黑色素瘤

疾病概述
黑色素瘤又称恶性黑色素瘤，与皮肤黑色素瘤和黑色素瘤有关，皮肤恶性1，症状包括出疹、瘙痒等。与黑色素瘤相关的一个重要基因是 BRAF（B-Raf 原癌基因，丝氨酸/苏氨酸激酶），其相关途径/超途径包括 ERK 信号传导和信号转导。在这种疾病的背景下提到了长春地辛和曲安西龙药物。附属组织包括皮肤、淋巴结和T细胞，相关表型正常且有色素沉着

主要靶点
TUBB3 | GSK3A | HMOX1 | PTGFRN | DCC | E2F1 | SOX6 | G10413 | LILRB1 | CARD8 | TLR7 | G238 | CD209 | G114548 | CDK4/Cyclin D3 | AFG3L1P | GSTP1 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | SCN5A | TNFRSF9 | JAK3 | MMP16 | NCK2 | PTPN6 | HAND2-AS1 | TNFRSF10B | HAND2 | APC | BIRC2 | IL2RB | JAK1 | SYCP1 | MIR6774 | RNLS | CHEK2 | G6647 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | MAGEA3 | RASSF1 | MCAM | TIMP3 | PIK3CG | IL36B | HLA-DQB1 | RHOJ | G596 | YES1 | MLANA | KDR | TERF2 | CXCL9 | XRCC1 | DEF8 | CACNA1H | CTNNB1 | G6714 | FCGR2B | CRBN | BCL2L12 | BIVM-ERCC5 | ICOS | NFKB1 | UGT1A10 | MMP24-AS1-EDEM2 | AMOT | NTRK2 | IL21-AS1 | CCR10 | UMODL1 | HCK | CHRNB3 | MAS1L | Sphingosine kinase (nonspecified subtype) | MLH1 | TERF2IP | ACTA2 | DNA Methyltransferase (DNMT) (nonspecified subtype) | LRP6 | PARP3 | Na+/H+ Exchanger (NHE) (nonspecified subtype) | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | ERCC5 | G472 | FGR | STN1 | ZBTB38 | G3576 | TPM3 | Cyclin B (nonspecified subtype) | SHANK3 | SPINT2 | PTPN2 | CDK4/Cyclin D1 | AURKA | G1956 | LDLR | ABL1 | IGSF8 | DNA-Directed DNA Polymerase Complex | IL13RA1 | G3845 | CSF3 | Integrin alpha4beta1 (VLA-4) receptor | ERP29 | POTED | SDC1 | HDAC10 | WNT3A | GSR | MC1R | XPC | TLR8 | CDH13 | NORAD | EPHB2 | G3309 | IL1B | JAK2 | GTSE1 | CAMK4 | IL12B | Interleukin 17 (nonspecified subtype) | LYST | F2RL1 | FAP | ADAMTS20 | PREP | CEACAM5 | MAGEA4 | ARHGEF26 | RAC1 | BDNF | RMDN2 | TLR3 | NOTCH3 | AP3B1 | CYTIP | MIR106B | ABTB3 | MCC | MELTF | GDF15 | Melanin | PDIA2 | Rho GTPase (nonspecified subtype) | SLCO4C1 | G6774 | DUSP4 | THBS1 | RASA1 | Serine/Threonine Kinase (nonspecified subtype) | SSTR2 | EPCAM | G2335 | SLFN12 | LRRK2 | KISS1 | Tyrosine-Protein Kinases Src (nonspecified subtype) | MLPH | CDK2 | G3569 | IL13RA2 | CSK | G7015 | CD99 | MYT1L | UGT1A8 | SRF | DUSP5 | KCNH5 | LOC107987026 | CTNNA1 | BSG | VPS41 | HDAC8 | PRKCZ | HAFML | CHRM4 | ABCB5 | MYO18B | HDAC6 | IL2RG | SMO | PAK2 | LILRB4 | GAS5 | FGFR2 | NOS1 | G3620 | CTAG1A | Integrin alphavbeta3 (vitronectin) receptor | AMP-activated protein kinase (AMPK) | LEF1 | HDAC2 | MAGEA10 | ACP1 | HOXD12 | FAT4 | BTK | NAIF1 | NR1H2 | BUB1B | NCAM1 | GPNMB | Heat shock protein 90 (nonspecified subtype) | PRMT5 | HOXB13 | RPS6KA3 | GFRAL | BPIFA3 | KMT2C | G595 | CSPG4 | C-X-C Chemokine Receptor CXCR1/CXCR2 (IL-8 Receptor) (nonspecified subtype) | KCND3 | STAT6 | HMOX2 | C5 | PADI6 | CTSS | ELANE | NAV3 | DYNC1I1 | SLC24A5 | TGFB1 | TRRAP | FILIP1 | IL10RA | PALLD | PRKCA | TICAM1 | MAGEA12 | MT1A | NRAS | SPAG16 | CDK6 | TNC | IL2RA | GM-CSF Receptor (GM-CSF-R) | VWA3B | SIGMAR1 | HRH2 | ASAH1 | G207 | CASC8 | VGF | HDAC7 | CHEK1 | Ephrin Receptor (nonspecified subtype) | G1432 | FBXL13 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | PDE1C | AURKB | CCR4 | CPT1A | G6352 | NF-kappaB (NFkB) | C11orf65 | MAP3K5 | LINC00518 | PAX3 | PIGU | Integrin alpha4beta7 (LPAM-1) receptor | LCK | MITF | NR1H3 | AXL | PROCR | SORT1 | G7099 | IL17D | FLACC1 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | RNF145 | LAG3 | PAG1 | Transforming growth factor (nonspecified subtype) | SOCS5 | G3479 | NID1 | RALY | UGT1A7 | CDKAL1 | LOC102724428 | ATG5 | BRD2 | Protein kinase C (nonspecified subtype) | TYR | EML4 | G1950 | G842 | CSF1R | G5133 | TNFRSF18 | LOC105369366 | OR4C3 | CFAP45 | CACNA1G | MAOA | CDKN2B | G5728 | EPB41L4A | CD3 Complex (T Cell Receptor Complex) | G7295 | CDK5 | DHODH | PMS2 | TP73 | SIX6 | PDGFD | DCK | MRC1 | CDK4 | G4780 | PBX1 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | IDH1 | KIT | TOP1 | ERBB3 | SF3B1 | GP5 | ATG16L1 | NR4A1 | LOC338694 | E2F2 | KITLG | ESR2 | GOLIM4 | G29126 | CD86 | HLA-B | Glutamate Transporter (nonspecified subtype) | CEACAM1 | SHOX2 | CD14 | TLX3 | HMGCR | CDK9/Cyclin T1 | CXCR1 | G4851 | GNAQ | CHFR | FCRL1 | LY75 | PIK3CB | PIK3R1 | BTNL2 | DDR2 | NOD2 | FAT2 | NOTCH4 | HDAC11 | GART | ELP1 | KLLN | CIT | ARG1 | BRCA2 | SERPINC1 | ZNF415 | COL5A1 | G7852 | DPP7 | ICAM1 | BCR | IL-5 receptor | MAP2K1 | NADH dehydrogenase (Complex I) | CLIP1 | IL-2 receptor | OR5H6 | G23411 | FGFR3 | FZD7 | XIAP | NEK10 | WIF1 | CNR1 | Raf kinase (nonspecified subtype) | BRD4 | Guanylate cyclase (nonspecified subtype) | CACNA1C | HLA-DRB1 | MARCKS | HYKK | PIK3CD | FCMR | SOX4 | TMEM106C | DPP8 | PDPN | LCN2 | ARNT | TK2 | RGS20 | PLXNC1 | MR1 | PMEL | DNA Topoisomerase II (nonspecified subtype) | SLC44A4 | CDKN2B-AS1 | EIF2S2 | ROS1 | ITGB2 | G673 | FACT complex | Estrogen receptor (nonspecified subtype) | FHIT | CDK9 | TPT1 | PLCE1 | PPP1R3A | IL15 | EDNRB | C3AR1 | CCR2 | HDAC3 | SEMA4D | G5595 | IRF4 | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | SLC16A1 | TPBG | SH3BP4 | PDPK1 | CD44 | CD8 | MTDH | ZAP70 | CD40 | SIRPA | Integrin alphavbeta5 receptor | DNMT3B | XPO1 | ACRBP | UBASH3A | GCLC | CASC21 | G142 | MAP4K4 | SNTB2 | MC3R | NTRK3 | LINC00673 | P3H2 | NFATC4 | KLRK1 | GPC3 | CTSA | G1029 | CYP7B1 | SP110 | DPP4 | PDGFRB | ADORA2A | ITK | SYK | AKR1B1 | G581 | LILRB2 | BACH2 | ZNF208 | ADGRV1 | TET2 | Reverse transcriptase (Telomerase) | KLC3 | UGT1A6 | UGT1A9 | Tyrosine Kinase (nonspecified subtype) | STK11 | TINF2 | CCNT1 | PRKCD | HDAC1 | DHPS | G4170 | MUC1 | CDKN2A-DT | PTCH1 | NFIB | XDH | NCOA6 | PTGS1 | DCT | EBF1 | MMP7 | PTK2B | G2309 | POT1 | PPARG | HERC2 | CEBPB | PTPN1 | TBC1D16 | PLA2G6 | Voltage-Gated Sodium Channel Complex | FYB1 | MAGI3 | ERCC3 | MTAP | LURAP1L-AS1 | GRIN2A | IL15RA | CCDC140 | GIMAP7 | MIR210 | G4609 | GOLM1 | CAV1 | ACHE | AKT2 | SERPINE1 | CASP8 | CXCR3 | TSPO | BIRC3 | DDIT3 | G920 | NTRK1 | EYS | RHPN2 | GSK3B | CMTM5 | Heme Oxygenase (HO) (nonspecified subtype) | ARAF | HEATR9 | Interferon (nonspecified subtype) | PNKP | COL4A2 | FERMT3 | HIC1 | HLA-A | ACP2 | MEN1 | NCL | STK19 | ACVRL1 | SELPLG | SEMA4A | LIPC | G9429 | BCL2A1 | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | RPSA | LOC285626 | SORCS2 | CXCL12 | TLR2 | G2475 | LINC01162 | MS4A1 | CD70 | ACKR2 | Class III phosphatidylinositol 3-kinase (PI3-kinase) sub-complex | CDK1/Cyclin B | BDNF-AS | PDE3B | ZIC5 | CDH11 | CHUK | DAPK1 | TBX5 | DTNBP1 | MERTK | NRXN1 | CD93 | LOC105369749 | DLL3 | XPO5 | Vacuolar H+ ATPase | RASGEF1C | ALX3 | G3480 | G3630 | EPHB6 | FLT4 | PPP1R3C | Elastase (nonspecified subtype) | MX2 | NR1H4 | VOPP1 | PIK3C3 | HECTD2-AS1 | CCND3 | LOC107984647 | CBL | PRKCI | Integrin alphaLbeta2 (LFA-1) receptor | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | CHRNA3 | C17orf50 | IL25 | GNRHR | KIF11 | STAT4 | EDN1 | ERCC2 | STAB1 | DOCK3 | G2099 | Actin (nonspecified subtype) | PVRIG | ANKH | CSF2 | Sodium channel (nonspecified subtype) | KDM1A | Caspase (nonspecified subtype) | Mitogen-Activated Protein Kinase (nonspecified subtype) | FRK | SOX9 | PREX2 | FUT1 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | LEPR | SEM1 | MAGEC2 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | TNFAIP6 | FLT1 | G836 | FGFR1 | RAD51 | RARB | EEF1A2 | BNC2 | CHI3L1 | IL5RA | TGFB2 | G4318 | KLRC4-KLRK1 | CDK2/Cyclin A | SCN1A | LAMA1 | CD3E | RAF1 | IFIH1 | Heat shock protein 70 (nonspecified subtype) | KNSTRN | TDO2 | Invariant T Cell Receptor | BTLA | PROM1 | HOXB7 | KCNMA1 | FANCF | CLPTM1L | DOT1L | GRM1 | NFAT5 | BLK | IRF6 | TEK | G7157 | TPCN2 | FGFR4 | SIK2 | TMEM97 | BSN | EPHA2 | SIGLEC7 | ADAM9 | TNK2 | Integrin alphavbeta6 receptor | Poly [ADP-ribose] polymerase (nonspecified subtype) | SDHD | Adenosine receptor (nonspecified subtype) | DDR1 | OCA2 | SLC45A2 | MBP | ADAMTS3 | HK2 | Protein Tyrosine Phosphatase Type IVA (nonspecified subtype) | NPAS2 | APOA1 | IL16 | CXCL10 | GP6 | ADAM7 | CTSK | CA2 | CDKN1B | SLC16A3 | IRF8 | G4193 | VCP | ACD | TLL2 | CD160 | BRD3 | GC | PRLR | AKR1B10 | IKZF2 | CDK10 | SLC24A4 | NLRP1 | ENTPD1 | CD63 | ULK2 | FASLG | CTAG1B | LOC107985067 | MMP8 | TNFRSF4 | PCDHB8 | CNOT9 | IL21 | RPN2 | CXCR2 | ERCC4 | CHD4 | Aurora Kinase (nonspecified subtype) | SOX10 | HOXC8 | LYN | GAA | HAVCR2 | PDE5A | NGLY1 | TIGIT | TTN | DDB1 | IL20 | PPP6C | CDK6/Cyclin D3 | NMDA receptor | PALB2 | SLC30A10 | PPARGC1B | SIK1 | Tubulin | G1786 | MMP2 | CTSB | LRP2 | FANCA | LRRC32 | MIA-RAB4B | MAP2K2 | G3082 | G5743 | EPN1 | NF1 | NR4A2 | TLR9 | Cyclin A (nonspecified subtype) | AGER | VDR | NT5E | CADM1 | ATG10 | AMD1 | TNFRSF14 | RAB4B-EGLN2 | NAMPT | NOS2 | PARP2 | Nitric oxide synthase (NOS) (nonspecified subtype) | SLC11A1 | G4233 | LRP1B | MAPK13 | FAS | EXOC2 | TNFRSF8 | APOB | CTLA4 | MYO5A | PLCH1 | P2RX7 | PEX6 | IFNG | SPATA33 | G367 | WT1 | XPA | GATA3 | WSB2 | KIR2DS1 | PIK3CA | CTXND2 | CD47 | MAP4K2 | PORCN | LINC02627 | CD28 | KRR1 | TEAD1 | ROR2 | GNMT | G925 | CCR5 | COL2A1 | Integrin alphavbeta8 Receptor | G672 | PAK4 | SIAH2 | TYRP1 | CA3 | MMP14 | MYCN | NEK11 | G2064 | ALB | FTO | AKT3 | GSPT1 | ABCC1 | LINC02218 | G7124 | CLDN11 | FYN | GNAS | COL6A3 | FGL1 | OPCML | PNLIPRP1 | MRTFA | STING1 | MYH7B | PTPN11 | VSIR | Dual Specificity Mitogen-Activated Protein Kinase Kinase (MEK) (nonspecified subtype) | Potassium Channels (nonspecified subtype) | BAP1 | GIMAP5 | CREBBP | RIPK1 | DPP9 | BIRC5 | COL14A1 | CXCL11 | TEAD4 | PDGFRA | KREMEN1 | GNA11 | LAMC3 | NLRP3 Inflammasome | OR8J3 | Melanocortin receptor (nonspecified subtype) | BIRC7 | FLT3 | CBLB | PTPRC | Interleukin-18 Receptor Complex | OR2T6 | ATR | ABCC3 | FREM2 | IL6R | IL10 | TFPI2 | RET | MICA | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | MAGEA1 | MGMT | FGF2 | ALOX5 | ENOX2 | ONECUT1 | MYBPC3 | IL4 | CASC15 | MC5R | VHL | IFNAR2 | ARG2 | TOP2A | CD276 | ULK1 | CD5 | SCARNA5 | alpha-Mannosidase (nonspecified subtype) | Histone deacetylase (nonspecified subtype) | PI3 | G2146 | PDE3A | G5243 | MIR499A | DUSP1 | CDK1 | LTF | DNAH9 | CHRNA5 | CYP19A1 | LRIG1 | DLGAP1 | IL-12 receptor | TERF1 | TLR1 | ODC1 | GLI1 | IL13 | IRF1-AS1 | RIGI | Monoamine oxidase (MAO) (nonspecified subtype) | KISS1R | CD226 | IL23R | G7422 | PRAME | CD19 | TNFSF4 | HLA-C | TGFBR2 | HSP90B1 | VTCN1

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•   靶点筛选与验证；
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•   成药性;
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研究报告有助于课题/项目申请、药物分子设计、研究进展汇报、研究论文发表、专利申请等。如果您希望获得该报告的完整版，请与我们联系： BD@silexon.ai

其它疾病

恶性黑色素瘤 | 葡萄膜黑色素瘤 | 黑酸尿症 | 鼻指声综合征 | 鼻炎 | 齐薇格综合症 | 齐默尔曼-拉班德综合征 | 齿甲真皮发育不良 | 龋齿