Celiac Disease

About the Disease
Celiac Disease 1, also known as celiac disease, is related to type 1 diabetes mellitus and autoimmune disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Celiac Disease 1 is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways/superpathways are Allograft rejection and CD28 co-stimulation. The drugs Prucalopride and Silicon have been mentioned in the context of this disorder. Affiliated tissues include small intestine to gliadin, small intestine and bone, and related phenotypes are vitamin b12 deficiency and failure to thrive

Common Targets
PTPN2 | CNR2 | TNFRSF21 | IL21-AS1 | TAGAP | IL-15 receptor | Glucosidase (nonspecified subtype) | CCDC91 | PPARA | LINC00824 | HLA-B | HLA-DRB1 | G7124 | TNFSF14 | CD6 | IL2RA | TYK2 | GRB10 | LOC105370548 | FKBP1A | MAP2K7 | C1QBP | TNFRSF10A | HP | SERPINE2 | LINC02656 | MADD | HLA-DQA1 | G7295 | F13A1 | ERAP2 | Interleukin 21 receptor complex | LAMB1 | M6PR | PPARG | C17orf78 | CTSS | TRAF4 | PPP3R2 | ICAM1 | PKIA | Integrin alpha4beta7 (LPAM-1) receptor | PPP3CC | LPP | CD14 | Alkaline Phosphatase (ALP) (nonspecified subtype) | GBGT1 | MAP3K8 | IL-2 receptor | NCF2 | NR1I2 | LOC105373781 | THEMIS | Tubulin | UBE2L3 | NR3C1 | PHLDB1 | ASH1L | REL | CD48 | IL15 | MMEL1 | TGM2 | KLRK1 | TLR2 | REL-DT | VSTM4 | LOC105375911 | HAS1 | PBX3 | NFIA | NR1H4 | UBASH3A | VDR | BACH2 | ELMO1 | PTPRK | TPTE | RAF1 | ULK3 | PKIA-AS1 | CTLA4 | LARGE1 | OSBPL5 | BLTP1 | RTEL1 | IL10 | STAT4 | LOC105371664 | MAP3K7 | IL2 | IL18RAP | TP53INP2 | CCR9 | KLRC4-KLRK1 | IFNG | LOC102725065 | DAG1 | PTPN22 | MEFV | G5970 | IL12A | IFIH1 | CFTR | CCR5 | AFF3 | PPP3CB | TNFRSF4 | IL12A-AS1 | POLA1 | PPP3R1 | ZC2HC1A | INAVA | GUCY2C | SCHIP1 | HSPA12A | CD28 | JAK3 | JAK2 | FUT2 | JAK1 | SH2B3 | G114548 | ARHGAP31 | TNIP1 | TAP1 | IRAK1 | ANK3 | PPP6C | HLA-DQB1 | TNFRSF1A | FERMT1 | ZNF335 | MICA | SLC9A4 | RGS21 | MAP4K2 | IL23R | ACACA | HLA Class II Histocompatibility Antigen DQ8 | LZTFL1 | AUTS2 | FOXP3 | Interleukin 23 complex (IL-23) | TNFRSF13B | ATXN2 | RTEL1-TNFRSF6B | ZMIZ1 | BANK1 | RAET1L | IL21R | ETS1 | AK5 | HECTD4 | Protein Phosphatase 2B | IRF1-AS1 | MYNN | CSAG1 | NKAIN2 | GYPA | BAZ2B | LOC105372832 | CCR3 | PUS10 | TRADD

Note: If you'd like to get a target analysis report for Celiac Disease, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Celiac Disease at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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