Parkinsonism

About the Disease
Parkinsonism, also known as paralysis agitans syndrome, is related to amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 and dystonia 12. An important gene associated with Parkinsonism is GRN (Granulin Precursor), and among its related pathways/superpathways are Neuroscience and Alpha-synuclein signaling. The drugs Varenicline and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, subthalamic nucleus and spinal cord, and related phenotypes are nervous system and homeostasis/metabolism

Common Targets
ITPR2 | COX2 | SLC1A3 | PSEN1 | GBA1 | MTCL1 | CHRM4 | GNAL | COMT | SYNJ1 | SPG11 | GXYLT1 | GCH1 | HTRA2 | PAPLN | COX3 | SPR | SLC19A3 | C9orf72 | CLSTN2 | VPS35 | COL4A1 | ATP13A2 | TAF1 | DNAJC12 | ANKK1 | PLP1 | ND1 | WARS2 | SOD2 | PTRHD1 | PRDM14 | CCDC88C | TWNK | WDR45 | G4137 | Nicotinic alpha4beta2 receptor | MYO16 | UQCRC1 | G836 | ND2 | ANO3 | SEMA5B | FBXO7 | CTSV | CSMD1 | EIF4G1 | PSMB11 | PPP2R5D | ADCY6 | ADCY5 | PLA2G6 | POLG | ND3 | HTR2A | PINK1 | RAB32 | SLC16A2 | BDNF-AS | BCL2L11 | CAPN1 | RALGDS | HMCN1 | GALNT7 | DNAJC6 | ND4 | DNAJB2 | DCTN1 | SLC2A1 | KCNMA1 | ATP6 | CACNA1A | SPTBN2 | HTR2C | DRD3 | LCN9 | LOXL4 | F2RL3 | HTT | THAP1 | SLC6A3 | LMNB1 | TRIB3 | SSR2 | ZNF285CP | MAOB | FIG4 | CASP8AP2 | PARK7 | ATP8 | GRIN2B | CHRNB2 | ARSA | VPS13C | RAB39B | TBK1 | RGS2 | PRKN | PGK1 | DAGLB | COL11A2 | STXBP1 | ATXN2 | MC1R | BDNF | GRIN3B | mu-Calpain (calpain 1) | CAT | SNCA | ADH1C | NOTCH2NLC | HK3 | DNAJC13 | GIGYF2 | LRRK2 | DRD2 | ALPL | SLC39A1

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