Congenital Disorders Of Glycosylation

About the Disease
Congenital Disorder of Glycosylation, Type in, also known as congenital disorder of glycosylation, is related to congenital disorder of glycosylation, type im and congenital disorder of glycosylation, type iim, and has symptoms including ataxia, muscle spasticity and myoclonus. An important gene associated with Congenital Disorder of Glycosylation, Type in is RFT1 (RFT1 Homolog), and among its related pathways/superpathways are Metabolism of proteins and Disease. The drugs Acetazolamide and Sorbitol have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and heart, and related phenotypes are global developmental delay and seizure

Common Targets
DPM2 | SLC35A2 | MAN2B2 | PKHD1L1 | CRIM1 | WDR41 | TMCC3 | PIGW | ALG2 | ALG12 | GALE | ALG11 | FUT8 | SRD5A3 | GALNT2 | DOLK | Chaperone (nonspecified subtype) | STPG2 | TRAPPC11 | PLXNA4 | HRNR | STT3B | SLC35A1 | MPI | DHDDS | COG4 | STT3A | XYLT2 | CKAP2 | MOGS | DDOST | COG6 | NBAS | COL6A2 | GALT | GLUL | MAN1B1 | DPAGT1 | EDEM3 | DPH7 | SSR4 | COG1 | CSGALNACT1 | ATP6V1A | STX5 | ALDOB | ALG3 | COG2 | ATP6AP1 | DPM3 | ALG1 | GMPPA | TMEM199 | OSTC | ALG6 | PGM1 | SLC5A2 | DPM1 | RFT1 | PIGS | PGM3 | FCSK | SLC39A8 | PMM2 | ALG13

Note: If you'd like to get a target analysis report for Congenital Disorders Of Glycosylation, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Congenital Disorders Of Glycosylation at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Fascioliasis | Pseudoachondroplasia | Pituitary Stalk Interruption Syndrome | Larsen Syndrome | Cerebellar Ataxia, Cayman Type | Hypolipoproteinemia | Primary Cutaneous Amyloidosis | Thymoma, Malignant | Mevalonate Kinase Deficiency | Congenital Adrenal Hyperplasia | Jacobsen Syndrome | Non-epidermolytic Palmoplantar Keratoderma | Schizencephaly | Basal Ganglia Disease, Biotin-responsive | Benign Hereditary Chorea | Trigonocephaly | Oligodendroglioma | Scleroderma | Rhizomelic Chondrodysplasia Punctata | Interstitial Lung Diseases | Primary Hyperoxaluria Type 1 | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Retinoschisis | Periodontitis | Schistosomiasis Mansoni | Camptocormia | Macular Corneal Dystrophy Type 1 | Amenorrhea | Glycogen Storage Disease Type 4 | Scabies | Polycystic Liver | Glucagonoma | Lipid Storage Diseases | Intracranial Hypertension | ICF Syndrome | Cryptococcal Meningitis | Myhre Syndrome | Aspartylglycosaminuria | Hypercholesterolemia | Pleomorphic Xanthoastrocytoma | Familial Hypobetalipoproteinemia | Subacute Sclerosing Panencephalitis | H Syndrome | L-2-Hydroxyglutaric Aciduria | Familial Hyperaldosteronism | Klippel-Feil Syndrome | Episodic Ataxia | Juvenile Myelomonocytic Leukemia | Diabetic Macular Edema | Hepatitis | Apraxia | Nager Acrofacial Dysostosis | Inflammatory Myopathy | Focal Cortical Dysplasia Type 2 | Chorioretinitis | Anal Fissure | Lyme Disease | Lattice Corneal Dystrophy | Stargardt Disease | Chronic Granulomatous Disease, X-linked | Hyperacusis | Neurofibromatosis-Noonan Syndrome | Muscular Dystrophy | Mastitis | Neurofibromatosis | Galactosialidosis | Barakat Syndrome | Rhabdomyosarcoma, Embryonal | Hypopigmentation | Congenital Primary Aphakia | Aromatic L-amino Acid Decarboxylase Deficiency | Chorea | Sclerosing Cholangitis | Pseudohypoaldosteronism | Gitelman Syndrome | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Malonyl-CoA Decarboxylase Deficiency | Osteopathia Striata With Cranial Sclerosis | C3 Glomerulopathy | Cornelia De Lange Syndrome | Micropenis | Hypertrophy | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Melnick-Needles Syndrome | Renal Oncocytoma | Sensory Neuropathy | Neurofibroma | Depression | Hypertriglyceridemia | Cold Agglutinin Disease | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Osteoporosis | Mitochondrial DNA Depletion Syndrome 13 | Hyperandrogenemia | Lymphoma, Mantle Cell | Hypersensitivity | Adams-Oliver Syndrome | Renal Failure | Coffin-Lowry Syndrome | Retinal Degeneration | Ehlers-Danlos Syndrome | Occipital Neuralgia | Schwartz-Jampel-Aberfeld Syndrome | Progressive Familial Intrahepatic Cholestasis Type 1 | Leri-Weill Dyschondrosteosis | Pseudoexfoliation Syndrome | Nevus | Neurodermatitis | Poretti-Boltshauser Syndrome | Dermatitis | Dengue Hemorrhagic Fever | Neurofibroma, Plexiform | Lymphoma | Glomerulonephritis | Adenylosuccinate Lyase Deficiency | Burn-McKeown Syndrome | X-linked Charcot-Marie-Tooth Disease | Moyamoya Disease | Tyrosine Hydroxylase Deficiency | Spondyloepiphyseal Dysplasia Tarda, X-linked | Retinal Coloboma | GLUT1 Deficiency Syndrome | Carcinoma In Situ | Meleda Disease | Citrullinemia | Primary Progressive Aphasia | Costello Syndrome | Hepatic Adenomatosis | Waardenburg Syndrome Type 4 | Barrett Esophagus | COACH Syndrome | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Nephritis, Interstitial | Coffin-Siris Syndrome | Dysfibrinogenemia | Gastritis, Atrophic | Ectodermal Dysplasia | Bulimia Nervosa | Anti-glomerular Basement Membrane Disease | Polyarteritis Nodosa | Mitochondrial Cytopathy | Fibrillation, Atrial | Lysosomal Acid Lipase Deficiency | Congenital Myopathy | Blomstrand Osteochondrodysplasia | Schizotypal Personality Disorder | Agnathia-Otocephaly Complex | Adrenoleukodystrophy, X-linked | Dystonia | Klinefelter Syndrome | Anxiety Disorders | Pleural Tuberculosis | Alexander Disease | Duodenal Atresia | Gliosarcoma | Constipation | Dysferlinopathy | Spinocerebellar Ataxia Type 27 | Persistent Mullerian Duct Syndrome | Charcot-Marie-Tooth Disease Type 2D | Primary Torsion Dystonia | Pineoblastoma | GM2-gangliosidosis AB Variant | Alveolar Capillary Dysplasia | Ectrodactyly | Waardenburg Syndrome | Preaxial Polydactyly | Early Infantile Epileptic Encephalopathy 28 | Asthma | Li-Fraumeni Syndrome | Hereditary Hemorrhagic Telangiectasia Type 2 | Fanconi Syndrome | Porphyria, Acute Intermittent | Cohen Syndrome | Haim-Munk Syndrome | Gerodermia Osteodysplastica | Alpha-1 Antitrypsin Deficiency | Hyperuricemic Nephropathy, Familial Juvenile | Analgesia | Central Pain Syndrome | Gilbert Syndrome | Acute Anterior Uveitis | Eosinophilic Asthma | Mucolipidosis Type III | Localized Scleroderma | Progressive Encephalopathy-optic Atrophy Syndrome | Hereditary Folate Malabsorption | Choroiditis | Schwannoma | Proteasome-associated Autoinflammatory Syndrome 2 | Pure Red Cell Aplasia | Epilepsy | Canavan Disease | Headache | Anorectal Fistula | Von Willebrand Disease | Nicotine Dependence | Diarrhea | Marinesco-Sjogren Syndrome | Polymicrogyria | Paget's Disease Of The Breast | Phenylketonuria II | Ocular Surface Squamous Neoplasia | Allan-Herndon-Dudley Syndrome | Vascular Calcification | Primary Progressive Nonfluent Aphasia | Thalassemia | Encephalopathy, Hepatic | Turner's Syndrome | X-linked Creatine Transporter Deficiency | Thyroid Dyshormonogenesis | Fibrosarcoma | Holt-Oram Syndrome | Lymphoma, AIDS-related | Fibronectin Glomerulopathy | NDH Syndrome | Allergic Contact Dermatitis | Familial Exudative Vitreoretinopathy | Colon Adenoma | Pearson Syndrome | Unverricht-Lundborg Syndrome | Ichthyosis, X-linked | Eclampsia | Meningioma, Benign | Brenner Tumor | Charcot-Marie-Tooth Disease Type 4B1 | Priapism | Hypobetalipoproteinemias | Congenital Adrenal Hyperplasia 1 | Myelofibrosis | Walker-Warburg Syndrome | Optic Neuropathy, Anterior Ischemic | Bartsocas-Papas Syndrome | Fanconi Anemia | Senior-Loken Syndrome | Multiple Sclerosis | Mohr-Tranebjaerg Syndrome | Frontotemporal Dementia | Chromosome 8q21.11 Deletion Syndrome | Hypotrichosis Simplex | Synpolydactyly | Esotropia | Carney-Stratakis Syndrome | Pulverulent Zonular Cataract | Kashin-Beck Disease | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Glycogen Storage Disease Type 3 | Learning Disability | Metachromatic Leukodystrophy | X-linked Sideroblastic Anemia | Lymphangiomatosis | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Pericarditis | Trichomegaly | Tyrosinemia Type 2 | Congenital Generalized Lipodystrophy | IgA Nephropathy | Esophageal Motility Disorders | Cryptosporidiosis | Purpura | Cocaine-Related Disorders | Glanzmann Thrombasthenia | Choroideremia | Keratitis-ichthyosis-deafness Syndrome | Corneal Dystrophies, Hereditary | Myofibromatosis | Coronary Heart Disease | Xeroderma Pigmentosum | Hypoplastic Left Heart Syndrome | Retinal Detachment | Myositis, Focal | Multiple Sclerosis, Relapsing-remitting | Guttate Psoriasis | Vertigo | Osteogenesis Imperfecta Type V | Epidermolytic Ichthyosis, Annular | Phenylketonuria | Motor Neuron Diseases | POEMS Syndrome | Otopalatodigital Syndrome Type 2 | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Pulmonary Alveolar Microlithiasis | Snyder-Robinson Syndrome | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Glomerulonephritis, Membranoproliferative | Pyruvate Carboxylase Deficiency Disease | Gerstmann-Straussler-Scheinker Syndrome | Congenital Fiber-type Disproportion Myopathy | Vitamin B12 Deficiency | Carcinoid Tumor | Epiphyseal Chondrodysplasia, Miura Type | Asperger Syndrome | Down Syndrome | Diabetes Gestational | Situs Inversus | Bardet-Biedl Syndrome | Cystitis | Carcinoma, Small Cell | VACTERL/VATER Association | Borderline Personality Disorder | Infectious Diarrhea | Aicardi-Goutieres Syndrome | Tietze Syndrome | Angiomyolipoma | Facioscapulohumeral Muscular Dystrophy Type 2 | Pituitary Dwarfism | Cholestasis, Intrahepatic | Hyperinsulinism-hyperammonemia Syndrome | HIBCH Deficiency | Lattice Corneal Dystrophy Type 1 | Dermatomyositis | Trichothiodystrophy | Meningococcal Infections | Cenani-Lenz Syndactyly Syndrome | Pontocerebellar Hypoplasia Type 7 | Spinocerebellar Ataxia Type 7 | Craniofrontonasal Syndrome | Familial Glucocorticoid Deficiency | Congenital Disorders Of Glycosylation Type II | Hypotrichosis | Facioscapulohumeral Muscular Dystrophy Type 1 | Hydrolethalus Syndrome | Mabry Syndrome | Tyrosinemia Type 1 | Ocular Albinism Type 1 | Charcot-Marie-Tooth Disease | Cold-induced Sweating Syndrome | Nemaline Myopathy | Hereditary Mixed Polyposis Syndrome | Vitreoretinal Degeneration, Snowflake Type | Acromicric Dysplasia | Stiff-man Syndrome | Pompe Disease | Lathosterolosis | Frontometaphyseal Dysplasia | Immunoproliferative Disorders | Charcot-Marie-Tooth Disease, Type 2A | Discoid Lupus Erythematosus | Focal Segmental Glomerulosclerosis | Osteogenesis Imperfecta Type IV | Connective Tissue Disorders | Familial Pheochromocytoma-paraganglioma | Sick Sinus Syndrome 1 | Keratocystic Odontogenic Tumor | Patent Foramen Ovale | Congenital Lipoid Adrenal Hyperplasia | Leukoencephalopathy, Progressive Multifocal | Leber Hereditary Optic Neuropathy | Neurofibrosarcoma | Nestor-Guillermo Progeria Syndrome | Campomelic Dysplasia | Hydrops Fetalis | Congenital Bile Acid Synthesis Defect | Inflammatory Linear Verrucous Epidermal Nevus | Acute Coronary Syndrome | Cardiomyopathy, Restrictive | Measles | Achromatopsia | Corneal Ulcer | Migraine | Odonto-onycho-dermal Dysplasia | Dyslipidemia | Stuttering | Duane Retraction Syndrome | Okihiro Syndrome | Cardiac Arrest | Xeroderma Pigmentosum Variant Type | Myopia | Hypereosinophilic Syndrome | Adenomyosis | Yellow Fever | Renal Hypomagnesemia 3 | Saul-Wilson Syndrome | Rubeosis Iridis | Non-Langerhans Cell Histiocytosis | Silicosis | Epilepsy, Generalized | Pancytopenia | Prune Belly Syndrome | Coenzyme Q10 Deficiency | Ulcerative Colitis | Lichen Planus | Primary Hyperoxaluria | Pseudohypoparathyroidism Type 2 | Paronychia | Angina Pectoris | Idiopathic Multicentric Castleman Disease | Adrenomyeloneuropathy | Acrodermatitis | Renal Tubular Acidosis | Hemangioblastoma | REM Sleep Behavior Disorder | Kidney Stones | Microcephalic Primordial Dwarfism | Craniolenticulosutural Dysplasia | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Macrodactyly | Kleine-Levin Syndrome | Neurocutaneous Syndromes | Hemangioendothelioma