Disease

Bilateral Optic Nerve Hypoplasia

About the Disease
Optic Nerve Hypoplasia, Bilateral, also known as optic nerve hypoplasia, is related to aniridia 2 and gillespie syndrome. An important gene associated with Optic Nerve Hypoplasia, Bilateral is PAX6 (Paired Box 6), and among its related pathways/superpathways is Transcriptional Regulatory Network in Embryonic Stem Cell. The drugs Hormones and Melatonin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, eye and brain, and related phenotypes are optic nerve hypoplasia and optic disc hypoplasia

Common Targets
KANSL1 | UBE3B | KIF7 | COL4A1 | WNK3 | FGF8 | NALCN-AS1 | CYP26C1 | COL4A2 | ATOH7 | SPG7 | CYP26A1 | NBAS | SLC25A1 | PAX6 | CASK | OPA1 | ALDH1A3

疾病靶点研报
Bilateral Optic Nerve Hypoplasia

Note: If you'd like to get a target analysis report for Bilateral Optic Nerve Hypoplasia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Bilateral Optic Nerve Hypoplasia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Gigantism | Myasthenia Gravis | Microtia | Hoyeraal-Hreidarsson Syndrome | Chudley-McCullough Syndrome | Neuropathy | Absence Epilepsy | Urticaria | Chorea | Vasculitis | Familial Pheochromocytoma-paraganglioma | Esophagitis | Progressive Myoclonic Epilepsy | Sarcoidosis, Pulmonary | Scabies | Spondyloepiphyseal Dysplasia Tarda, X-linked | Diffuse Palmoplantar Keratoderma | Juvenile Myoclonic Epilepsy | Encephalocele | Congenital Hypofibrinogenemia | Common Variable Immunodeficiency | Panniculitis | Guanidinoacetate Methyltransferase Deficiency | Vitiligo | Amyloidosis | Porphyria, Acute Intermittent | Familial Hypertrophic Cardiomyopathy | Achromatopsia | Galactosemia | Maple Syrup Urine Disease | Hepatitis, Autoimmune | Infantile Nephropathic Cystinosis | AIDS | Aromatic L-amino Acid Decarboxylase Deficiency | Heavy Chain Disease | Glucagonoma | Anuria | Membranous Nephropathy | Borjeson-Forssman-Lehmann Syndrome | Cardiac Arrest | Ghosal Syndrome | Epithelial-myoepithelial Carcinoma | Prolactinoma | Dermatofibrosarcoma | Hypokalemic Periodic Paralysis | Schizotypal Personality Disorder | Pain | Pendred Syndrome | Von Hippel-Lindau Disease | Lamellar Ichthyosis | Spinal And Bulbar Muscular Atrophy | Infectious Diarrhea | Knobloch Syndrome | Nasodigitoacoustic Syndrome | Carney-Stratakis Syndrome | Hyperinsulinism-hyperammonemia Syndrome | Renal Oncocytoma | Microphthalmia | Methemoglobinemia Type IV | Erythema Nodosum | Behavioral Variant Of Frontotemporal Dementia | Sclerosteosis 2 | Hypoproteinemia, Hypercatabolic | Conduct Disorder | Autoimmune Polyendocrinopathy Syndrome Type I | Autoimmune Autonomic Ganglionopathy | Familial Episodic Pain Syndrome | Irritable Bowel Syndrome | Kohlschutter-Tonz Syndrome | Muckle-Wells Syndrome | Okihiro Syndrome | Glioblastoma | Vitamin K Deficiency | Mitochondrial DNA Depletion Syndrome 13 | Donnai-Barrow Syndrome | Demyelinating Diseases | Duchenne Muscular Dystrophy | Hypotrichosis Simplex | Osteoporosis-pseudoglioma Syndrome | Mesothelioma, Malignant | Fatty Aldehyde Dehydrogenase Deficiency | Congenital Stationary Night Blindness | Myoclonic Atonic Epilepsy | Early Infantile Epileptic Encephalopathy | Sclerosing Cholangitis | Cholelithiasis | Ileitis | Analgesia | Carotid Artery Disease | Milk Allergy | Basal Cell Nevus Syndrome | Malonyl-CoA Decarboxylase Deficiency | Lysosomal Acid Lipase Deficiency | Infantile Liver Failure Syndrome 1 | Acute Kidney Injury | Pre-eclampsia | Coronary Heart Disease | Cohen Syndrome | Fibrosarcoma | Hydrolethalus Syndrome | Bipolar Disorder | Carcinoma, Small Cell | Ophthalmoplegia | Smith-Magenis Syndrome | Filariasis | Acute Motor Axonal Neuropathy | Alexander Disease | Benign Familial Neonatal Convulsions | Perry Syndrome | Paget's Disease Of The Breast | Optic Nerve Hypoplasia, Bilateral | Cartilage Disorders | Crouzon Syndrome With Acanthosis Nigricans | Progressive Encephalopathy-optic Atrophy Syndrome | Chromosome 17q21.31 Deletion Syndrome | Paronychia | Aneurysm, Thoracic Aortic | Fanconi Syndrome | Fibrillation, Atrial | Ichthyosis | Otopalatodigital Syndrome Type 2 | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | CEDNIK Syndrome | Arteriosclerosis | Intestinal Pseudo-obstruction | Endocarditis | Primary Progressive Nonfluent Aphasia | Phenylketonuria | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Bullous Pemphigoid | Rhabdomyosarcoma, Alveolar | Vitamin A Deficiency | Hyperinsulinemia | Leiomyosarcoma | Thrombasthenia | Birt-Hogg-Dube Syndrome | Hypercalciuria | Metatropic Dysplasia | Acromegaly | Premature Ejaculation | Amelanotic Melanoma | Erythromelalgia | Mountain Sickness | Renpenning Syndrome | Antenatal Bartter Syndrome Type 1 | Agammaglobulinemia | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Cholecystitis | Cerebrotendinous Xanthomatosis | Binge Eating Disorder | COACH Syndrome | Eosinophilic Asthma | Immunoproliferative Disorders | Waardenburg Syndrome Type 2E | Hereditary Xerocytosis | Malnutrition | Pseudohermaphroditism | Rett Syndrome | Chordoid Glioma | Asthma, Nocturnal | Pseudohypoparathyroidism Type 1B | Congenital Generalized Lipodystrophy | Lyme Disease | Neurodegeneration With Brain Iron Accumulation | Dentinogenesis Imperfecta | Duane Retraction Syndrome | Polymyalgia Rheumatica | Uremia | Inflammatory Joint Disease | Kashin-Beck Disease | Usher Syndrome Type III | Congenital Nystagmus | Bronchitis, Chronic | Kindler Syndrome | Overactive Bladder | Alpers Syndrome | Rhabdoid Tumor | Diabetes Type 2 | Histiocytic Sarcoma | Fibrosis | Antithrombin III Deficiency | Chondromyxoid Fibroma | Spondylosis | Spermatocele | Spinocerebellar Ataxia Type 21 | Aspergillosis | Angina Pectoris | Partington Syndrome | Localized Scleroderma | Hemorrhoids | Emery-Dreifuss Muscular Dystrophy | Eosinophilia | Spinocerebellar Ataxia Type 17 | Desmosterolosis | GNE Myopathy | Congenital Central Hypoventilation Syndrome | Myocardial Infarction | Hereditary Hemorrhagic Telangiectasia Type 2 | Recurrent Respiratory Papillomatosis | Orthostatic Intolerance | Adrenal Insufficiency | Holoprosencephaly | Connective Tissue Disorders | Sepiapterin Reductase Deficiency | Sialidosis | Rheumatic Heart Disease | Bicuspid Aortic Valve | Cardiomyopathy, Restrictive | Hypoalbuminemia | Hyperinsulinemic Hypoglycemia | Homocystinuria | Thyroid Dyshormonogenesis | Lathosterolosis | Hypertensive Retinopathy | Congenital Sodium Diarrhea | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Medulloblastoma | Schistosomiasis | Pleomorphic Xanthoastrocytoma | Spinocerebellar Ataxia Type 20 | Snyder-Robinson Syndrome | Chronic Periodontitis | Amyotrophic Lateral Sclerosis, Juvenile | Hidradenitis | Giant Axonal Neuropathy | Premenstrual Syndrome | Platelet Disorders | Colitis, Lymphocytic | Waardenburg Syndrome Type 2 | Tricho-hepato-enteric Syndrome | Kidney Stones | Hypogammaglobulinemia | Congenital Nephrotic Syndrome | Ameloblastic Carcinoma | Epilepsy, Generalized | Restless Legs Syndrome | Spinocerebellar Ataxia Type 14 | Fabry's Disease | High Molecular Weight Kininogen Deficiency | Keratopathy | Poirier-Bienvenu Neurodevelopmental Syndrome | Cholestasis, Intrahepatic | Megalencephaly | Periodic Limb Movement Disorder | Diabetic Nephropathy | Ganglioglioma | Hydrocephalus | Oligoasthenoteratozoospermia | Tuberculosis | Liver Diseases | Spondyloperipheral Dysplasia | Stroke | Optic Neuropathy | Stickler Syndrome | Cardiomyopathy, Hypertrophic | Treacher Collins Syndrome | Carbonic Anhydrase VA Deficiency | Infertility, Male | Pneumothorax | Myopathy | Tardive Dyskinesia | Malaria | Bare Lymphocyte Syndrome | Carcinoid Syndrome | Narcolepsy | Angiosarcoma Of The Breast | Vitamin D Deficiency | Hypermetropia | Aspartylglycosaminuria | Heroin Dependence | Sitosterolemia | Keratosis, Actinic | Dementia, Vascular | Rubeosis Iridis | Brachial Plexus Neuropathy | Nicolaides-Baraitser Syndrome | Meesmann Corneal Dystrophy | Oligodendroglioma | Dental Caries | Hyperostosis | Pulmonary Alveolar Microlithiasis | Antley-Bixler Syndrome | Growth Hormone Excess | AIDS Dementia Complex | Familial Hyperaldosteronism | Acute Tubular Necrosis | Vitreoretinopathy, Proliferative | MELAS Syndrome | Fibronectin Glomerulopathy | Renal Failure | Glycogen Storage Disease | Hemangioma | Stuttering | Adenoid Cystic Carcinoma | Torticollis | Autosomal Recessive Spastic Paraplegia Type 54 | Nephronophthisis | Essential Fructosuria | Diamond-Blackfan Anemia | Dominant Optic Atrophy | Rotor Syndrome | Primary Cutaneous Amyloidosis | Placenta Previa | Coloboma | Retinal Diseases | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Lattice Corneal Dystrophy | Congenital Dyserythropoietic Anemia Type 1 | Tylosis With Esophageal Cancer | Hypohidrotic Ectodermal Dysplasia | Primary Hyperoxaluria Type 1 | Cri-du-chat Syndrome | Macrophagic Myofasciitis | Hyperekplexia | Gaucher Disease | Blepharospasm | Hyperbilirubinemia, Neonatal | Occipital Neuralgia | Gynecomastia | Angioedema, Acquired | Corneal Dystrophies, Hereditary | Aldosterone Synthase Deficiency | Costello Syndrome | Burn-McKeown Syndrome | Depression | Moyamoya Disease | Muscle Wasting | Hypertension, Pulmonary | Retinal Degeneration | Sleep Apnea | Hypertrophy | Macular Degeneration | Idiopathic Pulmonary Fibrosis | Diarrhea | Encephalitis | Hypolipoproteinemia | Osteogenesis Imperfecta Type III | Hyperparathyroidism, Secondary | Familial Isolated Hyperparathyroidism | Dysfibrinogenemia | Cantu Syndrome | Periodontitis | Spinocerebellar Ataxia Type 23 | Cramp Fasciculation Syndrome | Glutaric Aciduria Type 2 | Primary Familial Brain Calcification | Short-chain Acyl-CoA Dehydrogenase Deficiency | Creatine Deficiency Syndrome | Neurogenic Bladder | Avian Influenza | Primary Ovarian Insufficiency | Dent Disease | Thanatophoric Dysplasia Type 1 | Encephalopathy | Sensory Neuropathy | Esophageal Carcinoma | Dyslipidemia | Alzheimer Disease, Late Onset | Hypoglycemia | Hemorrhagic Disorders | Nicotine Dependence | DOCK8 Immunodeficiency Syndrome | Sulfite Oxidase Deficiency | Oligoastrocytoma | Eclampsia | Glycogen Storage Disease Type 3 | Kleine-Levin Syndrome | Schizophrenia, Paranoid | Cholangiocarcinoma | Synpolydactyly | Familial Thoracic Aortic Aneurysm | Prurigo Nodularis | Mevalonate Kinase Deficiency | Intestinal Obstruction | Cutaneous Angiosarcoma | Hypokalemia | 3C Syndrome | Dystonia Musculorum Deformans | Preaxial Polydactyly | Cyclic Vomiting Syndrome | Ectodermal Dysplasia | Focal Segmental Glomerulosclerosis | Gitelman Syndrome | Cryptosporidiosis | Sjogren Syndrome | Anterior Segment Dysgenesis | T-cell Lymphoma, Subcutaneous Panniculitis-like | Angioimmunoblastic T-cell Lymphoma | Cone Dystrophy | Basal Ganglia Disease, Biotin-responsive | Esthesioneuroblastoma | Auriculocondylar Syndrome | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Leukocyte Adhesion Deficiency | Osteopetrosis | Chorioretinitis | Pyruvate Decarboxylase Deficiency | Sarcoma | Chronic Granulomatous Disease, X-linked | Relapsing Polychondritis