Pleomorphic Xanthoastrocytoma

About the Disease
Pleomorphic Xanthoastrocytoma, also known as pxa, is related to glioma susceptibility 1 and malignant astrocytoma, and has symptoms including seizures An important gene associated with Pleomorphic Xanthoastrocytoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are "Cell Cycle, Mitotic" and Prolactin Signaling. The drugs Dabrafenib and Trametinib have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and temporal lobe, and related phenotypes are neoplasm and normal

Common Targets
RPTOR | NOTCH3 | FANCD2 | ETV4 | CSF1R | RARA | RAD52 | CHEK1 | NUP93 | CDK4 | G673 | CDKN2B | TRRAP | PPP2R1A | G1029 | G4851 | PDGFRB | ARID2 | NOTCH4 | ROS1 | XPO1 | TBX3 | FLT4 | G7157 | GATA2 | G999 | SMARCA4 | MRE11 | GSK3B | MEN1 | FANCI | RAF1 | G2033 | FGFR4 | FGF19 | FGF23 | CCNE1 | G4233 | DOT1L | VCP | PBRM1 | NF1 | FANCA | RUNX1 | MGMT | LRP1B | NOTCH2 | PARP4 | ARID1A | G2146 | G3845 | MSH6 | PIK3CG | RNF43 | G472 | KDM5A | FANCM | MED12

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