nerve Hypoplasia, Bilateral | Malignant Peripheral Nerve Sheath Tumor | Polymicrogyria | Asthma | Systemic Lupus Erythematosus | Cholestasis | Angioimmunoblastic T-cell Lymphoma | Parkinson's Disease | Tuberculosis | Tremor | Syncope | Nephrotic Syndrome Type 1 | Aromatic L-amino Acid Decarboxylase Deficiency | Hypercalciuria | Dominant Optic Atrophy | Pseudoachondroplasia | Vitiligo | Schistosomiasis | Hypotension, Orthostatic | Primary Hyperoxaluria Type 1 | Peters-plus Syndrome | Congenital Primary Aphakia | Hashimoto Thyroiditis | McLeod Syndrome | Prediabetes | Pernicious Anemia | Liver Diseases | Hypophosphatasia | Familial Cerebral Amyloid Angiopathy | Infantile Neuroaxonal Dystrophy | Common Variable Immunodeficiency | Multifocal Motor Neuropathy | Familial Advanced Sleep Phase Syndrome | Skin Papilloma | Beta-Propeller Protein-associated Neurodegeneration | Birk-Barel Syndrome | Perry Syndrome | Thanatophoric Dysplasia Type 1 | Antiphospholipid Syndrome | Autosomal Recessive Bestrophinopathy | Waardenburg Syndrome | Eosinophilic Asthma | Depression | Coffin-Lowry Syndrome | Primary Hyperoxaluria Type 3 | Neuromyelitis Optica | Conduct Disorder | Dysfibrinogenemia | Neurogenic Bladder | Holoprosencephaly | Hereditary Pyropoikilocytosis | Pulmonary Veno-occlusive Disease | Tendinopathy | Alpha-mannosidosis | Mohr-Tranebjaerg Syndrome | Myoclonus | Filariasis | Non-epidermolytic Palmoplantar Keratoderma | Pancreatitis, Chronic | Uveitis, Anterior | Sialoadenitis | Thalassemia, Beta | Stiff-man Syndrome | Primary Hyperoxaluria | Wilson's Disease | Idiopathic Multicentric Castleman Disease | Snyder-Robinson Syndrome | Schizotypal Personality Disorder | ACTH-independent Macronodular Adrenal Hyperplasia | Gastroenteritis | Miyoshi Myopathy | Pulmonary Alveolar Proteinosis | T-cell Leukemia | Amyotrophic Lateral Sclerosis | Dent Disease | Nephropathy | Transient Bullous Dermolysis Of The Newborn | Hypersensitivity Pneumonitis | VACTERL/VATER Association | Spinocerebellar Ataxia Type 38 | Barakat Syndrome | Fontaine Progeroid Syndrome | Methylmalonic Acidemia | Tendinitis | Blomstrand Osteochondrodysplasia | Glioblastoma | Cenani-Lenz Syndactyly Syndrome | Best Macular Dystrophy | Enterocolitis, Necrotizing | Mitochondrial DNA Depletion Syndrome 13 | ICF Syndrome | Hyperlipidemia Type V | Carpenter Syndrome | Schwartz-Jampel-Aberfeld Syndrome | Lassa Fever | Congenital Generalized Lipodystrophy | Hyperinsulinemic Hypoglycemia | Rubinstein-Taybi Syndrome | Mucormycosis | Diabetic Neuropathy | Macular Corneal Dystrophy | Necrotizing Autoimmune Myopathy | Congestive Heart Failure | Renal Hypouricemia | Hepatitis D | Blood Protein Disorders | Palmoplantar Keratoderma | Platelet Disorders | Sensorineural Hearing Loss | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Niemann-Pick Disease | Oligoastrocytoma | Thrombosis | Cardiac Sarcoidosis | Bicuspid Aortic Valve | Leiomyoma | Macular Degeneration | Spinocerebellar Ataxia Type 27 | Spondyloarthritis | Lamellar Ichthyosis | Hypopigmentation | H Syndrome | Panuveitis | Leber Hereditary Optic Neuropathy | Congenital Stromal Corneal Dystrophy | Glycogen Storage Disease Type 1 | Familial Mediterranean Fever | Ichthyosis | Odonto-onycho-dermal Dysplasia | DICER1 Syndrome | Cornelia De Lange Syndrome | Esophageal Adenocarcinoma | Persistent Hyperplastic Primary Vitreous | Autoimmune Polyendocrine Syndrome | Branchiootorenal Syndrome | Central Retinal Artery Occlusion | Infectious Diarrhea | Pyruvate Kinase Deficiency | Brugada Syndrome 1 | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Cold-induced Sweating Syndrome | Genee-Wiedemann Syndrome | Gerstmann-Straussler-Scheinker Syndrome | Hyperthermia, Malignant | Hypothalamic Obesity | Adenomyosis | Left Ventricular Noncompaction | Shock, Cardiogenic | Pseudohypoparathyroidism Type 1B | Bone Marrow Necrosis | Menkes Disease | Ovarian Hyperstimulation Syndrome | Pain | Glycogen Storage Disease Type 6 | Splenomegaly | Beckwith-Wiedemann Syndrome | Macrodactyly | Still Disease | Spondylocarpotarsal Synostosis Syndrome | Erythema Nodosum | Mucolipidosis Type IV | Astigmatism | Angiosarcoma Of The Breast | Dysgerminoma | Hairy Cell Leukemia | Chanarin-Dorfman Syndrome | Ichthyosis Hystrix, Curth-Macklin Type | Martsolf Syndrome | Iron Overload | Spermatocele | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Chronic Enteropathy Associated With SLCO2A1 Gene | Adenoid Cystic Carcinoma | Retinal Diseases | Congenital Mirror Movements | Choroiditis | Spinocerebellar Ataxia Type 17 | Barrett Esophagus | Tyrosinemia | Cyst | Leprosy | Cryptosporidiosis | Meningioma, Benign | ADNP Syndrome | Wolcott-Rallison Syndrome | Osteoporosis, Postmenopausal | Hyperuricemic Nephropathy, Familial Juvenile | Epidermolytic Hyperkeratosis | Oculodentodigital Dysplasia | Asperger Syndrome | Robinow Syndrome | Proctitis | Vasculitis | Exfoliative Dermatitis | Wolman Disease | Neuroectodermal Tumors, Primitive | Hidradenitis | Gastroenteritis, Eosinophilic | Medulloblastoma | Hemochromatosis Type 1 | Glutathione Synthetase Deficiency | Carcinoma, Squamous Cell | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Papilledema | Congenital Fiber-type Disproportion Myopathy | Immunoproliferative Disorders | Nicotine Addiction | Thyroid Dyshormonogenesis | Macular Corneal Dystrophy Type 1 | Poirier-Bienvenu Neurodevelopmental Syndrome | Lymphangioleiomyomatosis | Dental Caries | Plasma Cell Dyscrasia | Cataplexy | Porphyria Cutanea Tarda | Hyperparathyroidism, Primary | Creutzfeldt-Jakob Disease | Pleurisy | Neuromyotonia | Sarcomatoid Carcinoma Of The Lung | Myocarditis | Ischemia | Retinoschisis | Pseudo-pseudohypoparathyroidism | Erdheim-Chester Disease | Juvenile Myoclonic Epilepsy | Myosin Storage Myopathy | Huntington's Disease | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Mitochondrial Encephalomyopathy | Acrodermatitis | Malaria, Cerebral | Fukuyama Congenital Muscular Dystrophy | Spondylometaphyseal Dysplasia | Meier-Gorlin Syndrome | Pouchitis | Episodic Ataxia Type 2 | Alstrom Syndrome | Recurrent Respiratory Papillomatosis | Chorea-acanthocytosis | Rheumatic Heart Disease | 3-methylglutaconic Aciduria Type IV | Glioblastoma Multiforme | Open-angle Glaucoma | Purpura, Thrombotic Thrombocytopenic | Dystonia-parkinsonism, X-linked | Neuropathy | Aspartylglycosaminuria | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Dermatofibrosarcoma | Meningococcal Infections | Hypoglycemia | Giant Axonal Neuropathy | Tuberculous Meningitis | Adams-Oliver Syndrome | Dupuytren Disease | Sleep Apnea, Obstructive | Myhre Syndrome | Split Hand-foot Malformation | Lattice Corneal Dystrophy | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Melanoma, Malignant | Trachoma | Paraplegia | Vici Syndrome | Leishmaniasis, Visceral | Cryptococcal Meningitis | Hepatitis | Sick Sinus Syndrome | Analgesia | Pyoderma Gangrenosum | Chromosome 5q Deletion Syndrome | Keratocystic Odontogenic Tumor | Congenital Aniridia | Neuromuscular Disorders | Anemia | Subacute Sclerosing Panencephalitis | Hemoglobinopathies | Thyroiditis | Chronic Lymphocytic Leukemia | Chloridorrhea, Congenital | Overactive Bladder | Hyperbilirubinemia | Keratosis, Seborrheic | Antenatal Bartter Syndrome Type 1 | Erectile Dysfunction | Familial Partial Lipodystrophy | Leishmaniasis, Cutaneous | Donnai-Barrow Syndrome | Aarskog-Scott Syndrome | Cancer, Skin | Dysthymia | C3 Glomerulonephritis | Disseminated Intravascular Coagulation | Congenital Hereditary Endothelial Dystrophy Type II | Opisthorchiasis | Sezary Syndrome | Thrombophilia | Hypervalinemia | Dysferlinopathy | Lipid Metabolism Disorders | Burn-McKeown Syndrome | Esotropia | Presbyopia | Oculocutaneous Albinism | Facioscapulohumeral Muscular Dystrophy Type 2 | Hydronephrosis | Enhanced S-cone Syndrome | Purpura | Mannosidase Deficiency Diseases | Cheilitis | Renal-hepatic-pancreatic Dysplasia | Tumoral Calcinosis | Vaginitis | Alpha-1 Antitrypsin Deficiency | Cholelithiasis | Rhabdoid Tumor | Bronchitis | Antisynthetase Syndrome | Angiomyolipoma | Takenouchi-Kosaki Syndrome | Autoimmune Hemolytic Anemia