Congenital Disorders Of Glycosylation

About the Disease
Congenital Disorder of Glycosylation, Type in, also known as congenital disorder of glycosylation, is related to congenital disorder of glycosylation, type im and congenital disorder of glycosylation, type iim, and has symptoms including ataxia, muscle spasticity and myoclonus. An important gene associated with Congenital Disorder of Glycosylation, Type in is RFT1 (RFT1 Homolog), and among its related pathways/superpathways are Metabolism of proteins and Disease. The drugs Acetazolamide and Sorbitol have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and heart, and related phenotypes are global developmental delay and seizure

Common Targets
DPM2 | SLC35A2 | MAN2B2 | PKHD1L1 | CRIM1 | WDR41 | TMCC3 | PIGW | ALG2 | ALG12 | GALE | ALG11 | FUT8 | SRD5A3 | GALNT2 | DOLK | Chaperone (nonspecified subtype) | STPG2 | TRAPPC11 | PLXNA4 | HRNR | STT3B | SLC35A1 | MPI | DHDDS | COG4 | STT3A | XYLT2 | CKAP2 | MOGS | DDOST | COG6 | NBAS | COL6A2 | GALT | GLUL | MAN1B1 | DPAGT1 | EDEM3 | DPH7 | SSR4 | COG1 | CSGALNACT1 | ATP6V1A | STX5 | ALDOB | ALG3 | COG2 | ATP6AP1 | DPM3 | ALG1 | GMPPA | TMEM199 | OSTC | ALG6 | PGM1 | SLC5A2 | DPM1 | RFT1 | PIGS | PGM3 | FCSK | SLC39A8 | PMM2 | ALG13

Note: If you'd like to get a target analysis report for Congenital Disorders Of Glycosylation, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Congenital Disorders Of Glycosylation at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Hereditary Spastic Paraplegia | Glycogen Storage Disease Type 6 | Eclampsia | Myasthenia Gravis | Arteriosclerosis | Fanconi Syndrome | Chordoma | Spinocerebellar Ataxia Type 8 | Schindler Disease | Oligoastrocytoma | Parvovirus B19 Infection | Congenital Generalized Lipodystrophy | Ophthalmia, Sympathetic | Lafora Disease | Borjeson-Forssman-Lehmann Syndrome | Holoprosencephaly | Colitis, Collagenous | Dyggve-Melchior-Clausen Disease | Pulmonary Alveolar Proteinosis | Osteogenesis Imperfecta | Infantile Refsum Disease | Cardiomyopathy, Restrictive | Primary Hyperoxaluria | Heimler Syndrome | Pierpont Syndrome | Riboflavin Transporter Deficiency Neuronopathy | Acute Lymphocytic Leukemia | Peeling Skin Syndrome Type B | Scoliosis | Polycystic Kidney, Autosomal Recessive | Hepatitis C, Chronic | Cornelia De Lange Syndrome | Nicotine Dependence | Hereditary Neuropathy With Liability To Pressure Palsies | Congenital Poikiloderma | T-cell Prolymphocytic Leukemia | Jawad Syndrome | Loeys-Dietz Syndrome | Premenstrual Syndrome | Myoclonus | Renal Hypomagnesemia 3 | Keratosis, Seborrheic | Thyroid Hormone Resistance | Hydrolethalus Syndrome | Myocardial Infarction | Megalencephaly | Renal-hepatic-pancreatic Dysplasia | Porphyria, Variegate | Rett Syndrome | Subcortical Band Heterotopia | Schuurs-Hoeijmakers Syndrome | Focal Facial Dermal Dysplasia | Necrobiosis Lipoidica | Malaria | Peripheral T-cell Lymphoma | Hereditary Multiple Exostoses | Alazami Syndrome | Mitochondrial Encephalomyopathy | Polyomavirus Nephropathy | Opisthorchiasis | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Cancer, Brain | Influenza | Anthrax | Gray Platelet Syndrome | DiGeorge Syndrome | Myopia | Protein C Deficiency | Carney Triad | Cystinosis | Coenzyme Q10 Deficiency | Congenital Bile Acid Synthesis Defect | Nasodigitoacoustic Syndrome | Tinea Versicolor | Conn Syndrome | X-linked Sideroblastic Anemia | Metachondromatosis | Tularemia | Charcot-Marie-Tooth Disease, Type 2 | Nephrosclerosis | Campomelic Dysplasia | Achromatopsia | Cherubism | Waardenburg Syndrome Type 2 | Mast Cell Leukemia | Microphthalmia | Waardenburg Syndrome Type 2A | Cousin Syndrome | Hemorrhage | Fibrillation, Atrial | McCune-Albright Syndrome | Lattice Corneal Dystrophy | Angioedema, Acquired | Marinesco-Sjogren Syndrome | Gastritis | Ganglioneuroma | Plasmacytoma | Distal Myopathy | Van Der Knaap Disease | Smith-Lemli-Opitz Syndrome | Polydactyly | Orthostatic Intolerance | Hypertelorism | Epidermolytic Palmoplantar Keratoderma | Multiple Sulfatase Deficiency | Carcinoma, Transitional Cell | Hemangioblastoma | Thin Basement Membrane Disease | Pseudohermaphroditism | Urticaria | Niemann-Pick Disease | Hypersensitivity | Hemochromatosis | Intermittent Explosive Disorder | Primary Familial Brain Calcification | Glycogen Storage Disease Type 9 | Anorchia | Hypertension | Delayed Sleep Phase Syndrome | Waardenburg Syndrome | Tyrosinemia Type 2 | Nephropathy | Skin Carcinoma | Alexander Disease | Oculocutaneous Albinism Type 1 | Orotic Aciduria | Pancytopenia | Ganglioglioma | Loeys-Dietz Syndrome Type 4 | Ollier Disease | HELLP Syndrome | Osteochondrosis | Waardenburg Syndrome Type 2E | Leukoplakia | Pituitary Stalk Interruption Syndrome | Diamond-Blackfan Anemia | Mevalonate Kinase Deficiency | Von Willebrand Disease | Blue Nevus | Leukocyte Adhesion Deficiency Type 1 | Myoclonus-dystonia Syndrome | Stevens-Johnson Syndrome | Brachial Plexus Neuropathy | Polymicrogyria | Synpolydactyly | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Mitochondrial DNA Depletion Syndrome 13 | Cardiomyopathy, Peripartum | Necrotizing Autoimmune Myopathy | Raine Syndrome | Ebstein Anomaly | Renal Medullary Carcinoma | Malnutrition | Inflammatory Linear Verrucous Epidermal Nevus | Dyslipidemia | Renpenning Syndrome | Mycosis Fungoides | Cranial Nerve Disease | Lipodystrophy | Intestinal Pseudo-obstruction | Huntington's Disease-like 2 | Infertility, Male | Kohlschutter-Tonz Syndrome | Lichen Planus | Schistosomiasis | Lewy Body Dementia | Amyotrophic Lateral Sclerosis, Juvenile | Corneal Edema | Rosacea | Charcot-Marie-Tooth Disease Type 2T | Spinocerebellar Ataxia Type 23 | Acrodermatitis Enteropathica | Hydrops Fetalis | Enhanced S-cone Syndrome | Treacher Collins Syndrome | Juvenile Xanthogranuloma | Congenital Ichthyosiform Erythroderma | Exotropia | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Encephalopathy, Glycine | Dystonia Musculorum Deformans | Syndactyly | Angiomyolipoma | Prostatitis | Atherosclerosis | Atrioventricular Septal Defect | Congenital Dyserythropoietic Anemia Type 4 | Oculopharyngeal Muscular Dystrophy | Gingivitis | Addison Disease | Bartter Syndrome | Cystitis, Interstitial | Overactive Bladder | Pneumonia, Viral | Blood Protein Disorders | Peeling Skin Syndrome, Acral Type | Neural Tube Defect | Keratopathy | Spinocerebellar Ataxia Type 1 | IMAGe Syndrome | Congenital Myopathy | Iron Overload | Larsen Syndrome | Posterior Polar Cataract | Hidradenitis Suppurativa | Cholelithiasis | Malignant Fibrous Histiocytoma | Osteoporosis | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Acute Anterior Uveitis | Antley-Bixler Syndrome | Sclerosteosis 2 | Wolcott-Rallison Syndrome | Pineoblastoma | Superficial Spreading Melanoma | X-linked Creatine Transporter Deficiency | Porphyria, Acute Intermittent | Intestinal Tuberculosis | Chondrodysplasia Punctata 1, X-linked Recessive | Basal Ganglia Disease, Biotin-responsive | Oligospermia | Relapsing Polychondritis | Ameloblastic Carcinoma | Tic Disorder | Nephronophthisis | Pycnodysostosis | Asperger Syndrome | Cataplexy | Fragile X Syndrome | Esophagitis | Localized Scleroderma | Acne Vulgaris | Esophageal Adenocarcinoma | Intestinal Obstruction | Sarcomatoid Carcinoma Of The Lung | Spinocerebellar Ataxia Type 27 | Zygomycosis | Graft-versus-host Disease | Limb Girdle Muscular Dystrophy | Keratosis | Progressive Familial Intrahepatic Cholestasis Type 3 | Cellulitis | Leber Congenital Amaurosis | Metabolic Diseases | Multiple Sclerosis, Secondary Progressive | Systemic Mastocytosis | Kawasaki Disease | Ocular Surface Squamous Neoplasia | Inflammatory Bowel Disease | Alcoholism | Hemoglobinopathies | Chiari Malformation Type I | Basan Syndrome | TARP Syndrome | Exocrine Pancreatic Insufficiency | Hypertension, Renal | Hydrocephalus | Speech Disorders | HANAC Syndrome | Seizures | Basal Ganglia Disease | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Interstitial Lung Diseases | B-cell Chronic Lymphocytic Leukemia | Congenital Nephrotic Syndrome | Familial Dysautonomia | Cystitis | Brooke-Spiegler Syndrome | Cluster Headache | Epidermolytic Hyperkeratosis | Aldosteronism | Periventricular Nodular Heterotopia | Pyruvate Decarboxylase Deficiency | Galactosemia | Persistent Hyperplastic Primary Vitreous | Rhabdomyosarcoma, Embryonal | Rothmund-Thomson Syndrome | Carney-Stratakis Syndrome | Nevus | Fibrosarcoma | Feingold Syndrome | Down Syndrome | Stromal Corneal Dystrophy | Carbohydrate Metabolism Disorders | Acromicric Dysplasia | Hamartoma | IgA Nephropathy | Idiopathic Pulmonary Fibrosis | Heterotaxy | Eccrine Porocarcinoma | Chondrodysplasia Punctata 2, X-linked Dominant | Alpha-mannosidosis | Combined Malonic And Methylmalonic Acidemia | Cenani-Lenz Syndactyly Syndrome | Familial Isolated Hyperparathyroidism | Congenital Aniridia | Glycogen Storage Disease Type 0 | 3C Syndrome | Lung Diseases | Glycogen Storage Disease Type 4 | Diabetic Encephalopathy | Androgenic Alopecia | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Evans Syndrome | Colitis, Microscopic | Infertility | Amyloidosis | Angiosarcoma | Myositis, Focal | Auriculocondylar Syndrome | Maple Syrup Urine Disease | Christianson Syndrome | Craniosynostosis | Paraganglioma | Varices | PASLI Disease | Primary Aldosteronism | Discoid Lupus Erythematosus | Osteitis | Johanson-Blizzard Syndrome | Chronic Beryllium Disease | Optic Nerve Diseases | Choroiditis | Adenylosuccinate Lyase Deficiency | Charcot-Marie-Tooth Disease, Type 6 | Mucormycosis | Psoriasis | Osteochondroma | Erythematotelangiectatic Rosacea | Benign Hereditary Chorea | Panniculitis | Amenorrhea | Vitreoretinal Degeneration, Snowflake Type | Postpoliomyelitis Syndrome | Stuttering | Infantile Neuroaxonal Dystrophy | Intellectual Disability, Autosomal Dominant 5 | Homocystinuria | Meningioma | Spondylocarpotarsal Synostosis Syndrome | Neuroblastoma | Cat Eye Syndrome | Scapuloperoneal Spinal Muscular Atrophy | Stuve-Wiedemann Syndrome | Eczema | Irritable Bowel Syndrome | Donnai-Barrow Syndrome | Nager Acrofacial Dysostosis | Tyrosine Hydroxylase Deficiency | Basal Cell Nevus Syndrome | Retinal Degeneration | Adenoma, Villous | Dementia | Osteogenesis Imperfecta Type II | Leber Hereditary Optic Neuropathy | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Anosmia, Congenital | 3-hydroxy-3-methylglutaric Aciduria | Familial Hypertrophic Cardiomyopathy | Progressive Osseous Heteroplasia | Dysplastic Nevus | Pseudo-pseudohypoparathyroidism | Chordoid Glioma | Melanocytic Nevus | Carcinoma, Small Cell | Acute Coronary Syndrome | Hypercholesterolemia | Schaaf-Yang Syndrome | Familial Advanced Sleep Phase Syndrome | Tuberculous Meningitis | Meesmann Corneal Dystrophy | Proopiomelanocortin Deficiency | Autosomal Recessive Congenital Ichthyosis | Autonomic Neuropathy | Axenfeld-Rieger Syndrome | Obesity, Morbid | Aspartylglycosaminuria | N-acetylglutamate Synthase Deficiency | Erectile Dysfunction | Charcot-Marie-Tooth Disease, Type 2C | Bone Giant Cell Tumor | Dyslexia | Diabetes Type 2 | Walker-Warburg Syndrome | Ureteropelvic Junction Obstruction | Holt-Oram Syndrome | Cold Agglutinin Disease | Hyperphenylalaninemia | Encephalitis, Tick-borne | Ulcerative Colitis | Gigantism | Menetrier Disease | Splenomegaly | Arthritis, Gouty | Phenylketonuria II | Nephrotic Syndrome | Epidermolytic Ichthyosis, Annular | CREST Syndrome | Leukoencephalopathy, Progressive Multifocal