Disease

Metabolic Diseases

About the Disease
3-Hydroxyacyl-Coa Dehydrogenase Deficiency, also known as hadh deficiency, is related to long-chain 3-hydroxyacyl-coa dehydrogenase deficiency and hyperinsulinemic hypoglycemia, familial, 4, and has symptoms including emaciation An important gene associated with 3-Hydroxyacyl-Coa Dehydrogenase Deficiency is HADH (Hydroxyacyl-CoA Dehydrogenase). The drugs Naloxone and Buprenorphine have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and skeletal muscle, and related phenotypes are feeding difficulties in infancy and growth delay

Common Targets
SLC6A3 | PCSK1 | GLP1R | G5743 | IFNG | BRDT | MDH1 | KCNQ2 | F12 | GCGR | CDK7 | GRB2 | NLRP3 Inflammasome | Complement component 1q | FLT3 | GRIN2B | BRD7 | HAO1 | ECHS1 | RUNX1T1 | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | Superoxide dismutase (SOD) (nonspecified subtype) | Diacylglycerol Acyltransferase (DGAT) (nonspecified subtype) | MTHFR | PTPN6 | CYP19A1 | Histone deacetylase (nonspecified subtype) | SLC5A2 | BDKRB2 | SOS1 | SIRT2 | PASK | TMEM70 | HMOX1 | G238 | APOA2 | ICOS | HTR7 | INPPL1 | ITGAM | ADAMTS7 | LPL | MLKL | MIPEP | G3320 | LRP6 | ENPP2 | PIK3CG | CARM1 | FFAR4 | GPR119 | MMUT | HRH3 | JAK3 | GPBAR1 | MIR33B | TGFBR3 | G5599 | CTNNB1 | ASNS | NTRK2 | G6647 | EDNRA | PRMT6 | PTPN2 | MIR33A | ANGPTL4 | GPR35 | GFPT2 | Protein farnesyltransferase | JAK1 | CISD2 | TMPRSS15 | G596 | MCOLN2 | MPDZ | ALDH1A2 | APOA4 | Integrin alphaMbeta2 (MAC-1) Receptor | G3845 | LDLR | NR2E1 | RORC | KCNQ4 | TTR | F2RL1 | FAP | FKBP4 | C1S | VEGFB | OXCT1 | POLRMT | KISS1 | ABL1 | G114548 | DAO | Interleukin 17 (nonspecified subtype) | CRBN | GBA1 | PRMT8 | KDR | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | MKNK2 | DNA-Directed RNA Polymerase (nonspecified subtype) | G1956 | DGAT1 | APOA5 | CPS1 | FFAR1 | IVD | CYB5A | TFRC | NR1I3 | KCNA3 | RXFP3 | GHSR | Carbonic Anhydrase (nonspecified subtype) | TLR8 | THRB | SLC13A2 | PRKCZ | CCNH | LanC-like proteins (nonspecified subtype) | SMARCA2 | TAFAZZIN | ARRB2 | FZD1 | ACP1 | COG7 | HDAC8 | Tyrosine-Protein Kinases Src (nonspecified subtype) | LRRK2 | JAK2 | AHCY | TLR3 | FCGRT | RARA | GFRAL | PNPLA3 | E3 ubiquitin-protein ligase (nonspecified subtype) | NR3C2 | LGALS3 | PRMT5 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | ADRA2B | NR1H2 | CYSLTR1 | GIP | IGFALS | DUSP22 | HSP90AB1 | G7124 | HADHA | ANGPTL3 | HDAC2 | PDE4B | DGAT2 | MGLL | Acid-Sensing Ion Channel (ASIC) (nonspecified subtype) | AGT | YWHAG | DCUN1D1 | LPAR1 | POMC | AMP-activated protein kinase (AMPK) | MIR208A | HDAC6 | TRPV6 | MCOLN1 | Integrin alphavbeta3 (vitronectin) receptor | GCK | CISD3 | RTN4 | KCNQ3 | Phospholipase A2 (nonspecified subtype) | FFAR3 | Alkaline Phosphatase (ALP) (nonspecified subtype) | G3620 | UGCG | MKRN1 | CD320 | EPHX2 | SCD | CYP17A1 | CA1 | CDT1 | ANGPTL6 | BTK | PKLR | PYCR1 | EIF2AK2 | CHIT1 | Folate Receptor (nonspecified subtype) | APLNR | G207 | C5 | ACSS2 | HIF1A | ROCK1 | G6774 | SCARB1 | SORT1 | MAP3K5 | HRH2 | CCR4 | HIBADH | TMPRSS6 | EML4 | NR1H3 | MMP3 | ACOX2 | ADP-Ribosyl Cyclase/cyclic ADP-Ribose Hydrolase (ADPRC) (nonspecified subtype) | KHK | MAP3K11 | BACE2 | CCKBR | SLC22A12 | ELANE | Protein Kinase B (PKB/Akt) (nonspecified subtype) | LAG3 | MIR122 | ARRB1 | TIPARP | DNAJC15 | BRD2 | P2RY6 | MKNK1 | TNFRSF18 | Fibroblast growth factor (FGF) (nonspecified subtype) | LCK | FKBP1A | GBE1 | HCRTR1 | PPARA | MRC1 | S1PR2 | CNR2 | IL1B | KRT18 | PDE10A | TYR | Survival of motor neuron (SMN) complex | FKTN | MAP3K14 | ACVR2A | CSF1R | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | ANGPTL2 | PIP4K2B | PFKFB3 | TNFSF11 | HDAC11 | IAPP | ADORA2B | CD3 Complex (T Cell Receptor Complex) | KEAP1 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | TOP1 | G3569 | Oxysterols receptor LXR (nonspecified subtype) | ESR2 | TYK2 | DDR2 | G5133 | SLC13A5 | APOC3 | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | ATP5F1D | Amylin receptor | PCSK9 | IKZF1 | TANGO2 | KIT | SUCLA2 | SLC6A2 | MAOA | G29126 | BCR | PGAM5-KEAP1-NRF2 Complex | UTS2R | FFAR2 | Neurotrophic Tyrosine Kinase Receptor (TRK) (nonspecified subtype) | Arrestin (nonspecified subtype) | G4780 | G23411 | NTMT1 | Adenosine deaminase (nonspecified subtype) | MAP1LC3B | L2HGDH | PRMT1 | GIPR | NR1I2 | ITGB2 | CCN2 | ADA | AASS | NF-kappaB (NFkB) | G5595 | BRD4 | HDAC3 | DYRK1A | ANGPT2 | LCP2 | G673 | G7852 | OPRL1 | PIK3CD | Casein kinase II (CKII) | Prokineticin Receptor (PK-R) (nonspecified subtype) | cAMP-Dependent protein kinase (PKA) | TNKS2 | MAP4K4 | Estrogen receptor (nonspecified subtype) | ACAT1 | MC3R | NTRK3 | CNR1 | SCTR | CCR2 | MCOLN3 | HSD11B1 | FKBP5 | OGT | MAPK9 | CES1 | CD38 | SUGCT | PPARD | MAPKAPK2 | RORA | IRAK4 | ABHD6 | EZH1 | FABP5 | DLST | SUCNR1 | DPP4 | ACVR2B | MFN2 | RNF4 | Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) (nonspecified subtype) | OXT | MAP4K1 | G142 | AKT2 | GRIN2A | G7099 | PDGFRB | STK17B | HDAC1 | ESRRA | Pyruvate dehydrogenase kinase (nonspecified subtype) | AKR1B1 | TRNT1 | SYK | CDK12/Cyclin K | Retinoid acid receptor (nonspecified subtype) | ADRB1 | SMARCA4 | G3605 | HCRTR2 | HSD17B13 | GPR183 | GPR84 | PNPLA2 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | NTSR1 | FDPS | TRPV1 | BCAT1 | LIPC | ATF3 | UBE2M | NUAK1 | XDH | ADCYAP1R1 | ACMSD | NTRK1 | AKR1C3 | STS | CHIA | PTGS1 | PTPN1 | NR1H4 | SGMS2 | ACHE | AMT | G9429 | SI | FBP1 | ADM | IKZF3 | PPARG | Transforming growth factor beta (nonspecified subtype) | LDHA | IL1RAP | G2033 | FOLR1 | SLC34A1 | TPH1 | G2475 | MSTN | RARB | KDM1A | GRK5 | FAAH | UCHL1 | USP30 | LANCL2 | MEFV | ROR1 | ALDH5A1 | MCEE | RORB | SMN1 | TALDO1 | G2099 | Fatty Acid Binding Protein (nonspecified subtype) | SIRT5 | ENPP1 | ACACB | FGFR1 | CLK1 | TNFRSF17 | G3630 | Integrin alphavbeta6 receptor | INHBE | Ikzf1 | PIN1 | CCKAR | Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase (SERCA) (nonspecified subtype) | ERN1 | CISD1 | NR1D2 | SLC2A1 | SURF4 | GMNN | LDHB | Glutaminase (nonspecified subtype) | DAGLA | FASN | SIK2 | G836 | HTT | APOA1 | Mitogen-Activated Protein Kinase (nonspecified subtype) | Poly [ADP-ribose] polymerase (nonspecified subtype) | MYB | PIM1 | DYRK1B | GLP2R | MAPK10 | DDR1 | FPR2 | TEK | MSR1 | GLB1 | PBRM1 | ESRRG | PDHA1 | SLC5A1 | NPR1 | AP-1 Transcription Factor Complex | OTC | EGLN1 | Sphingolipid delta(4)-desaturase (nonspecified subtype) | SLC22A5 | ATF4 | G196 | BRD3 | BCAT2 | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | ACLY | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | MANBA | ERBB4 | TNFRSF4 | NOS3 | METAP2 | DDB1 | SMN2 | SSTR5 | TIGIT | HNF4A | CAMKK1 | GHRHR | NR1D1 | CDK7/Cyclin H | MC4R | FMO3 | PIP4K2A | alpha1-Adrenoceptor (nonspecified subtype) | G8678 | RXFP4 | Complement Complex | CMKLR1 | LIPE | ROCK2 | TREML4 | SLC6A4 | LPA | SHPK | RYK | Nuclear Receptor ROR (nonspecified subtype) | FABP4 | GAA | PNLIP | CALCR | ATP6AP1 | RIPK3 | DEGS2 | Major histocompatibility complex class II antigens (nonspecified subtype) | DYRK2 | GPR39 | APOB | NADK2 | Retinoid RXR receptor (nonspecified subtype) | AGTR1 | NNMT | GALR2 | G3146 | SLC2A3 | NMDA receptor | USP7 | DEGS1 | PARP2 | NAMPT | ETFDH | SIRT3 | NT5E | PRMT3 | ACACA | GRK2 | CAV3 | BRD9 | NQO1 | FGL1 | NR3C1 | G8878 | MCHR1 | IL22RA1 | G367 | ECHDC1 | ALDH1A3 | RARG | FKBP1B | HTR2C | LGALS1 | TBK1 | 11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype) | REN | ALB | KRR1 | TAAR1 | GRK6 | CCL2 | CRP | CYP11B2 | DLL4 | CREBBP | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | CDK12 | PNLIPRP2 | GLDC | IKBKE | HTR2A | PTPN11 | FADS1 | G2064 | PIK3CA | PNPO | CAMKK2 | Tubulin | CD5 | Eukaryotic translation initiation factor 2B | LPIN1 | VDR | P2RX7 | SIRT6 | Acyl-CoA Synthetase Short-Chain (nonspecified subtype) | EPAS1 | RIPK1 | FTCD | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | STING1 | NOS2 | HRH4 | MIF | OXTR | ALOX5 | LIPG | RET | G2146 | SLC22A11 | INPP5D | PDGFRA | VHL

疾病靶点研报
Metabolic Diseases

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