Other Name(s): Bax
Assay:Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization assay
Type:Ki
SMILES:CCOc1ccccc1N/N=C1/C(=O)N(c2nc(-c3ccccc3)cs2)N=C1C
Value:=1100nM
Source:Homo sapiens
Assay:Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization assay
Type:Ki
SMILES:CC1=NN(c2nc(-c3ccccc3)cs2)C(=O)/C1=C/C(c1ccccc1)c1ccccc1
Value:=13500nM
Source:Homo sapiens
Assay:Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization assay
Type:Ki
SMILES:CC1=NN(c2nc(-c3ccccc3)cs2)C(=O)/C1=C/c1ccc(-c2ccccc2)cc1
Value:=12900nM
Source:Homo sapiens
Assay:Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization assay
Type:Ki
SMILES:CC1=NN(c2nc(-c3ccccc3)cs2)C(=O)/C1=C/c1ccc2ccccc2c1
Value:=12600nM
Source:Homo sapiens
Assay:Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization assay
Type:Ki
SMILES:CC1=NN(c2nc(-c3ccccc3)cs2)C(=O)/C1=C/c1ncc[nH]1
Value:=15800nM
Source:Homo sapiens
Assay:Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization assay
Type:Ki
SMILES:CCOc1ccccc1CC(=O)C1C(=O)N(c2nc(-c3ccccc3)cs2)N=C1C
Value:=63100nM
Source:Homo sapiens
Assay:Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization assay
Type:Ki
SMILES:CCOc1ccccc1C(=O)C(=O)C1C(=O)N(c2nc(-c3ccccc3)cs2)N=C1C
Value:=85100nM
Source:Homo sapiens
Assay:Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization assay
Type:Ki
SMILES:CCOc1ccccc1N/N=C1\C(=O)N(c2cc(O)cc(-c3ccc(N(C)C)cc3)c2)N=C1C
Value:=800nM
Source:Homo sapiens
Assay:Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization assay
Type:Ki
SMILES:CCOc1ccccc1N/N=C1\C(=O)N(c2cc(O)cc(-c3ccccc3)c2)N=C1C
Value:=9100nM
Source:Homo sapiens
Assay:Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization assay
Type:Ki
SMILES:CCOc1ccccc1N/N=C1\C(=O)N(c2cc(O)cc(-c3ccncc3)c2)N=C1C
Value:=1700nM
Source:Homo sapiens
Assay:Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization assay
Type:Ki
SMILES:CCOc1ccccc1N/N=C1\C(=O)N(c2cc(O)cc(-c3cccs3)c2)N=C1C
Value:=30900nM
Source:Homo sapiens
Assay:Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization assay
Type:Ki
SMILES:CCOc1ccccc1N/N=C1\C(=O)N(c2cc(O)cc(-c3cccc(N)c3)c2)N=C1C
Value:=1300nM
Source:Homo sapiens
Assay:Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization assay
Type:Ki
SMILES:CCOc1ccccc1N/N=C1\C(=O)N(c2cc(O)cc(-c3ccc(C(C)C)cc3)c2)N=C1C
Value:=1200nM
Source:Homo sapiens
Assay:Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization assay
Type:Ki
SMILES:CCOc1ccccc1N/N=C1\C(=O)N(c2cccc(-c3ccc(N(C)C)cc3)c2)N=C1C
Value:=1300nM
Source:Homo sapiens
Assay:Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization assay
Type:Ki
SMILES:CC1=NN(c2cc(O)cc(-c3ccc(N(C)C)cc3)c2)C(=O)/C1=N\Nc1ccc2ccccc2c1
Value:=1000nM
Source:Homo sapiens
Assay:Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization assay
Type:Ki
SMILES:CC1=NN(c2nc(-c3ccccc3)cs2)C(=O)/C1=C/c1ccccc1
Value:=2500nM
Source:Homo sapiens
Assay:Activation of Bax in human HuH7 cells assessed as inhibition of mitochondrial accumulation of fluorescent probe Mitotracker Red after 12 to 72 hrs by spectrophotometric analysis
Type:EC50
SMILES:CCOc1ccccc1N/N=C1/C(=O)N(c2nc(-c3ccccc3)cs2)N=C1C
Value:=8200nM
Source:Homo sapiens
Assay:Activation of Bax in human HuH7 cells assessed as inhibition of mitochondrial accumulation of fluorescent probe Mitotracker Red after 12 to 72 hrs by spectrophotometric analysis
Type:EC50
SMILES:CCOc1ccccc1N/N=C1\C(=O)N(c2cc(O)cc(-c3ccc(N(C)C)cc3)c2)N=C1C
Value:=700nM
Source:Homo sapiens
Assay:Displacement of fluorescent Bak BH3 peptide domain from human recombinant Bax by competition fluorescence polarization assay
Type:IC50
SMILES:O=[N+]([O-])c1ccc2c(c1)C(=Cc1ccccc1O)c1ccccc1-2
Value:=43nM
Source:Homo sapiens
Assay:Activation of Bax in human SMMC7721 cells
Type:IC50
SMILES:O=C(N/N=C/c1ccc2c(c1)OCO2)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O
Value:=3000nM
Source:Homo sapiens

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