Disease

Huntington's Disease

About the Disease
Huntington Disease, also known as huntington's disease, is related to huntington disease-like 1 and choreatic disease, and has symptoms including back pain, headache and myoclonus. An important gene associated with Huntington Disease is HTT (Huntingtin), and among its related pathways/superpathways is miRNAs involved in DNA damage response. The drugs Memantine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include Brain, eye and globus pallidus, and related phenotypes are chorea and mental deterioration

Common Targets
CHRM1 | D2HGDH | SLC1A3 | KEAP1 | Lipoxygenase (nonspecified subtype) | Calpain (nonspecified subtype) | mTOR complex 1 | ADORA1 | KCNC1 | MSH3 | G7295 | G842 | GPR88 | SETDB1 | HDAC8 | DNA Topoisomerase II (nonspecified subtype) | MGLL | IFNB1 | GABRG2 | GRIN1 | NOS3 | G598 | MAP3K5 | C9orf72 | CDK13 | T-Type Calcium Channel | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | HDAC3 | CCNH | PTPN7 | GRIN2C | ADORA2A | CASP8 | CDK5 | TRPC5 | G3480 | CDK5/p25 | MAP3K9 | DYRK1A | NTRK1 | Hedgehog Protein (nonspecified subtype) | XDH | PDE10A | HSD11B1 | RET | AVPR1B | PTCH1 | HTR4 | TLR2 | GPR52 | PTPN1 | IRS2 | G1/S-specific cyclin-E (nonspecified subtype) | CHRNA7 | Neuropeptide Y receptor (NPY-R) (nonspecified subtype) | Eukaryotic translation initiation factor 2-alpha kinase (nonspecified subtype) | BMI1 | MAP3K10 | AKR1B1 | MIR485 | HSP90AB1 | Neurotrophic Factor (nonspecified subtype) | GSK3B | Chymotrypsin (nonspecified subtype) | SLC6A4 | NTRK3 | BCHE | HDAC7 | G836 | HTR2A | Glutamate Transporter (nonspecified subtype) | CTSL | NF-kappaB (NFkB) | CALM1 | PDE1C | PDE9A | cGMP-Dependent Protein Kinase (nonspecified subtype) | MKNK1 | MCOLN1 | PTPN12 | MMP2 | HCRTR1 | HDAC5 | KCNN4 | GRIN2D | GRM2 | HSF1 | RYR2 | PGAM5-KEAP1-NRF2 Complex | Calmodulin (nonspecified subtype) | KCNC2 | MAP3K11 | Mitogen-Activated Protein Kinase (nonspecified subtype) | XPO1 | ACSS2 | EIF2AK2 | SMPD1 | TGM2 | KYNU | G4137 | DNM1L | Chaperone (nonspecified subtype) | NPY2R | NMDA receptor | G5595 | GPR3 | KIT | GRIN2A | Nicotinic alpha4beta2 receptor | TLR9 | SUPT5H | DRD5 | RARB | G673 | Histone acetyltransferase (HAT) (nonspecified subtype) | RNF216 | ATXN3 | CHRM3 | FAAH | TSPO | NOS2 | VHL | PARP11 | Survival of motor neuron (SMN) complex | DRD1 | VPS13A | G472 | CCND3 | SLC16A1 | KCNC3 | 15-Lipoxygenase (nonspecified subtype) | EIF2AK4 | JAK3 | DDR1 | G114548 | beta-Adrenoceptor (nonspecified subtype) | SLC1A6 | GABRB3 | MAPK9 | TBP | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | Proteasome Complex | NLRP3 Inflammasome | CRBN | ROCK2 | Histone deacetylase (nonspecified subtype) | C3AR1 | SEMA4D | NOX3 | HDAC4 | MAP4K1 | KDM1A | CASP2 | HCRTR2 | CCNE1 | MFN2 | CDK4/Cyclin D | DLG4 | FDPS | QPCTL | CDK1/Cyclin B | CAPN1 | LILRB3 | PTPN11 | G9734 | PINK1 | ABHD6 | QPCT | Pyruvate dehydrogenase kinase (nonspecified subtype) | sigma Receptor (nonspecified subtype) | FOLH1 | PDE2A | PTPN5 | Immunoproteasome | Anandamide membrane transporter (AMT) | ABL1 | Dopamine receptor (nonspecified subtype) | HTR6 | Poly [ADP-ribose] polymerase (nonspecified subtype) | NADPH Oxidase Complex | PDE1B | Cyclin D (nonspecified subtype) | EPOR | CTSC | Nitric oxide synthase (NOS) (nonspecified subtype) | OGA | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | S1PR5 | AGER | PIP4K2C | APP | SCN5A | DRD3 | VCP | SLC6A3 | GABRA5 | Cyclooxygenase (COX) (nonspecified subtype) | GLP1R | MLH1 | TMEM97 | NAMPT | G1029 | Cannabinoid receptor (nonspecified subtype) | APOA1 | CLK1 | UCHL1 | GRM3 | STING1 | G6774 | TDO2 | G2146 | GRM1 | MAOB | MAPK10 | Peptidylprolyl Isomerase (nonspecified subtype) | ATN1 | NT5E | SIN3B | KCNH3 | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | SMPD3 | CHRM5 | NADPH Oxidase (nonspecified subtype) | SLC1A1 | ASIC1 | CDK6/Cyclin D3 | AMP-activated protein kinase (AMPK) | SLC6A1 | NQO2 | OPRM1 | KRR1 | NQO1 | CASP1 | G2475 | HTT | Soluble guanylyl cyclase | SMN1 | MYB | RIPK1 | CDK1 | 5-Hydroxytryptamine Receptor (nonspecified subtype) | PDE4A | ATXN1 | GABRA2 | SLC16A3 | CTSB | HDAC6 | GRIN2B | Rho kinase (ROCK) (nonspecified subtype) | MMP1 | CDK2/Cyclin E | EIF2AK3 | SIN3A | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | Transglutaminase (nonspecified subtype) | G4780 | G5243 | RIPK3 | STX1A | CNR2 | GRM4 | CHRM2 | RAB5A | NTRK2 | PDIA3 | HDAC2 | MPO | FGF2 | CDK7 | CDK7/Cyclin H | G6647 | DRD2 | PDE4D | SMN2 | PPARG | DRB sensitivity-inducing factor complex | NR4A2 | PPARGC1A | PTPRC | SLC29A1 | CHRNA6 | SIRT3 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | Glutamate Receptor Ionotropic AMPA Receptor | ABAT | CDK12 | Phosphodiesterase (nonspecified subtype) | PRKG1 | G8878 | IRS1 | NGF | CDK4 | CDK6 | HRH3 | TAAR1 | CASP6 | ADRA2C | ALOX15 | GABRA6 | PPP1R15B | PPARA | SLC1A2 | PDE1A | CDK2 | STXBP1 | AVPR1A | Calcium channel (nonspecified subtype) | LRRK2 | Heat shock protein 90 (nonspecified subtype) | GPR17 | SNCA | G142 | Tubulin | CNR1 | mu-Calpain (calpain 1) | L3MBTL1 | G7124 | SMO | Protein kinase C (nonspecified subtype) | TRPV1 | SLC6A2 | Monoamine oxidase (MAO) (nonspecified subtype) | APEH | Protein Kinase B (PKB/Akt) (nonspecified subtype) | CYP46A1 | G3569 | MAOA | PDE4B | SP1 | CACNA1B | CGAS | Acyl-CoA Synthetase Short-Chain (nonspecified subtype) | ACHE | DDR2 | KAT2B | MFN1 | G5599 | HDAC1 | HTR1A | C5 | SV2A | CST3 | KMO | cAMP Responsive Element Binding Protein (CREB) (nonspecified subtype) | TTR | Cyclin B (nonspecified subtype) | PTGS1 | SIRT2 | GRM5 | PREP | GABA(A) receptor | HAAO | CASP7 | KDM5B | Complement component 1q | VDR | SLC18A2 | G3320 | Voltage-Gated Sodium Channel Complex | DNM1 | SIGMAR1 | IL1B | Sodium channel (nonspecified subtype) | G23411 | MKNK2 | ATXN7 | MMP3 | NOS1 | ROCK1 | TYR | CHRM4 | MLKL | G4318 | G1432 | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | TARDBP | BCR

疾病靶点研报
Huntington's Disease

Note: If you'd like to get a target analysis report for Huntington's Disease, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Huntington's Disease at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Klippel-Feil Syndrome | Dysplastic Nevus | Retinoschisis | Li-Fraumeni Syndrome | Globozoospermia | Renal Dysplasia | Tuberculosis | Galactosemia | Keratoacanthoma | Primary Hyperoxaluria | Primary Lateral Sclerosis | Chondrodysplasia Punctata 2, X-linked Dominant | Meckel-Gruber Syndrome | Diabetes | Distal Myopathy | Primary Pigmented Nodular Adrenocortical Disease | Connective Tissue Disorders | Congenital Dyserythropoietic Anemia Type 1 | Fatty Aldehyde Dehydrogenase Deficiency | Alexander Disease | HANAC Syndrome | Microcephaly | Macrophagic Myofasciitis | Marinesco-Sjogren Syndrome | Peyronie's Disease | Gilbert Syndrome | Neurofibromatosis | Myositis, Focal | Mastitis | Hypermetropia | Kleine-Levin Syndrome | Polyradiculopathy | Split Hand-foot Malformation | Wilson's Disease | Lymphangiomatosis | Iron Overload | Epidermodysplasia Verruciformis | Cutaneous Lupus Erythematosus | Infantile Neuroaxonal Dystrophy | Epidermolysis Bullosa Simplex, Generalized | Apert Syndrome | Joubert Syndrome | Granuloma Annulare | Congenital Bile Acid Synthesis Defect | Chronic Enteropathy Associated With SLCO2A1 Gene | Chronic Neutrophilic Leukemia | Schindler Disease | Pontocerebellar Hypoplasia Type 7 | Spinocerebellar Ataxia Type 38 | Early Infantile Epileptic Encephalopathy 4 | Takenouchi-Kosaki Syndrome | Localized Scleroderma | Giant Cell Arteritis | Infertility, Male | Waardenburg Syndrome Type 2E | Osteogenesis Imperfecta Type I | Intellectual Disability, Autosomal Dominant 5 | Hyperlipidemia, Familial Combined | Behcet's Disease | Hyperuricemic Nephropathy, Familial Juvenile | Desmosterolosis | Paracoccidioidomycosis | Restrictive Dermopathy | Beckwith-Wiedemann Syndrome | Babesiosis | LMNA-related Congenital Muscular Dystrophy | Hypotension, Orthostatic | Cannabis Abuse | Specific Granule Deficiency | Lafora Disease | Fucosidosis | Esophagitis, Eosinophilic | Glomerulonephritis, Membranoproliferative | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Gnathodiaphyseal Dysplasia | Ghosal Syndrome | Cellulitis | Spitzoid Melanoma | Zygomycosis | Obesity | Acquired Partial Lipodystrophy | Pleurisy | Acute Kidney Injury | Galloway-Mowat Syndrome | Corneal Dystrophies, Hereditary | Erdheim-Chester Disease | Sickle Cell Disease | Exostoses | Aphasia | Cardiomyopathy, Peripartum | Peters-plus Syndrome | Esophageal Adenocarcinoma | Subacute Sclerosing Panencephalitis | Arteriosclerosis | Clouston Hidrotic Ectodermal Dysplasia | Graves Disease | Hypertension, Pulmonary | Chronic Idiopathic Myelofibrosis | Glaucomatocyclitic Crisis | Hepatitis B, Chronic | IMAGe Syndrome | Peeling Skin Syndrome Type B | Spinocerebellar Ataxia Type 20 | Coffin-Siris Syndrome | Narcolepsy | Empyema | Acromegaly | Communication Disorders | Compartment Syndrome | Atopy | Hemoglobinopathies | Agnathia-Otocephaly Complex | Retinitis Pigmentosa | Neuromyotonia | Mitochondrial Cytopathy | Seminoma | Hyperhomocysteinemia | Alpha-1 Antitrypsin Deficiency | Nicotine Addiction | Leishmaniasis, Cutaneous | Renal Hypomagnesemia 3 | Neuromyelitis Optica | Myosin Storage Myopathy | Castleman Disease | Early Infantile Epileptic Encephalopathy | Williams Syndrome | Histiocytic Sarcoma | Tendinopathy | Pityriasis Rubra Pilaris | Hypokalemia | LRBA Deficiency | Cardiomyopathy, Restrictive | Microphthalmia | Scleroderma, Diffuse | Astigmatism | Intestinal Tuberculosis | Optic Nerve Diseases | DRESS Syndrome | Aromatic L-amino Acid Decarboxylase Deficiency | Myasthenia Gravis | Cancer, Skin | Glycogen Storage Disease Type 9 | Progressive Familial Intrahepatic Cholestasis | Tardive Dyskinesia | Otosclerosis | Hoyeraal-Hreidarsson Syndrome | Thyroiditis, Autoimmune | Sarcosinemia | Tyrosinemia | Cushing Syndrome | Ornithine Transcarbamylase Deficiency | Chloridorrhea, Congenital | Microvillus Inclusion Disease | Cholesteryl Ester Storage Disease | Lymphangioma | Temporal Lobe Epilepsy | Persistent Truncus Arteriosus | Juvenile Xanthogranuloma | Gerstmann-Straussler-Scheinker Syndrome | Dental Caries | Reye Syndrome | Congenital Adrenal Hyperplasia 1 | Epilepsy Of Infancy With Migrating Focal Seizures | Corticobasal Syndrome | Cataract | Double Outlet Right Ventricle | Aldosterone Synthase Deficiency | Systemic Lupus Erythematosus | Parapsoriasis | Prolymphocytic Leukemia | Cardiomyopathy, Dilated, 1L | Endometriosis | Spinocerebellar Ataxia Type 17 | Cleidocranial Dysplasia | Centronuclear Myopathy | Metaphyseal Chondrodysplasia, Schmid Type | Spondyloarthritis | Scoliosis | Hyperinsulinemic Hypoglycemia | Intracerebral Hemorrhage | Cheilitis | Cone Dystrophy | Infertility | Amelanotic Melanoma | Ganglioglioma | Tangier Disease | Encephalopathy, Glycine | Aneurysm, Abdominal Aortic | Disseminated Superficial Actinic Porokeratosis | Fibrosarcoma | Lymphoma, AIDS-related | Fontaine Progeroid Syndrome | Papillon-Lefevre Syndrome | Cardiomyopathy, Hypertrophic | Prune Belly Syndrome | Melnick-Needles Syndrome | DOCK8 Immunodeficiency Syndrome | Peritonitis | Triphalangeal Thumb-polysyndactyly Syndrome | Primary Progressive Aphasia | Teratozoospermia | Speech Disorders | Spastic Paraplegia Type 7 | Nicolaides-Baraitser Syndrome | Epiphyseal Chondrodysplasia, Miura Type | Placenta Previa | Pulmonary Capillary Hemangiomatosis | Glycogen Storage Disease Type 0, Muscle | Syphilis | Familial Mediterranean Fever | Lipid Storage Diseases | Thrombotic Microangiopathy | Japanese Encephalitis | Delayed Sleep Phase Syndrome | Osteogenesis Imperfecta Type III | Prolactinoma | Usher Syndrome Type I | Myotonic Disorders | Thrombophilia | Maple Syrup Urine Disease | Hypersomnia | Botulism | Epilepsy | Synovitis | Opisthorchiasis | Multiple Epiphyseal Dysplasia | Autism | Congenital Stationary Night Blindness | Kawasaki Disease | Larsen Syndrome | Heavy Chain Disease | Pregnancy, Ectopic | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Brenner Tumor | Hypertension, Renal | Dysmorphophobia | Aplastic Anemia | Autoimmune Disease | Tietze Syndrome | Pseudohypoparathyroidism Type 1C | Prurigo Nodularis | Hernia, Inguinal | Bullous Pemphigoid | Sarcoma, Alveolar Soft Part | Progressive Osseous Heteroplasia | Periventricular Nodular Heterotopia | Hemimegalencephaly | Proximal Symphalangism | Von Hippel-Lindau Disease | Neurofibromatosis Type 2 | Trichothiodystrophy | Leiomyoma | Niemann-Pick Disease, Type A | Hypercalciuria | Cancer, Lung | Brachial Plexus Neuropathy | Chediak-Higashi Syndrome | Neuroleptic Malignant Syndrome | Acanthosis Nigricans | Sitosterolemia | Batten Disease | Giant Axonal Neuropathy | Malonyl-CoA Decarboxylase Deficiency | Gaucher Disease | Fabry's Disease | Uremia | Chronic Beryllium Disease | Familial Partial Lipodystrophy | Triple A Syndrome | Meningococcal Meningitis | Corneal Neovascularization | Small Lymphocytic Lymphoma | Gitelman Syndrome | Glioblastoma | Twin-to-twin Transfusion Syndrome | Sleep Apnea | Hyperlipidemia | Coloboma | Hypervalinemia | 3-hydroxy-3-methylglutaric Aciduria | Amebiasis | Encephalitis, Tick-borne | T-cell Lymphoma, Subcutaneous Panniculitis-like | Lewy Body Dementia | Antithrombin III Deficiency | Primary Erythromelalgia | Brachydactyly | Alpha-mannosidosis | Rheumatic Heart Disease | Hidradenitis Suppurativa | Waardenburg Syndrome Type 1 | Potocki-Shaffer Syndrome | Epidermolysis Bullosa Dystrophica | Osteoarthritis | Echinococcosis | Adrenoleukodystrophy, X-linked | Axenfeld-Rieger Syndrome | Inflammatory Myopathy | Kohlschutter-Tonz Syndrome | Seasonal Mood Disorder | Riboflavin Transporter Deficiency Neuronopathy | Non-epidermolytic Palmoplantar Keratoderma | Oculopharyngeal Muscular Dystrophy | Neutrophilia | Nemaline Myopathy 8 | Kashin-Beck Disease | Glomerulonephritis | Acne Vulgaris | Focal Facial Dermal Dysplasia | NDH Syndrome | Biotinidase Deficiency | Pseudoachondroplasia | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Congenital Ichthyosiform Erythroderma | Rash | Monilethrix | Osteosarcoma | Anti-glomerular Basement Membrane Disease | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Systemic Mastocytosis | Ellis-Van Creveld Syndrome | Mast Cell Leukemia | Van Der Knaap Disease | Cousin Syndrome | Gynecomastia | Mucolipidosis Type III | Chondroma | Immunoproliferative Disorders | Autosomal Recessive Spastic Paraplegia Type 75 | Trachoma | DEND Syndrome | Pulmonary Stenosis | Synpolydactyly | Hepatic Adenomatosis | Familial Hyperaldosteronism | Pancreatitis, Chronic | Thyroid Hormone Resistance | Major Depression | Meleda Disease | Hereditary Coproporphyria | Thanatophoric Dysplasia Type 1 | Acute Lymphocytic Leukemia | Congenital Heart Block | Tylosis With Esophageal Cancer | Atopic Dermatitis | Anemia | Kidney Stones | Spinocerebellar Ataxia Type 1 | Ollier Disease | Paronychia | Budd-Chiari Syndrome | Woodhouse-Sakati Syndrome | Intestinal Pseudo-obstruction | Spondyloperipheral Dysplasia | Necrobiosis Lipoidica | Nijmegen Breakage Syndrome | Lentigo | Liver Failure | Multiple Sclerosis, Secondary Progressive | Leber Hereditary Optic Neuropathy | Progressive Encephalopathy-optic Atrophy Syndrome | Vulvovaginitis | Epithelial-myoepithelial Carcinoma | Sickle Cell Anemia | Shprintzen-Goldberg Syndrome | Hypodontia | Zimmermann-Laband Syndrome | Pathological Gambling | Kearns-Sayre Syndrome | Holt-Oram Syndrome | Plasma Cell Leukemia | Pfeiffer Syndrome | Autoimmune Autonomic Ganglionopathy | Sotos Syndrome | Avian Influenza | Thrombophlebitis | L-2-Hydroxyglutaric Aciduria | Aldosteronism | Interstitial Lung Diseases | Leukoplakia | Blue Rubber Bleb Nevus Syndrome | Usher Syndrome Type III | Hyperkalemic Periodic Paralysis | Congenital Nystagmus | Vertebrobasilar Insufficiency | Autosomal Recessive Spastic Paraplegia Type 54 | Cabezas Syndrome | Greenberg Dysplasia | Tendinitis | Hepatitis | Infantile Refsum Disease | Autoimmune Polyendocrinopathy Syndrome Type I | Spasticity | Cholangiocarcinoma | Rhizomelic Chondrodysplasia Punctata | Epicondylitis | Niemann-Pick Disease, Type C | Bronchitis, Chronic | Wolcott-Rallison Syndrome | Encephalopathy, Hepatic