Melanoma

About the Disease
Melanoma, also known as malignant melanoma, is related to skin melanoma and melanoma, cutaneous malignant 1, and has symptoms including exanthema and pruritus. An important gene associated with Melanoma is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Vindesine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and t cells, and related phenotypes are normal and pigmentation

Common Targets
TUBB3 | GSK3A | HMOX1 | PTGFRN | DCC | E2F1 | SOX6 | G10413 | LILRB1 | CARD8 | TLR7 | G238 | CD209 | G114548 | CDK4/Cyclin D3 | AFG3L1P | GSTP1 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | SCN5A | TNFRSF9 | JAK3 | MMP16 | NCK2 | PTPN6 | HAND2-AS1 | TNFRSF10B | HAND2 | APC | BIRC2 | IL2RB | JAK1 | SYCP1 | MIR6774 | RNLS | CHEK2 | G6647 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | MAGEA3 | RASSF1 | MCAM | TIMP3 | PIK3CG | IL36B | HLA-DQB1 | RHOJ | G596 | YES1 | MLANA | KDR | TERF2 | CXCL9 | XRCC1 | DEF8 | CACNA1H | CTNNB1 | G6714 | FCGR2B | CRBN | BCL2L12 | BIVM-ERCC5 | ICOS | NFKB1 | UGT1A10 | MMP24-AS1-EDEM2 | AMOT | NTRK2 | IL21-AS1 | CCR10 | UMODL1 | HCK | CHRNB3 | MAS1L | Sphingosine kinase (nonspecified subtype) | MLH1 | TERF2IP | ACTA2 | DNA Methyltransferase (DNMT) (nonspecified subtype) | LRP6 | PARP3 | Na+/H+ Exchanger (NHE) (nonspecified subtype) | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | ERCC5 | G472 | FGR | STN1 | ZBTB38 | G3576 | TPM3 | Cyclin B (nonspecified subtype) | SHANK3 | SPINT2 | PTPN2 | CDK4/Cyclin D1 | AURKA | G1956 | LDLR | ABL1 | IGSF8 | DNA-Directed DNA Polymerase Complex | IL13RA1 | G3845 | CSF3 | Integrin alpha4beta1 (VLA-4) receptor | ERP29 | POTED | SDC1 | HDAC10 | WNT3A | GSR | MC1R | XPC | TLR8 | CDH13 | NORAD | EPHB2 | G3309 | IL1B | JAK2 | GTSE1 | CAMK4 | IL12B | Interleukin 17 (nonspecified subtype) | LYST | F2RL1 | FAP | ADAMTS20 | PREP | CEACAM5 | MAGEA4 | ARHGEF26 | RAC1 | BDNF | RMDN2 | TLR3 | NOTCH3 | AP3B1 | CYTIP | MIR106B | ABTB3 | MCC | MELTF | GDF15 | Melanin | PDIA2 | Rho GTPase (nonspecified subtype) | SLCO4C1 | G6774 | DUSP4 | THBS1 | RASA1 | Serine/Threonine Kinase (nonspecified subtype) | SSTR2 | EPCAM | G2335 | SLFN12 | LRRK2 | KISS1 | Tyrosine-Protein Kinases Src (nonspecified subtype) | MLPH | CDK2 | G3569 | IL13RA2 | CSK | G7015 | CD99 | MYT1L | UGT1A8 | SRF | DUSP5 | KCNH5 | LOC107987026 | CTNNA1 | BSG | VPS41 | HDAC8 | PRKCZ | HAFML | CHRM4 | ABCB5 | MYO18B | HDAC6 | IL2RG | SMO | PAK2 | LILRB4 | GAS5 | FGFR2 | NOS1 | G3620 | CTAG1A | Integrin alphavbeta3 (vitronectin) receptor | AMP-activated protein kinase (AMPK) | LEF1 | HDAC2 | MAGEA10 | ACP1 | HOXD12 | FAT4 | BTK | NAIF1 | NR1H2 | BUB1B | NCAM1 | GPNMB | Heat shock protein 90 (nonspecified subtype) | PRMT5 | HOXB13 | RPS6KA3 | GFRAL | BPIFA3 | KMT2C | G595 | CSPG4 | C-X-C Chemokine Receptor CXCR1/CXCR2 (IL-8 Receptor) (nonspecified subtype) | KCND3 | STAT6 | HMOX2 | C5 | PADI6 | CTSS | ELANE | NAV3 | DYNC1I1 | SLC24A5 | TGFB1 | TRRAP | FILIP1 | IL10RA | PALLD | PRKCA | TICAM1 | MAGEA12 | MT1A | NRAS | SPAG16 | CDK6 | TNC | IL2RA | GM-CSF Receptor (GM-CSF-R) | VWA3B | SIGMAR1 | HRH2 | ASAH1 | G207 | CASC8 | VGF | HDAC7 | CHEK1 | Ephrin Receptor (nonspecified subtype) | G1432 | FBXL13 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | PDE1C | AURKB | CCR4 | CPT1A | G6352 | NF-kappaB (NFkB) | C11orf65 | MAP3K5 | LINC00518 | PAX3 | PIGU | Integrin alpha4beta7 (LPAM-1) receptor | LCK | MITF | NR1H3 | AXL | PROCR | SORT1 | G7099 | IL17D | FLACC1 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | RNF145 | LAG3 | PAG1 | Transforming growth factor (nonspecified subtype) | SOCS5 | G3479 | NID1 | RALY | UGT1A7 | CDKAL1 | LOC102724428 | ATG5 | BRD2 | Protein kinase C (nonspecified subtype) | TYR | EML4 | G1950 | G842 | CSF1R | G5133 | TNFRSF18 | LOC105369366 | OR4C3 | CFAP45 | CACNA1G | MAOA | CDKN2B | G5728 | EPB41L4A | CD3 Complex (T Cell Receptor Complex) | G7295 | CDK5 | DHODH | PMS2 | TP73 | SIX6 | PDGFD | DCK | MRC1 | CDK4 | G4780 | PBX1 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | IDH1 | KIT | TOP1 | ERBB3 | SF3B1 | GP5 | ATG16L1 | NR4A1 | LOC338694 | E2F2 | KITLG | ESR2 | GOLIM4 | G29126 | CD86 | HLA-B | Glutamate Transporter (nonspecified subtype) | CEACAM1 | SHOX2 | CD14 | TLX3 | HMGCR | CDK9/Cyclin T1 | CXCR1 | G4851 | GNAQ | CHFR | FCRL1 | LY75 | PIK3CB | PIK3R1 | BTNL2 | DDR2 | NOD2 | FAT2 | NOTCH4 | HDAC11 | GART | ELP1 | KLLN | CIT | ARG1 | BRCA2 | SERPINC1 | ZNF415 | COL5A1 | G7852 | DPP7 | ICAM1 | BCR | IL-5 receptor | MAP2K1 | NADH dehydrogenase (Complex I) | CLIP1 | IL-2 receptor | OR5H6 | G23411 | FGFR3 | FZD7 | XIAP | NEK10 | WIF1 | CNR1 | Raf kinase (nonspecified subtype) | BRD4 | Guanylate cyclase (nonspecified subtype) | CACNA1C | HLA-DRB1 | MARCKS | HYKK | PIK3CD | FCMR | SOX4 | TMEM106C | DPP8 | PDPN | LCN2 | ARNT | TK2 | RGS20 | PLXNC1 | MR1 | PMEL | DNA Topoisomerase II (nonspecified subtype) | SLC44A4 | CDKN2B-AS1 | EIF2S2 | ROS1 | ITGB2 | G673 | FACT complex | Estrogen receptor (nonspecified subtype) | FHIT | CDK9 | TPT1 | PLCE1 | PPP1R3A | IL15 | EDNRB | C3AR1 | CCR2 | HDAC3 | SEMA4D | G5595 | IRF4 | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | SLC16A1 | TPBG | SH3BP4 | PDPK1 | CD44 | CD8 | MTDH | ZAP70 | CD40 | SIRPA | Integrin alphavbeta5 receptor | DNMT3B | XPO1 | ACRBP | UBASH3A | GCLC | CASC21 | G142 | MAP4K4 | SNTB2 | MC3R | NTRK3 | LINC00673 | P3H2 | NFATC4 | KLRK1 | GPC3 | CTSA | G1029 | CYP7B1 | SP110 | DPP4 | PDGFRB | ADORA2A | ITK | SYK | AKR1B1 | G581 | LILRB2 | BACH2 | ZNF208 | ADGRV1 | TET2 | Reverse transcriptase (Telomerase) | KLC3 | UGT1A6 | UGT1A9 | Tyrosine Kinase (nonspecified subtype) | STK11 | TINF2 | CCNT1 | PRKCD | HDAC1 | DHPS | G4170 | MUC1 | CDKN2A-DT | PTCH1 | NFIB | XDH | NCOA6 | PTGS1 | DCT | EBF1 | MMP7 | PTK2B | G2309 | POT1 | PPARG | HERC2 | CEBPB | PTPN1 | TBC1D16 | PLA2G6 | Voltage-Gated Sodium Channel Complex | FYB1 | MAGI3 | ERCC3 | MTAP | LURAP1L-AS1 | GRIN2A | IL15RA | CCDC140 | GIMAP7 | MIR210 | G4609 | GOLM1 | CAV1 | ACHE | AKT2 | SERPINE1 | CASP8 | CXCR3 | TSPO | BIRC3 | DDIT3 | G920 | NTRK1 | EYS | RHPN2 | GSK3B | CMTM5 | Heme Oxygenase (HO) (nonspecified subtype) | ARAF | HEATR9 | Interferon (nonspecified subtype) | PNKP | COL4A2 | FERMT3 | HIC1 | HLA-A | ACP2 | MEN1 | NCL | STK19 | ACVRL1 | SELPLG | SEMA4A | LIPC | G9429 | BCL2A1 | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | RPSA | LOC285626 | SORCS2 | CXCL12 | TLR2 | G2475 | LINC01162 | MS4A1 | CD70 | ACKR2 | Class III phosphatidylinositol 3-kinase (PI3-kinase) sub-complex | CDK1/Cyclin B | BDNF-AS | PDE3B | ZIC5 | CDH11 | CHUK | DAPK1 | TBX5 | DTNBP1 | MERTK | NRXN1 | CD93 | LOC105369749 | DLL3 | XPO5 | Vacuolar H+ ATPase | RASGEF1C | ALX3 | G3480 | G3630 | EPHB6 | FLT4 | PPP1R3C | Elastase (nonspecified subtype) | MX2 | NR1H4 | VOPP1 | PIK3C3 | HECTD2-AS1 | CCND3 | LOC107984647 | CBL | PRKCI | Integrin alphaLbeta2 (LFA-1) receptor | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | CHRNA3 | C17orf50 | IL25 | GNRHR | KIF11 | STAT4 | EDN1 | ERCC2 | STAB1 | DOCK3 | G2099 | Actin (nonspecified subtype) | PVRIG | ANKH | CSF2 | Sodium channel (nonspecified subtype) | KDM1A | Caspase (nonspecified subtype) | Mitogen-Activated Protein Kinase (nonspecified subtype) | FRK | SOX9 | PREX2 | FUT1 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | LEPR | SEM1 | MAGEC2 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | TNFAIP6 | FLT1 | G836 | FGFR1 | RAD51 | RARB | EEF1A2 | BNC2 | CHI3L1 | IL5RA | TGFB2 | G4318 | KLRC4-KLRK1 | CDK2/Cyclin A | SCN1A | LAMA1 | CD3E | RAF1 | IFIH1 | Heat shock protein 70 (nonspecified subtype) | KNSTRN | TDO2 | Invariant T Cell Receptor | BTLA | PROM1 | HOXB7 | KCNMA1 | FANCF | CLPTM1L | DOT1L | GRM1 | NFAT5 | BLK | IRF6 | TEK | G7157 | TPCN2 | FGFR4 | SIK2 | TMEM97 | BSN | EPHA2 | SIGLEC7 | ADAM9 | TNK2 | Integrin alphavbeta6 receptor | Poly [ADP-ribose] polymerase (nonspecified subtype) | SDHD | Adenosine receptor (nonspecified subtype) | DDR1 | OCA2 | SLC45A2 | MBP | ADAMTS3 | HK2 | Protein Tyrosine Phosphatase Type IVA (nonspecified subtype) | NPAS2 | APOA1 | IL16 | CXCL10 | GP6 | ADAM7 | CTSK | CA2 | CDKN1B | SLC16A3 | IRF8 | G4193 | VCP | ACD | TLL2 | CD160 | BRD3 | GC | PRLR | AKR1B10 | IKZF2 | CDK10 | SLC24A4 | NLRP1 | ENTPD1 | CD63 | ULK2 | FASLG | CTAG1B | LOC107985067 | MMP8 | TNFRSF4 | PCDHB8 | CNOT9 | IL21 | RPN2 | CXCR2 | ERCC4 | CHD4 | Aurora Kinase (nonspecified subtype) | SOX10 | HOXC8 | LYN | GAA | HAVCR2 | PDE5A | NGLY1 | TIGIT | TTN | DDB1 | IL20 | PPP6C | CDK6/Cyclin D3 | NMDA receptor | PALB2 | SLC30A10 | PPARGC1B | SIK1 | Tubulin | G1786 | MMP2 | CTSB | LRP2 | FANCA | LRRC32 | MIA-RAB4B | MAP2K2 | G3082 | G5743 | EPN1 | NF1 | NR4A2 | TLR9 | Cyclin A (nonspecified subtype) | AGER | VDR | NT5E | CADM1 | ATG10 | AMD1 | TNFRSF14 | RAB4B-EGLN2 | NAMPT | NOS2 | PARP2 | Nitric oxide synthase (NOS) (nonspecified subtype) | SLC11A1 | G4233 | LRP1B | MAPK13 | FAS | EXOC2 | TNFRSF8 | APOB | CTLA4 | MYO5A | PLCH1 | P2RX7 | PEX6 | IFNG | SPATA33 | G367 | WT1 | XPA | GATA3 | WSB2 | KIR2DS1 | PIK3CA | CTXND2 | CD47 | MAP4K2 | PORCN | LINC02627 | CD28 | KRR1 | TEAD1 | ROR2 | GNMT | G925 | CCR5 | COL2A1 | Integrin alphavbeta8 Receptor | G672 | PAK4 | SIAH2 | TYRP1 | CA3 | MMP14 | MYCN | NEK11 | G2064 | ALB | FTO | AKT3 | GSPT1 | ABCC1 | LINC02218 | G7124 | CLDN11 | FYN | GNAS | COL6A3 | FGL1 | OPCML | PNLIPRP1 | MRTFA | STING1 | MYH7B | PTPN11 | VSIR | Dual Specificity Mitogen-Activated Protein Kinase Kinase (MEK) (nonspecified subtype) | Potassium Channels (nonspecified subtype) | BAP1 | GIMAP5 | CREBBP | RIPK1 | DPP9 | BIRC5 | COL14A1 | CXCL11 | TEAD4 | PDGFRA | KREMEN1 | GNA11 | LAMC3 | NLRP3 Inflammasome | OR8J3 | Melanocortin receptor (nonspecified subtype) | BIRC7 | FLT3 | CBLB | PTPRC | Interleukin-18 Receptor Complex | OR2T6 | ATR | ABCC3 | FREM2 | IL6R | IL10 | TFPI2 | RET | MICA | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | MAGEA1 | MGMT | FGF2 | ALOX5 | ENOX2 | ONECUT1 | MYBPC3 | IL4 | CASC15 | MC5R | VHL | IFNAR2 | ARG2 | TOP2A | CD276 | ULK1 | CD5 | SCARNA5 | alpha-Mannosidase (nonspecified subtype) | Histone deacetylase (nonspecified subtype) | PI3 | G2146 | PDE3A | G5243 | MIR499A | DUSP1 | CDK1 | LTF | DNAH9 | CHRNA5 | CYP19A1 | LRIG1 | DLGAP1 | IL-12 receptor | TERF1 | TLR1 | ODC1 | GLI1 | IL13 | IRF1-AS1 | RIGI | Monoamine oxidase (MAO) (nonspecified subtype) | KISS1R | CD226 | IL23R | G7422 | PRAME | CD19 | TNFSF4 | HLA-C | TGFBR2 | HSP90B1 | VTCN1

Note: If you'd like to get a target analysis report for Melanoma, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Melanoma at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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