Hydrocephalus

About the Disease
Congenital Hydrocephalus, also known as hydrocephalus, nonsyndromic, autosomal recessive 1, is related to dandy-walker syndrome and congenital communicating hydrocephalus, and has symptoms including back pain, headache and pain. An important gene associated with Congenital Hydrocephalus is MPDZ (Multiple PDZ Domain Crumbs Cell Polarity Complex Component), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Hedgehog signaling events mediated by Gli proteins. The drugs Propofol and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cortex, and related phenotypes are hydrocephalus and macrocephaly

Common Targets
SIL1 | SEC16B | MPDZ | FZD3 | KIDINS220 | WDR81 | ATP10B | LNX1 | CCDC88C | L1CAM | CRB2 | EML1 | TRAPPC12 | SYTL2 | POMK | CEP55

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