Lamellar Ichthyosis

About the Disease
Autosomal Recessive Congenital Ichthyosis, also known as lamellar ichthyosis, is related to ichthyosis, congenital, autosomal recessive 1 and ichthyosis, congenital, autosomal recessive 2. An important gene associated with Autosomal Recessive Congenital Ichthyosis is ALOX12B (Arachidonate 12-Lipoxygenase, 12R Type), and among its related pathways/superpathways are Keratinization and Prostaglandin 2 biosynthesis and metabolism FM. The drugs Bezafibrate and Ustekinumab have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and subthalamic nucleus, and related phenotypes are ichthyosis and abnormality of the nail

Common Targets
SPINK5 | CYP17A1 | TGM1 | ALOXE3 | SDR9C7 | CYP4F22 | ALOX12B | CERS3 | NIPAL4 | RARG | SLC26A4 | PNPLA1

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