高血压

疾病概述
原发性高血压，又称原发性高血压，与肺动脉高压和肾血管性高血压有关，症状包括心绞痛、胸痛、水肿等。与高血压相关的一个重要基因，Essential 是 PTGIS（前列腺素 I2 合酶），其相关途径/超级途径包括 ERK 的发展血管紧张素激活和“作用于肾素-血管紧张素系统途径的药物，药效学”。在这种疾病的背景下提到了地高辛和华法林药物。附属组织包括心脏、肾脏和眼睛，相关表型是收缩压升高和舒张压升高

主要靶点
L-type voltage-dependent calcium channel complex | A1BG | PNMT | PTGES | ADRA1A | CLCNKA | MRGPRX1 | PPARG | TTR | UCP3 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | PTPRD | PIK3R5 | HSD17B2 | cAMP Phosphodiesterase (nonspecified subtype) | Nicotinic alpha4beta2alpha5 Receptor | SLC9A1 | TOP1 | KMT2C | KCNN3 | P2RY1 | ATG13 | RAC1 | SLC28A3 | DENND2B | MAS1L | COMT | Prolyl 4-hydroxylase | GPR119 | AXL | G59272 | SLC18A2 | MTERF2 | CNR1 | EPHX2 | ESR2 | SLC25A31 | HTR1A | MAOA | C1S | NR1H2 | ARSG | SLC6A2 | FRMD4B | GHRL | Nicotinic alpha6beta2alpha4beta2beta3 receptor | PIK3CD | SEC16B | OXSR1 | Alpha-2 Adrenergic receptors (nonspecified subtype) | G1950 | TRPV1 | ORAI1 | CRTC2 | CLCNKB | Serine/Threonine Kinase (nonspecified subtype) | PNPLA3 | NR3C1 | MRGPRD | CRY2 | CTF1 | MTNR1A | TYR | DGAT1 | FFAR1 | PTPN7 | ROCK1 | G142 | CTNNA3 | STAT6 | OVGP1 | KCND3 | ALDH2 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | CYP17A1 | BMAL1 | MMP3 | PLA2G4A | GNB3 | PRKCA | NISCH | Lipoxygenase (nonspecified subtype) | ADRA2B | SLC12A3 | AGT | LPAR1 | TRNT | PTGER3 | G7295 | CA5A | HDAC1 | ACY3 | ADAMTS13 | CHRM1 | P2RY2 | GPATCH2 | ADIPOQ | PTGIR | KEAP1 | NR1I3 | CFI | SCAP | NPBWR2 | PTGS1 | ESPNL | C9orf72 | G598 | Estrogen receptor (nonspecified subtype) | G2099 | MTHFR | SYNE2 | LOC101927825 | CASR | LINC02320 | HMGCR | PLCD3 | PIK3CB | MYOM2 | SOX1 | FCGRT | T-Type Calcium Channel | CYP21A2 | ZNF652 | CA1 | SH2B1 | Endothelin-Converting Enzymes (ECE) (nonspecified subtype) | APOA5 | GABA(A) receptor | MITF | NPY1R | PGR | PIK3CA | AVPR1B | G5743 | Glycogen phosphorylase (nonspecified subtype) | ACHE | ZMAT4 | FAM110D | ABI3BP | HTR2B | ADORA1 | KCNJ15 | DNA Topoisomerase II (nonspecified subtype) | G23411 | ICAM1 | APLNR | ALOX12 | G5243 | P4HA3 | G9429 | G3479 | Calcium release-activated channel (CRAC) | Neuropeptide Y receptor (NPY-R) (nonspecified subtype) | Acid-Sensing Ion Channel (ASIC) (nonspecified subtype) | AHCY | MYO3B | CES2 | ACSM3 | SCD | Voltage-Gated Sodium Channel Complex | ILKAP | GCK | GHRLOS | ADORA2B | CYBB | CYP1A1 | LINC02871 | FLT4 | CDKAL1 | BMP2 | P2RX3 | TRPV2 | CCKBR | HTR4 | DYRK1A | VAV3-AS1 | CACNA1G | RAC2 | Kir 3.1/3.4 | UGCG | SNHG32 | HDAC3 | ANO1 | MAPK11 | SCLT1 | cGMP-Dependent Protein Kinase (nonspecified subtype) | G1956 | CA12 | NEDD4L | CUZD1 | TNFSF11 | HSD11B1 | Steroid 5-alpha-Reductase (nonspecified subtype) | FLT1 | SGK1 | Tubulin | G4318 | PDE1C | DROSHA | SLC22A12 | CA6 | OAS3 | CDKN2B-AS1 | ATG9B | ZFAND4 | PTPN12 | G3630 | KCNA4 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | OR9K2 | ND1 | GFER | SSTR3 | CALM1 | HCRTR1 | IRAK3 | PDE9A | BORCS7 | Small Conductance Calcium-Activated Potassium Channel (SK) (nonspecified subtype) | SCNN1B | alpha-Adrenoceptor (nonspecified subtype) | TGFBR1 | CCR2 | PAX3 | ADORA2A | SLC14A1 | DBH | HAO2 | PPID | SYK | ABCA1 | VDR | GNAQ | AP3S1 | PAPPA2 | ARG1 | DPP4 | CYTB | FGF5 | SOD2 | ERG | EYA1 | P2RY4 | NOX4 | PPP2R5C | Sodium channel (nonspecified subtype) | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | MC2R | ATP8B1 | GJA5 | PPARD | TXNIP | Cholesterol esterase (nonspecified subtype) | KCNJ1 | KCNN4 | F10 | S1PR4 | NR1I2 | CHRNA7 | cGMP Phosphdiesterase (PDE) (nonspecified subtype) | AKR1B1 | KYNU | G protein-Coupled Inwardly-Rectifying Potassium Channel (GIRK) (nonspecified subtype) | KHK | CACNA1C | NCF2 | PCSK9 | S1PR2 | GSTT1 | NFATC2 | XDH | Opioid receptor (nonspecified subtype) | SLC9A3 | RPSAP52 | AVPR2 | SLC22A6 | PTPN1 | RAMP2 | ATP5IF1 | HNRNPH3 | ADRA2A | NOS3 | BCHE | KDR | Reverse transcriptase (Telomerase) | PGAM5-KEAP1-NRF2 Complex | SLC4A1 | GDF2 | GSK3B | HPGD | Guanylate cyclase (nonspecified subtype) | GADL1 | APOH | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | OXT | G3480 | LCA5 | CLU | G367 | ADRB3 | VCAM1 | NPY2R | SERPINE1 | Chloride channel (nonspecified subtype) | ZSCAN25 | UBXN10 | MAPK12 | HDC | BGLAP | NR5A2 | MASP2 | Nicotinic alpha3beta4 Receptor | Neuromedin U Receptor (nonspecified subtype) | EDNRB | TFIP11 | FGA | FLNA | LOC100130207 | APOC3 | Nicotinic alpha4beta2 receptor | TET2 | Epithelial Sodium Channel (ENaC) | TCF21 | RNF213 | G836 | SELENOS | WNK4 | NCF4 | SV2C | DICER1 | CES1 | CYP24A1 | Adenylate Cyclase (nonspecified subtype) | OPRD1 | TM6SF2 | IAPP | Calcium-Activated K(Ca) Potassium Channel (nonspecified subtype) | DIAPH3 | SMARCA4 | OPRL1 | PRKAG2 | SCN4A | CFHR5 | RAMP1 | ADD1 | CTSG | VIPR1 | PTGIS | IL1B | Myosin Class II (nonspecified subtype) | ANKFN1 | MMP2 | UTS2R | Kir 3.1/3.2 | Mitogen-Activated Protein Kinase (nonspecified subtype) | ADA | GIPR | ULK4 | CSMD1 | S1PR3 | CA7 | WNK3 | MC3R | CFHR4 | Amylin receptor | CHID1 | ADORA3 | G3569 | SCNN1G | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | SPINK14 | CABCOCO1 | PDK4 | PLG | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | Adenosine deaminase (nonspecified subtype) | SLC6A4 | ATG12 | SLC22A8 | PTGER4 | ADH1B | cAMP-Dependent protein kinase (PKA) | CA13 | SLC22A2 | NEDD4 | XKR6 | PYGL | HTR2A | LCN2 | DCN | FFAR2 | MMP7 | PDE5A | RAMP3 | CELSR1 | CFHR3 | RYR2 | NPPA | KANK1 | FLT3 | SRCAP | RAB22A | SLCO1B7 | G7422 | ATP2B1 | K(ATP) Channel (nonspecified subtype) | KCNJ3 | Na+/K+-ATPase (nonspecified subtype) | PAX5 | KCNA5 | WNK2 | TMTC2 | TEK | C3AR1 | FGFR4 | CYP3A5 | ADRB1 | ACTRT3 | UBASH3A | PTGDR | GLCCI1 | 15-Lipoxygenase (nonspecified subtype) | TSPO | MME | CAV1 | IL1A | DRD1 | PRKCH | MGA | ARHGEF12 | NPPA-AS1 | SOX5 | ABCC8 | PTK2B | PRKCD | BACH1 | CYP2R1 | MPG | FAAH | MLH3 | IL2 | ELAVL1 | THEM5 | HCRTR2 | WNK1 | MYH2 | NPY5R | Trypsin (nonspecified subtype) | DAW1 | P4HB | BORCS7-ASMT | beta-Adrenoceptor (nonspecified subtype) | FASN | MYL2 | G6PC1 | ABCC9 | NPY4R | Elastase (nonspecified subtype) | GNPDA2 | LOC157273 | FGB | NMDA receptor | TRPA1 | PRL | ANO2 | RB1CC1 | DNHD1 | F5 | NOS2 | TRNA | RTEL1 | PLA2G4D | IFNG | Prostanoid TP receptor (nonspecified subtype) | STAT2 | NEDD8 | CALCRL | NPPB | GPR84 | GRK4 | CYP1A2 | LIPC | ASS1 | LEPR | STS | PDGFRA | VNN1 | HRH1 | KCNK3 | AGTR1 | ADIPOR1 | GPX3 | sigma Receptor (nonspecified subtype) | G7015 | RTKN2 | BDNF-AS | ATP6AP2 | FASLG | Cysteine Protease (nonspecified subtype) | TNFRSF11A | SUCNR1 | AP-1 Transcription Factor Complex | SCN9A | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | LTBP1 | TIMP1 | JAK2 | LINC00700 | LINC02210-CRHR1 | CRHR1 | KCNJ5 | FGD5 | MALAT1 | CYB5R3 | G196 | CACNA1D | NTSR1 | UGGT2 | ROCK2 | CFTR | ADRB2 | PDE2A | GUCY1A1 | XPO5 | RBP1 | SOD3 | SORCS2 | ADRA1D | Dopamine receptor (nonspecified subtype) | L-Type calcium channel (nonspecified subtype) | NF-kappaB (NFkB) | NOX3 | PDE1B | PFN1 | HNF1A | RAN | Class III phosphatidylinositol 3-kinase (PI3-kinase) sub-complex | TMTC3 | PDE3B | HTR6 | VHL | CYP2C9 | EPHA4 | GAA | GNAS | HTR1B | CYP2J2 | EDN1 | CA2 | EEF2K | TXNRD1 | WTAPP1 | LOC105371702 | NTNG1 | FBXL7 | FPR2 | GSTM1 | PIK3C3 | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | G7124 | MYLK | Organic anion transporters (OATs) (nonspecified subtype) | alpha1-Adrenoceptor (nonspecified subtype) | 17-beta-Hydroxysteroid dehydrogenase (nonspecified subtype) | P2X Receptor (nonspecified subtype) | MEIG1 | FCN1 | PON1 | DUS2 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | Proteasome Complex | Vacuolar H+ ATPase | Histone deacetylase (nonspecified subtype) | MIR146A | HSD11B2 | NLRP3 Inflammasome | BDKRB1 | LAMA2 | LSS | ENO3 | ADM | CFAP298 | ATF3 | NOX5 | APOE | Vasopressin Receptor (nonspecified subtype) | SLC5A1 | Cyclooxygenase (COX) (nonspecified subtype) | CACNA1A | TMEM97 | TRPM7 | Gastric H+/K+-ATPase | CA9 | PTPN11 | HTR2C | ATP6 | G3576 | CRBN | G114548 | SLC14A2 | SPHK1 | TH | ENPEP | GRK5 | PIN1 | AOPEP | SNTG1 | ADH5 | KCNJ6 | Cannabinoid receptor (nonspecified subtype) | MIR214 | C3 | MIR4769 | Adenosine receptor (nonspecified subtype) | CYP19A1 | ADAMTS17 | SYN1 | MC4R | UMOD | ACACB | NADPH Oxidase Complex | AFF3 | BRS3 | DRD3 | NOX1 | AGER | FBLN2 | SYNE1 | PLAU | MAPK10 | TOGARAM2 | AGTR2 | TET2-AS1 | MYH6 | DYRK1B | GUCY2C | CFH | Nitric oxide synthase (NOS) (nonspecified subtype) | ASIC1 | P2RX2 | ALOX5 | ANKZF1 | AKR1B10 | LRRC15 | KLKB1 | PLA2G2D | KCNK5 | BMP10 | G3146 | CCL2 | Urea transporter (nonspecified subtype) | TNXB | FTO | POLA1 | GLP2R | Carbonic Anhydrase V (nonspecified subtype) | LOC101929710 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | P2RX7 | SIRT5 | ECE1 | FURIN | KL | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | CYP4F2 | MASP1 | Phospholipase A2, Secretory (sPLA2) (nonspecified subtype) | G596 | SLC6A3 | ZNF225 | ATP8B1-AS1 | Calcium-activated chloride channel regulators (nonspecified subtype) | Potassium Channels (nonspecified subtype) | NPR1 | CA14 | GLP1R | PTK7 | 5-Hydroxytryptamine Receptor (nonspecified subtype) | G7157 | FBXL17 | NPBWR1 | GPR55 | ADAMTS18 | TGFB1 | F2R | CORIN | Arginase (nonspecified subtype) | Endothiapepsin (nonspecified subtype) | KCNJ8 | FLNB | EXD3 | Myosin (nonspecified subtype) | Angiotensin receptor (AT) (nonspecified subtype) | LIPE | G7099 | PIK3CG | ANGPT1 | KCNMB1 | MAS1 | OXTR | SH2B3 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | MAOB | NELL1 | ABL1 | SRSF2 | ABHD17A | Endothelin receptor (nonspecified subtype) | KCNA1 | SDK1 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | CYP11B2 | MIR196A2 | NADPH Oxidase (nonspecified subtype) | PODN | C9 | ACLY | HMOX1 | Aurora Kinase (nonspecified subtype) | Soluble guanylyl cyclase | Tryptophan 5-Monooxygenase (nonspecified subtype) | Rho kinase (ROCK) (nonspecified subtype) | S1PR1 | HCAR2 | CRP | ADRA1B | TENM4 | SCN5A | SOAT2 | APLN | CDK1 | BTBD9 | RAG1 | G6774 | KLHL24 | Neurotensin receptor (nonspecified subtype) | IL18 | ARHGAP42 | LTA4H | TCF7L2 | TGFBR2 | LOC105370003 | IL23R | alpha-Amylase (nonspecified subtype) | ATP8 | CALCR | STK39 | RETN | Imidazoline I2 receptor (I2) | ND5 | ARMC5 | HSD3B1 | CHRM2 | SGMS1 | CHRNB2 | CRY1 | NPC1 | DDAH2 | ANPEP | DCLRE1C | KCNJ10 | CYP4A11 | EPAS1 | SLC35F3 | CX3CR1 | CYP27B1 | SLC29A1 | REN | UCP1 | PI3 | ACACA | PTPRC | HRH4 | GPR39 | BARD1 | RGS2 | SLIT1 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | LOC102723321 | SIRT3 | PRKG1 | LRP8 | NCF4-AS1 | PTAFR | PPARGC1A | AMP-activated protein kinase (AMPK) | MPO | PDE1A | BEST3 | GRK2 | PRCP | TAAR1 | FOXP3 | C9orf43 | IGF2 | CRHR2 | G6647 | OPRM1 | HLA Class II Histocompatibility Antigen DQ8 | CA3 | HDAC6 | HIF1A | Superoxide dismutase (SOD) (nonspecified subtype) | CMA1 | Neuronal acetylcholine receptor alpha2beta2 receptor | CDH23 | NPR2 | ADCY9 | PGK1 | PER3 | PKD2L1 | HTR1D | RHOA | DAGLB | MIR499A | ATXN2 | EDNRA | GPR182 | Ribosomal Protein S6 Kinase, 70kDa (p70S6K) (nonspecified subtype) | Phosphodiesterase (nonspecified subtype) | ADRA2C | ACE | P4HA2 | RORC | Vasopressin V1 Receptor (nonspecified subtype) | Imidazoline receptor (nonspecified subtype) | CYP3A4 | DCC | CD46 | LIPG | PDE3A | ALOX15 | PKN2 | BDNF | LINC01497 | HTR7 | CAPN12 | ENPP2 | CNNM2 | SLC47A1 | LOC105370115 | G3620 | SLC8A1 | FABP2 | Bradykinin receptor (nonspecified subtype) | LTF | OPRK1 | PPT1 | HDAC2 | SLC2A4 | GCGR | NLRP12 | HRH3 | IL12B | SELE | ITPR1 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | TBXAS1 | POLR1C | CYBA | Glutamate Receptor Ionotropic AMPA Receptor | ELANE | TRPM3 | FGFBP1 | NAALADL2 | RPS6KA5 | ECE2 | CHGA | VAV3 | CNR2 | SCN2A | TRPC3 | G4780 | ZC3H3 | AVPR1A | MAGI2 | Monoamine oxidase (MAO) (nonspecified subtype) | XBP1 | SLC12A1 | C2 | LDLR | TBL3 | DES | PLA2G2A | CDH13 | CTSD | SLC5A2 | GPBAR1 | Epoxide Hydrolase (nonspecified subtype) | Nicotinic alpha1beta1deltaepsilon Receptor | CR2 | KCNJ11 | Interleukin 17 (nonspecified subtype) | MIR219A1 | G207 | HECTD4 | EFNB2 | CA4 | LRRK2 | CIAO3 | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | Carbonic Anhydrase (nonspecified subtype) | BDKRB2 | KCND2 | CACNA1H | DRD2 | TNFRSF11B | PCSK1 | PDE4B | RNLS | PVT1 | KCNH2 | NKAIN2 | KCNAB1 | GPR35 | EGLN3 | Na+/H+ Exchanger (NHE) (nonspecified subtype) | NR3C2 | CETP | FTCD | FFAR4 | CCK receptor (nonspecified subtype) | CYP2C19 | SREBF1 | DDC | NPY4R2 | HFE | ABCA13 | TRNP | CACNA1B | G2475 | CAPZA1 | PDGFRB | PRH1-PRR4 | CASZ1 | SIGLEC12 | CAPN10 | COL3A1 | CFB | NPHS1 | PPARA | Heat shock protein 90 (nonspecified subtype) | C8A | PREP | CDK6 | CAPN13 | Phosphodiesterase 6 (PDE6) (nonspecified subtype) | SOX6 | Prostanoid Receptor (nonspecified subtype) | CSK | MYH9 | NELL2 | NPR3 | USP5 | LOC105370438 | LOC105377304 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | SLC22A1 | PHACTR1 | GHSR | ADK | Calcium channel (nonspecified subtype) | SLC12A2 | TRPM8 | Protein kinase C (nonspecified subtype) | LPL | VWF | PTPN5

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•   靶点/生物标志物基本信息；
•   蛋白结构及化合物结合；
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•   靶点/生物标志物重要性
•   靶点筛选与验证；
•   蛋白表达水平;
•   疾病相关性;
•   成药性;
•   相关联合用药;
•   药化试验;
•   相关专利分析;
•   靶点开发优势与风险...
研究报告有助于课题/项目申请、药物分子设计、研究进展汇报、研究论文发表、专利申请等。如果您希望获得该报告的完整版，请与我们联系： BD@silexon.ai

其它疾病

肺病高血压 | 肾病高血压 | 肾血管病高血压 | 门脉高血压 | 高血压性视网膜病变 | 高血压肾病 | 原发性高血压 | 高血糖 | 高钙尿症 | 高钙血症 | 高钾性周期性麻痹 | 高铁蛋白血症-白内障综合征 | 高铁血红蛋白血症 | 高雄激素血症 | 鱼鳞病 | 鲁宾斯坦-泰比综合征 | 鳃肾综合征 | 鸟氨酸转氨甲酰酶缺乏症 | 麦克劳德综合征 | 麦库恩-奥尔布赖特综合征 | 麻疹 | 脑性瘫痪 | 麻风 | 黄斑变性 | 黄斑角膜营养不良 | 黄斑角膜营养不良1型 | 黄热病 | 梗阻性黄疸 | 黑斑息肉综合征 | 黑棘皮症 | 黑素细胞痣 | 黑色素瘤 | 恶性黑色素瘤 | 葡萄膜黑色素瘤 | 黑酸尿症 | 鼻指声综合征 | 鼻炎 | 齐薇格综合症 | 齐默尔曼-拉班德综合征 | 齿甲真皮发育不良 | 龋齿