Glioblastoma Multiforme

About the Disease
Glioblastoma, also known as glioblastoma multiforme, is related to brain cancer and glioma, and has symptoms including headache and seizures. An important gene associated with Glioblastoma is MIR21 (MicroRNA 21), and among its related pathways/superpathways is miRNAs involved in DNA damage response. The drugs Trametinib and Dabrafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and eye, and related phenotypes are glioblastoma multiforme and abnormal cell morphology

Common Targets
PTPN6 | XRCC1 | YES1 | G6714 | RASSF1 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | HCK | CTNNB1 | GPR174 | ITGAM | Glutamate Receptor Ionotropic AMPA Receptor | MPO | GDNF | AURKA | DNA-Directed DNA Polymerase Complex | G472 | ABL1 | BCL2L12 | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | G1956 | FGR | PDE4D | SCN2A | MST1R | G3576 | JAK2 | SLK | Protein farnesyltransferase | CDK4/Cyclin D1 | MIR222 | MDM4 | CCDC26 | CDC42BPB | LDLR | DPYD | TPM3 | CKMT2 | ZNF146 | PFAS | Protein Phosphatase 2A | GSR | H3-3B | HLA-E | ITGA1 | MTURN | SH3BP5 | G3309 | FAP | Integrin alphaMbeta2 (MAC-1) Receptor | Carbonic Anhydrase (nonspecified subtype) | MYO7B | PRR15 | AKAP12 | G6774 | CYP4X1 | Kainate Receptor (GluR) (nonspecified subtype) | G7015 | TLR3 | TTC12 | gamma-Secretase | GUCY2D | CSK | THBS1 | MDK | G2335 | Tyrosine-Protein Kinases Src (nonspecified subtype) | Serine/Threonine Kinase (nonspecified subtype) | SPEM2 | NLRP11 | LRRK2 | BTK | HDAC6 | HFE | CD99 | HDAC2 | L-type voltage-dependent calcium channel complex | IL13RA2 | LIPI | PKD2 | HDAC8 | SMO | ME1 | G3620 | Integrin alphavbeta3 (vitronectin) receptor | Heat shock protein 90 (nonspecified subtype) | CTAG1A | PDE4B | Cyclin-dependent kinase (nonspecified subtype) | SMARCA2 | PRMT5 | NAE1 | Inhibitor of Apoptosis Proteins (IAPs) (nonspecified subtype) | G59272 | G595 | HIF1A | BMI1 | NR1H2 | Thioredoxin-disulfide reductase (TrxR) (nonspecified subtype) | DRD4 | ELANE | CDK6 | KCND3 | VIM | Thyroid hormone receptor (nonspecified subtype) | MIR10B | MIR23B | SLC7A5 | ATRX | CSPG4 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | CNR2 | NF-kappaB (NFkB) | NMRK1 | AXL | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | LRRC55 | FAN1 | Hedgehog Protein (nonspecified subtype) | Ephrin Receptor (nonspecified subtype) | CA1 | T-Type Calcium Channel | HER (erbB) (nonspecified subtype) | Ribonucleoside-diphosphate reductase | TNC | ANO1 | LCK | BMX | CA12 | CALM1 | HDAC7 | SIGMAR1 | CCR7 | SCD | G1432 | CD3 Complex (T Cell Receptor Complex) | G5133 | MAPK11 | G598 | SGK1 | CSF1R | LOC102724428 | Calcium channel (nonspecified subtype) | NR1H3 | KLK11 | KIT | G1950 | EML4 | LOX | CSNK2A1 | CDK4 | Heat Shock Protein 27 (Hsp27) (nonspecified subtype) | G7295 | ALDH2 | IKZF1 | mTOR complex 1 | FPR1 | TNFRSF18 | CDKN2B | G29126 | DHODH | G5728 | IL4R | TOP1 | IDH1 | G4780 | CDK9/Cyclin T1 | SCN8A | SDCBP | G7852 | PMS2 | S1PR4 | SPTA1 | TACC3 | Fibroblast growth factor (FGF) (nonspecified subtype) | GCOM1 | EMP2 | KEAP1 | DDR2 | PIK3CB | KIF23 | BCR | TRPM8 | PIK3R1 | CYP4F12 | MIR17 | BRD4 | ENG | CLU | ARG1 | ELP1 | POU5F1 | DNM2 | PIK3CD | SULT1B1 | HARS1 | CCL8 | LACC1 | DNA Topoisomerase II (nonspecified subtype) | PHLDB1 | XIAP | DRD2 | FGFR3 | PFKFB3 | Chloride channel (nonspecified subtype) | LINC02908 | WEE1 | CDK9 | DOCK4 | CNR1 | Raf kinase (nonspecified subtype) | G673 | ADGRE1 | HDAC3 | ROS1 | IL-4 receptor | CCN2 | CDKN2B-AS1 | PDPN | Integrin alpha5beta1 (VLA-5) receptor | PMEL | DYRK1A | XPO1 | Chaperone (nonspecified subtype) | ITGB2 | TRPV2 | PBK | G1029 | MSI1 | PDGFRB | ANGPT2 | Integrin alphavbeta5 receptor | G142 | DYRK3 | KLRK1 | LDB3 | LAMP1 | MIR21 | FLI1 | RACK1 | HDAC1 | LOC283731 | CCNT1 | GPC3 | LOXL1 | G4170 | Tyrosine Kinase (nonspecified subtype) | Reverse transcriptase (Telomerase) | EPHA3 | TRPV1 | OLIG2 | PTCH1 | STAT5 (nonspecified subtype) | EFEMP1 | CCDC180 | PYGM | TGFBR1 | CLCN1 | CCL14 | PPARG | ANO2 | COL1A2 | CSMD1 | CEBPB | LHX5 | DNHD1 | SOCS3 | HLA-A | NEDD8-activating enzyme E1 | DCT | Voltage-Gated Sodium Channel Complex | LONRF3 | JAG1 | TSPO | G9429 | KLF11 | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | G2475 | MTSS1 | WWTR1 | CD70 | BCL2A1 | SMARCA4 | SLC22A18 | Interferon (nonspecified subtype) | XRCC3 | Pyruvate dehydrogenase kinase (nonspecified subtype) | TLR2 | CXCL12 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | RTEL1 | TES | MERTK | LOC105376244 | ACKR3 | LIPC | CDH18 | sigma Receptor (nonspecified subtype) | FLT4 | G3480 | EPHB6 | CCND3 | mTOR complex 2 | LRP1 | CD93 | FOLH1 | STK17A | PPP5C | WEE2 | KIF11 | CCDC8 | TCIRG1 | IDH2 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | HIPK2 | FOXA2 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | SEMA3F | KDM1A | FLT1 | FRK | CLCN3 | RAD51 | G7157 | ADP/ATP Translocase (nonspecified subtype) | Sodium channel (nonspecified subtype) | LDHA | TYRO3 | ABTB1 | GRM3 | BLK | G4318 | FGFR1 | PPP1R3B | KLRC4-KLRK1 | Dopamine receptor (nonspecified subtype) | LOXL2 | HID1 | RARB | PKM | BCL2L2 | PROM1 | CHI3L1 | RAF1 | Transcriptional Enhancer Factor (TEAD) (nonspecified subype) | FASN | SIK2 | IFT46 | DDR1 | ADGRE5 | CLK1 | TEK | EPHA2 | L-Type calcium channel (nonspecified subtype) | PIM1 | Poly [ADP-ribose] polymerase (nonspecified subtype) | ERN1 | PRKCB | G4193 | Cannabinoid receptor (nonspecified subtype) | LOXL4 | BRD3 | PDCD1LG2 | CA2 | DYRK1B | Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase (SERCA) (nonspecified subtype) | Tubulin | PRLR | FASLG | CA9 | KL | CTAG1B | MSR1 | SCN9A | LYN | TNFRSF4 | TMEM71 | CRAMP1 | HAVCR2 | BAZ1B | CDC42BPA | PLAU | ADRB2 | PGF | NGLY1 | SIK1 | MMP2 | LOXL3 | Notch receptor (nonspecified subtype) | Focal Adhesion Kinases (FAK) (nonspecified subtype) | LIPE | G1786 | ERBB4 | CDK6/Cyclin D3 | TLR9 | ALKBH5 | SEMA3A | HPSE | LRP2 | CTLA4 | NMDA receptor | G5743 | RRAD | NF1 | G3082 | CTSB | ANGPT1 | Cyclin-dependent kinase inhibitor (nonspecified subtype) | G4233 | WT1 | PIK3CA | LTC4S | MIR600HG | PARP2 | CD47 | FAS | NOS2 | NT5E | ADCY1 | CTDSP1 | AGER | G7124 | STARD9 | IL-13 receptor | G367 | G2064 | MAPK7 | CCR5 | HES3 | CALCR | FLT3 | EXOC3L4 | TACSTD2 | ALB | DYRK2 | FYN | IL1RAPL2 | NQO1 | ABCC1 | MYCN | TRPA1 | BST2 | MMP14 | ATF5 | BIRC5 | AQP1 | FTO | COL6A3 | SLC2A3 | PDGFRA | STING1 | TNFRSF1A | OR4X1 | Integrin alpha2beta1 (VLA-2) receptor | RARG | PCDHAC1 | Proteasome Complex | RET | Potassium Channels (nonspecified subtype) | 11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype) | NLRP3 Inflammasome | TOP2A | VHL | MGMT | G5243 | CLK2 | Histone deacetylase (nonspecified subtype) | ALDH1A3 | DRD3 | TXK | ALOX5 | PLAUR | DLL4 | RTEL1-TNFRSF6B | MAGEA1 | FGF2 | CD19 | DNA-Dependent Protein Kinase (DNA-PK) | CD276 | R3HDM4 | ARG2 | LIPG | CHRM2 | KCNN2 | alpha-Mannosidase (nonspecified subtype) | CYP19A1 | EPAS1 | HOTAIR | G238 | MFSD9 | PPT1 | TYMP | RIPK2 | SHMT1 | GSTP1 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | G596 | LHPP | G5347 | WNT4 | GPR55 | MSH6 | NOM1 | CRBN | APEH | TGFBR2 | G114548 | CDK4/Cyclin D3 | Protein Phosphatase (nonspecified subtype) | KDR | PIK3CG | G10413 | HNMT | MMP1 | EWSR1

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