Splenomegaly

About the Disease
Splenomegaly is related to myeloid and lymphoid neoplasms associated with pdgfra rearrangement and leukemia, chronic myeloid. An important gene associated with Splenomegaly is SBDS (SBDS Ribosome Maturation Factor), and among its related pathways/superpathways are PI3K-Akt signaling pathway and NF-kappaB Signaling. The drugs Lenalidomide and Obinutuzumab have been mentioned in the context of this disorder. Affiliated tissues include spleen, bone marrow and bone, and related phenotypes are homeostasis/metabolism and cellular

Common Targets
G7157 | MIR21 | TLR2 | CBL | IL1B | TLR9 | JAK2 | IFNL4 | G7099 | IL12B | SOS1 | CD209

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