Other Name(s): Cxcr4
Assay:Inhibitory activity based on the inhibition of [Ca2+] mobilization induced by human SDF-1alpha stimulation through C-X-C chemokine receptor type 4
Type:IC50
SMILES:C[C@H]1/C=C\[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)C(CCCNC(N)=O)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O
Value:=27000nM
Source:
Assay:Inhibitory activity based on the inhibition of [Ca2+] mobilization induced by human SDF-1alpha stimulation through C-X-C chemokine receptor type 4
Type:IC50
SMILES:C[C@H]1/C=C\[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)C(CCCNC(N)=O)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O
Value:=30000nM
Source:
Assay:Binding affinity towards CXCR4 receptor
Type:Activity
SMILES:Brc1ccc(-c2[nH]c3ccc4ccccc4c3c2CCCNC2CCC(c3ccccc3)C2)cc1
Value:=1520nM
Source:
Assay:Compound was evaluated for its inhibitory activity against C-X-C chemokine receptor type 4
Type:IC50
SMILES:C=CCN(C(=O)OCc1ccccc1)C1CCN(CCC(Cn2c(CC)nc3ccccc32)c2ccccc2)CC1
Value:>1000nM
Source:
Assay:Compound was evaluated for its inhibitory activity against C-X-C chemokine receptor type 4
Type:IC50
SMILES:C=CCN(C(=O)OCc1ccccc1)C1CCN(CCC(Cn2cnc3ccccc32)c2ccccc2)CC1
Value:>1000nM
Source:
Assay:Compound was evaluated for its inhibitory activity against C-X-C chemokine receptor type 4
Type:IC50
SMILES:C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CCC(Cn2cnc3ccccc32)c2ccccc2)CC1
Value:>1000nM
Source:
Assay:Inhibitory activity against C-X-C chemokine receptor type 4
Type:IC50
SMILES:C=CCN(C(=O)OCc1ccccc1)C1CCN(CCC(C)(CN2C(=O)N[C@H](Cc3c[nH]c4ccccc34)C2=O)c2ccccc2)CC1
Value:>1000nM
Source:
Assay:Inhibitory activity against C-X-C chemokine receptor type 4
Type:IC50
SMILES:C=CCN(C(=O)OCc1ccccc1)C1CCN(CCC(CN2C(=O)N[C@H](Cc3c[nH]c4ccccc34)C2=O)c2cccc(Cl)c2)CC1
Value:>1000nM
Source:
Assay:Inhibitory activity against C-X-C chemokine receptor type 4
Type:IC50
SMILES:CCN(C(=O)OCc1ccccc1)C1CCN(CCC(CN2C(=O)N[C@H](Cc3c[nH]c4ccccc34)C2=O)c2ccccc2)CC1
Value:>1000nM
Source:
Assay:Inhibitory activity against C-X-C chemokine receptor type 4
Type:IC50
SMILES:C=CCN(C(=O)OCc1ccccc1)C1CCN(CCC(CN2C(=O)N[C@H](Cc3c[nH]c4ccccc34)C2=O)c2ccccc2)CC1
Value:>1000nM
Source:
Assay:Inhibitory activity against C-X-C chemokine receptor type 4
Type:IC50
SMILES:CCN(C(=O)OCc1ccccc1)C1CCN(CCC(CN2C(=O)N[C@H](Cc3c[nH]c4ccccc34)C2=O)c2cccc(Cl)c2)CC1
Value:>1000nM
Source:
Assay:Inhibitory activity against C-X-C chemokine receptor type 4
Type:IC50
SMILES:CCN(C(=O)OCc1ccccc1)C1CCN(CCC(C)(CN2C(=O)N[C@H](Cc3c[nH]c4ccccc34)C2=O)c2ccccc2)CC1
Value:>1000nM
Source:
Assay:Inhibitory activity against C-X-C chemokine receptor type 4
Type:IC50
SMILES:C=CCN(C(=O)OCc1ccccc1)C1CCN(CCC(C)(CN2C(=O)N[C@H](Cc3c[nH]c4ccccc34)C2=O)c2cccc(Cl)c2)CC1
Value:>1000nM
Source:
Assay:Compound was evaluated for its inhibitory activity against C-X-C chemokine receptor type 4
Type:IC50
SMILES:C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CCC(C)(Cn2cnc3ccccc32)c2ccccc2)CC1
Value:>1000nM
Source:
Assay:Compound was evaluated for its inhibitory activity against C-X-C chemokine receptor type 4
Type:IC50
SMILES:C=CCN(C(=O)OCc1ccccc1)C1CCN(CCC(C)(Cn2cnc3ccccc32)c2ccccc2)CC1
Value:>1000nM
Source:
Assay:Compound was evaluated for its inhibitory activity against C-X-C chemokine receptor type 4
Type:IC50
SMILES:C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CCC(Cn2c(CC)nc3ccccc32)c2ccccc2)CC1
Value:>1000nM
Source:
Assay:Inhibitory activity against CX3C chemokine receptor 4-specific monoclonal antibody 12G5 (mAb-12G5) binding to human chemokinin receptor CXCR4 in lymphocytic SUP-T1 cells
Type:IC50
SMILES:Cl.c1cc(CN2CCCOCCOCCCNCC2)ccc1CN1CCCOCCOCCCNCC1
Value:>35000nM
Source:
Assay:Inhibitory activity against CX3C chemokine receptor 4-specific monoclonal antibody 12G5 (mAb-12G5) binding to human chemokinin receptor CXCR4 in lymphocytic SUP-T1 cells
Type:IC50
SMILES:Br.c1cc2nc(c1)CNCCN(Cc1ccc(CN3CCNCc4cccc(n4)CNCC3)cc1)CCNC2
Value:=4363nM
Source:
Assay:Inhibitory activity against CX3C chemokine receptor 4-specific monoclonal antibody 12G5 (mAb-12G5) binding to human chemokinin receptor CXCR4 in lymphocytic SUP-T1 cells
Type:IC50
SMILES:Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl.O.O.c1cc(CN2CCCNCCNCCCNCC2)ccc1CN1CCCNCCNCCCNCC1
Value:=7nM
Source:
Assay:Inhibitory activity against CX3C chemokine receptor 4-specific monoclonal antibody 12G5 (mAb-12G5) binding to human chemokinin receptor CXCR4 in lymphocytic SUP-T1 cells
Type:IC50
SMILES:Br.c1cc(CN2CCCNCCCCCNCCC2)ccc1CN1CCCNCCCCCNCCC1
Value:>35000nM
Source:

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