Molecules to CDKN1A (P38936) Target Generated and Optimized

Molecules against Target CDKN1A

Uniprot ID: P38936

Other Name(s): P21, Waf1, P21

Assay:	Inhibitory concentration against human p21 deficient cell (p21-/-) proliferation
Type:	IC50
SMILES:	COc1ccc(-c2nc(O)c3c4c(sc3n2)CCCC4)cc1OC
Value:	>20000nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against human p21 proficient cell (p21+/+) proliferation
Type:	IC50
SMILES:	COc1ccc(-c2nc(O)c3c4c(sc3n2)CCCC4)cc1OC
Value:	>20000nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against human p21 deficient cell (p21+/+) proliferation
Type:	IC50
SMILES:	COc1cc(-c2nc(O)c3c4c(sc3n2)CCCC4)cc(OC)c1OC
Value:	>20000nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against human p21 deficient cell (p21+/+) proliferation
Type:	IC50
SMILES:	O=C(c1cccs1)c1cnn2c(-c3cccc(NC(=O)C4CC4)c3)ccnc12
Value:	=12000nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against p21 deficient cell (p21-/-) proliferation
Type:	IC50
SMILES:	COC(=O)c1ccc(-c2nc(O)c3c4c(sc3n2)CCCC4)cc1
Value:	>20000nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against p21 deficient cell (p21-/-) proliferation
Type:	IC50
SMILES:	Oc1nc(-c2ccc(-c3ccccc3)cc2)nc2sc3c(c12)CCCC3
Value:	>20000nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against p21 deficient cell (p21-/-) proliferation
Type:	IC50
SMILES:	COc1cc(-c2nc(O)c3c4c(sc3n2)CCCC4)cc(OC)c1OC
Value:	=2300nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against p21 deficient cell (p21-/-) proliferation
Type:	IC50
SMILES:	Cc1ccc(-c2nc(O)c3c4c(sc3n2)CCCC4)cc1
Value:	>20000nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against p21 deficient cell (p21-/-) proliferation
Type:	IC50
SMILES:	COc1ccc(-c2nc(O)c3c4c(sc3n2)CCC4)cc1
Value:	=2400nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against p21 deficient cell (p21-/-) proliferation
Type:	IC50
SMILES:	COc1cc(OC)cc(-c2nc(O)c3c4c(sc3n2)CCCC4)c1
Value:	>20000nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against p21 deficient cell (p21-/-) proliferation
Type:	IC50
SMILES:	COc1ccc(-c2nc(O)c3c4c(sc3n2)CCCC4)cc1
Value:	=2400nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against p21 deficient cell (p21-/-) proliferation
Type:	IC50
SMILES:	CCOc1ccc(-c2nc(O)c3c4c(sc3n2)CCCC4)cc1
Value:	=8400nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against p21 deficient cell (p21-/-) proliferation
Type:	IC50
SMILES:	O=C(c1cccs1)c1cnn2c(-c3cccc(NC(=O)C4CC4)c3)ccnc12
Value:	=400nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against p21 deficient cell (p21-/-) proliferation
Type:	IC50
SMILES:	Oc1nc(-c2ccc(Cl)cc2)nc2sc3c(c12)CCCC3
Value:	>20000nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against p21 deficient cell (p21-/-) proliferation
Type:	IC50
SMILES:	COc1cc(-c2nc(O)c3ccsc3n2)cc(OC)c1OC
Value:	>20000nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against p21 deficient cell (p21-/-) proliferation
Type:	IC50
SMILES:	CCN(CC)c1ccc(-c2nc(O)c3c4c(sc3n2)CCCC4)cc1
Value:	>20000nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against p21 deficient cell (p21-/-) proliferation
Type:	IC50
SMILES:	COc1cc(-c2nc(O)c3c4c(sc3n2)CCC4)cc(OC)c1OC
Value:	=3500nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against p21 deficient cell (p21-/-) proliferation
Type:	IC50
SMILES:	COc1ccc(-c2nc(O)c3sccc3n2)cc1
Value:	>20000nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against p21 deficient cell (p21-/-) proliferation
Type:	IC50
SMILES:	COc1cc(-c2nc(O)c3sccc3n2)cc(OC)c1OC
Value:	>20000nM
Source:	Homo sapiens

Assay:	Inhibitory concentration against p21 deficient cell (p21-/-) proliferation
Type:	IC50
SMILES:	O=[N+]([O-])c1ccc(-c2nc(O)c3c4c(sc3n2)CCCC4)cc1
Value:	>20000nM
Source:	Homo sapiens

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