Microphthalmia

About the Disease
Microphthalmia, also known as microphthalmos, is related to microphthalmia, syndromic 3 and microphthalmia, syndromic 1. An important gene associated with Microphthalmia is VSX2 (Visual System Homeobox 2), and among its related pathways/superpathways are Mesodermal commitment pathway and Neural crest differentiation. Affiliated tissues include eye, retina and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Common Targets
OTX2 | TMEM98 | POMT1 | FAT1 | WNT2B | COL4A1 | MYO10 | SMOC1 | WDR37 | SOX2 | CRX | IQGAP1 | RERE | MAB21L1 | HMX1 | GJA8 | MKI67 | PXDN | NAA10 | ADAMTS9 | VSX2 | WFS1 | CDON | BCOR | MICU1 | GDF6 | PAX6 | POLR2A | CASK | TENM3 | PRR12 | PRSS56 | MFRP | KIF26B | ALDH1A3 | STRA6 | FOXE3 | COX7B | DHX37 | LRP6

Note: If you'd like to get a target analysis report for Microphthalmia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Microphthalmia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

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