Meleda Disease

About the Disease
Mal De Meleda, also known as meleda disease, is related to palmoplantar keratosis and erythrokeratodermia variabilis et progressiva 1. An important gene associated with Mal De Meleda is SLURP1 (Secreted LY6/PLAUR Domain Containing 1), and among its related pathways/superpathways are Post-translational modification: synthesis of GPI-anchored proteins and Burn wound healing. Affiliated tissues include skin and heart, and related phenotypes are palmoplantar keratoderma and superficial dermal perivascular inflammatory infiltrate

Common Targets
SLURP1

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