Disease

Motor Neuron Diseases

About the Disease
Motor Neuron Disease, also known as anterior horn cell disease, is related to amyotrophic lateral sclerosis 1 and frontotemporal dementia and/or amyotrophic lateral sclerosis 1, and has symptoms including ataxia, muscular fasciculation and hemiplegia. An important gene associated with Motor Neuron Disease is SOD1 (Superoxide Dismutase 1), and among its related pathways/superpathways are Neuroscience and Amyotrophic lateral sclerosis (ALS). The drugs Mexiletine and Cannabidiol have been mentioned in the context of this disorder. Affiliated tissues include Neural Tube, and related phenotypes are nervous system and homeostasis/metabolism

Common Targets
TRPV4 | C9orf72 | G3480 | DYNC1H1 | NTRK1 | CFC1 | CPLANE1 | CEP126 | CHRNA7 | NTRK3 | NF-kappaB (NFkB) | CHCHD10 | Oxysterols receptor LXR (nonspecified subtype) | RARB | G114548 | NLRP3 Inflammasome | HSPB8 | OPTN | PDE2A | SPG7 | HSPB1 | VCP | ATP6 | VRK1 | TECPR2 | NTRK2 | G6647 | UBQLN2 | UBQLN1 | HRH3 | Heat shock protein 90 (nonspecified subtype) | CACNA1B | NOTCH2NLC | SV2A | FGFR1 | AIFM1

疾病靶点研报
Motor Neuron Diseases

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