Disease

Primary Sclerosing Cholangitis

About the Disease
Cholangitis, Primary Sclerosing, also known as primary sclerosing cholangitis, is related to portal hypertension and autoimmune pancreatitis, and has symptoms including icterus An important gene associated with Cholangitis, Primary Sclerosing is SEMA4D (Semaphorin 4D), and among its related pathways/superpathways is Defensins. The drugs Vancomycin and Bezafibrate have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and thyroid, and related phenotypes are autoimmunity and portal hypertension

Common Targets
G5133 | MALT1 | THBS1 | Integrin alpha4beta1 (VLA-4) receptor | TGFB1 | CYP7A1 | GAL | PNPLA3 | G4780 | PPARA | MAOA | G142 | DHODH | UGT1A7 | Integrin alpha4beta7 (LPAM-1) receptor | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | NR1I2 | CCR2 | SHC1 | TM6SF2 | PPARD | SEMA4D | GIPR | G3630 | NR1H4 | AOC1 | HSD17B13 | Caspase (nonspecified subtype) | G5743 | LOXL2 | IL2 | Integrin alphavbeta6 receptor | VDR | TLR9 | IL10 | SLC10A2 | G1956 | CCR5 | Integrin alphavbeta1 | UGT1A1 | CCL24 | MADCAM1 | ACACA | MRGPRX4 | GLP1R | MAOB | Galanin receptor (nonspecified subtype) | CMA1 | G3576 | AOC3 | UGT1A3

疾病靶点研报
Primary Sclerosing Cholangitis

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