LEOPARD Syndrome

About the Disease
Leopard Syndrome 1, also known as noonan syndrome with multiple lentigines 1, is related to noonan syndrome 1 and noonan syndrome with multiple lentigines, and has symptoms including hyposmia An important gene associated with Leopard Syndrome 1 is PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), and among its related pathways/superpathways is Interleukin-37 signaling. Affiliated tissues include ovary, heart and skin, and related phenotypes are hypertrophic cardiomyopathy and pulmonic stenosis

Common Targets
MAP2K1 | WDR5 | MLL1/MLL Complex | SASH1 | RAF1 | KMT2A | VHL | G673 | PTPN11 | CRBN | SOS1

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