Large Granular Lymphocytic Leukemia

About the Disease
T-Cell Large Granular Lymphocyte Leukemia, also known as proliferation of large granular lymphocytes, is related to lymphoproliferative syndrome and prolymphocytic leukemia. An important gene associated with T-Cell Large Granular Lymphocyte Leukemia is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Levoleucovorin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, t cells and bone, and related phenotypes are immune system and hematopoietic system

Common Targets
IL-15 receptor | KLRD1 | IL-2 receptor | IL9R | KLRC1

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