Molecules to HGF (P14210) Target Generated and Optimized

Molecules against Target HGF

Uniprot ID: P14210

Other Name(s): None

Assay:	Inhibition of human recombinant HGF-mediated cMet phosphorylation in human PC3 cells
Type:	IC50
SMILES:	COc1cc2nccc(Oc3ccc(-c4cnc(Cc5ccccc5)n(C)c4=O)cc3F)c2cc1OC
Value:	=313nM
Source:	Homo sapiens

Assay:	Inhibition of human recombinant HGF-mediated cMet phosphorylation in human PC3 cells
Type:	IC50
SMILES:	COc1cc2c(Oc3ccc(-c4cnc(Nc5ccc(F)cc5)n(C)c4=O)nc3)ccnc2cc1OCCCN1CCOCC1
Value:	=69nM
Source:	Homo sapiens

Assay:	Inhibition of human recombinant HGF-mediated cMet phosphorylation in human PC3 cells
Type:	IC50
SMILES:	COc1cc2c(Oc3ccc(-c4cnc(Nc5ccc(F)cc5)n(C)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1
Value:	=64nM
Source:	Homo sapiens

Assay:	Inhibition of human recombinant HGF-mediated cMet phosphorylation in human PC3 cells
Type:	IC50
SMILES:	COc1cc2c(Oc3ccc(-c4cnc(Cc5ccc(F)cc5)n(C)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1
Value:	=161nM
Source:	Homo sapiens

Assay:	Inhibition of human recombinant HGF-mediated cMet phosphorylation in mouse CT26 cells
Type:	IC50
SMILES:	COc1cc2nccc(Oc3ccc(-c4cnc(Cc5ccccc5)n(C)c4=O)cc3F)c2cc1OC
Value:	=368nM
Source:	Homo sapiens

Assay:	Inhibition of human recombinant HGF-mediated cMet phosphorylation in mouse CT26 cells
Type:	IC50
SMILES:	COc1cc2c(Oc3ccc(-c4cnc(Nc5ccc(F)cc5)n(C)c4=O)nc3)ccnc2cc1OCCCN1CCOCC1
Value:	=59nM
Source:	Homo sapiens

Assay:	Inhibition of human recombinant HGF-mediated cMet phosphorylation in mouse CT26 cells
Type:	IC50
SMILES:	COc1cc2c(Oc3ccc(-c4cnc(Nc5ccc(F)cc5)n(C)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1
Value:	=82nM
Source:	Homo sapiens

Assay:	Inhibition of human recombinant HGF-mediated cMet phosphorylation in mouse CT26 cells
Type:	IC50
SMILES:	COc1cc2c(Oc3ccc(-c4cnc(Cc5ccc(F)cc5)n(C)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1
Value:	=196nM
Source:	Homo sapiens

Assay:	Binding affinity to immobilized HGF (unknown origin) by surface plasmon resonance analysis
Type:	Kd
SMILES:	Nc1c(S(=O)(=O)[O-])cc(Nc2ccc(-c3ccc(Nc4cc(S(=O)(=O)[O-])c(N)c5c4C(=O)c4ccccc4C5=O)cc3)cc2)c2c1C(=O)c1ccccc1C2=O.[Na+].[Na+]
Value:	=1950nM
Source:	Homo sapiens

Assay:	Inhibitory concentration of the compound against HGF-stimulated c-Met signaling�Cactivation using ELISA method
Type:	IC50
SMILES:	CN1C=C(C=N1)C1=CN2C(C=C1)=NC=C2S(=O)(=O)N1N=CC2=C1C=C(C=N2)C1=CN(C)N=C1
Value:	=8.8nM
Source:

Assay:	In vitro inhibitory concentration of the compound against HGF receptor
Type:	IC50
SMILES:	COC1=C(OCCCN2CCOCC2)C=C2N=CC=C(OC3=CC=C(NC(=O)C4(CC4)C(=O)NC4=CC=C(F)C=C4)C=C3F)C2=C1
Value:	=3nM
Source:

Assay:	Inhibitory concentration of the compound against HGF expressing A-431 cell line
Type:	IC50
SMILES:	[H]O[C@@H]1[C@@H](COS(=O)(=O)C2=CC(=CC=C2)C(F)(F)F)O[C@H](OC3=CC=C(I)C=C3)[C@H](OC(=O)CCC4=CC=CC=C4)[C@H]1OCC=C
Value:	=2uM
Source:

Assay:	Binding affinity (KD) of compound towards activation of pro Hepatocyte Growth Factor beta binding to met Receptor
Type:	Kd
SMILES:	CC[C@H](C)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(O)=O
Value:	=34uM
Source:

Assay:	Binding affinity (KD) of compound towards activation of pro Hepatocyte Growth Factor beta binding to met Receptor
Type:	Kd
SMILES:	CC[C@H](C)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(O)=O
Value:	=85uM
Source:

Assay:	Binding affinity (KD) of compound towards activation of pro Hepatocyte Growth Factor beta binding to met Receptor
Type:	Kd
SMILES:	CC[C@H](C)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CC(O)C[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(O)=O
Value:	=14uM
Source:

Assay:	Binding affinity (KD) of compound towards activation of pro Hepatocyte Growth Factor beta binding to met Receptor
Type:	Kd
SMILES:	CC[C@H](C)[C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CC(O)C[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(O)=O
Value:	=5uM
Source:

Assay:	Binding affinity (KD) of compound towards activation of pro Hepatocyte Growth Factor beta binding to met Receptor
Type:	Kd
SMILES:	CC[C@H](C)[C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CN=CN1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(O)=O
Value:	=6uM
Source:

Assay:	Binding affinity (KD) of compound towards activation of pro Hepatocyte Growth Factor beta binding to met Receptor
Type:	Kd
SMILES:	CC[C@H](C)[C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)NCC(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O
Value:	=0.3uM
Source:

Assay:	Binding affinity (KD) of compound towards activation of pro Hepatocyte Growth Factor beta binding to met Receptor
Type:	Kd
SMILES:	CC[C@H](C)[C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O
Value:	=59uM
Source:

Assay:	Binding affinity (KD) of compound towards activation of pro Hepatocyte Growth Factor beta binding to met Receptor
Type:	Kd
SMILES:	CC[C@H](C)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(O)=O
Value:	=21uM
Source:

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