Other Name(s): BRCA
Assay:Inhibition of BRCA1 assessed as BRCT-BACH1 interaction
Type:Ki
SMILES:O=C1c2ccccc2S(=O)(=O)c2cc(N3CCC(Cc4ccccc4)CC3)ccc21
Value:=38000nM
Source:Homo sapiens
Assay:Inhibition of BRCA1 assessed as BRCT-BACH1 interaction
Type:Ki
SMILES:NC(=O)C1CCN(c2ccc3c(c2)S(=O)(=O)c2ccccc2C3=O)CC1
Value:=30000nM
Source:Homo sapiens
Assay:Inhibition of BRCA1 assessed as BRCT-BACH1 interaction
Type:Ki
SMILES:CC1CCN(c2ccc3c(c2)S(=O)(=O)c2ccccc2C3=O)CC1
Value:=39000nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ]
Type:Potency
SMILES:CN(C)[C@@H]1C(O)=C(C(N)=O)C(=O)[C@]2(O)C(O)=C3C(=O)c4c(O)cccc4[C@](C)(O)[C@H]3C[C@@H]12.CS(=O)(=O)O
Value:=7943.3nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ]
Type:Potency
SMILES:COc1cc(-c2ccc(/N=N\c3ccc4c(S(=O)(=O)O)cc(S(=O)(=O)O)c(N)c4c3O)c(OC)c2)ccc1/N=N\c1ccc2c(S(=O)(=O)O)cc(S(=O)(=O)O)c(N)c2c1O
Value:=19952.6nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ]
Type:Potency
SMILES:O=C1Nc2ccc(I)cc2/C1=C/c1cc(Br)c(O)c(Br)c1
Value:=31622.8nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ]
Type:Potency
SMILES:O=C1c2ccccc2-c2onc3ccc(NCCCn4ccnc4)c1c23
Value:=631nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ]
Type:Potency
SMILES:O=C(Nc1cc(C(=O)Nc2ccc(S(=O)(=O)[O-])cc2S(=O)(=O)[O-])cc(C(=O)Nc2ccc(S(=O)(=O)[O-])cc2S(=O)(=O)[O-])c1)Nc1cc(C(=O)Nc2ccc(S(=O)(=O)[O-])cc2S(=O)(=O)[O-])cc(C(=O)Nc2ccc(S(=O)(=O)[O-])cc2S(=O)(=O)[O-])c1.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Value:=631nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ]
Type:Potency
SMILES:CC[n+]1c(-c2ccccc2)c2cc(N)ccc2c2ccc(N)cc21.[Br-]
Value:=19952.6nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ]
Type:Potency
SMILES:Cn1c(NC(=O)c2ccccc2Br)cc(=O)n(C)c1=O
Value:=10000nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ]
Type:Potency
SMILES:CC[C@@]1(O)CC(O)c2c(cc3c(c2O)C(=O)c2c(O)ccc(O)c2C3=O)C1C(=O)OC
Value:=3981.1nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ]
Type:Potency
SMILES:CN(N=O)c1ccc(O)c(O)c1
Value:=6309.6nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ]
Type:Potency
SMILES:O=C1CC(/C=C/c2ccco2)=Nc2ccccc2N1
Value:=39810.7nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ]
Type:Potency
SMILES:CN1C(=O)/C(=N\CCO)c2c3ccccc3c(O)c3cccc1c23
Value:=25118.9nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ]
Type:Potency
SMILES:Cc1cc(O)c2c(c1)C(=O)c1cccc(O)c1C2=O
Value:=39810.7nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ]
Type:Potency
SMILES:CC1N(C)c2cc(NC(=O)c3ccco3)ccc2C1(C)C
Value:=31622.8nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ]
Type:Potency
SMILES:O=C1c2ccc(O)c(O)c2C(=O)c2c(O)ccc(O)c21
Value:=31622.8nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ]
Type:Potency
SMILES:O=C1c2ccccc2C(=O)c2c(O)c(O)cc(O)c21
Value:=39810.7nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ]
Type:Potency
SMILES:c1coc(C2Nc3cccc4cccc(c34)N2)c1
Value:=6309.6nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore). (Class of assay: confirmatory) [Related pubchem assays: 875 ]
Type:Potency
SMILES:O=C(O)/C=C\c1c2ccc(=O)c(O)c-2oc2c(O)c(O)ccc12
Value:=1000nM
Source:Homo sapiens

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ABCB1 | ABCG2 | ACE2 | AHR | AKT1 | ALK | AR | ATM | BAX | BCL2 | BCL2L1 | BRAF | BRCA1 | CASP3 | CASP9 | CCL5 | CCND1 | CD274 | CD4 | CDKN1A | CXCL8 | CXCR4 | DNMT1 | EGF | EGFR | EP300 | ERBB2 | ESR1 | EZH2 | FN1 | FOXO3 | HDAC9 | HGF | HMGB1 | HSP90AA1 | HSPA5 | IDO1 | IGF1 | IGF1R | IL17A | IL6 | INS | JUN | KRAS | MAPK1 | MAPK14 | MAPK3 | MAPK8 | MAPT | MCL1 | MMP9 | MTOR | MYC | NFE2L2 | NLRP3 | NOTCH1 | PARP1 | PCNA | PDCD1 | PLK1 | PRKAA1 | PRKAA2 | PTEN | PTGS2 | PTK2 | RELA | SIRT1 | SRC | STAT1 | STAT3 | STAT5A | TERT | TLR4 | TNF | TP53 | TXN | VEGFA | YAP1