高脂血症

疾病概述
家族性高脂血症，又称家族性高脂蛋白血症，与v型高脂蛋白血症和i型高脂蛋白血症有关。与家族性高脂血症相关的一个重要基因是 APOB（载脂蛋白 B），其相关途径/超途径包括无机阳离子/阴离子和氨基酸/寡肽的代谢和运输。在这种疾病的背景下提到了 Evolocumab 和 Dapagliflozin 药物。附属组织包括心脏、肝脏和内皮，相关表型无影响和无影响

主要靶点
LIPG | PTAFR | MAOB | VHL | APOE | GLP1R | G5743 | GPR31 | GCGR | NLRP3 Inflammasome | PLA2G2A | IL13 | ALOX15 | SREBF1 | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | ASGR1 | Diacylglycerol Acyltransferase (DGAT) (nonspecified subtype) | Asialoglycoprotein Receptor (ASGPR) (nonspecified subtype) | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | MMP1 | PRDX1 | CYP19A1 | PASK | SLC5A2 | APOA2 | CETP | SPP1 | LPL | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | HRH3 | GPR119 | GPBAR1 | FFAR4 | SLC28A3 | CYP3A4 | MOGAT2 | G5243 | CRTC2 | ANGPTL4 | TLR7 | TMPRSS15 | Carnitine O-Palmitoyltransferase (CPT) (nonspecified subtype) | SCAP | Protein farnesyltransferase | APOA4 | SLC12A3 | LDLR | RORC | PNPLA7 | DAO | G114548 | Interleukin 17 (nonspecified subtype) | MKNK2 | DGAT1 | CHKA | gamma-Secretase | CRBN | NR1I3 | APOA5 | SLC22A1 | FFAR1 | MGAT2 | GHSR | Glycogen phosphorylase (nonspecified subtype) | Carbonic Anhydrase (nonspecified subtype) | CYP2D6 | NPY1R | THRB | ACP1 | PTGIR | NPC1L1 | MIR34A | OAS3 | CYSLTR1 | IKBKB | Thyroid hormone receptor (nonspecified subtype) | TM7SF2 | NR1H2 | FDFT1 | ANGPTL3 | DGAT2 | G7124 | GCK | TXNIP | AMP-activated protein kinase (AMPK) | IL17RA | SCD | Phospholipase A2 (nonspecified subtype) | Cholesterol esterase (nonspecified subtype) | MAPK11 | Mucin (nonspecified subtype) | BTK | HIF1A | SCARB1 | G6774 | ABCG1 | NR1H3 | CTSL | SLC22A12 | KHK | Liver Bile Transporters (LBAT) (nonspecified subtype) | ACE | MIR122 | MKNK1 | ALDH2 | PPARA | Calcium channel (nonspecified subtype) | NFATC2 | CNR2 | IL1B | Lipoxygenase (nonspecified subtype) | CSF1R | HDAC11 | CPT2 | WEE1 | SLC13A5 | ADRB3 | Oxysterols receptor LXR (nonspecified subtype) | Adenylate Cyclase (nonspecified subtype) | HPGD | G3569 | CACNA1C | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | ESR2 | ADORA1 | VCAM1 | PYGL | MAOA | PCSK9 | HMGCR | G23411 | G4780 | MTNR1B | MYL2 | GIPR | NR1I2 | HPN | ABCA1 | G5595 | ICAM1 | PGR | ABCG5 | NF-kappaB (NFkB) | P2RX4 | Casein kinase II (CKII) | INSR | GABA(A) receptor | CNR1 | Estrogen receptor (nonspecified subtype) | HSD11B1 | Glucagon-like peptide receptor (GLP-R) (nonspecified subtype) | DHCR24 | CES1 | RORA | FABP5 | PPARD | CHKB | 15-Lipoxygenase (nonspecified subtype) | LYPLA1 | SLC10A1 | SLC22A2 | DPP4 | K(ATP) Channel (nonspecified subtype) | PTGDR | RYR2 | MTTP | ADORA2A | ADRB1 | AKR1B1 | Trypsin (nonspecified subtype) | MAP3K7 | Prostanoid TP receptor (nonspecified subtype) | Carnitine O-palmitoyltransferase 2 (nonspecified subtype) | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | SOAT1 | TRPV1 | LIPC | LSS | CHIA | PDE6D | PTGS1 | PTPN1 | FBP1 | NR1H4 | ACHE | G9429 | SQLE | PPARG | DNA topoisomerase (nonspecified subtype) | CYP3A5 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | Serine protease (nonspecified subtype) | STK25 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | RORB | PDE2A | FGFR4 | ACACB | TXNRD1 | Heat shock protein 70 (nonspecified subtype) | G2099 | CCKAR | G3630 | DAGLA | HCAR3 | SLC10A2 | FASN | APOA1 | FPR2 | PON1 | SLC2A9 | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | Mitogen-Activated Protein Kinase (nonspecified subtype) | ESRRG | PLA2G2D | ASIC1 | ACAA2 | SLC5A1 | Phospholipase A2, Secretory (sPLA2) (nonspecified subtype) | 3-Ketoacyl-CoA Thiolase (3-KAT) (nonspecified subtype) | ACLY | NOS3 | Glutathione S-Transferase (GST) (nonspecified subtype) | FASLG | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | SOAT2 | Angiotensin receptor (AT) (nonspecified subtype) | TACR1 | ADRB2 | MC4R | G7157 | HRH1 | LIPE | SLCO1B1 | FABP4 | GAA | PNLIP | HCAR2 | CTSB | AGTR2 | alpha-Amylase (nonspecified subtype) | AGTR1 | Retinoid RXR receptor (nonspecified subtype) | APOB | CA3 | SIRT3 | ACACA | THRA | REN | G367 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | HTR2A | NSDHL | ITPR1 | HECTD4 | Potassium Channels (nonspecified subtype) | LCAT | TRPA1 | ENOX2 | CYP51A1 | EPAS1 | TLR9 | UCP2 | MYLIP | TRPM3 | ODC1 | ALOX5 | LIPF

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•   靶点/生物标志物基本信息；
•   蛋白结构及化合物结合；
•   蛋白生物学机制；
•   靶点/生物标志物重要性
•   靶点筛选与验证；
•   蛋白表达水平;
•   疾病相关性;
•   成药性;
•   相关联合用药;
•   药化试验;
•   相关专利分析;
•   靶点开发优势与风险...
研究报告有助于课题/项目申请、药物分子设计、研究进展汇报、研究论文发表、专利申请等。如果您希望获得该报告的完整版，请与我们联系： BD@silexon.ai

其它疾病

家族性混合型高脂血症 | 高苯丙氨酸血症 | 高草酸尿症 | 高蛋氨酸血症 | 高血压 | 肺病高血压 | 肾病高血压 | 肾血管病高血压 | 门脉高血压 | 高血压性视网膜病变 | 高血压肾病 | 原发性高血压 | 高血糖 | 高钙尿症 | 高钙血症 | 高钾性周期性麻痹 | 高铁蛋白血症-白内障综合征 | 高铁血红蛋白血症 | 高雄激素血症 | 鱼鳞病 | 鲁宾斯坦-泰比综合征 | 鳃肾综合征 | 鸟氨酸转氨甲酰酶缺乏症 | 麦克劳德综合征 | 麦库恩-奥尔布赖特综合征 | 麻疹 | 脑性瘫痪 | 麻风 | 黄斑变性 | 黄斑角膜营养不良 | 黄斑角膜营养不良1型 | 黄热病 | 梗阻性黄疸 | 黑斑息肉综合征 | 黑棘皮症 | 黑素细胞痣 | 黑色素瘤 | 恶性黑色素瘤 | 葡萄膜黑色素瘤 | 黑酸尿症 | 鼻指声综合征 | 鼻炎 | 齐薇格综合症 | 齐默尔曼-拉班德综合征 | 齿甲真皮发育不良 | 龋齿