DEND Syndrome

About the Disease
Diabetes Mellitus, Permanent Neonatal, 1, also known as permanent diabetes mellitus of infancy, is related to diabetes mellitus, permanent neonatal, 4 and cantu syndrome. An important gene associated with Diabetes Mellitus, Permanent Neonatal, 1 is GCK (Glucokinase), and among its related pathways/superpathways are Integration of energy metabolism and Disorders of transmembrane transporters. Affiliated tissues include skeletal muscle, pancreas and lung, and related phenotypes are hyperglycemia and elevated hemoglobin a1c

Common Targets
ABCC8 | KCNJ11

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Other Diseases

Mucormycosis | Polycystic Kidney, Autosomal Dominant | Cancer, Breast | Agammaglobulinemia | Acral Lentiginous Melanoma | Hyperoxaluria | Epidermodysplasia Verruciformis | Superficial Spreading Melanoma | Frontotemporal Dementia | Congenital Hereditary Endothelial Dystrophy Type I | Congenital Stationary Night Blindness | Conduct Disorder | Carcinoma, Small Cell | Fowler's Syndrome | HUPRA Syndrome | Dupuytren Disease | Bethlem Myopathy | Neuromuscular Disorders | Erythema Multiforme | Omenn Syndrome | Achondrogenesis | Oculocutaneous Albinism Type 1 | Gingivitis | Arterial Tortuosity Syndrome | Dysplastic Nevus | Antley-Bixler Syndrome | Bardet-Biedl Syndrome | Dent Disease | Mandibuloacral Dysplasia With Type A Lipodystrophy | Hypertension, Pulmonary | Antisocial Personality Disorder | Neurofibromatosis | Hypobetalipoproteinemias | Autonomic Nervous System Disorders | Renal Tubular Dysgenesis | Membranous Nephropathy | Cholestasis, Intrahepatic | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Myofibromatosis | Spinocerebellar Ataxia Type 6 | Pituitary Dwarfism | Mumps | Multiple System Atrophy | COACH Syndrome | Hypersomnia | Hepatic Veno-occlusive Disease | AIDS | Spondylometaphyseal Dysplasia | Glycogen Storage Disease Type 1a | Pneumoconiosis | Lipid Metabolism Disorders | Babesiosis | Diffuse Mesangial Sclerosis | Myosin Storage Myopathy | Uveitis | Persistent Fetal Circulation | Bare Lymphocyte Syndrome | Chronic Myeloid Leukemia | Contact Dermatitis | Hyperkalemic Periodic Paralysis | Cardiospondylocarpofacial Syndrome | Primary Cutaneous Amyloidosis | Gigantism | Retinal Dystrophy, Early-onset Severe | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Toxoplasmosis | Ectopia Lentis, Isolated, Autosomal Recessive | Papulopustular Rosacea | Preaxial Polydactyly | Myasthenia | Opisthorchiasis | Incontinentia Pigmenti | Metaphyseal Chondrodysplasia, Schmid Type | Sleep Apnea, Obstructive | Dwarfism | Porphyria, Acute Intermittent | Waardenburg Syndrome Type 2 | Dementia, Vascular | Anuria | CHARGE Syndrome | Gastroenteritis, Eosinophilic | Alagille Syndrome | Amelanotic Melanoma | Seizures-scoliosis-macrocephaly Syndrome | Cole-Carpenter Syndrome | Hereditary Elliptocytosis | Sponastrime Dysplasia | Neurodermatitis | Lamellar Ichthyosis | Sarcomatoid Carcinoma Of The Lung | Sclerocornea | Epidermolytic Ichthyosis, Annular | Porphyria Cutanea Tarda | Esophageal Adenocarcinoma | Liver Diseases | Multiple Sclerosis | Autosomal Recessive Spastic Paraplegia Type 35 | Ganglioglioma | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Epidermolysis Bullosa Dystrophica | Takenouchi-Kosaki Syndrome | Schnyder Crystalline Corneal Dystrophy | Mitochondrial Disease | Hypertension | Scleroderma, Diffuse | Hypercalcemia | Niemann-Pick Disease | Otopalatodigital Syndrome Type 2 | Vertigo | Ischemia | Roberts Syndrome | Thyroid Dyshormonogenesis | Uterine Leiomyoma | Alopecia | Dysferlinopathy | Nance-Horan Syndrome | Myoclonus | Albinism | Stevens-Johnson Syndrome | Aneurysm, Abdominal Aortic | Oligodendroglioma | Hereditary Spastic Paraplegia | Kawasaki Disease | Wiskott-Aldrich Syndrome | Canavan Disease | Bronchitis | Diffuse Palmoplantar Keratoderma | Wolfram Syndrome 2 | Familial Mediterranean Fever | Spitz Nevus | Coloboma | Pseudohypoparathyroidism Type 1C | Oculodentodigital Dysplasia | Neuroendocrine Cancer | Castleman Disease | Speech Disorders | Pregnancy, Ectopic | 3-M Syndrome | Pseudo-pseudohypoparathyroidism | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Language Disorders | Seizures | Primary Hyperoxaluria | Gliosarcoma | Greig Cephalopolysyndactyly Syndrome | Leigh Syndrome | DiGeorge Syndrome | Spinocerebellar Ataxia Type 1 | Silicosis | Renal-hepatic-pancreatic Dysplasia | Anemia | Congenital Hypofibrinogenemia | Achromatopsia | Subacute Sclerosing Panencephalitis | Diabetes Insipidus | Gitelman Syndrome | Hartnup Disease | Impetigo | Panic Disorder | Geleophysic Dysplasia | Branchiootorenal Syndrome | Pyloric Stenosis, Infantile Hypertrophic | Osteoporosis, Postmenopausal | Rash | Neuroectodermal Tumors, Primitive | Adenosine Deaminase 2 Deficiency | Polymicrogyria | Spinal Muscular Atrophy Type 3 | Osteomyelitis | Vogt-Koyanagi-Harada Syndrome | Hypoalbuminemia | Corneal Dystrophies, Hereditary | Hypertension, Portal | Iron Deficiency Anemia | Japanese Encephalitis | Eiken Syndrome | Snyder-Robinson Syndrome | Melnick-Needles Syndrome | Spinocerebellar Ataxia Type 10 | Multiple Sclerosis, Primary Progressive | Fukuyama Congenital Muscular Dystrophy | Liver Failure | Galactosialidosis | Plasma Cell Dyscrasia | Mucolipidosis | Tetanus | Spinocerebellar Ataxia Type 42 | Arthritis, Reactive | Cyst | Erdheim-Chester Disease | Charcot-Marie-Tooth Disease Axonal Type 2N | Chylomicron Retention Disease | Hepatitis, Alcoholic | Hyperprolactinemia | Scleroderma | Diverticulitis | Emery-Dreifuss Muscular Dystrophy | Oculocutaneous Albinism Type 4 | Episodic Ataxia | Charcot-Marie-Tooth Disease, Type 6 | Panuveitis | Short-chain Acyl-CoA Dehydrogenase Deficiency | Pancreatitis, Chronic | Hypercholesterolemia | Adenosine Deaminase Deficiency | Asthma, Exercise-induced | Double Outlet Right Ventricle | Shwachman-Bodian-Diamond Syndrome | Cataract | Cousin Syndrome | Retinopathy Of Prematurity | Epidermolysis Bullosa Acquisita | Hydronephrosis | Mitochondrial Encephalomyopathy | Motion Sickness | Meleda Disease | Osteogenesis Imperfecta | Epilepsy | Astrocytoma, Anaplastic | Hypoparathyroidism | Keratoacanthoma | Swine Influenza | Marshall-Smith Syndrome | Congenital Myopathy | Bacterial Meningitis | Spondyloepiphyseal Dysplasia Tarda, X-linked | Pseudohypoparathyroidism Type 1A | Nephroblastoma | Cardiac Sarcoidosis | Peeling Skin Syndrome, Acral Type | Ataxia-ocular Apraxia 2 | LMNA-related Congenital Muscular Dystrophy | Vitamin B12 Deficiency | Colorectal Adenoma | Fetal Akinesia Deformation Sequence | WAGR Syndrome | Osteogenesis Imperfecta Type V | Blastoma, Pleuropulmonary | Pulmonary Capillary Hemangiomatosis | IgA Deficiency | Congenital Central Hypoventilation Syndrome | Atherosclerosis | Paracoccidioidomycosis | Perivascular Epithelioid Cell Tumor | Corneal Dystrophy And Perceptive Deafness | Vascular Cognitive Impairment | Frontometaphyseal Dysplasia | Rheumatoid Arthritis | Benign Recurrent Intrahepatic Cholestasis 1 | Rosacea | Peutz-Jeghers Syndrome | Left Ventricular Noncompaction | Thrombophilia | Glioblastoma | Familial Digital Arthropathy-brachydactyly | Esotropia | Myeloid Leukemia | Multiple Hamartoma Syndrome | X-linked Acrogigantism | Paraplegia | Kindler Syndrome | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Desbuquois Syndrome | Limb Girdle Muscular Dystrophy | Sporadic Inclusion Body Myositis | Anthrax | Medulloblastoma | Carcinoma In Situ | Polycystic Liver | Niemann-Pick Disease, Type B | Tyrosinemia | Pyruvate Kinase Deficiency | Acute Lymphocytic Leukemia | Encephalitis, Tick-borne | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Pulmonary Tuberculosis | Tatton-Brown-Rahman Syndrome | Myopia | Epidermolytic Palmoplantar Keratoderma | Spina Bifida | Cancer, Brain | Discoid Lupus Erythematosus | Blue Nevus | Sclerosteosis 2 | Cardiofaciocutaneous Syndrome | Fetal Alcohol Syndrome | Tendinitis | Tyrosinemia Type 1 | Hereditary Inclusion Body Myopathy | Blepharo-cheilo-odontic Syndrome | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Tonsillitis | Fucosidosis | Glanzmann Thrombasthenia | Ependymoma | Premenstrual Syndrome | Ichthyosis Bullosa Of Siemens | Myositis, Focal | Spinocerebellar Ataxia Type 40 | Myelomeningocele | Vascular Calcification | Presbyopia | Postpartum Depression | Restrictive Dermopathy | Hyperuricemic Nephropathy, Familial Juvenile | Alpers Syndrome | Thyrotoxic Periodic Paralysis | Pelizaeus-Merzbacher Disease | Cholangiocarcinoma | Epithelial-myoepithelial Carcinoma | Hypohidrotic Ectodermal Dysplasia, X-linked | Craniolenticulosutural Dysplasia | Smoldering Myeloma | Persistent Hyperplastic Primary Vitreous | Platelet Disorders | Anorchia | Angina Pectoris | Juvenile Myoclonic Epilepsy | Traboulsi Syndrome | Seborrheic Dermatitis | Cerebrotendinous Xanthomatosis | Primary Carnitine Deficiency | Hidradenitis | Pseudohypoaldosteronism | Usher Syndrome Type IIC | Pierson Syndrome | Mucolipidosis Type IV | Knobloch Syndrome | Dystrophy, Cone-rod | Purpura, Thrombotic Thrombocytopenic | Sensory Neuropathy | Fibromyalgia | Myoclonus-dystonia Syndrome | Depression | Spinocerebellar Ataxia Type 23 | Exocrine Pancreatic Insufficiency | Cervical Dystonia | Antithrombin III Deficiency | Apraxia | Infertility, Male | Corneal Edema | Crigler-Najjar Syndrome | Sitosterolemia | Primary Sclerosing Cholangitis | Hemoglobinopathies | Acromicric Dysplasia | Multifocal Motor Neuropathy | Periodontitis | Pathological Gambling | Hypertelorism | Dysgerminoma | Kallmann Syndrome | Restless Legs Syndrome | Congenital Disorders Of Glycosylation Type II | Dental Caries | Nail Disorder, Nonsyndromic Congenital | Pulmonary Vein Stenosis | Pseudomyxoma Peritonei | Anxiety Disorders | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Carney Triad | Giant Cell Glioblastoma | Centronuclear Myopathy | Familial Male-limited Precocious Puberty | Oligoasthenoteratozoospermia | Neurodegeneration With Brain Iron Accumulation | Galloway-Mowat Syndrome | Crohn's Disease | Congenital Mirror Movements | Neural Tube Defect | Fragile X Syndrome | Loeys-Dietz Syndrome | Succinic Semialdehyde Dehydrogenase Deficiency | Facioscapulohumeral Muscular Dystrophy Type 1 | Arts Syndrome | Erysipelas | Atelosteogenesis Type 2 | Spermatocele | Liver Failure, Acute Infantile | Eosinophilia | Heimler Syndrome | Endometrial Hyperplasia | Hypopigmentation | Schizotypal Personality Disorder | Huntington's Disease-like 2 | B-cell Prolymphocytic Leukemia | Congenital Bile Acid Synthesis Defect | Hyperthyroidism | Glioma | Urea Cycle Disorder | Kaposi Sarcoma | Gynecomastia | Bartsocas-Papas Syndrome | Spondylo-ocular Syndrome | Huntington's Disease | Porencephaly | Hypospadias | GNE Myopathy | Ghosal Syndrome | Hodgkin Lymphoma