Migraine

About the Disease
Migraine with or Without Aura 1, also known as migraine, is related to familial hemiplegic migraine and migraine without aura, and has symptoms including back pain, headache and hemiplegia. An important gene associated with Migraine with or Without Aura 1 is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways are Type II diabetes mellitus and Cellular roles of Anthrax toxin. The drugs Mineral oil and Betamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and cortex, and related phenotypes are photophobia and vomiting

Common Targets
CACNA2D1 | BIVM-ERCC5 | Prostanoid Receptor (nonspecified subtype) | PHACTR1 | GRM5 | CYSLTR1 | ADCYAP1 | HTR1F | L-type voltage-dependent calcium channel complex | ADRA1A | Calcium channel (nonspecified subtype) | TRPM8 | Kainate Receptor (GluR) (nonspecified subtype) | CACNA2D2 | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | HCN4 | ESR2 | NOS1 | BPIFC | CHRM4 | Interleukin-1 (nonspecified subtype) | NPTX2 | COMT | DRD4 | MAOA | GRIK1 | HTR1A | CNR1 | MTNR1A | Tachykinin Receptor (nonspecified subtype) | KCNQ4 | TRMT9B | Alpha-2 Adrenergic receptors (nonspecified subtype) | SLC6A2 | LTA | PHF20 | CAMK1 | CDH12 | GRIN2C | TRPV1 | Lipoxygenase (nonspecified subtype) | MIR452 | GH1 | NR3C1 | SIGMAR1 | PRDM16 | MGLL | SYNE2 | CHRM1 | SRR | Estrogen receptor (nonspecified subtype) | HDAC1 | T-Type Calcium Channel | NPY1R | PTGS1 | KCNK18 | KCNQ3 | GABRG2 | ACSF3 | G2099 | PGR | ADORA1 | GABA(A) receptor | GABRB2 | ADARB2 | ARPC4-TTLL3 | ACHE | HLA-A | HTR2B | HTR4 | POMC | ADORA2B | P2RX3 | G5743 | Voltage-Gated Sodium Channel Complex | CA12 | CRH | ANKK1 | LOC105375655 | OGG1 | SLC22A3 | SSTR3 | Small Conductance Calcium-Activated Potassium Channel (SK) (nonspecified subtype) | MTHFR | Glutamate Transporter (nonspecified subtype) | SCN8A | alpha-Adrenoceptor (nonspecified subtype) | G5243 | CCR2 | ADORA2A | G3630 | KCNK2 | DBH | SLC17A8 | GRIK2 | GRIN2D | GRM2 | PRRT2 | CHRNA7 | Opioid receptor (nonspecified subtype) | Sodium channel (nonspecified subtype) | LOC101927995 | TNFSF10 | GRIA2 | NAPEPLD | KCNS1 | Gap junction Connexin ( (nonspecified subtype) | ADRA2A | OXT | SLC6A9 | CFDP1 | PIEZO1 | SERPINE1 | MTNR1B | PLCE1 | GRM7 | NOS3 | RNF213 | RAMP1 | IL10 | XRCC3 | ANO3 | HEY2-AS1 | OPRD1 | OPRL1 | KCNK10 | GRIA3 | HTR5A | ERCC2 | NSD1 | SSTR4 | GRIN2A | ADAMTSL1 | PTGER4 | ADORA3 | Prolactin receptor (isoform 1) | MEF2D | KDM2A | SLC6A4 | KCNQ Channels (K(v) 7) (nonspecified subtype) | P2RX4 | GABRA1 | IL-6 receptor | KLC1 | DRD1 | GABRB3 | KLC3 | PDE5A | ZNF555 | POMT2 | ADRB1 | MME | FAAH | NRP1 | HCRTR2 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | WFS1 | HTR2A | beta-Adrenoceptor (nonspecified subtype) | ABCC8 | CALCA | SUGCT | GRIK3 | HCN2 | CHIA | CALCRL | NBEA | sigma Receptor (nonspecified subtype) | NOS2 | TRPA1 | NMDA receptor | LRP1 | LOC101927066 | TRPV3 | HRH1 | RMI1 | GHR | CHRNA3 | PDE2A | LOC105378316 | ADRA1D | Dopamine receptor (nonspecified subtype) | NF1 | AOC1 | TACR1 | AGTR1 | NOX3 | ASTN1 | L-Type calcium channel (nonspecified subtype) | ADRB2 | GABRQ | HTR6 | CA2 | ADCYAP1R1 | SCN1A | TPH1 | GAA | APEX1 | HTR1B | Glycine receptor | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | USH2A | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | BDKRB1 | NF-kappaB (NFkB) | Histone deacetylase (nonspecified subtype) | OPN4 | TMEM97 | alpha1-Adrenoceptor (nonspecified subtype) | Gastric H+/K+-ATPase | GJA1 | CA9 | GRM1 | NLRP3 Inflammasome | Cyclooxygenase (COX) (nonspecified subtype) | TH | G3576 | CACNA1A | ARPC4 | LOC105378525 | SSTR5 | HTR2C | CYP19A1 | G114548 | MAPK10 | PTGER1 | DRD3 | NADPH Oxidase Complex | G472 | ASIC1 | HLA-C | KLKB1 | KCNK5 | Nitric oxide synthase (NOS) (nonspecified subtype) | P2RX7 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | DAGLA | Gap Junction Protein (nonspecified subtype) | 5-Hydroxytryptamine Receptor (nonspecified subtype) | Histamine Receptor (HR) (nonspecified subtype) | MPPED2 | G7124 | GLP1R | SLC6A3 | Potassium Channels (nonspecified subtype) | XRCC1 | STX1A | GPR55 | SSTR1 | OXTR | KCNA1 | TGFB1 | GRM4 | MRGPRX2 | Endothelin receptor (nonspecified subtype) | MAOB | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | PCDHB8 | Tryptophan 5-Monooxygenase (nonspecified subtype) | NADPH Oxidase (nonspecified subtype) | SLC24A3 | ATR | ITGAL | alpha-Amylase (nonspecified subtype) | Soluble guanylyl cyclase | HPSE2 | CSNK1D | ASTN2 | GABRE | G7099 | GRIN2B | CHRM2 | G7157 | TRNL1 | ANPEP | PCDHB6 | ABAT | GABRA6 | TAAR1 | MRGPRX4 | HCG20 | Glutamate Receptor Ionotropic (nonspecified subtype) | SLC1A2 | FHL5 | HTR1D | AMP-activated protein kinase (AMPK) | GPR17 | KCNQ2 | ADRA2C | HTR7 | LOC105377013 | SVEP1 | IRAG1 | G10413 | GABRA3 | G5728 | Glutamate Receptor Ionotropic AMPA Receptor | OPRM1 | HRH3 | BDNF | TBXAS1 | SLC6A5 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | MIR4761 | SCN2A | Monoamine oxidase (MAO) (nonspecified subtype) | ERCC5 | CHRNA1 | APEH | CSF1R | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | ACE | TACR3 | OPRK1 | CNR2 | CARF | HLA-B | SV2A | CACNA1B | SSTR2 | TACR2 | HTR1E | SH2D5 | DRD2 | F2RL1

Note: If you'd like to get a target analysis report for Migraine, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Migraine at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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