Disease

Acute Chest Syndrome

About the Disease
Acute Chest Syndrome, also known as acute chest syndrome in sickle cell disease, is related to sickle cell disease and hereditary persistence of fetal hemoglobin-sickle cell disease syndrome, and has symptoms including fever, pleuritic chest pain and tachypnea. An important gene associated with Acute Chest Syndrome is NOS3 (Nitric Oxide Synthase 3), and among its related pathways/superpathways are Innate Immune System and Myometrial relaxation and contraction pathways. The drugs Heparin, bovine and Reviparin have been mentioned in the context of this disorder. Affiliated tissues include lung, placenta and bone marrow, and related phenotypes are homeostasis/metabolism and cellular

Common Targets
PADI4 | NR3C1 | GSTT1 | TLR2 | IL1B | G7422 | GSTM1 | MYLK | PLA2G2D | Phospholipase A2, Secretory (sPLA2) (nonspecified subtype) | HMOX1 | PLA2G2A

疾病靶点研报
Acute Chest Syndrome

Note: If you'd like to get a target analysis report for Acute Chest Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Acute Chest Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Glucagonoma | Neurodermatitis | Epidermolysis Bullosa Simplex, Localized | Craniometaphyseal Dysplasia | Light Chain Amyloidosis | Arthritis, Psoriatic | Huntington's Disease | Lamellar Ichthyosis | Adult Polyglucosan Body Disease | Birk-Barel Syndrome | Ectodermal Dysplasia | Cerebellar Ataxia, Cayman Type | Hyperlipidemia, Familial Combined | T-cell Lymphoma, Subcutaneous Panniculitis-like | Pontocerebellar Hypoplasia | Cancer, Bladder | Hyperinsulinemia | Thyroiditis | Myotonic Disorders | Cri-du-chat Syndrome | Menetrier Disease | Mood Disorder | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Thrombotic Microangiopathy | Multicystic Renal Dysplasia | Atelosteogenesis Type 2 | Transient Bullous Dermolysis Of The Newborn | Pantothenate Kinase-associated Neurodegeneration | Alpers Syndrome | Cold-induced Sweating Syndrome | Bainbridge-Ropers Syndrome | Ocular Surface Squamous Neoplasia | Fetal And Neonatal Alloimmune Thrombocytopenia | Malignant Peripheral Nerve Sheath Tumor | Vestibular Disease | Common Variable Immunodeficiency | Progressive Encephalopathy-optic Atrophy Syndrome | Focal Dermal Hypoplasia | VACTERL Association | Non-Hodgkin Lymphoma | Sotos Syndrome | Ichthyosis, X-linked | Follicular Dendritic Cell Sarcoma | Hypercholesterolemia | Hemolytic Uremic Syndrome | Pyelonephritis | Tinea Versicolor | Unverricht-Lundborg Syndrome | Pachyonychia Congenita | X-linked Sideroblastic Anemia | Tracheal Disorders | Keratosis, Actinic | Primary Cutaneous Amyloidosis | Trigonocephaly | Melanoma | Long QT Syndrome Type 1 | Apparent Mineralocorticoid Excess Syndrome | Mucolipidosis | Charcot-Marie-Tooth Disease Type 3 | Cranioectodermal Dysplasia | Porphyria | Niemann-Pick Disease, Type A | Acute Coronary Syndrome | Ophthalmia, Sympathetic | Tremor | Polycythemia | Hereditary Spastic Paraplegia | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Glomerulonephritis | Bethlem Myopathy | Kernicterus | Spermatocele | Metachromatic Leukodystrophy | Keratocystic Odontogenic Tumor | Kindler Syndrome | Oligodendroglioma | Spinocerebellar Ataxia Type 23 | Diastrophic Dysplasia | Lattice Corneal Dystrophy Type 1 | Oculocutaneous Albinism Type 2 | Anorexia Nervosa | Pontocerebellar Hypoplasia Type 2 | HELLP Syndrome | Chromosome 5q Deletion Syndrome | Spondylosis | Spinocerebellar Ataxia Type 12 | Lipid Storage Diseases | Cannabis Abuse | Fahr Disease | Bronchiectasis | Eccrine Porocarcinoma | Pseudoachondroplasia | DOCK8 Immunodeficiency Syndrome | Paraplegia | Hartsfield Syndrome | Malaria | Neuropathy | Bursitis | Skin Papilloma | Wolfram Syndrome 2 | Mixed Connective Tissue Disease | Nance-Horan Syndrome | Chorea | Vitreoretinopathy, Proliferative | Mosaic Variegated Aneuploidy Syndrome 2 | Maternally Inherited Diabetes And Deafness | Rhinitis | Hypospadias | Cyst | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Acute Tubular Necrosis | Cenani-Lenz Syndactyly Syndrome | Acne Vulgaris | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Hereditary Sensory And Autonomic Neuropathy | Avian Influenza | Spondylo-ocular Syndrome | Hepatitis, Chronic | Norrie Disease | Epithelial-myoepithelial Carcinoma | Seborrheic Dermatitis | Adenosine Deaminase 2 Deficiency | Diabetes Type 2 | Angioedema, Acquired | Hypoalbuminemia | Glutathione Synthetase Deficiency | Persistent Mullerian Duct Syndrome | Acute Leukemia | X-linked Myotubular Myopathy | Diabetes Insipidus, Neurogenic | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Tyrosinemia Type 2 | Chronic Myelomonocytic Leukemia | Corticobasal Syndrome | Cancer, Brain | Hyperammonemia | Phenylketonuria II | Meniere's Disease | Spinocerebellar Ataxia Type 14 | Mucormycosis | Infectious Diarrhea | Lipid Storage Myopathy | Johanson-Blizzard Syndrome | Vasculitis | Hypersensitivity Pneumonitis | McCune-Albright Syndrome | Hypohidrotic Ectodermal Dysplasia, X-linked | Usher Syndrome Type I | Hyperuricemic Nephropathy, Familial Juvenile | Glaucoma, Congenital | Hyperinsulinemic Hypoglycemia | Fowler's Syndrome | Hypertrophy | Adenoma, Villous | Pelvic Inflammatory Disease | Cystinuria | Hyperkalemic Periodic Paralysis | Crimean-Congo Hemorrhagic Fever | Neonatal Progeroid Syndrome | Addison Disease | Varicocele | Galactosialidosis | Sclerosteosis | Charcot-Marie-Tooth Disease Type 2E | Barrett Esophagus | Niemann-Pick Disease, Type C | Neutropenia | Kohlschutter-Tonz Syndrome | Martsolf Syndrome | Language Disorders | Congenital Mirror Movements | Fetal Akinesia Deformation Sequence | Endometritis | Cholestasis, Intrahepatic | 3-hydroxy-3-methylglutaric Aciduria | Trichothiodystrophy | Hyperostosis | Adenoma, Pleomorphic | Rothmund-Thomson Syndrome | Acquired Partial Lipodystrophy | Hemophilia | Familial Glucocorticoid Deficiency | Ileitis | Kallmann Syndrome | Silver-Russell Syndrome | Hydrocephalus | Ligneous Conjunctivitis | Conduct Disorder | C3 Glomerulopathy | Osteogenesis Imperfecta Type VI | Cysticercosis | Waardenburg Syndrome Type 4 | Amenorrhea | Dysthymia | Mycosis Fungoides | Hypotrichosis Simplex | Hyperlipidemia | Waldenstrom Macroglobulinemia | Acrodermatitis | Adenocarcinoma | Dubin-Johnson Syndrome | Spinocerebellar Ataxia Type 27 | COACH Syndrome | Withdrawal Syndrome | Congenital Absence Of Vas Deferens | B-cell Chronic Lymphocytic Leukemia | PHARC Syndrome | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Partington Syndrome | Parkinson Disease 6, Autosomal Recessive Early-onset | Recurrent Respiratory Papillomatosis | Colitis, Collagenous | Oral Lichen Planus | Gestational Trophoblastic Disease | Ulcerative Colitis | Polymicrogyria | Congenital Stationary Night Blindness | Robinow Syndrome | Bronchiolitis | Hypohidrotic Ectodermal Dysplasia | Measles | Conjunctivitis, Allergic | Congenital Fiber-type Disproportion Myopathy | Adrenomyeloneuropathy | Glycogen Storage Disease Type 4 | Anxiety Disorders | FG Syndrome | Macular Corneal Dystrophy Type 1 | Restless Legs Syndrome | Osteoarthritis | Anthrax | Hemorrhage | Thromboembolism | Lyme Disease | Hidradenitis | Acute Anterior Uveitis | Marfan Syndrome | Diabetic Encephalopathy | Common Cold | Lactose Intolerance | Spinocerebellar Ataxia Type 6 | Galloway-Mowat Syndrome | Carcinoma, Squamous Cell | Pterygium | Nephrocalcinosis | Nager Acrofacial Dysostosis | Urolithiasis | Sensorineural Hearing Loss | Cutaneous Lupus Erythematosus | Nemaline Myopathy 8 | Sclerosteosis 2 | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Imerslund-Grasbeck Syndrome | Hepatitis B, Chronic | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Liddle Syndrome | Goldenhar Syndrome | Glioblastoma Multiforme | Osmotic Demyelination Syndrome | Fetal Alcohol Syndrome | Acute Lung Injury | LMNA-related Congenital Muscular Dystrophy | Corneal Edema | Necrotizing Autoimmune Myopathy | Chronic Granulomatous Disease | Skin Fragility-woolly Hair Syndrome | Neovascular Glaucoma | Esophageal Motility Disorders | Alpha-thalassemia Myelodysplasia Syndrome | Hereditary Pyropoikilocytosis | Retinal Diseases | Opisthorchiasis | Bipolar Disorder | Myasthenia | Hypoparathyroidism | Li-Fraumeni Syndrome | Melanocytic Nevus | Syncope | Dengue Shock Syndrome | Batten Disease | Infertility | Hidradenitis Suppurativa | Trichomegaly | Methemoglobinemia Type IV | Osteomalacia | DEND Syndrome | Split Hand-foot Malformation | Systemic Lupus Erythematosus | Osteochondrosis | Spinal And Bulbar Muscular Atrophy | Otopalatodigital Syndrome Type 2 | B-cell Prolymphocytic Leukemia | Hemophagocytic Lymphohistiocytosis | Mevalonate Kinase Deficiency | Dysequilibrium Syndrome | Spinocerebellar Ataxia Type 3 | Megalencephaly | Methylmalonic Acidemia | Hydronephrosis | Kearns-Sayre Syndrome | Paronychia | Heavy Chain Disease | Menkes Disease | Alagille Syndrome | Charcot-Marie-Tooth Disease Axonal Type 2N | Waardenburg Syndrome Type 1 | Keratopathy | Stromal Corneal Dystrophy | Spondylocostal Dysostosis | Membranous Nephropathy | Beare-Stevenson Syndrome | Pernicious Anemia | Reye Syndrome | Infertility, Male | Giant Cell Arteritis | Inflammatory Linear Verrucous Epidermal Nevus | Wolfram Syndrome | Osteogenesis Imperfecta | Fibrosis | Fontaine Progeroid Syndrome | Inborn Errors Of Metabolism | Epilepsy | Vaginitis | Choriocarcinoma | Chondromyxoid Fibroma | Retinopathy Of Prematurity | Androgenic Alopecia | Episodic Ataxia Type 2 | Bare Lymphocyte Syndrome | Charcot-Marie-Tooth Disease, Type 2 | Pulmonary Stenosis | Leukodystrophies | Hypermethioninemia | Greenberg Dysplasia | Joubert Syndrome 2 | Atelosteogenesis Type 1 | Christianson Syndrome | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Vertigo | Proteus Syndrome | Hyperparathyroidism, Secondary | Onchocerciasis | Pyruvate Carboxylase Deficiency Disease | Cancer, Skin | Triple A Syndrome | Diffuse Palmoplantar Keratoderma | Trimethylaminuria | Bronchitis, Chronic | Asthma | Ellis-Van Creveld Syndrome | Hemochromatosis | Tay-Sachs Disease | Corneal Ulcer | Sengers Syndrome | Granuloma Annulare | Wilson's Disease | Anorectal Malformations | Situs Inversus | 3-methylglutaconic Aciduria Type I | Hypersensitivity | Hereditary Hemorrhagic Telangiectasia Type 2 | Gitelman Syndrome | Bronchitis | Splenomegaly | Pneumoconiosis | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Angioimmunoblastic T-cell Lymphoma | Cataract | Bladder Exstrophy | Pseudohypoaldosteronism | Hypertension, Essential | Myofibrillar Myopathy | Prurigo Nodularis | Kawasaki Disease | KBG Syndrome | Pontocerebellar Hypoplasia Type 7 | Papilloma | Chloridorrhea, Congenital | Creatine Deficiency Syndrome | Danon Disease | Charcot-Marie-Tooth Disease Type 2D | Nijmegen Breakage Syndrome | Acral Lentiginous Melanoma | Graves Disease | Metabolic Diseases | Lentigo | Prolactinoma | Leukemia | TARP Syndrome | Intestinal Obstruction | POEMS Syndrome | Meesmann Corneal Dystrophy | Pemphigus | Desbuquois Syndrome | Epidermolytic Palmoplantar Keratoderma | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Chondrodysplasia Punctata 2, X-linked Dominant | Exocrine Pancreatic Insufficiency | Cardiofaciocutaneous Syndrome | Dentinogenesis Imperfecta