Turner's Syndrome

About the Disease
Turner Syndrome, also known as monosomy x, is related to 45,x/46,xy mixed gonadal dysgenesis and noonan syndrome 1. An important gene associated with Turner Syndrome is SHOX (Short Stature Homeobox), and among its related pathways/superpathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Endochondral ossification. The drugs Propofol and Cilostazol have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and kidney, and related phenotypes are short neck and osteopenia

Common Targets
SHANK3 | TGFB1 | CDK4 | BMP4 | MYO9B | LHX4 | GH1 | MYOD1 | MTRR | NR5A1 | ZFAT | G2099 | PTPN1 | G3480 | IGFBP3 | NIPBL | ZFPM2 | PPP1CB | G367 | GHR | VDR | PTPN22 | AIRE | MTHFR | G3845 | SYCE1 | PIK3R3 | 11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype) | PPARGC1A | NOBOX

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