Other Name(s): Tau, Tau
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:O=C(Oc1cncc(Cl)c1)c1ccco1
Value:=44668.4nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:CC(=O)c1ccc(NC(=O)c2ccc3c(c2)N(Cc2cccc(Cl)c2)C(=O)c2ccccc2[S+]3[O-])cc1
Value:=31622.8nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:O=c1c(-c2cc(O)c(O)c(O)c2)coc2cc(O)c(O)c(O)c12
Value:=7079.5nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:CCOC(=O)/C(=C\c1cccnc1)C(=O)c1cc(C(C)=O)c(Nc2ccccc2)s1
Value:=35481.3nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:CCCN1C(=O)/C(=C/c2ccc(N3CCCC3)c(C)c2)NC1=S
Value:=10000nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:CCc1ccc(-n2c(=O)c3ccc(C(=O)NCCc4ccccc4)cc3n(CC(N)=O)c2=O)cc1
Value:=28183.8nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:O=c1oc2ccccc2c(N2CCC(c3ccccc3)CC2)c1[N+](=O)[O-]
Value:=44668.4nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(Br)s3)sc2c1
Value:=12589.3nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:O=C(CSc1ccc(Cl)cc1)Nc1ccc(-c2nc3ccccc3[nH]2)cc1
Value:=39810.7nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:COc1cccc(C(=O)Nc2cccc(NC(=O)c3ccc(Cl)cc3Cl)c2)c1
Value:=14125.4nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:N#CCCn1cc(/C=C/C(=O)O)c(-c2ccc(F)cc2)n1
Value:=8912.5nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:CC[n+]1c(C)sc2c(C)cc(C)cc21.[I-]
Value:=10000nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:NC(=O)c1ccc(N=Nc2c(O)nc3ccccc3c2O)cc1
Value:=25.1nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:CCN1C[C@@]2(OC(=O)c3ccccc3NC(C)=O)CCC(OC)[C@@]34C5CC6C(OC)C[C@@](O)(C(CC32)[C@@H]14)C5(O)C6OC
Value:=8912.5nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:Cc1nnc(N2CCOCC2)c2nn(-c3ccccc3)c(C)c12
Value:=2511.9nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:Cc1c(C(=O)NCc2ccccc2Cl)sc2nc3n(c(=O)c12)CCCCC3
Value:=19952.6nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:COc1cc(NC(=O)CSCC(=O)Nc2cccc(C(F)(F)F)c2)c(Cl)cc1Cl
Value:=22387.2nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:Cc1ccc2nc(N3C(=O)CNC3=S)sc2c1
Value:=17782.8nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:CC(=O)c1c(C)[nH]c(C(=O)OCC(=O)Nc2sc3c(c2C#N)CCCC3)c1C
Value:=35481.3nM
Source:Homo sapiens
Assay:PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]
Type:Potency
SMILES:COc1ccc(C(c2c(O)n(C)c(SC)nc2=O)c2c(O)n(C)c(SC)nc2=O)cc1O
Value:=10000nM
Source:Homo sapiens

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