Alagille Syndrome

About the Disease
Alagille Syndrome 1, also known as alagille syndrome, is related to cholestasis and biliary atresia. An important gene associated with Alagille Syndrome 1 is JAG1 (Jagged Canonical Notch Ligand 1), and among its related pathways/superpathways are Disease and Signal Transduction. The drugs Atorvastatin and Lipid Regulating Agents have been mentioned in the context of this disorder. Affiliated tissues include Head Mesenchyme and Liver, and related phenotypes are failure to thrive and hepatomegaly

Common Targets
G4851 | ATP8B1 | NR1H4 | DGUOK | JAG1 | ATP7B | SLC10A2 | NOTCH2

Note: If you'd like to get a target analysis report for Alagille Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Alagille Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Inflammatory Myofibroblastic Tumor | Spitzoid Melanoma | Hemorrhoids | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Camurati-Engelmann Disease | X-linked Myotubular Myopathy | Proopiomelanocortin Deficiency | Esophagitis, Eosinophilic | Tuberculous Meningitis | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Congenital Stationary Night Blindness | Porphyria, Acute Intermittent | Familial Male-limited Precocious Puberty | Hereditary Sensory Neuropathy Type 1 | Spinal Muscular Atrophy Type 3 | 3-M Syndrome | Precocious Puberty | Duchenne Muscular Dystrophy | Hypotension, Orthostatic | Spinocerebellar Ataxia Type 7 | Sialidosis | Rickets | Hemolytic Uremic Syndrome, Atypical | Progressive Familial Intrahepatic Cholestasis Type 2 | Vitelliform Macular Dystrophy | Giant Cell Arteritis | Gangliosidosis, GM1 | Pyruvate Decarboxylase Deficiency | Osteonecrosis | Usher Syndrome Type I | Constipation | Peyronie's Disease | Wolfram Syndrome 2 | Schizophrenia | Retinitis | Corneal Neovascularization | Creutzfeldt-Jakob Disease | Asplenia | Cutaneous T-cell Lymphoma | Pachyonychia Congenita | Non-small Cell Lung Cancer | Amish Infantile Epilepsy Syndrome | Familial Dysautonomia | Enhanced S-cone Syndrome | Sarcoidosis | Autism | Veno-occlusive Disease | Colitis | Hemoglobinopathies | Heart Septal Defects | Stuttering | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Retinal Coloboma | Autonomic Nervous System Disorders | Rett Syndrome | Gastroenteritis, Eosinophilic | Hepatic Adenomatosis | Corneal Dystrophies, Hereditary | Carcinoma, Merkel Cell | Glomerulonephritis, Membranous | Orthostatic Intolerance | Hepatitis E | Glycogen Storage Disease Type 1 | Lissencephaly 2 | Cancer, Bladder | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Spondyloarthritis | Growth Hormone Excess | CDKL5 Deficiency Disorder | Hemophilia | Snyder-Robinson Syndrome | Autoimmune Autonomic Ganglionopathy | Myelitis, Transverse | Facioscapulohumeral Muscular Dystrophy Type 1 | Calcium Pyrophosphate Deposition Disease | Varices | Aldosterone Synthase Deficiency | Aicardi-Goutieres Syndrome | Dementia, Vascular | Traboulsi Syndrome | Teratozoospermia | Stroke | Lafora Disease | Chromosome 8q21.11 Deletion Syndrome | Budd-Chiari Syndrome | Chronic Granulomatous Disease | Lysosomal Acid Lipase Deficiency | Warsaw Breakage Syndrome | Spondylocarpotarsal Synostosis Syndrome | Waardenburg Syndrome Type 2A | Purpura, Thrombotic Thrombocytopenic | Premature Ejaculation | Peripheral Neuropathy | Insulin Resistance | Spinocerebellar Ataxia Type 12 | Multisystemic Smooth Muscle Dysfunction Syndrome | Bethlem Myopathy | Androgen Insensitivity | Spinocerebellar Ataxia Type 15 | Tumoral Calcinosis | Hypertensive Nephropathy | Combined Malonic And Methylmalonic Acidemia | Herpes Simplex Dermatitis | Cranioectodermal Dysplasia | Pseudohypoparathyroidism Type 1A | Encephalopathy, Hepatic | Primary Cutaneous Amyloidosis | Ollier Disease | Venous Insufficiency | Fowler's Syndrome | Otitis Externa | Hypercalciuria | Infertility | Tremor | Alopecia | Spinocerebellar Ataxia Type 6 | Blau Syndrome | Peripheral T-cell Lymphoma | Methemoglobinemia | Zellweger Syndrome | Hyperphenylalaninemia | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Dermatomyositis | Spinocerebellar Ataxia Type 5 | T-cell Prolymphocytic Leukemia | Papilloma | N-acetylglutamate Synthase Deficiency | Inflammatory Bowel Disease | ICF Syndrome | Congenital Afibrinogenemia | McKusick Type Metaphyseal Chondrodysplasia | Dubin-Johnson Syndrome | Congenital Ichthyosiform Erythroderma | Communication Disorders | Polyneuropathy | Pyruvate Dehydrogenase Deficiency | Craniofacial Dysostosis | Anosmia, Congenital | Synpolydactyly | Spinal And Bulbar Muscular Atrophy | Extramammary Paget's Disease | Congenital Bilateral Absence Of Vas Deferens | Heavy Chain Disease | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Bipolar Disorder | Gingivitis | Irritable Bowel Syndrome | Acquired Partial Lipodystrophy | Epilepsy | Oculocutaneous Albinism | Colitis, Lymphocytic | Gray Platelet Syndrome | Desbuquois Syndrome | Cellulitis | Hemangioendothelioma | Enlarged Vestibular Aqueduct | Mucormycosis | Phosphoglycerate Dehydrogenase Deficiency | Neurofibroma | Thrombotic Microangiopathy | Seizures-scoliosis-macrocephaly Syndrome | Vitamin B12 Deficiency | Renal Oncocytoma | Hepatitis A | Marinesco-Sjogren Syndrome | Cannabis Abuse | Corneal Dystrophy And Perceptive Deafness | GNE Myopathy | Persistent Hyperplastic Primary Vitreous | X-linked Sideroblastic Anemia | Myocardial Infarction | Antley-Bixler Syndrome | Angioedema, Acquired | Raine Syndrome | Focal Cortical Dysplasia Type 2 | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Cystinuria | Pulmonary Sclerosing Hemangioma | Neuroleptic Malignant Syndrome | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Retinal Vasculitis | Tinea Versicolor | Congenital Myasthenic Syndrome | Renpenning Syndrome | Plasmacytoma | Sleep Apnea, Obstructive | Hyperbilirubinemia, Neonatal | Patent Ductus Arteriosus | Atherosclerosis | Van Der Knaap Disease | Rash | Coma | Pregnancy, Ectopic | Pelizaeus-Merzbacher Disease | Lipid Metabolism Disorders | Epicondylitis | Spinocerebellar Ataxia Type 3 | Antithrombin III Deficiency | Pycnodysostosis | Superficial Spreading Melanoma | Neurogenic Bladder | Withdrawal Syndrome | Infertility, Male | Sclerosing Cholangitis | Alveolar Capillary Dysplasia | Jawad Syndrome | Sezary Syndrome | Hypoparathyroidism | Sarcoma, Alveolar Soft Part | Duane Retraction Syndrome | Hartnup Disease | Carcinoma, Squamous Cell | Triple A Syndrome | Hereditary Hemorrhagic Telangiectasia | Hepatopulmonary Syndrome | Peeling Skin Syndrome Type B | Poirier-Bienvenu Neurodevelopmental Syndrome | Hyperbilirubinemia | Autosomal Recessive Spastic Paraplegia Type 35 | Obesity | Erythema Multiforme | Dent Disease | Osteomyelitis | Sickle Cell Disease | Cockayne Syndrome | Fragile X Syndrome | Congenital Nephrotic Syndrome | Primary Erythromelalgia | Congenital Bile Acid Synthesis Defect | Mucolipidosis Type II | Lung Diseases | Cold Agglutinin Disease | Progressive External Ophthalmoplegia | Toxoplasmosis | Vici Syndrome | Varicocele | Chromosome 17q21.31 Deletion Syndrome | GLUT1 Deficiency Syndrome | Fucosidosis | Tatton-Brown-Rahman Syndrome | Early Infantile Epileptic Encephalopathy | Stromal Corneal Dystrophy | Stargardt Disease | Chorioretinitis | Focal Dermal Hypoplasia | Hyperinsulinemic Hypoglycemia | Chylothorax, Congenital | Crimean-Congo Hemorrhagic Fever | Cancer, Lung | Congenital Stromal Corneal Dystrophy | Obesity, Morbid | Brugada Syndrome 1 | Keratoconjunctivitis | Myelitis | Agammaglobulinemia | Bardet-Biedl Syndrome | Cancer, Colon | Periventricular Leukomalacia | Non-epidermolytic Palmoplantar Keratoderma | Hypereosinophilic Syndrome | Familial Advanced Sleep Phase Syndrome | Cardiomyopathy, Hypertrophic | Hyperlipidemia Type V | Ebstein Anomaly | Glutaric Aciduria Type 3 | Gastritis | Birk-Barel Syndrome | Cohen Syndrome | Cardiomyopathy, Restrictive | Gyrate Atrophy Of The Choroid And Retina | Azoospermia | Subcortical Band Heterotopia | Persistent Fetal Circulation | Neuroma | Spondyloperipheral Dysplasia | Adrenal Insufficiency | Lymphoma | Spinocerebellar Ataxia Type 2 | Leukemia-lymphoma, Adult T-cell | Hyperkalemic Periodic Paralysis | Schistosomiasis | Fundus Albipunctatus | Brachydactyly | Cold-induced Sweating Syndrome | Protein C Deficiency | Waardenburg Syndrome Type 2 | Pierpont Syndrome | Takayasu's Arteritis | Neural Tube Defect | Narcolepsy | Combined Pituitary Hormone Deficiency | Primary Hyperoxaluria | Rhabdomyosarcoma, Embryonal | Multiple Sclerosis, Secondary Progressive | Melanoma, Malignant | Chromosome 5q Deletion Syndrome | Hypercholesterolemia, Familial | Erythromelalgia | Congenital Adrenal Hyperplasia 1 | Sleep Apnea | Ovarian Sex Cord-stromal Tumor | Bloom Syndrome | Connective Tissue Disorders | Spinocerebellar Ataxia Type 38 | Lesch-Nyhan Syndrome | Swine Influenza | Hepatorenal Syndrome | Encephalopathy, Ethylmalonic | Congenital Heart Defects | Spinocerebellar Ataxia Type 31 | Pre-eclampsia | Graves Disease | Dystonia-parkinsonism, X-linked | Hyperthyroidism | Pilomatrix Carcinoma | Esophageal Carcinoma | Dementia | Achromatopsia | Ophthalmoplegia | Oral Lichen Planus | Anuria | Fahr Disease | Anthrax | SAPHO Syndrome | Glycogen Storage Disease Type 1b | Malaria | Chudley-McCullough Syndrome | Pericarditis | Martsolf Syndrome | Prolymphocytic Leukemia | Spinocerebellar Ataxia Type 14 | Cholangiocarcinoma | Acute Tubular Necrosis | Liver Failure, Acute Infantile | Oguchi Disease-2 | Pneumococcal Meningitis | Motion Sickness | Agranulocytosis | Retinoschisis | Blepharospasm | Gastroschisis | Tay-Sachs Disease | Central Pain Syndrome | Frontotemporal Dementia | Arrhythmogenic Right Ventricular Cardiomyopathy | Pulmonary Stenosis | Congenital Hereditary Endothelial Dystrophy Type I | Hyperthermia, Malignant | Beckwith-Wiedemann Syndrome | Keratosis, Seborrheic | Primary Pigmented Nodular Adrenocortical Disease | Rotor Syndrome | Von Willebrand Disease | Aldosteronism | Wolman Disease | Osteogenesis Imperfecta | Hepatitis C, Chronic | Early Infantile Epileptic Encephalopathy 1 | Pneumonia, Mycoplasma | Takenouchi-Kosaki Syndrome | Rhabdoid Tumor | PASLI Disease | Lymphomatoid Granulomatosis | Stuve-Wiedemann Syndrome | Paronychia | Uremia | Emery-Dreifuss Muscular Dystrophy | Diverticulitis | Familial Cerebral Amyloid Angiopathy | Endometrial Hyperplasia | Avian Influenza | Oligoasthenoteratozoospermia | Coronary Heart Disease | Adrenomyeloneuropathy | Hyperostosis | Myoclonus-dystonia Syndrome | Intracerebral Hemorrhage | Epithelial-myoepithelial Carcinoma | Neurocutaneous Syndromes | Congenital Sodium Diarrhea | Majeed Syndrome | Hypertelorism | Spina Bifida | Protein S Deficiency | Whipple's Disease | McCune-Albright Syndrome | Moyamoya Disease | Carney Triad | Crigler-Najjar Syndrome | Meningococcal Meningitis | B-cell Chronic Lymphocytic Leukemia | Hyperandrogenemia | Nicolaides-Baraitser Syndrome | Huntington's Disease-like 2 | Nijmegen Breakage Syndrome | Osteogenesis Imperfecta Type VI | Robinow Syndrome | Lathosterolosis | Riboflavin Transporter Deficiency Neuronopathy | Sick Sinus Syndrome 1