Orthostatic Intolerance

About the Disease
Orthostatic Intolerance, also known as mitral valve prolapse, is related to postural orthostatic tachycardia syndrome and mitral valve prolapse 1, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Orthostatic Intolerance is SLC6A2 (Solute Carrier Family 6 Member 2), and among its related pathways/superpathways are Extracellular matrix organization and "Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics". The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include heart, thyroid and lung, and related phenotypes are elevated urinary norepinephrine and orthostatic tachycardia

Common Targets
MIR4761 | COMT

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