Motor Neuron Diseases

About the Disease
Motor Neuron Disease, also known as anterior horn cell disease, is related to amyotrophic lateral sclerosis 1 and frontotemporal dementia and/or amyotrophic lateral sclerosis 1, and has symptoms including ataxia, muscular fasciculation and hemiplegia. An important gene associated with Motor Neuron Disease is SOD1 (Superoxide Dismutase 1), and among its related pathways/superpathways are Neuroscience and Amyotrophic lateral sclerosis (ALS). The drugs Mexiletine and Cannabidiol have been mentioned in the context of this disorder. Affiliated tissues include Neural Tube, and related phenotypes are nervous system and homeostasis/metabolism

Common Targets
TRPV4 | C9orf72 | G3480 | DYNC1H1 | NTRK1 | CFC1 | CPLANE1 | CEP126 | CHRNA7 | NTRK3 | NF-kappaB (NFkB) | CHCHD10 | Oxysterols receptor LXR (nonspecified subtype) | RARB | G114548 | NLRP3 Inflammasome | HSPB8 | OPTN | PDE2A | SPG7 | HSPB1 | VCP | ATP6 | VRK1 | TECPR2 | NTRK2 | G6647 | UBQLN2 | UBQLN1 | HRH3 | Heat shock protein 90 (nonspecified subtype) | CACNA1B | NOTCH2NLC | SV2A | FGFR1 | AIFM1

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Neurodevelopmental Disorders | 3-methylglutaconic Aciduria Type I | Dyslipidemia | Open-angle Glaucoma | Schizotypal Personality Disorder | Iron Deficiency Anemia | Chromosome 16p11.2 Deletion Syndrome | Spinocerebellar Ataxia Type 2 | Botulism | Mixed Connective Tissue Disease | Pleomorphic Xanthoastrocytoma | Jaundice, Obstructive | Neurofibroma, Plexiform | Gyrate Atrophy Of The Choroid And Retina | Constipation | Cutaneous T-cell Lymphoma | Gangliosidosis | Myasthenia | Cranioectodermal Dysplasia | Chanarin-Dorfman Syndrome | Autonomic Nervous System Disorders | Riboflavin Transporter Deficiency Neuronopathy | Paroxysmal Kinesigenic Dyskinesia | Li-Fraumeni Syndrome | Non-small Cell Lung Cancer | Ulcerative Colitis | Spasticity | Pyruvate Kinase Deficiency | Cholecystitis | Amyotrophic Lateral Sclerosis | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Fibrodysplasia Ossificans Progressiva | Exotropia | Inflammatory Myofibroblastic Tumor | Glycogen Storage Disease 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Coloboma | Encephalopathy, Glycine | Muir-Torre Syndrome | Cardiofaciocutaneous Syndrome | Mitochondrial DNA Depletion Syndrome | Oculopharyngeal Muscular Dystrophy | Autosomal Recessive Bestrophinopathy | Craniosynostosis | Azoospermia | Myopia | MIRAGE Syndrome | Arthrogryposis | Central Core Disease | Antenatal Bartter Syndrome Type 1 | Pneumonia, Mycoplasma | Heterotopic Ossification | Phosphoglycerate Dehydrogenase Deficiency | Asthma, Exercise-induced | Gerstmann-Straussler-Scheinker Syndrome | Neurocutaneous Syndromes | Multicystic Renal Dysplasia | Metabolic Diseases | Preaxial Polydactyly | Cardiac Sarcoidosis | Kohlschutter-Tonz Syndrome | Glomerulonephritis, Membranoproliferative | Norrie Disease | Hereditary Xerocytosis | Congenital Adrenal Hyperplasia 1 | Charcot-Marie-Tooth Disease Type 4E | Aspergillosis | Hypolipoproteinemia | Non-bullous Congenital Ichthyosiform Erythroderma | Adenomyosis | Infectious Diarrhea | Hypoparathyroidism | Endophthalmitis | Glycogen Storage 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