Thalassemia, Beta

About the Disease
Beta-Thalassemia, also known as beta thalassemia, is related to thrombocytopenia with beta-thalassemia, x-linked and hemoglobin lepore-beta-thalassemia syndrome. An important gene associated with Beta-Thalassemia is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Golgi-to-ER retrograde transport. The drugs Busulfan and Metformin have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and bone, and related phenotypes are splenomegaly and pallor

Common Targets
PPARG | CYP2D6 | HAMP | GDF11 | ATRX | CFP | HDAC1 | PRMT5 | KEAP1 | BCL11A | G5243 | G9429 | CYP1A1 | HDAC3 | TNFSF11 | ZNF644 | EHMT1 | PKLR | PDE9A | EED | VDR | ABCC2 | TMPRSS6 | XDH | NOS3 | FTSJ1 | SLC6A9 | XPO1 | CYP24A1 | WIZ | IL1B | LOC105378010 | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | ERFE | INHBA | CYP1A2 | GATAD2A | Transforming growth factor beta (nonspecified subtype) | NF-kappaB (NFkB) | HBB | Polycomb Repressive Complex 2 | SLC40A1 | CCR5 | GC | G1786 | G7124 | KLF1 | Proteasome Complex | UGT1A1 | NFIX | EHMT2 | HBBP1 | CRBN | HBD | HBG1 | HBG2 | CD19 | EPAS1 | CYP27B1 | MBD2 | HDAC2 | G4780 | UGT1A3 | TNFRSF11B | DDC | HFE | G2475

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