Primary Hyperoxaluria Type 1

About the Disease
Hyperoxaluria, Primary, Type I, also known as primary hyperoxaluria type 1, is related to primary hyperoxaluria and chromosome 2q37 deletion syndrome, and has symptoms including bone pain An important gene associated with Hyperoxaluria, Primary, Type I is AGXT (Alanine--Glyoxylate Aminotransferase), and among its related pathways/superpathways are Gene expression (Transcription) and Metabolism of proteins. The drugs Lumasiran and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include kidney, eye and liver, and related phenotypes are anemia and nephrocalcinosis

Common Targets
HAO1 | LDHA | AGXT

Note: If you'd like to get a target analysis report for Primary Hyperoxaluria Type 1, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Primary Hyperoxaluria Type 1 at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Waardenburg Syndrome Type 2A | Holt-Oram Syndrome | Cerebellofaciodental Syndrome | CHARGE Syndrome | Pituitary Disorders | Ligneous Conjunctivitis | Congenital Nephrotic Syndrome | Graves Disease | Japanese Encephalitis | Cystinosis | Vici Syndrome | Glycogen Storage Disease Type 6 | Onchocerciasis | Chronic Thromboembolic Pulmonary Hypertension | Familial Digital Arthropathy-brachydactyly | Bicuspid Aortic Valve | Chediak-Higashi Syndrome | Myocardial Infarction | Non-Hodgkin Lymphoma | Sickle Cell Anemia | Rothmund-Thomson Syndrome | POEMS Syndrome | Alpers Syndrome | Hepatitis C, Chronic | Riboflavin Transporter Deficiency Neuronopathy | Intellectual Disability, Autosomal Dominant 5 | Gastrointestinal Disorders | Paraganglioma | Van Der Knaap Disease | Cancer, Brain | Nevus | Acute Tubular Necrosis | Hypohidrotic Ectodermal Dysplasia, X-linked | Sclerosteosis | Mosaic Variegated Aneuploidy Syndrome 2 | Hypermetropia | Thanatophoric Dysplasia Type 1 | Centronuclear Myopathy | Neuroblastoma | Ocular Hypertension | Bernard-Soulier Syndrome | Diabetes Gestational | Osteogenesis Imperfecta Type V | Paternal Uniparental Disomy Of Chromosome 14 | Iron Metabolism Disorders | Myasthenia | Adenosine Deaminase Deficiency | Endocarditis | Mast Cell Leukemia | Hepatitis, Chronic | Hydronephrosis | Sjogren Syndrome | Sarcoidosis | GNE Myopathy | Cerebral Amyloid Angiopathy | C3 Glomerulonephritis | Mucolipidosis | Microcephaly | Common Variable Immunodeficiency | Glomerulonephritis | Toxic Epidermal Necrolysis | Choroideremia | Giant Axonal Neuropathy | Angina Pectoris | Hypophosphatasia | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Aphasia | Micropenis | Pemphigus Foliaceus | Focal Dermal Hypoplasia | Prediabetes | Waardenburg Syndrome Type 1 | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Neurodegeneration With Brain Iron Accumulation | Thrombophilia | Synovitis | Benign Familial Pemphigus | Pulmonary Sclerosing Hemangioma | Paracoccidioidomycosis | Cutaneous Mastocytosis | Patent Ductus Arteriosus | Metaphyseal Chondrodysplasia, Schmid Type | Inflammatory Bowel Disease | Lung Diseases | Feingold Syndrome | Hyperandrogenemia | Chronic Lymphocytic Leukemia | Myopathy | Martsolf Syndrome | Antenatal Bartter Syndrome Type 1 | Glanzmann Thrombasthenia | Usher Syndrome Type IIC | Niemann-Pick Disease, Type C | Charcot-Marie-Tooth Disease Type 4D | Walker-Warburg Syndrome | Thrombocytopenia | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Turner's Syndrome | Colitis, Microscopic | Spinocerebellar Ataxia Type 5 | KBG Syndrome | Wiedemann-Steiner Syndrome | Adenoma, Pleomorphic | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Craniometaphyseal Dysplasia | T-cell Prolymphocytic Leukemia | Retinopathy, Diabetic | Colitis, Lymphocytic | Veno-occlusive Disease | Epilepsy | Hemangioendothelioma | Tyrosinemia | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Neurodermatitis | Multiple Sclerosis, Relapsing-remitting | Palmoplantar Keratoderma | Ileitis | 3-hydroxy-3-methylglutaric Aciduria | Hereditary Coproporphyria | Viral Meningitis | Persistent Fetal Circulation | T-cell Leukemia | Primary Carnitine Deficiency | Osteochondroma | Proximal Symphalangism | Leishmaniasis, Visceral | Myositis, Focal | Metanephric Adenoma | Eiken Syndrome | Glycogen Storage Disease Type 3 | Hypogammaglobulinemia | Diffuse Palmoplantar Keratoderma | Hypercalcemia | Lymphoproliferative Disorders | Melnick-Needles Syndrome | Subcortical Band Heterotopia | Polyradiculopathy | Hereditary Xerocytosis | Inflammatory Linear Verrucous Epidermal Nevus | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Uterine Leiomyoma | Congenital Torticollis | Myositis | Acute Chest Syndrome | Atelosteogenesis Type 1 | Polycystic Liver | Spinocerebellar Ataxia Type 10 | Goiter, Nodular | Lateral Meningocele Syndrome | Primary Hyperoxaluria Type 3 | Bloom Syndrome | Brooke-Spiegler Syndrome | HANAC Syndrome | Scabies | Myelomeningocele | Macular Corneal Dystrophy | Hereditary Hemorrhagic Telangiectasia | Tietze Syndrome | Renal Hypouricemia | Allan-Herndon-Dudley Syndrome | Axenfeld-Rieger Syndrome | Neurofibromatosis | Erythropoietic Protoporphyria | Pleomorphic Xanthoastrocytoma | Becker Muscular Dystrophy | Meningitis | LRBA Deficiency | Pernicious Anemia | Melanoma | Postpoliomyelitis Syndrome | Chondromyxoid Fibroma | Fascioliasis | Majeed Syndrome | Camptocormia | Dyskeratosis Congenita | Bardet-Biedl Syndrome | Pyruvate Decarboxylase Deficiency | Acrocallosal Syndrome | Hyperuricemia | Cutaneous T-cell Lymphoma | Hodgkin Lymphoma | Micro Syndrome | CREST Syndrome | Dermatofibrosarcoma | Hypervalinemia | Retinitis | Seizures-scoliosis-macrocephaly Syndrome | Partington Syndrome | Atelosteogenesis Type 2 | Blue Rubber Bleb Nevus Syndrome | Astigmatism | Optic Neuritis | Carney Triad | Sleep Apnea, Central | Influenza | Hypereosinophilic Syndrome | Familial Hypobetalipoproteinemia | Optic Neuropathy, Anterior Ischemic | Melanoma, Malignant | Chondrosarcoma | Pyoderma Gangrenosum | Microcephalic Primordial Dwarfism | Combined Malonic And Methylmalonic Acidemia | Cryopyrin-associated Periodic Syndromes | Waardenburg Syndrome Type 4 | Ectodermal Dysplasia | Spinocerebellar Ataxia Type 1 | Otitis Externa | Intermittent Claudication | Meier-Gorlin Syndrome | Melanocytic Nevus | Inborn Errors Of Metabolism | Charcot-Marie-Tooth Disease Type 4B1 | Alopecia Areata | Primary Torsion Dystonia | Atrioventricular Septal Defect | Amish Infantile Epilepsy Syndrome | Oligospermia | Early Infantile Epileptic Encephalopathy 28 | Cranioectodermal Dysplasia | Pseudohypoparathyroidism Type 1C | Primary Lateral Sclerosis | Vitreoretinopathy, Proliferative | Osteoporosis-pseudoglioma Syndrome | Christianson Syndrome | Paroxysmal Nocturnal Hemoglobinuria | Angiosarcoma Of The Breast | Lymphedema | Precocious Puberty | Cardiomyopathy, Peripartum | Hyperparathyroidism | Shwachman-Bodian-Diamond Syndrome | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Schizophrenia | Stroke | Esotropia | Early Infantile Epileptic Encephalopathy | Neurofibromatosis Type 1 | Agnathia-Otocephaly Complex | Tyrosinemia Type 1 | Dystrophy, Cone-rod | Renal Medullary Carcinoma | Malnutrition | Temtamy Preaxial Brachydactyly Syndrome | Hepatitis A | Spinocerebellar Ataxia Type 28 | Familial Retinal Arterial Macroaneurysm | Vascular Calcification | Hypercholesterolemia | Polycystic Ovary Syndrome | Heroin Dependence | Leiomyoma | Metatropic Dysplasia | Fowler's Syndrome | Osteoporosis, Postmenopausal | Hereditary Sensory Neuropathy Type 1 | Myoclonus | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Lattice Corneal Dystrophy | Robinow Syndrome | Cancer, Prostate | Spondylocostal Dysostosis | Glycogen Storage Disease Type 1a | Nephroblastoma | Lattice Corneal Dystrophy Type 1 | Temporal Lobe Epilepsy | Myotonic Disorders | Brachydactyly | Pityriasis Rubra Pilaris | Arthritis, Psoriatic | Smith-Kingsmore Syndrome | Schizophrenia, Paranoid | Lymphoma, AIDS-related | Familial Isolated Hyperparathyroidism | Genitopatellar Syndrome | Frank-ter Haar Syndrome | Barrett Esophagus | Stroke, Hemorrhagic | Cutaneous Lupus Erythematosus | Woodhouse-Sakati Syndrome | Juvenile Xanthogranuloma | Progressive Osseous Heteroplasia | Hypospadias | Marshall-Smith Syndrome | Primary Cutaneous Amyloidosis | Panuveitis | Behavioral Variant Of Frontotemporal Dementia | Tinea | Goldenhar Syndrome | Encephalocele | Asthma, Exercise-induced | Carey-Fineman-Ziter Syndrome | Malonyl-CoA Decarboxylase Deficiency | Addison Disease | Occipital Neuralgia | Xeroderma Pigmentosum | Tularemia | Vitamin B12 Deficiency | Cholera | Paget's Disease Of The Breast | Glycogen Storage Disease Type 1 | Hypertension, Portal | Corneal Dystrophy | Hypersensitivity | Warsaw Breakage Syndrome | Fibromuscular Dysplasia | Bruck Syndrome | Gastritis | Neurofibroma | Cockayne Syndrome | Schizotypal Personality Disorder | DNA Ligase IV Deficiency | Cholestasis, Intrahepatic | Constipation | Hypolipoproteinemia | Dent Disease | 3-methylglutaconic Aciduria Type I | Porphyria Cutanea Tarda | Pituitary Dwarfism | Aspartylglycosaminuria | Absence Epilepsy | Keratoconjunctivitis | Charcot-Marie-Tooth Disease Type 4 | CHOPS Syndrome | Tangier Disease | Autosomal Recessive Congenital Ichthyosis | Macular Degeneration | Retinal Detachment | DEND Syndrome | Brenner Tumor | Myeloid Leukemia | Lymphangiomatosis | Inflammatory Myopathy | Stomatitis | Orotic Aciduria | Osteonecrosis | Insulin Resistance | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Carpal Tunnel Syndrome | Glutathione Synthetase Deficiency | Aspergillosis | Situs Inversus | Chronic Granulomatous Disease | Sialidosis | Takotsubo Cardiomyopathy | Congenital Hereditary Endothelial Dystrophy Type I | Pemphigus Vulgaris | Leukoplakia, Oral | Achondrogenesis | Charcot-Marie-Tooth Disease, Type 2A | Autosomal Recessive Spastic Paraplegia Type 35 | Pericarditis | Chorea-acanthocytosis | Bladder Exstrophy | Hypertension, Renal | Barakat Syndrome | Aplasia Cutis Congenita | Deafness, Dystonia, And Cerebral Hypomyelination | Chronic Neutrophilic Leukemia | Cystinuria | Sarcoidosis, Pulmonary | Congenital Myasthenic Syndrome | Scleroderma, Diffuse | Anorectal Malformations | Oligoasthenoteratozoospermia | Hyperinsulinemic Hypoglycemia | Osteochondrosis | Blepharo-cheilo-odontic Syndrome | Osteonecrosis Of The Jaw | Clouston Hidrotic Ectodermal Dysplasia | Amyotrophic Lateral Sclerosis | Osteitis | X-linked Charcot-Marie-Tooth Disease | Lipoma | Myopia | Pyruvate Carboxylase Deficiency Disease | Proteasome-associated Autoinflammatory Syndrome 2 | Osteogenesis Imperfecta | Myelofibrosis | Cholesteryl Ester Storage Disease | Primary Progressive Nonfluent Aphasia | Dengue Shock Syndrome | Impulse Control Disorder | Arteriovenous Malformations | Stuttering | Fibromyalgia | Argininosuccinic Aciduria | Disseminated Superficial Actinic Porokeratosis | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | L-2-Hydroxyglutaric Aciduria | Presbyopia | Congenital Hemolytic Anemia | Moyamoya Disease | VACTERL/VATER Association | Coronary Artery Disease | Silver-Russell Syndrome | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Schwannoma | Raynaud Phenomenon | Fibrillation, Atrial