Disease

Kallmann Syndrome

About the Disease
Hypogonadotropic Hypogonadism 1 with or Without Anosmia, also known as dysplasia olfactogenitalis of de morsier, is related to hypogonadotropic hypogonadism 23 with or without anosmia and normosmic congenital hypogonadotropic hypogonadism. An important gene associated with Hypogonadotropic Hypogonadism 1 with or Without Anosmia is ANOS1 (Anosmin 1), and among its related pathways/superpathways are Negative regulation of FGFR1 signaling and Signaling by FGFR2. The drugs Zinc cation and Follitropin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, breast and eye, and related phenotypes are facial asymmetry and micropenis

Common Targets
HESX1 | SEMA7A | PTCH1 | GLI3 | IGFALS | PROK2 | CHD7 | IL17RD | NRP2 | GNRH1 | FEZF1 | PLXNA1 | PNPLA6 | FGF8 | NRP1 | EBF2 | GNRHR | PTPN11 | CCDC141 | ANOS1 | POLR3B | DMXL2 | SEMA3A | SOX10 | WDR11 | POLR3A | KISS1R | PROKR2 | AXL | FGFR1

疾病靶点研报
Kallmann Syndrome

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