Huntington's Disease

About the Disease
Huntington Disease, also known as huntington's disease, is related to huntington disease-like 1 and choreatic disease, and has symptoms including back pain, headache and myoclonus. An important gene associated with Huntington Disease is HTT (Huntingtin), and among its related pathways/superpathways is miRNAs involved in DNA damage response. The drugs Memantine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include Brain, eye and globus pallidus, and related phenotypes are chorea and mental deterioration

Common Targets
CHRM1 | D2HGDH | SLC1A3 | KEAP1 | Lipoxygenase (nonspecified subtype) | Calpain (nonspecified subtype) | mTOR complex 1 | ADORA1 | KCNC1 | MSH3 | G7295 | G842 | GPR88 | SETDB1 | HDAC8 | DNA Topoisomerase II (nonspecified subtype) | MGLL | IFNB1 | GABRG2 | GRIN1 | NOS3 | G598 | MAP3K5 | C9orf72 | CDK13 | T-Type Calcium Channel | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | HDAC3 | CCNH | PTPN7 | GRIN2C | ADORA2A | CASP8 | CDK5 | TRPC5 | G3480 | CDK5/p25 | MAP3K9 | DYRK1A | NTRK1 | Hedgehog Protein (nonspecified subtype) | XDH | PDE10A | HSD11B1 | RET | AVPR1B | PTCH1 | HTR4 | TLR2 | GPR52 | PTPN1 | IRS2 | G1/S-specific cyclin-E (nonspecified subtype) | CHRNA7 | Neuropeptide Y receptor (NPY-R) (nonspecified subtype) | Eukaryotic translation initiation factor 2-alpha kinase (nonspecified subtype) | BMI1 | MAP3K10 | AKR1B1 | MIR485 | HSP90AB1 | Neurotrophic Factor (nonspecified subtype) | GSK3B | Chymotrypsin (nonspecified subtype) | SLC6A4 | NTRK3 | BCHE | HDAC7 | G836 | HTR2A | Glutamate Transporter (nonspecified subtype) | CTSL | NF-kappaB (NFkB) | CALM1 | PDE1C | PDE9A | cGMP-Dependent Protein Kinase (nonspecified subtype) | MKNK1 | MCOLN1 | PTPN12 | MMP2 | HCRTR1 | HDAC5 | KCNN4 | GRIN2D | GRM2 | HSF1 | RYR2 | PGAM5-KEAP1-NRF2 Complex | Calmodulin (nonspecified subtype) | KCNC2 | MAP3K11 | Mitogen-Activated Protein Kinase (nonspecified subtype) | XPO1 | ACSS2 | EIF2AK2 | SMPD1 | TGM2 | KYNU | G4137 | DNM1L | Chaperone (nonspecified subtype) | NPY2R | NMDA receptor | G5595 | GPR3 | KIT | GRIN2A | Nicotinic alpha4beta2 receptor | TLR9 | SUPT5H | DRD5 | RARB | G673 | Histone acetyltransferase (HAT) (nonspecified subtype) | RNF216 | ATXN3 | CHRM3 | FAAH | TSPO | NOS2 | VHL | PARP11 | Survival of motor neuron (SMN) complex | DRD1 | VPS13A | G472 | CCND3 | SLC16A1 | KCNC3 | 15-Lipoxygenase (nonspecified subtype) | EIF2AK4 | JAK3 | DDR1 | G114548 | beta-Adrenoceptor (nonspecified subtype) | SLC1A6 | GABRB3 | MAPK9 | TBP | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | Proteasome Complex | NLRP3 Inflammasome | CRBN | ROCK2 | Histone deacetylase (nonspecified subtype) | C3AR1 | SEMA4D | NOX3 | HDAC4 | MAP4K1 | KDM1A | CASP2 | HCRTR2 | CCNE1 | MFN2 | CDK4/Cyclin D | DLG4 | FDPS | QPCTL | CDK1/Cyclin B | CAPN1 | LILRB3 | PTPN11 | G9734 | PINK1 | ABHD6 | QPCT | Pyruvate dehydrogenase kinase (nonspecified subtype) | sigma Receptor (nonspecified subtype) | FOLH1 | PDE2A | PTPN5 | Immunoproteasome | Anandamide membrane transporter (AMT) | ABL1 | Dopamine receptor (nonspecified subtype) | HTR6 | Poly [ADP-ribose] polymerase (nonspecified subtype) | NADPH Oxidase Complex | PDE1B | Cyclin D (nonspecified subtype) | EPOR | CTSC | Nitric oxide synthase (NOS) (nonspecified subtype) | OGA | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | S1PR5 | AGER | PIP4K2C | APP | SCN5A | DRD3 | VCP | SLC6A3 | GABRA5 | Cyclooxygenase (COX) (nonspecified subtype) | GLP1R | MLH1 | TMEM97 | NAMPT | G1029 | Cannabinoid receptor (nonspecified subtype) | APOA1 | CLK1 | UCHL1 | GRM3 | STING1 | G6774 | TDO2 | G2146 | GRM1 | MAOB | MAPK10 | Peptidylprolyl Isomerase (nonspecified subtype) | ATN1 | NT5E | SIN3B | KCNH3 | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | SMPD3 | CHRM5 | NADPH Oxidase (nonspecified subtype) | SLC1A1 | ASIC1 | CDK6/Cyclin D3 | AMP-activated protein kinase (AMPK) | SLC6A1 | NQO2 | OPRM1 | KRR1 | NQO1 | CASP1 | G2475 | HTT | Soluble guanylyl cyclase | SMN1 | MYB | RIPK1 | CDK1 | 5-Hydroxytryptamine Receptor (nonspecified subtype) | PDE4A | ATXN1 | GABRA2 | SLC16A3 | CTSB | HDAC6 | GRIN2B | Rho kinase (ROCK) (nonspecified subtype) | MMP1 | CDK2/Cyclin E | EIF2AK3 | SIN3A | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | Transglutaminase (nonspecified subtype) | G4780 | G5243 | RIPK3 | STX1A | CNR2 | GRM4 | CHRM2 | RAB5A | NTRK2 | PDIA3 | HDAC2 | MPO | FGF2 | CDK7 | CDK7/Cyclin H | G6647 | DRD2 | PDE4D | SMN2 | PPARG | DRB sensitivity-inducing factor complex | NR4A2 | PPARGC1A | PTPRC | SLC29A1 | CHRNA6 | SIRT3 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | Glutamate Receptor Ionotropic AMPA Receptor | ABAT | CDK12 | Phosphodiesterase (nonspecified subtype) | PRKG1 | G8878 | IRS1 | NGF | CDK4 | CDK6 | HRH3 | TAAR1 | CASP6 | ADRA2C | ALOX15 | GABRA6 | PPP1R15B | PPARA | SLC1A2 | PDE1A | CDK2 | STXBP1 | AVPR1A | Calcium channel (nonspecified subtype) | LRRK2 | Heat shock protein 90 (nonspecified subtype) | GPR17 | SNCA | G142 | Tubulin | CNR1 | mu-Calpain (calpain 1) | L3MBTL1 | G7124 | SMO | Protein kinase C (nonspecified subtype) | TRPV1 | SLC6A2 | Monoamine oxidase (MAO) (nonspecified subtype) | APEH | Protein Kinase B (PKB/Akt) (nonspecified subtype) | CYP46A1 | G3569 | MAOA | PDE4B | SP1 | CACNA1B | CGAS | Acyl-CoA Synthetase Short-Chain (nonspecified subtype) | ACHE | DDR2 | KAT2B | MFN1 | G5599 | HDAC1 | HTR1A | C5 | SV2A | CST3 | KMO | cAMP Responsive Element Binding Protein (CREB) (nonspecified subtype) | TTR | Cyclin B (nonspecified subtype) | PTGS1 | SIRT2 | GRM5 | PREP | GABA(A) receptor | HAAO | CASP7 | KDM5B | Complement component 1q | VDR | SLC18A2 | G3320 | Voltage-Gated Sodium Channel Complex | DNM1 | SIGMAR1 | IL1B | Sodium channel (nonspecified subtype) | G23411 | MKNK2 | ATXN7 | MMP3 | NOS1 | ROCK1 | TYR | CHRM4 | MLKL | G4318 | G1432 | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | TARDBP | BCR

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