Mandibuloacral Dysplasia With Type A Lipodystrophy

About the Disease
Mandibuloacral Dysplasia with Type a Lipodystrophy, also known as mandibuloacral dysplasia, is related to hutchinson-gilford progeria syndrome and restrictive dermopathy 1, and has symptoms including joint stiffness An important gene associated with Mandibuloacral Dysplasia with Type a Lipodystrophy is LMNA (Lamin A/C), and among its related pathways/superpathways are Adipogenesis and Overlap between signal transduction pathways contributing to LMNA laminopathies. Affiliated tissues include skin, bone and eye, and related phenotypes are high palate and short stature

Common Targets
ZMPSTE24 | LMNA | POLD1

Note: If you'd like to get a target analysis report for Mandibuloacral Dysplasia With Type A Lipodystrophy, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Mandibuloacral Dysplasia With Type A Lipodystrophy at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Scapuloperoneal Myopathy, X-linked Dominant | Rash | Pseudohypoaldosteronism | Rotor Syndrome | Temporal Lobe Epilepsy | Iron Metabolism Disorders | Opisthorchiasis | Episodic Ataxia Type 2 | Epidermolysis Bullosa Acquisita | Exfoliative Dermatitis | 3-methylcrotonyl-CoA Carboxylase Deficiency | Familial Partial Lipodystrophy | Tylosis With Esophageal Cancer | Erdheim-Chester Disease | Brachial Plexus Neuropathy | Stromal Corneal Dystrophy | Presbycusis | Angioedema, Acquired | Kearns-Sayre Syndrome | Recurrent Respiratory Papillomatosis | Thalassemia | Acute Leukemia | Kaposiform Hemangioendothelioma | REM Sleep Behavior Disorder | Osteosclerosis | Pseudohermaphroditism | Cranioectodermal Dysplasia | Wagner Disease | Gliosarcoma | Saethre-Chotzen Syndrome | Tetraplegia | Adenylosuccinate Lyase Deficiency | Esophageal Carcinoma | Diffuse Intrinsic Pontine Glioma | Hoyeraal-Hreidarsson Syndrome | Cantu Syndrome | Charcot-Marie-Tooth Disease Type 4D | Multiple Sclerosis, Primary Progressive | Farber Disease | Sleep Apnea | Oculodentodigital Dysplasia | Fetal Alcohol Syndrome | Hypertelorism | Retinal Telangiectasia | Mood Disorder | Pontocerebellar Hypoplasia | Epidermolytic Palmoplantar Keratoderma | Spinocerebellar Ataxia Type 13 | Hypermethioninemia | Pulmonary Capillary Hemangiomatosis | Pseudohypoparathyroidism Type 1A | Ollier Disease | Chiari Malformation Type I | Urethritis | Lateral Meningocele Syndrome | Glioma | Ocular Hypertension | MELAS Syndrome | Benign Familial Pemphigus | Peeling Skin Syndrome, Acral Type | Sorsby Fundus Dystrophy | TARP Syndrome | Tay-Sachs Disease | Corneal Dystrophy | DICER1 Syndrome | Osteogenesis Imperfecta Type V | Spinocerebellar Ataxia Type 1 | Cenani-Lenz Syndactyly Syndrome | Hydrocephalus | Pemphigus | Thymoma, Malignant | Protein S Deficiency | CREST Syndrome | Leber Hereditary Optic Neuropathy | Anovulation | Cataract | Perivascular Epithelioid Cell Tumor | Hypoparathyroidism | Spinocerebellar Ataxia Type 14 | Dent Disease | Gigantism | Renal Tubular Acidosis | Pulverulent Zonular Cataract | DiGeorge Syndrome | Lymphoma, Mantle Cell | Coffin-Siris Syndrome | Alopecia Totalis | Epilepsy | Alkaptonuria | Malaria, Cerebral | Peters-plus Syndrome | Acromicric Dysplasia | Cholera | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Hyperacusis | Cryoglobulinemia | HIBCH Deficiency | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Early Infantile Epileptic Encephalopathy 28 | Retinal Dystrophy | Waardenburg Syndrome Type 2 | Hydrops Fetalis | Sotos Syndrome | Sialidosis | Basal Ganglia Disease | Centronuclear Myopathy | Hemorrhage | Endometriosis | Insulinoma | Adenoma, Villous | Gastrointestinal Disorders | Reflex Epilepsy | Combined Pituitary Hormone Deficiency | Chordoid Glioma | Multisystemic Smooth Muscle Dysfunction Syndrome | Acrodysostosis | Platelet Disorders | Hypervalinemia | Generalized Epilepsy With Febrile Seizures Plus | Dengue Hemorrhagic Fever | Cerebrovascular Disorders | MIRAGE Syndrome | Brooke-Spiegler Syndrome | Wolcott-Rallison Syndrome | Pneumonia, Bacterial | Cryopyrin-associated Periodic Syndromes | Autosomal Recessive Congenital Ichthyosis | Behavioral Variant Of Frontotemporal Dementia | Noonan Syndrome-like Disorder With Loose Anagen Hair | Charcot-Marie-Tooth Disease Type 3 | Lupus Erythematosus | Spastic Paraplegia Type 7 | Pseudohypoparathyroidism Type 1C | Osteochondrosis | Retinopathy Of Prematurity | Progressive Encephalopathy-optic Atrophy Syndrome | Small Lymphocytic Lymphoma | Multiple System Atrophy | Pemphigus Foliaceus | Cleidocranial Dysplasia | Hyperuricemia | Leukoencephalopathy, Progressive Multifocal | Maternally Inherited Diabetes And Deafness | Crohn's Disease | Li-Fraumeni Syndrome | Neuronal Ceroid Lipofuscinosis | Panuveitis | Allan-Herndon-Dudley Syndrome | Nemaline Myopathy 8 | Parkinson Disease 6, Autosomal Recessive Early-onset | Bronchiolitis | Meniere's Disease | Methemoglobinemia Type IV | GM2-gangliosidosis AB Variant | Aldosteronism | Anal Fissure | Fibromyalgia | Hereditary Sensory Neuropathy Type 1 | McKusick Type Metaphyseal Chondrodysplasia | Ectopia Lentis, Isolated, Autosomal Recessive | Precocious Puberty | Plasmacytoma | Larsen Syndrome | Congenital Myopathy | Dysplastic Nevus | Neurofibroma, Plexiform | Camurati-Engelmann Disease | Basan Syndrome | Lentigo | Angina Pectoris | Sezary Syndrome | Cold Agglutinin Disease | Schistosomiasis Mansoni | Pyruvate Carboxylase Deficiency Disease | Neuromyotonia | Myofibromatosis | Granuloma Annulare | Familial Pheochromocytoma-paraganglioma | Renal Tubular Dysgenesis | Ichthyosis Hystrix, Curth-Macklin Type | Urofacial Syndrome | Sialoadenitis | Oligoasthenoteratozoospermia | Oligospermia | Liver Diseases | Neurocutaneous Melanocytosis | Budd-Chiari Syndrome | Esotropia | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Pyloric Stenosis, Infantile Hypertrophic | Intellectual Disability, Autosomal Dominant 5 | Phenylketonuria II | Chondrodysplasia Punctata 1, X-linked Recessive | AIDS Dementia Complex | Pneumonia, Mycoplasma | Cystitis, Interstitial | Pearson Syndrome | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Guttate Psoriasis | Sarcosinemia | Strabismus | Chorioretinitis | Carotid Artery Disease | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Myeloid Leukemia | Aneurysm, Thoracic Aortic | Hypoglycemia | Restrictive Dermopathy | Meningioma, Benign | Transient Bullous Dermolysis Of The Newborn | Hypoalbuminemia | Cardiomyopathy, Peripartum | Treacher Collins Syndrome | Homocystinuria | Pernicious Anemia | ADNP Syndrome | Adrenal Insufficiency | Behcet's Disease | Methemoglobinemia | Craniofacial Dysostosis | Mycosis Fungoides | Congenital Absence Of Vas Deferens | Contact Dermatitis | Neurocutaneous Syndromes | Porphyria | Alopecia | Keloid | Metachondromatosis | Hypertrophy | Hereditary Elliptocytosis | Atelosteogenesis Type 1 | Neurodevelopmental Disorders | Retinal Dystrophy, Early-onset Severe | Paroxysmal Kinesigenic Dyskinesia | Triple A Syndrome | Marinesco-Sjogren Syndrome | Tatton-Brown-Rahman Syndrome | Allergic Contact Dermatitis | Neural Tube Defect | Chronic Granulomatous Disease | Osmotic Demyelination Syndrome | Pleurisy | Panniculitis | Raynaud Phenomenon | Glycogen Storage Disease Type 9 | Intestinal Hypomagnesemia 1 | Citrullinemia | Otitis Media | Familial Hypertrophic Cardiomyopathy | Pain | Adenoid Cystic Carcinoma | Lafora Disease | Beckwith-Wiedemann Syndrome | Renal Medullary Carcinoma | Becker Muscular Dystrophy | Cutis Laxa | Down Syndrome | B-cell Chronic Lymphocytic Leukemia | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Smoldering Myeloma | Glomerulonephritis, Membranoproliferative | Ornithine Transcarbamylase Deficiency | Choriocarcinoma | Fundus Albipunctatus | Hemoglobinopathies | Dystonia-parkinsonism, X-linked | Melanocytic Nevus | Apparent Mineralocorticoid Excess Syndrome | Bardet-Biedl Syndrome | Pineoblastoma | Seborrheic Dermatitis | Familial Dysautonomia | Leukodystrophies | Lymphopenia | Rheumatic Heart Disease | Liver Failure, Acute Infantile | Majeed Syndrome | Mucolipidosis Type III | Hemorrhagic Disorders | Palsy, Cerebral | Osteoporosis-pseudoglioma Syndrome | Osteitis | Androgenic Alopecia | Preaxial Polydactyly | Renpenning Syndrome | High Molecular Weight Kininogen Deficiency | Atrioventricular Septal Defect | Carpenter Syndrome | Growth Hormone Excess | Meningococcal Infections | Sleep Apnea, Central | Frontotemporal Dementia | Cancer, Bladder | Neurofibromatosis Type 2 | Amyotrophic Lateral Sclerosis | Keratocystic Odontogenic Tumor | Hypothyroidism | Inflammatory Joint Disease | Infantile Spasm | Hennekam Lymphangiectasia-lymphedema Syndrome | Neurofibromatosis-Noonan Syndrome | Ameloblastic Carcinoma | Blepharospasm | Acanthosis Nigricans | Craniopharyngioma | Dermatofibrosarcoma | Bursitis | Hidradenitis | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Ichthyosis | Hyperlipidemia Type V | Membranous Nephropathy | Osteoarthritis | T-cell Chronic Lymphocytic Leukemia | Oral Lichen Planus | Fascioliasis | Menkes Disease | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Cryptococcal Meningitis | Schindler Disease | Hepatitis A | Rothmund-Thomson Syndrome | Alpha-mannosidosis | Early Infantile Epileptic Encephalopathy 1 | Hyperkeratosis | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Nevus | Congenital Disorders Of Glycosylation | Gout | Optic Nerve Hypoplasia, Bilateral | Anti-NMDA Receptor Encephalitis | Echinococcosis | Dermatitis Herpetiformis | Chronic Lymphocytic Leukemia | Chitayat Syndrome | Neurocysticercosis | Tricho-hepato-enteric Syndrome | Hypertension, Renal | Evans Syndrome | Hypercholesterolemia | Encephalitis | Hemangioma | Autoimmune Polyendocrine Syndrome | Speech Disorders | Renal Dysplasia | Familial Hemiplegic Migraine | Hodgkin Lymphoma | Desmosterolosis | Mumps | Hyperparathyroidism | Primary Biliary Cholangitis | Spondylo-ocular Syndrome | Hypercalcemia | Astrocytoma, Anaplastic | Bronchitis | Parkinson's Disease | Angioedema, Hereditary | Oguchi Disease-2 | Autosomal Recessive Spastic Paraplegia Type 54 | Mucolipidosis Type II | Progressive Myoclonic Epilepsy | Tyrosinemia | Glanzmann Thrombasthenia | Retinoblastoma | 3-hydroxy-3-methylglutaric Aciduria | Iron Deficiency Anemia | SAPHO Syndrome | Specific Granule Deficiency | Hypokalemia | Von Hippel-Lindau Disease | Angioimmunoblastic T-cell Lymphoma | Multiple Sclerosis, Relapsing-remitting | Tendinopathy | Inflammatory Myofibroblastic Tumor | Congenital Mirror Movements | Congenital Torticollis | Adenosine Deaminase 2 Deficiency | Duodenal Atresia | Birt-Hogg-Dube Syndrome | Hypotrichosis Simplex | Familial Digital Arthropathy-brachydactyly | Lipoma | Cousin Syndrome | Congenital Dyserythropoietic Anemia Type 4 | Schistosomiasis | Actinomycetoma | Blue Rubber Bleb Nevus Syndrome | Acute Motor Axonal Neuropathy | Spinocerebellar Ataxia Type 16 | Diabetes Mellitus, Transient Neonatal | Corneal Dystrophies, Hereditary | Pemphigoid | Pulmonary Alveolar Microlithiasis | Chondrodysplasia Punctata 2, X-linked Dominant | Carcinoma, Squamous Cell | Oculopharyngeal Muscular Dystrophy | Photosensitivity | Joubert Syndrome 2 | Glomerulonephritis | Glycogen Storage Disease Type 1b