DEND Syndrome

About the Disease
Diabetes Mellitus, Permanent Neonatal, 1, also known as permanent diabetes mellitus of infancy, is related to diabetes mellitus, permanent neonatal, 4 and cantu syndrome. An important gene associated with Diabetes Mellitus, Permanent Neonatal, 1 is GCK (Glucokinase), and among its related pathways/superpathways are Integration of energy metabolism and Disorders of transmembrane transporters. Affiliated tissues include skeletal muscle, pancreas and lung, and related phenotypes are hyperglycemia and elevated hemoglobin a1c

Common Targets
ABCC8 | KCNJ11

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Other Diseases

Aplastic Anemia | Joubert Syndrome | Congenital Lipoid Adrenal Hyperplasia | Macular Corneal Dystrophy Type 1 | Delirium | Von Hippel-Lindau Disease | Still Disease | Cranial Nerve Disease | Epidermolysis Bullosa | Histiocytic Sarcoma | Bartter Syndrome | Membranous Nephropathy | Juvenile Polyposis | Persistent Fetal Circulation | Acrodysostosis | Ectodermal Dysplasia | Holt-Oram Syndrome | Mumps | Chondrodysplasia Punctata 2, X-linked Dominant | Congenital Nystagmus | Ichthyosis | Rheumatoid Arthritis | Combined Pituitary Hormone Deficiency | Polymyositis | Stiff-man Syndrome | Zellweger Syndrome | Kabuki Syndrome | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Myofibromatosis | Choroideremia | Interstitial Lung Diseases | Muscular Dystrophy | Nephrotic Syndrome | Graft-versus-host Disease | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | GAPO Syndrome | Rotor Syndrome | Anti-NMDA Receptor Encephalitis | Maple Syrup Urine Disease | Methylmalonic Aciduria And Homocystinuria, CblC Type | Cryptosporidiosis | Thanatophoric Dysplasia | Hereditary Elliptocytosis | Congenital Hereditary Endothelial Dystrophy Type I | Babesiosis | Meningococcal Infections | Amenorrhea | Palmoplantar Keratoderma | Acute Tubular Necrosis | Parkinsonism | Cutis Laxa | Tremor | Hypercholesterolemia, Familial | Gnathodiaphyseal Dysplasia | Dent Disease | Emery-Dreifuss Muscular Dystrophy | Partington Syndrome | Optic Nerve Diseases | Episodic Ataxia Type 1 | Congenital Stationary Night Blindness | Spinocerebellar Ataxia Type 1 | Trichomegaly | Aneurysm, Thoracic Aortic | Leri-Weill Dyschondrosteosis | Multisystemic Smooth Muscle Dysfunction Syndrome | Bronchiectasis | Arthritis, Psoriatic | Hyperbilirubinemia | Early Infantile Epileptic Encephalopathy 1 | MIRAGE Syndrome | Intestinal Tuberculosis | Kaposi Sarcoma | Non-epidermolytic Palmoplantar Keratoderma | Periodic Limb Movement Disorder | Keratosis | Brooke-Spiegler Syndrome | Giant Cell Arteritis | Bardet-Biedl Syndrome | Waardenburg Syndrome | Diabetes Type 1 | Spinocerebellar Ataxia Type 23 | Neuronal Ceroid Lipofuscinosis | Hairy Cell Leukemia | Conn Syndrome | Anorectal Fistula | Coffin-Siris Syndrome | FG Syndrome | Wolcott-Rallison Syndrome | Adenomatoid Tumor | Cri-du-chat Syndrome | Intestinal Pseudo-obstruction | Oculocutaneous Albinism Type 1 | Hypotrichosis | Spinocerebellar Ataxia Type 40 | Erythema Multiforme | Menetrier Disease | Familial Isolated Hyperparathyroidism | Myasthenia | Neurotoxicity | Sandhoff Disease | Adenoma, Villous | Hemorrhoids | Usher Syndrome Type I | Cheilitis | Osteoarthritis | Chorea | Polycythemia Vera | Knobloch Syndrome | Renal-hepatic-pancreatic Dysplasia | Rash | Myhre Syndrome | Carbamoyl Phosphate Synthetase I Deficiency | Chondroma | Primary Torsion Dystonia | Combined Malonic And Methylmalonic Acidemia | Myopathy | Sialidosis | Stroke | Thyroid Dysgenesis | Hypobetalipoproteinemias | Sporadic Hemiplegic Migraine | Long QT Syndrome Type 3 | Cholesteryl Ester Storage Disease | Retinitis Pigmentosa 3 | Lymphoproliferative Disease, X-linked | Angioedema | Hypersensitivity Pneumonitis | DOCK8 Immunodeficiency Syndrome | Autoimmune Disease | Seizures | Pelizaeus-Merzbacher Disease | Arterial Tortuosity Syndrome | Lichen Sclerosus | Lymphangiomatosis | Uterine Leiomyoma | Meesmann Corneal Dystrophy | Spinocerebellar Ataxia Type 5 | Blue Nevus | Glycogen Storage Disease Type 1a | Shock, Cardiogenic | Marfan Syndrome | Meningeal Melanocytoma | Atrial Septal Defect | Hemophagocytic Lymphohistiocytosis | Veno-occlusive Disease | Tendinopathy | Kleine-Levin Syndrome | Silicosis | Macrophage Activation Syndrome | Congenital Nephrotic Syndrome | Spinocerebellar Ataxia Type 28 | Hyperlipidemia Type V | Early Infantile Epileptic Encephalopathy | Stroke, Hemorrhagic | Seborrheic Dermatitis | Spinocerebellar Ataxia Type 6 | Hereditary Neuropathy With Liability To Pressure Palsies | Osteoporosis, Postmenopausal | Cancer, Kidney | McCune-Albright Syndrome | Multiple Sclerosis, Primary Progressive | Hartsfield Syndrome | Juvenile Myelomonocytic Leukemia | Gerodermia Osteodysplastica | Cancer, Colon | Porphyria | Esophageal Motility Disorders | Alazami Syndrome | Connective Tissue Disorders | Hemangioblastoma | Hemochromatosis | LMNA-related Congenital Muscular Dystrophy | Hyperuricemia | Hypertension, Renal | Methylmalonic Acidemia | Fragile X Syndrome | Feingold Syndrome | Rett Syndrome | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Hyperhomocysteinemia | Pontocerebellar Hypoplasia Type 7 | Hennekam Lymphangiectasia-lymphedema Syndrome | Diabetes Insipidus, Neurogenic | Pheochromocytoma | Muckle-Wells Syndrome | Congenital Adrenal Hyperplasia 1 | Fetal Alcohol Syndrome | Pemphigus | Cold-induced Sweating Syndrome | Skin Papilloma | Behavioral Variant Of Frontotemporal Dementia | Hypohidrotic Ectodermal Dysplasia | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Hyperbilirubinemia, Neonatal | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Cysticercosis | Premature Ejaculation | Congenital Bile Acid Synthesis Defect | Pemphigoid | Hypokalemia | Charcot-Marie-Tooth Disease, Type 2 | Anorexia Nervosa | Long QT Syndrome Type 2 | Glycogen Storage Disease | Neurocysticercosis | Meningitis | Diffuse Intrinsic Pontine Glioma | Tetraplegia | Disseminated Intravascular Coagulation | Congenital Heart Block | Hepatorenal Syndrome | Paraplegia | Epithelial-myoepithelial Carcinoma | Vasculitis | Neuroleptic Malignant Syndrome | Chronic Mucocutaneous Candidiasis | Imerslund-Grasbeck Syndrome | Campomelic Dysplasia | Werner's Syndrome | Aspartylglycosaminuria | Scleroderma | Galactosemia | Blepharitis | Evans Syndrome | Ovarian Sex Cord-stromal Tumor | Histiocytosis | Amebiasis | COACH Syndrome | Chronic Enteropathy Associated With SLCO2A1 Gene | Coffin-Lowry Syndrome | Constipation | Thyrotoxic Periodic Paralysis | Coronary Heart Disease | Cataplexy | Cataract | Arts Syndrome | Pterygium | Cholangiocarcinoma | Hydrocephalus | Conduct Disorder | Hamartoma | Fibromuscular Dysplasia | Omenn Syndrome | Dysfibrinogenemia | Dementia, Vascular | Huntington's Disease-like 2 | Bursitis | Pachyonychia Congenita | Gyrate Atrophy Of The Choroid And Retina | Pyruvate Dehydrogenase Deficiency | Phosphoglycerate Dehydrogenase Deficiency | Currarino Syndrome | Ectopia Lentis, Isolated, Autosomal Recessive | Danon Disease | Sezary Syndrome | Hidradenitis Suppurativa | Lipid Metabolism Disorders | Dermatitis Herpetiformis | Spitz Nevus | Chondrodysplasia Punctata 1, X-linked Recessive | Infantile Refsum Disease | Sarcoma, Endometrial Stromal | Hypercalcemia | Oculocutaneous Albinism | Azoospermia | Meckel-Gruber Syndrome | Gastritis, Atrophic | Colitis, Collagenous | Congenital Hemolytic Anemia | Hyperandrogenemia | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Pfeiffer Syndrome | Basan Syndrome | Orotic Aciduria | Schindler Disease | Greig Cephalopolysyndactyly Syndrome | Hypertelorism | Meier-Gorlin Syndrome | Glycogen Storage Disease Type 5 | Bronchitis, Chronic | Neurodevelopmental Disorders | Dementia | Encephalopathy, Ethylmalonic | Osteitis | Hypertensive Retinopathy | Nephritis, Interstitial | Myasthenia Gravis | Amyotrophic Lateral Sclerosis, Juvenile | Wolff-Parkinson-White Syndrome | Torticollis | Blau Syndrome | Alagille Syndrome | Chylothorax, Congenital | Mosaic Variegated Aneuploidy Syndrome 2 | Astrocytoma, Anaplastic | Urethritis | Focal Segmental Glomerulosclerosis | Distal Myopathy | Hemochromatosis Type 2 | Hereditary Sensory Neuropathy Type 1 | Creatine Deficiency Syndrome | Lymphedema-distichiasis Syndrome | Cancer, Bladder | Small Lymphocytic Lymphoma | Myeloid Leukemia | Strabismus | Acne Vulgaris | Vaginitis | Becker Muscular Dystrophy | Cocaine-Related Disorders | Juvenile Myoclonic Epilepsy | Nestor-Guillermo Progeria Syndrome | Kidney Stones | Peritonitis | Pernicious Anemia | Orthostatic Intolerance | Goiter, Nodular | DEND Syndrome | Okihiro Syndrome | Personality Disorders | Neurofibromatosis Type 1 | Rolandic Epilepsy | Glioma | Glutaric Aciduria Type 2 | Osteomyelitis | Spinal Muscular Atrophy Type 3 | Renal Hypouricemia | Hypertension, Portal | Protein S Deficiency | Thrombocytopenia | Exfoliative Dermatitis | Hyperparathyroidism-jaw Tumor Syndrome | Melanoma, Malignant | Uremia | Lamellar Ichthyosis | Progressive Familial Intrahepatic Cholestasis Type 3 | Tularemia | Costello Syndrome | Exocrine Pancreatic Insufficiency | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Esophageal Adenocarcinoma | Pouchitis | Corneal Dystrophies, Hereditary | Allan-Herndon-Dudley Syndrome | Thyroiditis | Mucolipidosis Type III | Acute Generalized Exanthematous Pustulosis | Carey-Fineman-Ziter Syndrome | Filariasis | Acquired Partial Lipodystrophy | Glycogen Storage Disease Type 9 | D-2-Hydroxyglutaric Aciduria | Polycystic Kidney, Autosomal Recessive | Nephropathy | Mitochondrial Encephalomyopathy | Cystinosis | 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