Dementia

About the Disease
Dementia, also known as mental and behavioural disorders due to use of sedatives or hypnotics, residual and late-onset psychotic disorder, is related to dementia, lewy body and frontotemporal dementia, and has symptoms including angina pectoris, back pain and headache. An important gene associated with Dementia is PSEN1 (Presenilin 1), and among its related pathways/superpathways are Alzheimer's disease and miRNA effects and Neuroscience. The drugs Mirabegron and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and bone marrow, and related phenotypes are no effect and no effect

Common Targets
CYP17A1 | LOC105377329 | MTNR1A | APLNR | T-Type Calcium Channel | SCIMP | DYRK1A | C9orf72 | DAO | GRIN2C | HSD11B1 | CSNK1G1 | SLC6A4 | FKBP4 | GSK3B | CHRNA7 | HTR2A | FAM171A2 | CACNA1G | Neurotrophic Factor (nonspecified subtype) | BCHE | TRIM25 | PPARD | ABCA7 | CCDC6 | CYP7A1 | RBCK1 | PRKCZ | BMX | PSEN2 | SLC16A9 | PPID | CYP21A2 | ABCA1 | PPIB | SOD2 | SLC22A12 | NMDA receptor | PDZK1 | PDE9A | SIGLEC5 | HDAC7 | HSD17B10 | SERPINE1 | OPRD1 | TSPOAP1 | APH1B | OTUD4 | SERPINI1 | EPHA1-AS1 | CASS4 | OXT | GRM2 | ITM2B | MEIOSIN | G4137 | KCNK2 | beta-Secretase (nonspecified subtype) | PMS2P1 | SLC6A9 | MTNR1B | TSPAN14 | TRPA1 | NOS2 | CLU | AGTR1 | TWNK | SPARCL1 | F11-AS1 | Histone acetyltransferase (HAT) (nonspecified subtype) | DRD5 | IL34 | IL1A | PICALM | TSPO | CRBN | DRD1 | VHL | Histone deacetylase (nonspecified subtype) | EPHA1 | GCKR | IAPP | FXN | RNF216 | STAG3L5P | MIR142 | UTS2R | MME | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | STAG3L5P-PVRIG2P-PILRB | TSPOAP1-AS1 | HTR5A | APOE | LILRA5 | CHMP2B | FERMT2 | CALY | HDAC4 | RHOH | F5 | PTK2B | MUL1 | G6PC1 | AP-1 Transcription Factor Complex | TREM2 | BLK | G1786 | ZNF652-AS1 | BACE1 | G9734 | PON1 | QPCT | PDE2A | sigma Receptor (nonspecified subtype) | HTR6 | OPTN | HTR2C | Dopamine receptor (nonspecified subtype) | Nitric oxide synthase (NOS) (nonspecified subtype) | APP | CTSH | Potassium Channels (nonspecified subtype) | CPB2 | GPR55 | SNX1 | CCNY | ATP7B | MAOB | MEF2C-AS1 | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | IL6R | DRD3 | APAF1 | AGER | CR1 | SHARPIN | VCP | PRKD3 | CD33 | G5243 | TDO2 | ZNF594-DT | CSF1R | NFIC | SLC17A1 | ACE | HAVCR2 | ITGB3 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | OXTR | BTK | G1956 | MTHFR | GRIN2B | G7124 | DYRK1B | SPI1 | NQO2 | Soluble guanylyl cyclase | CARMIL1 | CTSB | Rho kinase (ROCK) (nonspecified subtype) | G595 | BCKDK | LOC105376413 | CRP | DRD2 | SEMA3A | G3620 | GSN | SLC2A9 | G5743 | SLC24A4 | BDNF | HRH3 | Superoxide dismutase (SOD) (nonspecified subtype) | AOC3 | TNIP1 | GRN | PTAFR | HTR7 | TRPV1 | TBK1 | SORL1 | NGF | ACHE | ALPK2 | NPC1 | ADRA2C | COMT | G8878 | UBQLN2 | Heat shock protein 90 (nonspecified subtype) | TRPM8 | PPIA | LRRK2 | SNCA | TYROBP | G2099 | DYRK2 | GALR2 | PTGS1 | PDE3A | GABA(A) receptor | SLC8A1 | PRNP | LRP4 | G9429 | Integrin alphavbeta3 (vitronectin) receptor | EEA1 | PDE4B | SLC2A4RG | EPHX2 | CACNA1H | INPP5D | ESR2 | NOTCH3 | G7852 | FAM157C | CETP | Nicotinic alpha3beta2beta3 receptor | GRM5 | DSG2 | SLC18A2 | UMAD1 | PREP | NPC2 | KMO | SIGMAR1 | PILRA | gamma-Secretase | CHRM1 | CCK receptor (nonspecified subtype) | IQCK | WWC1 | Lipoxygenase (nonspecified subtype) | ADORA1 | Gamma-Aminobutyric acid type B receptor | NYAP1 | ICA1 | AGT | GBA1 | IDUA | TOMM40 | NF-kappaB (NFkB) | PSEN1 | HTR2B | REST | ADORA2A | TARDBP | DRD4 | MYO15A | TRPV2 | PM20D1 | NOS3

Note: If you'd like to get a target analysis report for Dementia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Dementia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

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