Congenital Disorders Of Glycosylation

About the Disease
Congenital Disorder of Glycosylation, Type in, also known as congenital disorder of glycosylation, is related to congenital disorder of glycosylation, type im and congenital disorder of glycosylation, type iim, and has symptoms including ataxia, muscle spasticity and myoclonus. An important gene associated with Congenital Disorder of Glycosylation, Type in is RFT1 (RFT1 Homolog), and among its related pathways/superpathways are Metabolism of proteins and Disease. The drugs Acetazolamide and Sorbitol have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and heart, and related phenotypes are global developmental delay and seizure

Common Targets
DPM2 | SLC35A2 | MAN2B2 | PKHD1L1 | CRIM1 | WDR41 | TMCC3 | PIGW | ALG2 | ALG12 | GALE | ALG11 | FUT8 | SRD5A3 | GALNT2 | DOLK | Chaperone (nonspecified subtype) | STPG2 | TRAPPC11 | PLXNA4 | HRNR | STT3B | SLC35A1 | MPI | DHDDS | COG4 | STT3A | XYLT2 | CKAP2 | MOGS | DDOST | COG6 | NBAS | COL6A2 | GALT | GLUL | MAN1B1 | DPAGT1 | EDEM3 | DPH7 | SSR4 | COG1 | CSGALNACT1 | ATP6V1A | STX5 | ALDOB | ALG3 | COG2 | ATP6AP1 | DPM3 | ALG1 | GMPPA | TMEM199 | OSTC | ALG6 | PGM1 | SLC5A2 | DPM1 | RFT1 | PIGS | PGM3 | FCSK | SLC39A8 | PMM2 | ALG13

Note: If you'd like to get a target analysis report for Congenital Disorders Of Glycosylation, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Congenital Disorders Of Glycosylation at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Portal Vein Thrombosis | Melanoma, Uveal | Glycogen Storage Disease Type 0, Muscle | Common Cold | Aarskog-Scott Syndrome | Cancer, Breast | Impulse Control Disorder | Influenza | Periodic Limb Movement Disorder | Diastrophic Dysplasia | Congenital Afibrinogenemia | Scleritis | Kashin-Beck Disease | Anorexia Nervosa | Erythrokeratodermia Variabilis | Glycogen Storage Disease Type 5 | Woodhouse-Sakati Syndrome | Iron Deficiency Anemia | Malnutrition | Optic Neuropathy, Anterior Ischemic | Dentinogenesis Imperfecta | Pneumothorax | Hypocalcemia | Chondrodysplasia Punctata | Cannabis Abuse | Hyperthyroidism | GNE Myopathy | Chorioretinitis | Rett Syndrome | Martsolf Syndrome | Eclampsia | Yellow Fever | Fetal Akinesia Deformation Sequence | Krabbe Disease | Urea Cycle Disorder | Wiskott-Aldrich Syndrome | Inflammatory Myofibroblastic Tumor | Hemorrhagic Disorders | Lipid Storage Myopathy | ADNP Syndrome | Cluster Headache | Sleep Disorder | Panuveitis | HANAC Syndrome | Hemophagocytic Lymphohistiocytosis | Myotonic Disorders | HUPRA Syndrome | Myoclonic Epilepsy With Ragged Red Fibers | Dystonia Musculorum Deformans | Anuria | Tylosis With Esophageal Cancer | Congenital Myasthenic Syndrome | Corneal Edema | Amyotrophic Lateral Sclerosis | IgA Deficiency | Alzheimer Disease, Late Onset | Acute Tubular Necrosis | Wolman Disease | Thanatophoric Dysplasia Type 1 | Tenosynovial Giant Cell Tumor | Spinal Muscular Atrophy | Nicotine Dependence | Splenomegaly | Keratosis, Actinic | Hyperinsulinemia | Proteus Syndrome | Autosomal Recessive Spastic Paraplegia Type 35 | Hereditary Pyropoikilocytosis | Blepharitis | Hodgkin Lymphoma | Cholestasis, Intrahepatic | Seborrheic Dermatitis | Myopia | Spitz Nevus | Rosacea | Cancer, Prostate | Acrodermatitis | Heart Block | Adenomyosis | Migraine | Cardiospondylocarpofacial Syndrome | Retinal Dystrophy | Gestational Trophoblastic Disease | Retinoblastoma | Anencephaly | Polycythemia | Congenital Muscular Dystrophy | Infantile Refsum Disease | Analgesia | Multiple Sclerosis, Primary Progressive | Alopecia Totalis | Myositis, Focal | Cherubism | Malignant Fibrous Histiocytoma | Schistosomiasis | Tuberculous Meningitis | Angioedema, Acquired | Hypokalemia | Microphthalmia | Peroxisomal Disorder | Microcephaly | Alexander Disease | Bursitis | Proteasome-associated Autoinflammatory Syndrome 2 | Pearson Syndrome | Epithelial-myoepithelial Carcinoma | Focal Dermal Hypoplasia | Skin Papilloma | Oculocutaneous Albinism Type 2 | Agnathia-Otocephaly Complex | Wolfram Syndrome 2 | Diabetes Insipidus, Nephrogenic | Superficial Spreading Melanoma | Porphyria, Acute Intermittent | Neurocysticercosis | Adenoma, Pituitary | Sensorineural Hearing Loss | Progressive Familial Intrahepatic Cholestasis Type 2 | Schaaf-Yang Syndrome | Hypertrophy | Echinococcosis | Cancer, Bladder | Mucolipidosis Type IV | Cystinuria | Cervical Dystonia | Hereditary Sensory Neuropathy Type 1 | Pneumonia, Viral | Craniofacial Dysostosis | Keratosis | Mevalonate Kinase Deficiency | Ischemia | Iron Overload | Parvovirus B19 Infection | Sclerocornea | Schindler Disease | TARP Syndrome | B-cell Prolymphocytic Leukemia | Sporadic Inclusion Body Myositis | Insulin Resistance | Trichuriasis | Chordoid Glioma | Joubert Syndrome | Chronic Periodontitis | Thyroid Dyshormonogenesis | Alstrom Syndrome | Mucolipidosis | Tremor | Pituitary Dwarfism | Xeroderma Pigmentosum | Obsessive-compulsive Disorder | Genee-Wiedemann Syndrome | Papilloma | Diabetes Type 2 | Oguchi Disease-2 | Ameloblastoma | Myelomeningocele | Desbuquois Syndrome | Asthma | Nanophthalmos | Neurocutaneous Syndromes | Chloridorrhea, Congenital | Premature Ejaculation | Diamond-Blackfan Anemia | Hyperlipidemia, Familial Combined | Ureteropelvic Junction Obstruction | Poretti-Boltshauser Syndrome | Diverticulitis | Adenylosuccinate Lyase Deficiency | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Early Infantile Epileptic Encephalopathy | NGLY1 Deficiency | Hepatitis, Alcoholic | Erythema Multiforme | Focal Facial Dermal Dysplasia | Chromosome 16p11.2 Deletion Syndrome | Farber Disease | Synpolydactyly | Hereditary Xerocytosis | Abetalipoproteinemia | Phosphoglycerate Dehydrogenase Deficiency | Glycogen Storage Disease Type 9 | Methemoglobinemia | Tatton-Brown-Rahman Syndrome | Acute Kidney Injury | Bulimia Nervosa | Infectious Diarrhea | Genitopatellar Syndrome | Mastitis | Nail Disorder, Nonsyndromic Congenital | Birk-Barel Syndrome | Hepatitis | Gliosarcoma | Colitis, Lymphocytic | Occipital Neuralgia | Alveolar Capillary Dysplasia | Pseudohypoaldosteronism | Schizophrenia, Paranoid | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Acrocallosal Syndrome | Open-angle Glaucoma | Cutis Laxa | Dermatomyositis | Carcinoma, Signet Ring Cell | GLUT1 Deficiency Syndrome | ACTH-independent Macronodular Adrenal Hyperplasia | Congenital Fiber-type Disproportion Myopathy | Frontotemporal Dementia | Hemochromatosis Type 1 | Nevus | Plasmacytoma | Bronchitis, Chronic | Histiocytosis | Fowler's Syndrome | Cornelia De Lange Syndrome | Citrullinemia | Hereditary Spherocytosis | Acute Generalized Exanthematous Pustulosis | Charcot-Marie-Tooth Disease Type 3 | Usher Syndrome Type II | Choroiditis | Spina Bifida | Tardive Dyskinesia | Hypogonadism | Otitis Media | Tracheal Disorders | Subacute Sclerosing Panencephalitis | Sweet Syndrome | Leber Congenital Amaurosis | Blepharophimosis Syndrome | Chondrodysplasia Punctata 2, X-linked Dominant | Stroke, Hemorrhagic | Esotropia | Graves Disease | Stomatitis | Adult Polyglucosan Body Disease | Erythema Nodosum | Fibromuscular Dysplasia | Erythropoietic Protoporphyria | Vitamin A Deficiency | Metaphyseal Chondrodysplasia, Schmid Type | Hepatitis C, Chronic | Usher Syndrome Type I | Tumoral Calcinosis | Primary Hyperoxaluria Type 3 | Spinocerebellar Ataxia Type 40 | Oculocutaneous Albinism | Norrie Disease | Long QT Syndrome Type 2 | Fontaine Progeroid Syndrome | Congenital Tufting Enteropathy | Dengue Hemorrhagic Fever | Polymyositis | Carbonic Anhydrase VA Deficiency | Anthrax | Pernicious Anemia | Thyroiditis, Autoimmune | Sandhoff Disease | Dyggve-Melchior-Clausen Disease | Spitzoid Melanoma | Microcephaly, Seizures, And Developmental Delay | Primary Carnitine Deficiency | Spinocerebellar Ataxia Type 13 | Lissencephaly 2 | Juvenile Myoclonic Epilepsy | Localized Scleroderma | Glaucoma | Hyperandrogenemia | Hepatoblastoma | Perry Syndrome | Guttate Psoriasis | Spinocerebellar Ataxia Type 16 | High Molecular Weight Kininogen Deficiency | Metatropic Dysplasia | LEOPARD Syndrome | Wilson's Disease | Thyrotoxic Periodic Paralysis | Werner's Syndrome | Paracoccidioidomycosis | Thalassemia | Meningioma | Spinocerebellar Ataxia Type 3 | Epidermolytic Ichthyosis, Annular | Hypopituitarism | Leiomyoma | Skin Carcinoma | Hypersensitivity | Charcot-Marie-Tooth Disease, Type 2A | Hepatitis, Autoimmune | Rhabdomyosarcoma, Alveolar | Oculocutaneous Albinism Type 4 | Benign Hereditary Chorea | Gallstones | Autoimmune Disease | Nephritis, Interstitial | Chitayat Syndrome | Muscular Dystrophy | Basal Ganglia Disease | Schizoaffective Disorder | Idiopathic Multicentric Castleman Disease | Primrose Syndrome | Esophageal Adenocarcinoma | Familial Hyperaldosteronism | Eiken Syndrome | Neuroleptic Malignant Syndrome | Pyelonephritis | NDH Syndrome | Pierson Syndrome | Adenocarcinoma | Hemorrhoids | Asperger Syndrome | Reye Syndrome | Early Infantile Epileptic Encephalopathy 1 | Neurofibromatosis | Infertility | Major Depression | Facioscapulohumeral Muscular Dystrophy | T-cell Lymphoma, Subcutaneous Panniculitis-like | Congenital Hemolytic Anemia | Hypoglycemia | Ichthyosis Bullosa Of Siemens | Hamartoma | Progressive Familial Intrahepatic Cholestasis Type 1 | Lichen Planus | Hypothyroidism | Membranous Nephropathy | Endometrial Hyperplasia | KBG Syndrome | Venous Insufficiency | Congenital Dyserythropoietic Anemia Type 4 | Saethre-Chotzen Syndrome | Clouston Hidrotic Ectodermal Dysplasia | Cardiac Sarcoidosis | Cholelithiasis | Pulmonary Tuberculosis | Fibrillation, Atrial | Bullous Pemphigoid | Milk Allergy | Metanephric Adenoma | Tendinopathy | Aicardi-Goutieres Syndrome | Ulcerative Colitis | Long QT Syndrome Type 1 | Pigment Dispersion Syndrome | Intracerebral Hemorrhage | Treacher Collins Syndrome | Distal Myopathy | Leishmaniasis, Visceral | Erythromelalgia | Guanidinoacetate Methyltransferase Deficiency | Proximal Symphalangism | Multiple Myeloma | Pouchitis | Combined Pituitary Hormone Deficiency | Vertigo | Oligospermia | Lipid Storage Diseases | IgA Nephropathy | Van Der Knaap Disease | Corneal Dystrophy | Coronary Heart Disease | Branchiootorenal Syndrome | Erectile Dysfunction | Coma | Cancer, Brain | Optic Neuropathy | Ventricular Septal Defect | Spinocerebellar Ataxia Type 31 | Epilepsy Of Infancy With Migrating Focal Seizures | Sertoli Cell-only Syndrome | Enterocolitis, Necrotizing | Cutaneous Angiosarcoma | Trichorhinophalangeal Syndrome | Cerebellofaciodental Syndrome | Central Retinal Artery Occlusion | Crigler-Najjar Syndrome | Metabolic Diseases | Glioblastoma | Castleman Disease | Lattice Corneal Dystrophy | Best Macular Dystrophy | Cutaneous Mastocytosis | Cabezas Syndrome | Acne | Patent Foramen Ovale | Paraplegia | Gastroenteritis | Schnyder Crystalline Corneal Dystrophy | Juvenile Hyaline Fibromatosis | Sturge-Weber Syndrome | Shwachman-Bodian-Diamond Syndrome | Cancer, Kidney | Osteogenesis Imperfecta Type VI | Adenoma, Pleomorphic | Kernicterus | Malaria, Cerebral | Renal Failure | Basal Cell Nevus Syndrome | Crohn's Disease | 3-M Syndrome | Isovaleric Acidemia